Pharmacology/Pharmaceutical Industry
Special Report: The Covid-19 vaccines are a marvel of science. Here’s how we can make the best use of them
3 Dec, 2020 | 08:42h | UTCThe Covid-19 vaccines are a marvel of science. Here’s how we can make the best use of them – STAT
Review: Perioperative venous thromboembolism prophylaxis
3 Dec, 2020 | 08:28h | UTCPerioperative Venous Thromboembolism Prophylaxis – Mayo Clinic Proceedings
Opinion: “Put an end to publication by proclamation for Covid vaccines”
2 Dec, 2020 | 07:27h | UTCPut An End To Publication By Proclamation For Covid Vaccines – Forbes
CDC panel moves health workers, nursing home residents to front of COVID vaccine line
2 Dec, 2020 | 07:26h | UTCCDC panel moves health workers, nursing home residents to front of COVID vaccine line – CIDRAP
Cohort study: Higher dose Z-drug use in dementia is associated with increased fracture and stroke risks, similar or greater to that for higher dose benzodiazepines
1 Dec, 2020 | 08:25h | UTCCommentary: The danger of Z-drugs for dementia patients – University of Exeter
NICE COVID-19 guideline: Prevention of thromboembolism in patients with COVID-19. “For patients who are having advanced respiratory support: consider increasing pharmacological VTE prophylaxis to an intermediate dose”
1 Dec, 2020 | 08:19h | UTC
Moderna released more Covid-19 vaccine results. They’re very encouraging.
1 Dec, 2020 | 08:15h | UTCModerna released more Covid-19 vaccine results. They’re very encouraging. – Vox
Commentaries: ‘Absolutely remarkable’: No one who got Moderna’s vaccine in trial developed severe COVID-19 – Science AND Moderna to submit Covid-19 vaccine to FDA as full results show 94% efficacy – STAT AND More Good News For Moderna’s COVID-19 Vaccine Candidate – NPR AND Moderna to seek emergency authorization for COVID-19 vaccine – CIDRAP
Commentary on Twitter
Moderna has announced the final results of the 30,000-person efficacy trial for its #COVID19 vaccine candidate, reporting that the vaccine had 100% efficacy against severe disease. https://t.co/Cgg0I5nv9r
— News from Science (@NewsfromScience) November 30, 2020
Comprehensive review on the management of pharmaceutical and recreational drug poisoning
1 Dec, 2020 | 08:21h | UTCManagement of pharmaceutical and recreational drug poisoning – Annals of Intensive Care
Opinion: Pfizer and Moderna’s “95% effective” vaccines—let’s be cautious and first see the full data
1 Dec, 2020 | 08:13h | UTC
Colchicine to be investigated as a possible treatment for COVID-19 in the RECOVERY trial
1 Dec, 2020 | 08:08h | UTCCommentary: Gout drug Colchicine to be tested as COVID-19 treatment in UK trial – Reuters
AstraZeneca vaccine most attractive option for Africa, says WHO – Astra Zeneca CEO says company will run new trial to test more efficient dose
1 Dec, 2020 | 08:05h | UTC
Meta-analysis of statins for primary prevention: 100 adults (aged 50-75 years) without known cardiovascular disease would have to be treated for 2.5 years to prevent 1 major adverse cardiovascular event
30 Nov, 2020 | 00:56h | UTCEvaluation of Time to Benefit of Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years: A Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentary: Time to Benefit of Statins for Primary Prevention of Cardiovascular Events – American College of Cardiology
Commentary on Twitter
It takes 2.5 years for the benefits of #statins to be seen. Frail older adults with life expectancy <2.5 years may be more likely to be harmed than helped by statins https://t.co/jbdW7bXopt
— JAMA Internal Medicine (@JAMAInternalMed) November 16, 2020
Perspective: “With global push for COVID-19 vaccines, China aims to win friends and cut deals”
27 Nov, 2020 | 08:26h | UTCWith global push for COVID-19 vaccines, China aims to win friends and cut deals – Science
India coronavirus: How do you vaccinate a billion people?
27 Nov, 2020 | 08:24h | UTCIndia coronavirus: How do you vaccinate a billion people? – BBC
Should COVID-19 vaccines be mandatory? Two experts discuss
26 Nov, 2020 | 09:05h | UTCShould COVID-19 vaccines be mandatory? Two experts discuss – The Conversation
Opinion: “The AstraZeneca Covid Vaccine Data Isn’t Up to Snuff”
26 Nov, 2020 | 09:02h | UTCThe AstraZeneca Covid Vaccine Data Isn’t Up to Snuff – Wired
Commentaries: A timeline of the oxford-Astrazeneca Covid-19 vaccine trials – by Hilda Bastian AND After Admitting Mistake, AstraZeneca Faces Difficult Questions About Its Vaccine – The New York Times AND AstraZeneca manufacturing error clouds vaccine study results – Associated Press
Meta-analysis: Among the treatment interventions to maintain abstinence from alcohol in primary care, acamprosate was the only intervention with enough evidence of benefit
26 Nov, 2020 | 08:55h | UTC
Commentary on Twitter
Acamprosate was the only intervention with enough evidence of benefit for maintaining alcohol abstinence and acceptability up to 12 months after detoxification in primary care settings, concludes new #BMJResearchhttps://t.co/K7FutIC3yd
— The BMJ (@bmj_latest) November 25, 2020
Cohort study suggests there is no need to choose first-line drug treatment for hypertension according to age and ethnicity – guidelines could be simplified
26 Nov, 2020 | 08:56h | UTCCommentary: Study questions blood pressure drug guidance based on age and ethnicity – British Medical Journal AND Laurie Tomlinson: Shining a light into medicine’s dusty corners – The BMJ Opinion AND UK’s NICE Guidelines for Hypertension Tx Based on Age, Ethnicity May Need Updating – Physician’s Weekly AND
Commentary on Twitter
Current UK guidance on drug treatment for high blood pressure, which differs depending on a patient’s age and ethnicity, could be simplified in line with other international guidelines, suggests new @bmj_latest research @SarahJoSinnott https://t.co/bWLhXoFnV4
— The BMJ (@bmj_latest) November 21, 2020
Randomized trial: Nebulized magnesium does not benefit children with acute refractory asthma treated in the emergency department
26 Nov, 2020 | 08:58h | UTCEffect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary: Nebulized Magnesium Of Little Value for Emergency Tx of Kids’ Asthma Attacks – Physician’s Weekly
Commentary on Twitter
This RCT found that nebulized magnesium does not decrease hospitalization for children with refractory acute asthma in the emergency department, compared to albuterol or placebo https://t.co/9NjgPztY6V @sickkids #VisualAbstract
— JAMA (@JAMA_current) November 24, 2020
Cluster-randomized trial: Postexposure hydroxychloroquine does not prevent Covid-19 in healthy persons exposed to a PCR-positive case patient
25 Nov, 2020 | 09:15h | UTC
Commentary on Twitter
Another RCT in @NEJM of outpatient treatment with Hydroxychloroquine in high risk folks to prevent COVID transmission
No benefit
But about 10X rate of adverse events in HCQ group
Happy to keep studying HCQ
But it really doesn't look like it workshttps://t.co/9nAfir0CMX
— Ashish K. Jha, MD, MPH (@ashishkjha) November 24, 2020
With more data on its COVID-19 vaccine, Russian institute offers new evidence of success
25 Nov, 2020 | 09:13h | UTCWith more data on its COVID-19 vaccine, Russian institute offers new evidence of success – Science
Commentaries: Expert reaction to press release reporting the second interim analysis of the efficacy of the Sputnik V vaccine – Science Media Centre AND Russia says Sputnik V virus vaccine 95% effective – MedicalXpress
Latest COVID-19 guidelines come out against bamlanivimab, remdesivir
25 Nov, 2020 | 09:10h | UTCLatest COVID-19 guidelines come out against bamlanivimab, remdesivir – ACP Internist
Systematic review: Financial payments from the pharmaceutical industry is associated with more physician prescribing of the drug made by the company that they got the payments from
25 Nov, 2020 | 09:07h | UTCAre Financial Payments From the Pharmaceutical Industry Associated With Physician Prescribing? A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Financial payments from drug industry associated with physician prescribing – American College of Physicians
Commentary from the author on Twitter (thread – click for more)
"Are Financial Payments From the Pharmaceutical Industry Associated With Physician Prescribing?"
Our latest on physician-industry COI is out today in @AnnalsofIM!Not to bury the lede, the answer is "yes."
Thread to follow.https://t.co/2lfAjWSQuq
1/— Aaron Mitchell (@TheWonkologist) November 24, 2020
Why does the AstraZeneca-Oxford COVID-19 vaccine’s efficacy vary so much? Here’s what we know
24 Nov, 2020 | 09:30h | UTCWhy Does the AstraZeneca COVID-19 Vaccine’s Efficacy Vary So Much? Here’s What We Know – TIME
Related: Why Oxford’s positive COVID vaccine results are puzzling scientists – Nature
Why the AstraZeneca-Oxford Covid-19 vaccine is different. It does not require extremely cold temperatures for storage, and the price will be “a fraction” of the expense of the other vaccine candidates
24 Nov, 2020 | 09:32h | UTCWhy the AstraZeneca-Oxford Covid-19 vaccine is different – Vox