Randomized trial: In treatment naive early rheumatoid arthritis, a treatment based on methotrexate and low dose corticosteroids was safe and effective and non-inferior to certolizumab and tocilizumab, but not to abatacept 3 Dec, 2020 | 08:35h | UTC Active conventional treatment and three different biological treatments in early rheumatoid arthritis: phase IV investigator initiated, randomised, observer blinded clinical trial – The BMJ