RCT | New drug can improve constipation in patients with Parkinson Disease.

Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text) 

Commentaries:  

New Drug Could Ease Parkinson’s-Related Constipation – HealthDay 

Oral ENT-01 safe, significantly improves constipation in persons with Parkinson disease – American College of Physicians 

Commentary on Twitter 

A #RTC of 150 persons with #ParkinsonDisease has found that ENT-01 is safe for up to 25 days of treatment and significantly improves constipation and possibly neurological symptoms: https://t.co/JdDhaHiFOA @MayoClinic pic.twitter.com/IWWCBzvrWV

— Annals of Int Med (@AnnalsofIM) November 8, 2022