Pharmacology/Pharmaceutical Industry
Position paper: Chest CT diagnosis and clinical management of drug-related pneumonitis in patients receiving molecular targeting agents and immune checkpoint inhibitors
17 Jan, 2021 | 22:07h | UTC
Cardiovascular complications of opioid use: JACC state-of-the-art review
17 Jan, 2021 | 22:04h | UTC
Randomized trial: Inhaled Treprostinil in pulmonary hypertension due to interstitial lung disease
17 Jan, 2021 | 21:47h | UTCCommentaries: Inhaled Treprostinil Beneficial in Pulmonary Hypertension – HealthDay
Commentary on Twitter
Patients with pulmonary hypertension due to interstitial lung disease were randomly assigned to inhale treprostinil or placebo. At 16 weeks, there was a significant improvement in exercise capacity with inhaled treprostinil as compared with placebo, assessed by a 6-minute walk.
— NEJM (@NEJM) January 14, 2021
Meta-analysis: Safety and efficacy of dexmedetomidine in acutely ill adults requiring non-invasive ventilation
17 Jan, 2021 | 21:42h | UTCSafety and efficacy of dexmedetomidine in acutely ill adults requiring non-invasive ventilation: a systematic review and meta-analysis of randomized trials – CHEST (link to abstract – $ for full-text)
Meta-analysis: Effect of ultra-short-acting β-blockers on mortality in patients with persistent tachycardia despite initial resuscitation
17 Jan, 2021 | 21:41h | UTCEffect of ultra-short-acting β-blockers on mortality in patients with persistent tachycardia despite initial resuscitation: a systematic review and meta-analysis of randomized controlled trials – CHEST (link to abstract – $ for full-text)
Opinion: RCTs don’t justify using convalescent plasma or antibody cocktails
15 Jan, 2021 | 08:58h | UTCRCTs don’t justify using convalescent plasma or antibody cocktails – PulmCrit
Perspective: Ivermectin for COVID-19 — Breakthrough Treatment or Hydroxychloroquine Redux?
15 Jan, 2021 | 08:51h | UTCRelated video: Ivermectin For COVID-19 | A Doctor Explains – ZDoggMD
NIH Guideline Statement: “there are insufficient data to recommend either for or against the use of ivermectin for the treatment of COVID-19”
15 Jan, 2021 | 08:53h | UTC
Covid-19 Vaccine — Frequently Asked Questions
15 Jan, 2021 | 08:49h | UTCCovid-19 Vaccine — Frequently Asked Questions – New England Journal of Medicine
Randomized trial: Naltrexone-Bupropion combination may help some people (13.6% vs. 2.5% with placebo) with methamphetamine use disorder
15 Jan, 2021 | 08:39h | UTCBupropion and Naltrexone in Methamphetamine Use Disorder – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Combination of two drugs can help treat methamphetamine addiction for some, new clinical trial data shows – STAT AND Naltrexone-Bupropion Combination May Help People With Methamphetamine Use Disorder – Psychiatric News Alert
Meta-analysis of randomized trials: SGLT-2 inhibitors and GLP-1 receptor agonists reduce cardiovascular and renal outcomes in type 2 diabetes
15 Jan, 2021 | 08:41h | UTCCalculator based on the results: interactive decision support tool for outcomes
Clinical trial finds vitamin D does not ward off colds and flu
15 Jan, 2021 | 08:33h | UTC
Consequences to patients, clinicians, and manufacturers when very serious adverse drug reactions are identified (1997–2019)
15 Jan, 2021 | 08:26h | UTC
Commentary on Twitter
Great paper with lots of interesting data. What strikes me most: the drawbacks (retaliation) the clinicians experienced who reported the severe adverse drug reactions (several were sued by Big Pharma, one lost his professorship)https://t.co/NimX0rnsAt
— Michael P. Hengartner, PhD (@HengartnerMP) December 26, 2020
CoronaVac study in Brazil: Is the vaccine 50%, 78%, or 100% effective?
14 Jan, 2021 | 02:11h | UTCThird time’s the charm? Brazil scales back efficacy claims for COVID-19 vaccine from China – Science
See also: CoronaVac’s Overall Efficacy in Brazil Measured at 50.4% – Bloomberg
A guide to vaccinology: from basic principles to new developments
14 Jan, 2021 | 02:09h | UTCA guide to vaccinology: from basic principles to new developments – Nature Reviews Immunology
How COVID unlocked the power of RNA vaccines
14 Jan, 2021 | 02:09h | UTCHow COVID unlocked the power of RNA vaccines – Nature
Commentary: RNA Vaccines: A Suitable Platform for Tackling Emerging Pandemics? – Frontiers in Immunology
Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin
14 Jan, 2021 | 01:57h | UTCEditorial: Evolving Issues in the Use of Antibiotics for the Treatment of Uncomplicated Appendicitis
Commentary: More Support for Single-Drug Antibiotics for Uncomplicated Appendicitis – Physician’s Weekly
Commentary on Twitter
In this RCT comparing 7d oral moxifloxacin vs 2d IV ertapenam 5d oral levofloxacin metronidazole for adults w uncomplicated #appendicitis, Tx success was >65% for both, but oral #antibiotics did not meet noninferiority criteria vs IV PO https://t.co/SwcopsGZTm #VisualAbstract
— JAMA (@JAMA_current) January 12, 2021
A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients
14 Jan, 2021 | 01:42h | UTC
Immunogenicity and safety of fractional doses of yellow fever vaccines: A randomized, double-blind, non-inferiority trial
14 Jan, 2021 | 01:38h | UTCInvited commentary: Public health role for fractional dosage of yellow fever vaccine – The Lancet
Systematic review: Immunotherapy vs. chemotherapy for people with advanced non-small cell lung cancer who have not been previously treated
14 Jan, 2021 | 01:30h | UTC
#Immunotherapy vs #chemotherapy for people with advanced non‐small cell #lungcancer who have not been not previously been treated https://t.co/RJlDp1SHTc New @CochraneLibrary systematic review includes 7 studies with 5893 participants.
— The Cochrane Library (@CochraneLibrary) December 21, 2020
Randomized trial: First-line treatment with infliximab vs. conventional treatment in children with newly diagnosed moderate-to-severe Crohn’s disease
14 Jan, 2021 | 01:27h | UTC
Six RCTs to answer one question: what is the role of tocilizumab in COVID-19?
13 Jan, 2021 | 02:28h | UTCSix RCTs to answer one question: what is the role of tocilizumab in COVID-19? – PulmCrit
Related (study and commentaries): Randomized trial: Arthritis drugs improve survival in critically ill patients with Covid-19
Video (3 min): Which Covid vaccine is better? Pfizer v Oxford v Moderna
13 Jan, 2021 | 02:21h | UTCWhich Covid vaccine is better? Pfizer v Oxford v Moderna – BBC
Pregnant women & vaccines against emerging epidemic threats: Ethics guidance for preparedness, research, and response
13 Jan, 2021 | 02:10h | UTC
Commentaries on Twitter
New paper via our PREVENT Group w 22 concrete recs that provide a roadmap for the ethically responsible, socially just, & respectful inclusion of the interests of pregnant women in the development & deployment of vaccines against emerging pathogens. https://t.co/tp6gt20dh0
— Ruth Faden (@fadenethx) May 6, 2019
Infectious disease outbreaks can severely affect the health interests of pregnant women and their babies. PREVENT's guidance promotes the inclusion of pregnant women in the development and deployment of vaccines against emerging pathogens ➡️ https://t.co/P8IKXCU8tI pic.twitter.com/LYDHfQ2f9y
— CEPI (@CEPIvaccines) May 13, 2019
Covid-19: Breastfeeding women can have vaccine after guidance turnaround
13 Jan, 2021 | 02:11h | UTCCovid-19: Breastfeeding women can have vaccine after guidance turnaround – The BMJ
Related opinion: Why were breastfeeding women denied the covid-19 vaccine? – The BMJ