Pharmacology/Pharmaceutical Industry
Brief Review | Contraception in women with cardiovascular disease.
25 Jul, 2022 | 13:05h | UTCContraception in Women With Cardiovascular Disease – JAMA (free for a limited period)
Measuring contraceptive method mix, prevalence, and demand satisfied by age and marital status in 204 countries and territories, 1970–2019: a systematic analysis for the Global Burden of Disease Study 2019.
25 Jul, 2022 | 13:07h | UTCCommentary: Global Study Shows Contraception Needs Often Unmet for Young Women – HealthDay
Commentary on Twitter
NEW—160 million women worldwide have unmet #contraception needs.
Study reveals large differences in types of contraceptives used across regions and age groups: https://t.co/bIcDBxcLMf pic.twitter.com/o95QCUUFPX
— The Lancet (@TheLancet) July 21, 2022
Retrospective Cohort Study | Effectiveness of a fourth dose of mRNA COVID-19 vaccine against all-cause mortality in long-term care facility residents and in the oldest old.
25 Jul, 2022 | 13:03h | UTCRelated:
RCT | Efficacy and safety of Abrocitinib vs. Dupilumab in adults with moderate-to-severe atopic dermatitis.
25 Jul, 2022 | 12:44h | UTCEfficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial – The Lancet (link to abstract – $ for full-text)
Related: Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis – New England Journal of Medicine
Chasing LDL cholesterol to the bottom — PCSK9 in perspective.
22 Jul, 2022 | 11:36h | UTCChasing LDL cholesterol to the bottom — PCSK9 in perspective – Nature Cardiovascular Research (if the link is paywalled, try this one)
Commentary on Twitter
Review| @LaleTokgozoglu and Peter Libby discuss the management of #atherogenic #LDL cholesterol with an emphasis on the role #PCSK9 inhibition strategies https://t.co/k1wPKAdotU
— Nature Cardiovascular Research (@NatureCVR) June 17, 2022
Practical recommendations to combine small-molecule inhibitors and direct oral anticoagulants in patients with nonsmall cell lung cancer.
22 Jul, 2022 | 11:07h | UTC
Cohort Study | Effectiveness of the Pfizer vaccine against Omicron in children 5 to 11 years of age.
21 Jul, 2022 | 13:28h | UTC
Retrospective Cohort Study | Major adverse cardiovascular events in patients with renal cell carcinoma treated with targeted therapies.
21 Jul, 2022 | 12:54h | UTC
M-A | Effectiveness of interventions to improve medication adherence in adults with depressive disorders.
21 Jul, 2022 | 12:33h | UTC
M-A | Risk and benefit for umbrella trials in oncology.
21 Jul, 2022 | 12:27h | UTC
Open-label RCT | Moderate-intensity statin plus ezetimibe is noninferior to high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease.
20 Jul, 2022 | 12:32h | UTCLong-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING): a randomised, open-label, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
A prospective study of the association between SARS-CoV-2 infection and COVID-19 vaccination with changes in usual menstrual cycle characteristics.
20 Jul, 2022 | 12:27h | UTC
Review | Opioid sparing strategies for perioperative pain management other than regional anesthesia.
20 Jul, 2022 | 11:47h | UTC
Review | New antibiotics for hospital-acquired pneumonia and ventilator-associated pneumonia.
20 Jul, 2022 | 11:44h | UTC
Who to vaccinate first? A peek at decision-making in a pandemic.
19 Jul, 2022 | 13:40h | UTCWho to vaccinate first? A peek at decision-making in a pandemic – Nature
A pandemic treaty for equitable global access to medical countermeasures: seven recommendations for sharing intellectual property, know-how and technology.
19 Jul, 2022 | 13:38h | UTC
RCT | Effect of Dextromethorphan plus Bupropion vs. Bupropion alone in major depressive disorder.
19 Jul, 2022 | 13:19h | UTCEffect of AXS-05 (Dextromethorphan-Bupropion) in Major Depressive Disorder: A Randomized Double-Blind Controlled Trial – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentary: Dextromethorphan-Bupropion Significantly Improves Depression Symptoms, Study Finds – Psychiatry News Alert
RCT | Efficacy and safety of once-weekly Efpeglenatide monotherapy versus placebo in Type 2 Diabetes.
19 Jul, 2022 | 13:20h | UTC
M-A of RCTs | Effects of acetaminophen and ibuprofen monotherapy in febrile children.
19 Jul, 2022 | 13:15h | UTC
Network M-A | Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults.
18 Jul, 2022 | 11:41h | UTC
Cohort Study | Reactogenicity of simultaneous COVID-19 mRNA booster and influenza vaccination.
18 Jul, 2022 | 11:34h | UTCCommentaries:
More (mostly mild) side effects when flu vaccine given with COVID booster – CIDRAP
Incidence, risk factors, natural history, and hypothesized mechanisms of myocarditis and pericarditis following covid-19 vaccination: living evidence syntheses and review.
18 Jul, 2022 | 11:30h | UTCNews Release: New study updates evidence on rare heart condition after covid vaccination – BMJ Newsroom
Position Paper | Post-discharge and long-term follow-up after an acute coronary syndrome.
18 Jul, 2022 | 11:22h | UTC
Commentary on Twitter
Post-discharge and long-term follow-up after an acute coronary syndrome: International Collaborative Group of CNCF position paper, by Sabouret et alhttps://t.co/yqPzc0q7ya@SABOURETCardio pic.twitter.com/vd1NTKKZ57
— Giuseppe Biondi-Zoccai (@gbiondizoccai) July 16, 2022
Targeted cancer therapies: clinical pearls for primary care.
18 Jul, 2022 | 10:56h | UTCTargeted cancer therapies: Clinical pearls for primary care – Canadian Family Physicians
RCT | Pharmacogenomic testing for drug-gene interactions provides little benefit for the remission of symptoms in major depressive disorder.
14 Jul, 2022 | 13:05h | UTCEffect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Pharmacogenomic Testing for Next-Step Antidepressant Selection: Still a Work in Progress – JAMA (free for a limited period)
Commentary: Does Pharmacogenomic Testing Improve Outcomes in Major Depressive Disorder? — The evidence is unclear – MedPage Today (free registration required)
Commentary on Twitter
In this randomized clinical trial, pharmacogenomic testing for drug-gene interactions in major depressive disorder reduced prescription of medications with predicted drug-gene interactions but had small and nonpersistent effects on symptom remission. https://t.co/Z2OIK3h1Bo pic.twitter.com/8eKSipfBFN
— JAMA (@JAMA_current) July 12, 2022