Meta-analysis of statins for primary prevention: 100 adults (aged 50-75 years) without known cardiovascular disease would have to be treated for 2.5 years to prevent 1 major adverse cardiovascular event

Evaluation of Time to Benefit of Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years: A Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Time to Benefit of Statins for Primary Prevention of Cardiovascular Events – American College of Cardiology

Commentary on Twitter

It takes 2.5 years for the benefits of #statins to be seen. Frail older adults with life expectancy <2.5 years may be more likely to be harmed than helped by statins https://t.co/jbdW7bXopt

— JAMA Internal Medicine (@JAMAInternalMed) November 16, 2020