Pharmacology/Pharmaceutical Industry
FDA authorizes emergency use of Novavax COVID-19 vaccine.
14 Jul, 2022 | 13:01h | UTCCommentaries:
FDA authorizes Novavax Covid vaccine, in hopes the traditional shot will convince holdouts – STAT
US regulators OK new COVID-19 shot option from Novavax – Associated Press
Nationwide cohort study | Safety of heterologous primary and booster schedules with ChAdOx1-S and BNT162b2 or mRNA-1273 vaccines.
14 Jul, 2022 | 12:52h | UTC
M-A of RCTs | Megestrol Acetate not beneficial for cancer-related anorexia/cachexia.
14 Jul, 2022 | 12:50h | UTC
The EBMT nursing guidelines on CAR-T Therapy | A framework for patient care and managing common toxicities.
14 Jul, 2022 | 12:45h | UTC
Systematic Review | Anti‐IL‐5 therapies for asthma.
14 Jul, 2022 | 12:40h | UTCAnti‐IL‐5 therapies for asthma – Cochrane Library
Fever therapy in febrile adults: systematic review with meta-analyses and trial sequential analyses.
13 Jul, 2022 | 11:51h | UTC
Modern developments in germline pharmacogenomics for oncology prescribing.
13 Jul, 2022 | 11:21h | UTC
RCT | Adjunctive transdermal cannabidiol no better than placebo for drug-resistant focal epilepsy.
12 Jul, 2022 | 12:54h | UTC
Commentary on Twitter
In this randomized clinical trial, transdermal cannabidiol was well-tolerated and safe, but did not decrease seizure frequency at week 12 of the double-blind period among the placebo, 195-mg cannabidiol, and 390-mg cannabidiol treatments. https://t.co/lR3kEzPE5T
— JAMA Network Open (@JAMANetworkOpen) July 8, 2022
NLA scientific statement on statin intolerance: a new definition and key considerations for ASCVD risk reduction in the statin intolerant patient.
12 Jul, 2022 | 12:48h | UTCCommentary: National Lipid Association Scientific Statement on Statin Intolerance – American College of Cardiology
RCT | Leflunomide vs. azathioprine for maintenance therapy of lupus nephritis.
12 Jul, 2022 | 12:51h | UTC
Commentary on Twitter
🆕🔥Leflunomide versus azathioprine for maintenance therapy of lupus nephritis
🫘LEF=AZR in maintenance for SLE-LN
🫘Induction with NIH-CYC
🫘Chinese seem to love Lefno
🫘Generalisability difficult
Would have loved an MMF vs LEF#Rheumtwitter #Nephtwitterhttps://t.co/N2gTYISibM pic.twitter.com/nlP2LkSu8c— EnvisionRheumat (@ERheumat) July 5, 2022
Under a http://creativecommons.org/licenses/by-nc/4.0/ license
Opinion | Secrecy: a demon of gene therapy’s past bedevils its future.
12 Jul, 2022 | 12:31h | UTCSecrecy: A demon of gene therapy’s past bedevils its future – STAT
ESAIC/ESRA guideline | Regional anesthesia in patients on antithrombotic drugs.
11 Jul, 2022 | 12:46h | UTC
Commentary on Twitter
https://twitter.com/preopconsult/status/1546157273856315392
European Medicines Agency recommends second COVID booster for people over 60 – as WHO ponders guidance.
11 Jul, 2022 | 12:41h | UTC
Brief Review | Optimizing aerosolized therapies in critically ill patients.
11 Jul, 2022 | 12:37h | UTCOptimising aerosolized therapies in critically ill patients – Intensive Care Medicine (if the link is paywalled, try this one)
2022 ACR Guideline for the perioperative management of antirheumatic medication in patients with rheumatic diseases undergoing elective total hip or total knee arthroplasty.
11 Jul, 2022 | 12:29h | UTCSee also: Guideline Summary (PDF)
Systematic Review | Medical methods for first trimester abortion.
11 Jul, 2022 | 12:18h | UTCMedical methods for first trimester abortion – Cochrane Library
RCT | 20% albumin vs. plasmalyte in patients with cirrhosis and sepsis-induced hypotension.
11 Jul, 2022 | 12:16h | UTC
M-A | There is no convincing evidence supporting the use of vaginal progesterone in singleton gestations with a history of spontaneous preterm birth.
11 Jul, 2022 | 11:58h | UTCDoes vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Related:
Early vaginal progesterone versus Placebo in Twin Pregnancies for prevention of spontaneous preterm birth (EVENTS): A randomised double-blind trial – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Commentary on Twitter
AJOG Systematic Review: Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? – Effect of vaginal progesterone on preterm birth <37 weeks of gestation https://t.co/fsPlSZCnsr pic.twitter.com/2z6g3CFgX4
— AJOG (@AJOG_thegray) April 25, 2022
RCT | Neutralizing COVID-19 convalescent plasma does not benefit adults hospitalized with COVID-19.
8 Jul, 2022 | 11:59h | UTC
Interim Analysis | Oral Sabizabulin for high-risk, hospitalized adults with Covid-19.
8 Jul, 2022 | 12:02h | UTCOral Sabizabulin for High-Risk, Hospitalized Adults with Covid-19: Interim Analysis – NEJM Evidence
M-A | Associations of thiazide use with skin cancers.
8 Jul, 2022 | 11:55h | UTCAssociations of thiazide use with skin cancers: a systematic review and meta-analysis – BMC Medicine
Related:
Association of Hydrochlorothiazide Use and Risk of Malignant Melanoma – JAMA Internal Medicine
M-A | Antithyroid drug therapy in pregnancy and risk of congenital anomalies.
8 Jul, 2022 | 11:36h | UTC
M-A | Prenatal antibiotic exposure, asthma, and the atopic march.
8 Jul, 2022 | 11:31h | UTC
RCT | Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military.
8 Jul, 2022 | 11:26h | UTCDose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial – Neuropsychopharmacology (if the link is paywalled, try this one)
Commentary on Twitter
Glad to see this work published. Contrary to predictions from small studies, #ketamine failed in the largest #PTSD clinical trial.
Future studies should test the lower dose and 3x/wk. @npp_journal @YalePsych @bcmhouston @netteaverillhttps://t.co/7NcFsNTMKw
— Chadi Abdallah (@ChadiAbdallah3) January 19, 2022
Test-negative, case–control study | Effectiveness of a fourth dose of covid-19 mRNA vaccine against the omicron variant among long term care residents in Ontario, Canada.
7 Jul, 2022 | 13:00h | UTC