Pharmacology/Pharmaceutical Industry | Page 37 of 172 | Links Medicus Content Curation & Alerts in Medicine

The incidence of mRNA vaccine myocarditis or pericarditis in Italy in ~3 million vaccinees age 12-39. Excess cases per 100,000; orange is 2nd dose, blue 1st dose. https://t.co/xvdV4qSdHw
Pfizer:~1/100,000 age 12-39, all 2nd dose
Moderna,: >5/100,000, age 12-39, and some 1st dose pic.twitter.com/Y1jfGrU53v

— Eric Topol (@EricTopol) February 9, 2022

Systematic Review: Video-observed therapy vs. directly observed therapy in patients with tuberculosis.

9 Feb, 2022 | 08:35h | UTC

Video-Observed Therapy Versus Directly Observed Therapy in Patients With Tuberculosis – American Journal of Preventive Medicine (link to abstract – $ for full-text)

Commentary on Twitter

Our latest publication on @AmJPrevMed : Video-Observed Therapy Versus Directly Observed Therapy in Patients With Tuberculosis. Implementation of VOT improved medication adherence and bacteriological resolution compared with that of DOT in TB patients.https://t.co/xcWzrxLbHB? pic.twitter.com/4ldYJ2umd7

— Bang Truong (@bangphd_epi) December 13, 2021

M-A: Direct oral anticoagulants vs. warfarin in patients with atrial fibrillation.

9 Feb, 2022 | 08:29h | UTC

Direct Oral Anticoagulants versus Warfarin in Patients with Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials with Interaction Testing by Age and Sex – Circulation (link to abstract – $ for full-text)

Randomized crossover study shows regular use of Paracetamol increases systolic blood pressure by approximately 5 mm Hg when compared with placebo in hypertensive individuals.

8 Feb, 2022 | 10:11h | UTC

Regular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial – Circulation (link to abstract – $ for full-text)

Commentaries:

Regular paracetamol use linked to higher blood pressure, study finds – University of Edinburg

Expert reaction to study looking at regular, long-term paracetamol use and blood pressure, in people with high blood pressures – Science Media Centre

Blood pressure warning over long-term paracetamol use – BBC

Perspective | Three, four or more: what’s the magic number for booster shots?

8 Feb, 2022 | 10:03h | UTC

Three, four or more: what’s the magic number for booster shots? – Nature

In patients taking anticoagulants (DOAC or Warfarin), a respiratory tract infection not treated with antibiotics is associated with a greater than twofold increase in the risk of bleeding during the next 0-14 days.

8 Feb, 2022 | 08:46h | UTC

Respiratory tract infection and risk of bleeding in oral anticoagulant users: self-controlled case series – The BMJ

Commentary on Twitter

In new research of 1208 oral anticoagulant users, a greater than twofold increase was seen in the risk of major bleeding & clinically relevant non-major bleeding in the 0-14 days after a respiratory tract infection for which no antibiotics were prescribed https://t.co/wMIb2eDBKk

— The BMJ (@bmj_latest) December 21, 2021

Summary: 2021 CDC guidelines on sexually transmitted infections.

7 Feb, 2022 | 08:33h | UTC

2021 CDC guidelines on sexually transmitted infections – Family Medicine

Original Guideline: CDC releases new guidelines for the treatment of sexually transmitted infections.

RCT: Ketamine is a short-term effective treatment for some suicidal patients in hospital.

4 Feb, 2022 | 10:05h | UTC

News Release: Ketamine is a short-term effective treatment for some suicidal patients in hospital – BMJ

Original Article: Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial – The BMJ

Editorial: Ketamine for suicidal ideation – The BMJ

RCT: Ketamine induced remission in 46% of patients but was NOT non-inferior to electroconvulsive therapy for the treatment of hospitalized patients with unipolar depression.

Systematic Review: Ketamine for the treatment of mental health and substance use disorders.

Phase 2 RCT: Adjunctive ketamine with relapse prevention–based psychological therapy shows promise for the treatment of alcohol use disorder.

RCT: Effects of ketamine vs. midazolam on neurocognition at 24 hours in depressed patients with suicidal ideation.

Randomized trial: Repeated Ketamine administration for chronic posttraumatic stress disorder

Ketamine and Depression: A Narrative Review

Implementation of a pharmacist-to-dose direct oral anticoagulant (DOAC) protocol was associated with a 44% reduction in DOAC-related medication errors at an academic medical center.

7 Feb, 2022 | 08:10h | UTC

A pharmacist-to-dose direct oral anticoagulant protocol on medication errors at an academic medical center – Journal of the American College of Clinical Pharmacy (link to abstract – $ for full-text)

Commentary: Pharmacist-to-Dose DOAC Protocol Reduces Medication Errors – American College of Cardiology

Consensus Statement: Preoperative Management of Medications for Neurologic Diseases.

4 Feb, 2022 | 10:00h | UTC

Preoperative Management of Medications for Neurologic Diseases – Mayo Clinic Proceedings

Experts question unusual authorization plan for Covid vaccine for kids under 5.

4 Feb, 2022 | 09:57h | UTC

Experts question unusual authorization plan for Covid vaccine for kids under 5 – STAT

Pfizer and BioNTech seeking emergency use authorization from FDA for Covid-19 vaccine for children younger than 5 – CNN

Pfizer asks FDA to allow COVID-19 vaccine for kids under 5 – Associated Press

Pfizer Asks FDA to Approve Its Vaccine for the Youngest Children – HealthDay

Five-Year Survival Outcomes From the PACIFIC Trial: Durvalumab After Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer.

4 Feb, 2022 | 08:38h | UTC

Five-Year Survival Outcomes From the PACIFIC Trial: Durvalumab After Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer – Journal of Clinical Oncology

Original Study: Randomized Trial: Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC

Hyaluronic acid injections have increased for knee arthritis in the US, despite guideline recommendations against their use.

4 Feb, 2022 | 08:32h | UTC

Hyaluronic Acid Injections for Knee Osteoarthritis: Has Utilization Among Medicare Beneficiaries Changed Between 2012 and 2018? – The Journal of Bone & Joint Surgery (link to abstract – $ for full-text)

News Release: Hyaluronic acid injections have increased for knee arthritis – despite recommendations against their use

An observational study including 15.670 people using methotrexate and 2.689 using leflunomide showed the incidences of discontinuation related to cytopenia, liver enzyme elevation, or kidney function decline.

4 Feb, 2022 | 08:21h | UTC

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? – Rheumatology

Consensus Statement: Preoperative management of medications for psychiatric diseases.

3 Feb, 2022 | 09:59h | UTC

Preoperative Management of Medications for Psychiatric Diseases: Society for Perioperative Assessment and Quality Improvement Consensus Statement – Mayo Clinic Proceedings

RCT: In patients with advanced esophageal squamous-cell carcinoma, both nivolumab plus chemotherapy and nivolumab plus ipilimumab resulted in longer overall survival than chemotherapy alone.

3 Feb, 2022 | 09:46h | UTC

Nivolumab Combination Therapy in Advanced Esophageal Squamous-Cell Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary (2021 ASCO Annual Meeting): Nivolumab Plus Chemotherapy and Nivolumab Plus Ipilimumab as First-Line Treatment for Patients With Advanced Esophageal Cancer – The ASCO Post

Commentary on Twitter

First-line treatment of advanced esophageal squamous-cell carcinoma with either nivolumab plus chemo or nivolumab plus ipilimumab resulted in a significant overall survival benefit and durable responses as compared with chemo alone. https://t.co/a000bDsh1N pic.twitter.com/NuY2eX58gp

— NEJM (@NEJM) February 2, 2022

Cluster randomized controlled trial: An innovative telemedical network to improve infectious disease management in critically ill patients and outpatients.

3 Feb, 2022 | 08:53h | UTC

An innovative telemedical network to improve infectious disease management in critically ill patients and outpatients: a stepped-wedge, cluster randomized controlled trial (TELnet@NRW) – Journal of Medical Internet Research

The “Choosing Wisely” initiative in infectious diseases – German Society of Infectious Diseases (link to abstract – $ for full-text)

Infectious Diseases Society of America: Five Things Physicians and Patients Should Question

Outpatient Therapies for COVID-19: How do we choose?

2 Feb, 2022 | 08:53h | UTC

Outpatient Therapies for COVID-19: How do we choose? – Open Forum Infectious Diseases

Updated NIH COVID-19 Treatment Guidelines: Therapeutic management of nonhospitalized adults with COVID-19.

2 Feb, 2022 | 08:50h | UTC

Therapeutic Management of Nonhospitalized Adults With COVID-19 – NIH COVID-19 Treatment Guidelines

Commentary on Twitter

NIH update💥💥
Therapeutic Management of Nonhospitalized Adults With #COVID19 #TwitteRx #medtwitter #TwitteRx #MedEd https://t.co/QpKsVJArUj pic.twitter.com/HKb81dB5b8

— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) February 1, 2022

Ten billion COVID vaccinations: world hits new milestone.

2 Feb, 2022 | 08:48h | UTC

Ten billion COVID vaccinations: world hits new milestone – Nature

Commentary on Twitter

10 billion doses given, <1 billion were boosters
1 continent nearly left outhttps://t.co/DrCqQ4b7tJ
and @OurWorldInData

“It is a huge scientific achievement that ten billion doses of vaccines to a new pathogen were developed in two years from its identification”—@doctorsoumya pic.twitter.com/pyLXlvI22Q

— Eric Topol (@EricTopol) February 1, 2022