Pharmacology/Pharmaceutical Industry
2021 ACC Expert consensus decision pathway for optimization of heart failure treatment
13 Jan, 2021 | 02:01h | UTCCommentary: ACC Issues Updated Guidance For Managing Patients With HFrEF – American College of Cardiology
The Pharmacologic Treatment of Schizophrenia—2021
13 Jan, 2021 | 01:53h | UTCThe Pharmacologic Treatment of Schizophrenia—2021 – JAMA (free for a limited period)
Commentary on Twitter
Available treatments have transformed lives of people with schizophrenia, allowing many to live in the community & function independently. However, considerable unmet needs remain due to symptoms refractory to treatment, and adverse effects. @nyulangone https://t.co/tRh1fG6DMD
— JAMA Psychiatry (@JAMAPsych) January 9, 2021
Systematic review: Treatments for acute pain
13 Jan, 2021 | 01:55h | UTCTreatments for Acute Pain: A Systematic Review – Agency for Healthcare Research and Quality
Full text: Treatments for Acute Pain
Evidence summary: Treatments for Acute Pain
Randomized trial: Adjuvant capecitabine in triple-negative breast cancer
13 Jan, 2021 | 01:40h | UTCCommentaries: Capecitabine maintenance may improve TNBC outcomes – medwire News
Commentary on Twitter
In this RCT, low-dose #capecitabine maintenance therapy for 1y resulted in improved 5-y disease-free survival vs observation among women with early-stage triple-negative breast cancer who received standard adjuvant treatment https://t.co/sIgxUSjaYe #BCSM #SABCS20 #VisualAbstract
— JAMA (@JAMA_current) January 6, 2021
Systematic review: Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy
13 Jan, 2021 | 01:37h | UTC
Cohort study: Concomitant use of gabapentinoids with opioids linked to increased risk of opioid overdose and other opioid-related adverse events
13 Jan, 2021 | 01:42h | UTCCommentaries: Exploring the Combination of Gabapentinoids and Opioids for Postoperative Analgesia – JAMA Network Open AND Gabapentinoids Plus Opioids Up Overdose Risk After Surgery – MedPage Today
Commentary on Twitter
🆕 Postop concomitant use of #gabapentinoids with #opioids was associated with
👉🏼⬆️ risk of opioid overdose
👉🏼⬆️ opioid-related adverse events
🎯The absolute risk of adverse events was low.@JAMA_current @JAMASurgery
@amit_pawa @KalagaraHari @Ropivacainehttps://t.co/aw3cig2Rp8— Samer Narouze,MD,PhD,MMM (@NarouzeMD) December 30, 2020
Randomized trial: Renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with COVID-19
12 Jan, 2021 | 01:59h | UTC
NEW Research—renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with #COVID19
RCT from Julio Chirinos & colleagues https://t.co/ZNfqJ0NsRK pic.twitter.com/Kpg6xSsWKl
— The Lancet Respiratory Medicine (@LancetRespirMed) January 8, 2021
Perspective: Maintaining safety with SARS-CoV-2 vaccines
12 Jan, 2021 | 01:53h | UTCMaintaining Safety with SARS-CoV-2 Vaccines – New England Journal of Medicine
Commentary on Twitter
Anaphylactic reactions may be more likely with mRNA COVID-19 vaccines than other traditional vaccines (1 in 100,000 vs. 1 in 1,000,000); likely a reaction to carrier used to protect RNA component (polyethylene glycol, PEG), rather than the vaccine per se.https://t.co/lb7yBCavGQ pic.twitter.com/Pu2ju4K6qQ
— Dr Zoë Hyde (@DrZoeHyde) January 1, 2021
CDC Report: Anaphylaxis after Pfizer-BioNTech COVID-19 vaccine is rare (11.1 cases per million doses)
12 Jan, 2021 | 01:52h | UTCCommentaries: CDC says severe allergic reactions to coronavirus vaccine are rare – CNN AND CDC reports more allergic reactions to Covid-19 vaccines, but cases remain few – STAT
Managing conflicts of interest in the development of health guidelines
12 Jan, 2021 | 01:41h | UTCRelated Guidance: Guidelines International Network: Principles for Disclosure of Interests and Management of Conflicts in Guidelines – Annals of Internal Medicine
Another study suggests fluoroquinolone use may increase the risk of development of aortic aneurysms
12 Jan, 2021 | 01:38h | UTCAssociation of Fluoroquinolone Use With Short-term Risk of Development of Aortic Aneurysm – JAMA Surgery (free for a limited period)
Commentaries: Fluoroquinolones and Aortic Disease—Is It Time to Broaden the Warning? – JAMA (free for a limited period) AND Study links fluoroquinolones to higher risk of aneurysm – CIDRAP AND Analysis Links Fluoroquinolones to Increased Aortic Aneurysm Risk – Physician’s Weekly
Three-year follow-up of 2-dose versus 3-dose HPV vaccine
12 Jan, 2021 | 01:26h | UTCThree-Year Follow-up of 2-Dose Versus 3-Dose HPV Vaccine – Pediatrics (link to abstract – $ for full-text)
[Preprint] Randomized trial: Arthritis drugs improve survival in critically ill patients with Covid-19
10 Jan, 2021 | 20:56h | UTCCommentaries: Covid-19: Arthritis drugs improve survival in intensive care patients, shows study – The BMJ AND Arthritis drugs could help save lives of Covid patients, research finds – The Guardian AND Expert comment – Two potentially life-saving drugs for critically ill COVID-19 patients – London School of Hygiene & Tropical Medicine
Commentary on Twitter
Two rheumatoid arthritis drugs will now be used to treat the patients with severe covid-19 in intensive care, after new findings have shown that they significantly improve survival and cut the time spent in hospital by a week to 10 days https://t.co/cxNM64L5S6
— The BMJ (@bmj_latest) January 8, 2021
Randomized trial: Neutralizing monoclonal antibody not efficacious among hospitalized patients with covid-19
10 Jan, 2021 | 20:55h | UTCCommentaries: Covid-19: Trial of LY-CoV555 Stopped for Futility – Physician’s Weekly AND Results of NIH-sponsored ACTIV-3 trial published – NIH News Releases AND Bamlanivimab Flops in Hospitalized COVID-19 Patients – MedPage Today (free registration required)
Peter Doshi: Pfizer and Moderna’s “95% effective” vaccines—we need more details and the raw data
10 Jan, 2021 | 20:48h | UTC
Moderna COVID-19 vaccine phase III trial results published; it is 94.1% efficacious in preventing symptomatic COVID-19
10 Jan, 2021 | 20:49h | UTCEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine – New England Journal of Medicine
Commentaries: Peer-reviewed report on Moderna COVID-19 vaccine publishes – NIH News Releases AND Peer-reviewed data show high protection for leading COVID vaccines – CIDRAP AND The Moderna Vaccine’s Antibodies May Not Last As Long As We Hoped – Forbes
Commentary on Twitter
In the phase 3 mRNA-1273 trial participants received 2 doses of vaccine or placebo 28 days apart. The mRNA-1273 vaccine showed 94.1% efficacy in preventing #SARSCoV2, including severe disease. #IDTwitter
— NEJM (@NEJM) December 30, 2020
Debate: Should we delay second vaccine doses to give one dose of the Covid-19 vaccine to more people?
10 Jan, 2021 | 20:51h | UTC- Editorial: U.S. COVID-19 Vaccination Challenges Go Beyond Supply – Annals of Internal Medicine
- Speed Versus Efficacy: Quantifying Potential Tradeoffs in COVID-19 Vaccine Deployment – Annals of Internal Medicine
- A Public Health COVID-19 Vaccination Strategy to Maximize the Health Gains for Every Single Vaccine Dose – Annals of Internal Medicine
- Alternative Dose Allocation Strategies to Increase Benefits From Constrained COVID-19 Vaccine Supply – Annals of Internal Medicine
- Delaying the second COVID vaccine dose – a medical expert answers key questions – The Conversation
- Should we give one dose of the Covid-19 vaccine to more people? The debate, explained. – Vox
- Debates intensify over dosing plans for authorized COVID-19 vaccines – Science
- Covid-19 vaccination: What’s the evidence for extending the dosing interval? – The BMJ Opinion
- Covid-19 vaccines: to delay or not to delay second doses – The BMJ Opinion
- Britain takes a gamble with Covid-19 vaccines, upping the stakes for the rest of us – STAT
- UK Delay of Second COVID-19 Vaccine Dose – A Risky Strategy That Could Give Rise To More Virus Mutations, Some Experts Warn – Health Policy Watch
- What’s the scientific basis for delaying the Covid vaccine second dose? – The Guardian
- FDA says people need both doses of coronavirus vaccines – CNN
- WHO experts weigh in on COVID-19 vaccine dose interval – CIDRAP
- For mRNA vaccines, we should stick to the schedule – The Guardian
- Expert comment on whether giving two doses of COVID vaccine separated by a longer period is sensible – Science Media Centre
- How safe is it to switch and space COVID-19 vaccine doses? – Reuters
[Press release – results not published yet] International trials of blood thinners in critically ill COVID-19 patients pause due to futility
10 Jan, 2021 | 20:44h | UTC
Commentary on Twitter
The 3 largest RCTs of therapeutic #anticoagulation for #COVID19 pts in the ICU have ALL been stopped early for futility. (@remap_cap @ATTACC_COVID & #ACTIV4)
Nothing published yet, but given the large n of these RCTs, I'm increasingly skeptical about anticoagulation in COVID19. pic.twitter.com/RrLSoOsp3v
— Nick Mark MD (@nickmmark) December 22, 2020
Sinovac vaccine 78% effective in Brazil trial, experts call for more details
10 Jan, 2021 | 20:46h | UTCSinovac vaccine 78% effective in Brazil trial, experts call for more details – Reuters
Randomized trial: Low-dose digoxin results in similar patient-reported quality of life compared to bisoprolol for heart rate control in atrial fibrillation
10 Jan, 2021 | 20:37h | UTCEffect of Digoxin vs Bisoprolol for Heart Rate Control in Atrial Fibrillation on Patient-Reported Quality of Life: The RATE-AF Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Editorial: Digitalis Glycosides for Heart Rate Control in Atrial Fibrillation
Commentary: Digoxin Could Sub for Beta-Blockers in Certain Afib Patients – Physician’s Weekly
Commentary on Twitter
In this RCT, low-dose #digoxin led to no difference in patient-reported quality of life at 6 months vs bisoprolol in patients with permanent atrial fibrillation and symptoms of heart failure. @ICVS_UoB #afib https://t.co/XtCPdba5xg
— JAMA (@JAMA_current) December 28, 2020
Randomized trial: Proton pump inhibitors do not benefit patients with persistent throat symptoms
10 Jan, 2021 | 20:32h | UTC
Commentary on Twitter
Medicating random throat symptoms with proton pump inhibitors (for months) has, somehow, become routine care despite no gd evidence it actually helps.
So guess what happens if you compare 16 wk of double dose PPI with placebo in a proper trial?
…Yeah.https://t.co/mrnq4tcEUk pic.twitter.com/uZo630Sg9j
— Jussi Mustonen (@JusiMD) January 8, 2021
Randomized trial: Ultra-early tranexamic acid does not improve outcomes after subarachnoid hemorrhage
10 Jan, 2021 | 21:02h | UTCUltra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Tranexamic acid treatment in spontaneous subarachnoid haemorrhage, started immediately after CT diagnosis and continued until start of the aneurysm treatment as early as possible, does not improve clinical outcome, finds new randomised controlled trial: https://t.co/R0AhtszaY5 pic.twitter.com/Bnft9XgBA9
— The Lancet (@TheLancet) December 22, 2020
Observational study: Childhood growth hormone treatment linked to increased risks of cardiovascular events in early adulthood
10 Jan, 2021 | 20:27h | UTCAssociation of Childhood Growth Hormone Treatment With Long-term Cardiovascular Morbidity – JAMA Pediatrics (link to abstract – $ for full-text)
Commentaries: Childhood Tx with Growth Hormone May Up Cardiovascular Risks Later – Physician’s Weekly AND Growth Hormones in Childhood Tied to Heart Problems Later On – MedPage Today (free registration required)
Systematic review: Melatonin may have a similar effect to benzodiazepines in reducing preoperative and postoperative anxiety in adults
10 Jan, 2021 | 20:14h | UTCMelatonin for preoperative and postoperative anxiety in adults – Cochrane Library
Summary: Melatonin for preoperative and postoperative anxiety in adults – Cochrane Library
NICE Guideline: Do not use Vitamin D to prevent or treat COVID 19
18 Dec, 2020 | 10:03h | UTCCOVID-19 rapid guideline: vitamin D – National Institute for Health and Care Excellence
News release: NICE, PHE and SACN publish rapid COVID-19 guidance on vitamin D
Commentaries: Covid and vitamin D: ‘Not enough evidence’ for treatment – BBC AND Covid-19: Evidence is lacking to support vitamin D’s role in treatment and prevention – The BMJ
Commentary on Twitter
https://twitter.com/onisillos/status/1339485382501666816