M-A | There is no convincing evidence supporting the use of vaginal progesterone in singleton gestations with a history of spontaneous preterm birth.

Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

News Release: Progress toward personalized prevention of preterm birth: When progesterone works and when it does not – Wayne State University School of Medicine

Related:

A Randomized Trial of Progesterone in Women with Recurrent Miscarriages – New England Journal of Medicine

A Randomized Trial of Progesterone in Women with Bleeding in Early Pregnancy – New England Journal of Medicine

Early vaginal progesterone versus Placebo in Twin Pregnancies for prevention of spontaneous preterm birth (EVENTS): A randomised double-blind trial – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

Commentary on Twitter

AJOG Systematic Review: Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? – Effect of vaginal progesterone on preterm birth <37 weeks of gestation https://t.co/fsPlSZCnsr pic.twitter.com/2z6g3CFgX4

— AJOG (@AJOG_thegray) April 25, 2022