Pharmacology/Pharmaceutical Industry
UK to refine allergy warning on Pfizer vaccine sparked by two adverse reactions
10 Dec, 2020 | 08:41h | UTCUK to refine allergy warning on Pfizer vaccine sparked by two adverse reactions – Reuters
See also: UK probes whether COVID-19 vaccine caused allergic reactions – Associated Press AND NHS told not to give Covid vaccine to those with history of allergic reactions – The Guardian
Just published: AstraZeneca-Oxford Covid-19 vaccine shows moderate efficacy, but questions remain about the most effective dosing regimen
9 Dec, 2020 | 08:25h | UTCCommentaries: Oxford COVID vaccine paper highlights lingering unknowns about results – Nature AND Detailed data on AstraZeneca-Oxford Covid-19 vaccine show it has moderate efficacy – STAT AND Oxford–AstraZeneca COVID-19 vaccine efficacy – The Lancet AND Oxford COVID-19 vaccine is safe and protects against disease, first published results from phase 3 trials – The Lancet AND Expert reaction to a study on the results of phase 3 human trials of the Oxford/AZ COVID-19 vaccine – Science Media Centre
How rich countries are ‘hoarding’ the world’s vaccines, in charts
10 Dec, 2020 | 08:40h | UTCHow Rich Countries Are ‘Hoarding’ The World’s Vaccines, In Charts – NPR
See also: How COVID vaccines are being divvied up around the world – Nature AND Rich countries hoarding Covid vaccines, says People’s Vaccine Alliance – BBC AND Amnesty: rich countries have bought too many COVID-19 vaccines – Reuters
Another randomized trial shows hydroxychloroquine is not effective as postexposure prophylaxis to prevent Covid-19
9 Dec, 2020 | 08:19h | UTCSummary for patients: Summary for Patients: Postexposure Hydroxychloroquine Prophylaxis to Prevent SARS-CoV-2 Infection
New vaccine data is coming: Watch out for these 3 claims
9 Dec, 2020 | 08:17h | UTCNew Vaccine Data Is Coming: Watch Out for These 3 Claims – Wired
Randomized trial: No benefit and potential harm from Vitamin D at doses of 1000 IU/d or higher compared with 200 IU/d in older persons with elevated fall risk
9 Dec, 2020 | 08:13h | UTCCommentaries: Study Finds No Benefit, Possible Harm to Seniors’ Fall Risks with Higher Doses of Vitamin D – Johns Hopkins Medicine AND Does High-Dose Vitamin D Actually Heighten Fall Risk? – Physician’s Weekly
Commentary on Twitter (thread – click for more)
https://twitter.com/ErinMichos/status/1336091776994537472
WHO set to approve a COVID-19 vaccine by the end of 2020—increasing hopes for equitable access
8 Dec, 2020 | 08:09h | UTC
Opinion: “Get ready for vaccine false side effects”. When millions of people are vaccinated, naturally occurring health problems could be wrongly attributed to vaccines
8 Dec, 2020 | 07:55h | UTCGet Ready for False Side Effects – Science Translational Medicine
First-of-its-kind African trial tests common drugs to prevent severe COVID-19. “Could cheap, widely available drugs prevent patients with mild illness from becoming severely sick?”
8 Dec, 2020 | 07:46h | UTCFirst-of-its-kind African trial tests common drugs to prevent severe COVID-19 – Science
Observational study: Even low dose oral glucocorticoids linked to increased cardiovascular risk in people with immune-mediated inflammatory diseases
8 Dec, 2020 | 07:35h | UTCCommentary: Patients receiving low dose steroid at increased risk of cardiovascular disease – Public Library of Science
Randomized trial: In pregnant women with mild and moderate chronic hypertension, the use of labetalol was associated with more adverse events compared to methyldopa or no medication
8 Dec, 2020 | 07:26h | UTC
Spironolactone use is associated with improved outcomes in patients with heart failure with preserved ejection fraction and concomitant resistant hypertension
8 Dec, 2020 | 07:44h | UTC
WHO Guidance for improving acceptance and uptake of COVID-19 vaccines
7 Dec, 2020 | 01:16h | UTCCommentary: Guidance For Improving Vaccine Uptake Published By WHO TAG – Health Policy Watch
The UK has approved a COVID vaccine — but scientists still have many questions. One of them is if the vaccines will prevent the transmission of the disease
7 Dec, 2020 | 00:52h | UTCThe UK has approved a COVID vaccine — here’s what scientists now want to know – Nature
Case-control study: Meningococcus B vaccine prevents disease with 79 percent effectiveness in children and young adults
6 Dec, 2020 | 23:48h | UTCCommentary: Meningococcus B vaccine prevents disease with 79 per cent effectiveness in under-18s – University of Bristol
Commentary on Twitter
In this matched case-control study, children who developed meningococcal disease were less likely to have been vaccinated with 4CMenB vs matched controls without meningococcal disease during the first 5y of vaccine availability in Portugal https://t.co/dGagZ3aTIB @adamhfinn
— JAMA (@JAMA_current) December 3, 2020
Randomized trial: High-dose influenza vaccine shows no additional benefit for heart disease patients
7 Dec, 2020 | 00:44h | UTCEditorial: Influenza Vaccine for Patients With High-risk Cardiovascular Disease
Commentary: High-dose influenza vaccine shows no additional benefit for heart disease patients – NIH News Releases
Commentary on Twitter
In patients w high-risk CVD, high-dose trivalent influenza vaccine, vs standard-dose quadrivalent vaccine, did not significantly reduce all-cause mortality or cardiopulmonary hospitalizations https://t.co/I3XygBajQL
— JAMA (@JAMA_current) December 4, 2020
Meta-analysis reinforces the safety of betablockers in patients with COPD and cardiovascular disease
6 Dec, 2020 | 23:30h | UTCCommentary: Beta-Blockers in Patients With COPD and CVD – American College of Cardiology
Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program
4 Dec, 2020 | 08:33h | UTCEditorial: Evolving Strategies for Long-term Asthma Management – JAMA
Commentaries: New Asthma Guidelines Published in The Journal of Allergy and Clinical Immunology, an Official Journal of the AAAAI – American Academy of Allergy, Asthma & Immunology AND New updates to federal guidelines revamp asthma management – NHLBI News
Perspective: Why most countries won’t benefit from Moderna and Pfizer’s Covid-19 vaccines
4 Dec, 2020 | 08:14h | UTCWhy Most Countries Won’t Benefit From Moderna And Pfizer’s Covid-19 Vaccines – Forbes
Moderna vaccine: Antibody levels persist for at least 4 months
4 Dec, 2020 | 08:16h | UTCDurability of Responses after SARS-CoV-2 mRNA-1273 Vaccination – New England Journal of Medicine
China has promised millions of coronavirus vaccines to countries globally. And it is ready to deliver them.
4 Dec, 2020 | 08:12h | UTC
WHO looks at possible ‘e-vaccination certificates’ for travel
4 Dec, 2020 | 08:09h | UTCWHO looks at possible ‘e-vaccination certificates’ for travel – Reuters
UK becomes first country to authorize Pfizer/BioNTech’s Covid-19 vaccine, first shots roll out next week
3 Dec, 2020 | 08:44h | UTCPress release: UK medicines regulator gives approval for first UK COVID-19 vaccine – Medicines and Healthcare products Regulatory Agency
See also: Covid-19: Pfizer/BioNTech vaccine judged safe for use in UK – BBC AND Expert reaction to news that the MHRA has approved the Pfizer/BioNTech COVID-19 vaccine for mass UK roll out – Science Media Centre AND UK approves Pfizer/BioNTech Covid vaccine for rollout next week – The Guardian
WHO Solidarity Trial: Remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19
3 Dec, 2020 | 08:47h | UTCAudio Interview: Caring for Hospitalized Patients with Covid-19
Commentary on Twitter (thread – click for more)
The biggest multinational pandemic randomised trial #SOLIDARITYtrial published in the New England Journal of Medicine. https://t.co/VbpbpziFwm
WHO, trial leaders, numerous countries, hospitals, doctors, nurses, patients & many others are to be congratulated!
Key results 👇🏾 1/5 pic.twitter.com/Xe9K6EfUpc
— Kari Tikkinen (@KariTikkinen) December 2, 2020
Randomized trial: In treatment naive early rheumatoid arthritis, a treatment based on methotrexate and low dose corticosteroids was safe and effective and non-inferior to certolizumab and tocilizumab, but not to abatacept
3 Dec, 2020 | 08:35h | UTC