An observational study including 15.670 people using methotrexate and 2.689 using leflunomide showed the incidences of discontinuation related to cytopenia, liver enzyme elevation, or kidney function decline. 4 Feb, 2022 | 08:21h | UTC What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? – Rheumatology