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Pharmacology/Pharmaceutical Industry

Guideline: Management of chronic low back, osteoarthritic, and neuropathic pain in primary care.

21 Mar, 2022 | 10:02h | UTC

PEER simplified chronic pain guideline: Management of chronic low back, osteoarthritic, and neuropathic pain in primary care – Canadian Family Physician

 

Infographic: IDSA COVID-19 outpatient treatment guidelines roadmap.

21 Mar, 2022 | 09:51h | UTC

COVID-19 Outpatient Treatment Guidelines Roadmap – Infectious Diseases Society of America

 

Commentary on Twitter

 

CDC Report: Effectiveness of mRNA vaccination in preventing COVID-19–associated invasive mechanical ventilation and death in the US.

21 Mar, 2022 | 09:38h | UTC

Effectiveness of mRNA Vaccination in Preventing COVID-19–Associated Invasive Mechanical Ventilation and Death — United States, March 2021–January 2022 – CDC Morbidity and Mortality Weekly Report

Related Study: COVID-19–Associated Hospitalizations Among Adults During SARS-CoV-2 Delta and Omicron Variant Predominance, by Race/Ethnicity and Vaccination Status — COVID-NET, 14 States, July 2021–January 2022 – CDC Morbidity and Mortality Weekly Report

Commentary: Studies show vaccines protect against serious Omicron illness – CIDRAP

 

Commentary on Twitter

 

Effectiveness of the Johnson & Johnson vaccine in health-care workers in South Africa in a period when the beta and then the delta SARS-CoV-2 variants of concerns were dominant.

21 Mar, 2022 | 09:43h | UTC

Effectiveness of the Ad26.COV2.S vaccine in health-care workers in South Africa (the Sisonke study): results from a single-arm, open-label, phase 3B, implementation study – The Lancet

Invited Commentary: Sisonke: reaching several goals together – The Lancet

 

Commentary on Twitter (thread – click for more)

 

Myocarditis following a third Pfizer vaccination dose in military recruits in Israel.

21 Mar, 2022 | 09:37h | UTC

Myocarditis Following a Third BNT162b2 Vaccination Dose in Military Recruits in Israel – JAMA

Related:

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

Systematic Review: Strategies for using topical corticosteroids in children and adults with eczema.

21 Mar, 2022 | 08:33h | UTC

Strategies for using topical corticosteroids in children and adults with eczema – Cochrane Library

Summary: What is the best way to use topical corticosteroids to treat people with eczema? – Cochrane Library

 

Commentary on Twitter

https://twitter.com/CochraneUK/status/1504548242738102273

 

RCT: Oral contezolid vs. linezolid in adults with complicated skin and soft tissue infections.

18 Mar, 2022 | 07:54h | UTC

A Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections – Journal of Antimicrobial Therapy (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.

17 Mar, 2022 | 09:12h | UTC

Efficacy of a Fourth Dose of Covid-19 mRNA Vaccine against Omicron – New England Journal of Medicine

Related: [Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.

 

Effectiveness of the Sputnik V, AstraZeneca, and Sinopharm vaccines for the risk of infection and death due to COVID-19 in people older than 60 years in Argentina.

17 Mar, 2022 | 09:10h | UTC

Effectiveness of rAd26-rAd5, ChAdOx1 nCoV-19, and BBIBP-CorV vaccines for risk of infection with SARS-CoV-2 and death due to COVID-19 in people older than 60 years in Argentina: a test-negative, case-control, and retrospective longitudinal study – The Lancet

Commentary: Evaluating COVID-19 vaccines in the real world – The Lancet

 

Treatments for mild COVID-19: Cochrane evidence.

17 Mar, 2022 | 09:17h | UTC

Treatments for mild COVID-19: Cochrane evidence – Cochrane Library

 

[News release – not published yet] Empagliflozin phase III EMPA-KIDNEY trial will stop early due to evidence of efficacy in people with chronic kidney disease.

17 Mar, 2022 | 09:07h | UTC

Jardiance® phase III EMPA-KIDNEY trial will stop early due to clear positive efficacy in people with chronic kidney disease – Lilly

See also: Design, recruitment, and baseline characteristics of the EMPA-KIDNEY trial – Nephrology Dialysis Transplantation

 

Commentary on Twitter

 

Review: Mechanistic and clinical overview of cardiovascular toxicity with BRAF and MEK inhibitors.

17 Mar, 2022 | 08:34h | UTC

Mechanistic and Clinical Overview Cardiovascular Toxicity of BRAF and MEK Inhibitors: JACC: CardioOncology State-of-the-Art Review

 

Commentary on Twitter

 

Trends in HPV–associated cancers, demographic characteristics, and vaccinations in the US, 2001-2017.

17 Mar, 2022 | 08:16h | UTC

Trends in Human Papillomavirus–Associated Cancers, Demographic Characteristics, and Vaccinations in the US, 2001-2017 – JAMA Network Open

Author Interview: Trends in Human Papillomavirus–Associated Cancers, Demographic Characteristics, and Vaccinations

Related:

[Not published yet] Single-dose HPV vaccine highly effective, researchers say – “Results of randomized controlled trial in Kenya bring new energy to eliminate cervical cancer worldwide”.

A national HPV vaccination program in England was associated with an estimated reduction in cervical cancer rates of 87% for those offered the vaccine at age 12–13 years.

Three-year follow-up of 2-dose versus 3-dose HPV vaccine

Nationwide cohort study in Sweden shows HPV vaccination linked to reduced risk of invasive cervical cancer

CDC: 92% of Human Papillomavirus–Attributable Cancers can be Targeted by HPV Vaccination

Meta-Analysis: Population-level Impact of HPV Vaccination Programs

 

Cohort Study: TNF inhibitors increase the risk of nontuberculous mycobacteria in patients with seropositive rheumatoid arthritis in a mycobacterium tuberculosis endemic area.

16 Mar, 2022 | 08:44h | UTC

TNF inhibitors increase the risk of nontuberculous mycobacteria in patients with seropositive rheumatoid arthritis in a mycobacterium tuberculosis endemic area – Scientific Reports

 

Most antibiotic prophylaxis prescriptions prior to dental visits are inconsistent with guidelines.

16 Mar, 2022 | 08:33h | UTC

Antibiotic prophylaxis prescriptions prior to dental visits in the Veterans’ Health Administration (VHA), 2015–2019 – Infection Control & Hospital Epidemiology (link to abstract – $ for full-text)

Commentary: Most antibiotics prescribed for dental visits inconsistent with guidelines, study finds – Healio (link to abstract – $ for full-text)

 

Commentary on Twitter

 

M-A: Intraoperative redosing of surgical antibiotic prophylaxis in addition to preoperative prophylaxis vs. single-dose prophylaxis for the prevention of surgical site infection.

16 Mar, 2022 | 08:34h | UTC

Intraoperative Redosing of Surgical Antibiotic Prophylaxis in Addition to Preoperative Prophylaxis Versus Single Dose Prophylaxis for the Prevention of Surgical Site Infection: A Meta-Analysis and GRADE Recommendation – Annals of Surgery

 

M-A: Evaluating the association between LDL Cholesterol reduction and relative and absolute effects of statin treatment.

15 Mar, 2022 | 10:04h | UTC

Evaluating the Association Between Low-Density Lipoprotein Cholesterol Reduction and Relative and Absolute Effects of Statin Treatment: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Commentary from the author: Benefits of statins may have been overstated – new study – The Conversation

 

Commentary on Twitter

 

Review: Drug-induced acute kidney injury.

14 Mar, 2022 | 00:48h | UTC

Drug-Induced Acute Kidney Injury – Clinical Journal of the American Society of Nephrology

 

RCT: Methenamine Hippurate (a non-antibiotic preventive treatment) is noninferior to prophylactic antibiotics for treating recurrent urinary tract infections in women.

11 Mar, 2022 | 10:21h | UTC

Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial – The BMJ

News Release: Antiseptic drug as good as antibiotics for preventing recurrent urinary tract infections – BMJ Newsroom

Editorial: Methenamine hippurate for recurrent urinary tract infections – The BMJ

Commentaries:

Trial supports antibiotic alternative for recurrent urinary infections – CIDRAP

Nonantibiotic Prophylaxis Noninferior for Recurrent UTI – HealthDay

 

Commentary on Twitter

https://twitter.com/bmj_latest/status/1501800030608494596

 

Another study suggests that a third vaccine dose is necessary to protect populations against the omicron variant.

11 Mar, 2022 | 10:14h | UTC

Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study – The BMJ

News Release: Third vaccine dose critical for protecting populations against omicron variant – BMJ Newsroom

 

Commentary on Twitter

 

Association between statin use and daptomycin-related musculoskeletal adverse events: A mixed approach combining a meta-analysis and a disproportionality analysis.

11 Mar, 2022 | 09:39h | UTC

Association between statin use and daptomycin-related musculoskeletal adverse events: A mixed approach combining a meta-analysis and a disproportionality analysis – Clinical Infectious Diseases

 

Meta-analysis of randomized trials: benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery.

10 Mar, 2022 | 10:48h | UTC

Benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery: systematic review and network meta-analysis of randomised trials – The BMJ

 

Commentary on Twitter

https://twitter.com/KariTikkinen/status/1501532156786577415

 

Updated guideline summary introduces new recommendations for use of medications around total hip and knee replacement.

10 Mar, 2022 | 10:45h | UTC

News release: Updated guideline introduces new recommendations for use of medications around total hip and knee replacement – American College of Rheumatology

Guideline Summary (full guideline not available yet): 2022 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients with Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty – American College of Rheumatology

 

Extending the reach of antimicrobial stewardship to pediatric patients.

10 Mar, 2022 | 10:12h | UTC

Extending the Reach of Antimicrobial Stewardship to Pediatric Patients – Infectious Diseases and Therapy

 

RCT: Reliever-triggered inhaled glucocorticoid reduces severe exacerbations in black and latinx adults with moderate-to-severe asthma.

9 Mar, 2022 | 10:06h | UTC

Reliever-Triggered Inhaled Glucocorticoid in Black and Latinx Adults with Asthma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Patient-centered intervention improved asthma outcomes for Black and Latinx adults – Brigham and Women’s Hospital

 

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