Pharmacology/Pharmaceutical Industry
Post-hoc analysis | Can SGLT2 inhibitors reduce the risk of nephrolithiasis?
7 Jul, 2022 | 12:42h | UTC
RCT | Efficacy and safety of upadacitinib for active ankylosing spondylitis refractory to biological therapy.
7 Jul, 2022 | 12:44h | UTC
Commentary on Twitter
SELECT-AXIS 2 trial – patients with #AS and inadequate response to #bDMARDs. #RCT of upadacitinb vs placebo 14 weeks:
Improved signs and symptoms of active AS and was well tolerated for 14 weeks of treatment in bDMARD-IR patients!https://t.co/Z7fuxiXMDb pic.twitter.com/kGZX9AsaVE— Annals of the Rheumatic Diseases (@eular_ARD) July 5, 2022
Post-hoc analysis | Can SGLT2 inhibitors reduce the risk of hyperuricemia and gout?
7 Jul, 2022 | 12:40h | UTC
M-A | Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer’s disease.
7 Jul, 2022 | 12:34h | UTCCommentaries:
M-A | DOACs vs. VKAs in atrial fibrillation patients with bioprosthetic heart valve.
7 Jul, 2022 | 12:15h | UTC
Review | The vaccine-hesitant moment.
6 Jul, 2022 | 11:49h | UTCThe Vaccine-Hesitant Moment – New England Journal of Medicine
Age and sex-specific risks of myocarditis and pericarditis following Covid-19 messenger RNA vaccines.
6 Jul, 2022 | 11:48h | UTCRCT | Odevixibat treatment in progressive familial intrahepatic cholestasis.
6 Jul, 2022 | 11:35h | UTCInvited Commentary: The first new drug for progressive familial intrahepatic cholestasis – The Lancet Gastroenterology & Hepatology (free registration required)
Commentary on Twitter
New research – Thompson et al – Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial (PEDFIC 1)https://t.co/hPLmPLMcDt#livertwitter #cholestasis #PFIC pic.twitter.com/oUMMh1H0kv
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) July 1, 2022
RCT | Enterosgel (polymethylsiloxane polyhydrate) for the treatment of irritable bowel syndrome with diarrhea.
6 Jul, 2022 | 11:33h | UTCPodcast | Overview of checkpoint inhibitors for general practitioners.
6 Jul, 2022 | 11:29h | UTC#342 Checkpoint Inhibitors – The Curbsiders
Registry-based cohort study | Neonatal morbidity after fetal exposure to antipsychotics.
6 Jul, 2022 | 11:24h | UTCNeonatal morbidity after fetal exposure to antipsychotics – BMJ Open
RCT | Ozoralizumab vs. placebo in patients with active rheumatoid arthritis despite methotrexate therapy.
6 Jul, 2022 | 11:12h | UTCCommentary: Ozoralizumab shows promise in methotrexate-resistant RA – medwire News
M-A | Anticoagulants for thrombosis prophylaxis in acutely ill patients admitted to hospital.
5 Jul, 2022 | 12:19h | UTCDelphi-Based Consensus | Practical guidance on basal insulin initiation and titration in Asia.
5 Jul, 2022 | 12:03h | UTCRCT | Single-dose, bioadhesive Clindamycin 2% gel for bacterial vaginosis.
5 Jul, 2022 | 11:56h | UTCCommentary:
Single-Dose Clindamycin Gel Highly Effective for Bacterial Vaginosis – JAMA
Single-Dose Clindamycin Gel Highly Effective for Bacterial Vaginosis in Women – Medical Dialogues
Commentary on Twitter
FREE: Single-Dose, Bioadhesive Clindamycin 2% Gel for Bacterial Vaginosis: A Randomized Controlled Trial #obgyn https://t.co/ofIXGiFXbL pic.twitter.com/0nQigeCFP5
— The Green Journal (@greenjrnl) May 27, 2022
Bad news for Paxlovid? Coronavirus can find multiple ways to evade COVID-19 drug.
4 Jul, 2022 | 12:57h | UTCBad news for Paxlovid? Coronavirus can find multiple ways to evade COVID-19 drug – Science
See also: SARS-CoV-2 can evade Paxlovid by multiple mechanisms – News Medical
Opinion | FDA: Don’t rush a move to change the Covid-19 vaccine composition.
4 Jul, 2022 | 12:53h | UTCFDA: Don’t rush a move to change the Covid-19 vaccine composition – STAT
Antibodies to combat viral infections: development strategies and progress.
4 Jul, 2022 | 12:51h | UTCAntibodies to combat viral infections: development strategies and progress – Nature Reviews Drug Discovery (if the link is paywalled, try this one in PMC)
Using the intranasal route to administer drugs to treat neurological and psychiatric illnesses: rationale, successes, and future needs.
4 Jul, 2022 | 12:26h | UTCUsing the Intranasal Route to Administer Drugs to Treat Neurological and Psychiatric Illnesses: Rationale, Successes, and Future Needs – CNS Drugs (if the link is paywalled, try this one)
Review | Lowering and raising serum urate levels: off-label effects of commonly used medications.
4 Jul, 2022 | 12:10h | UTCM-A of randomized trials | Ondansetron vs. metoclopramide for managing hyperemesis gravidarum.
4 Jul, 2022 | 12:11h | UTCFDA warns about possible increased risk of death and serious side effects with duvelisib.
4 Jul, 2022 | 11:51h | UTC2022 Guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer, including patients with COVID-19.
1 Jul, 2022 | 11:50h | UTCRelated:
Two new studies show no benefit of Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19.
1 Jul, 2022 | 11:49h | UTCCommentaries:
Antithrombotic Prophylaxis No Help in Outpatients With COVID — Two trials show no differences between patients who received enoxaparin vs standard of care – MedPage Today (free registration required)
Commentary on Twitter (thread – click for more)
Early in the pandemic we wondered whether antithrombotic therapy in outpatients with #COVID19 would prevent #thrombosis ❓
Several trials were started globally and the ACTIV-4B trial was previously reported⬇️ https://t.co/Q15WcZwDIA
Now, we publish the OVID and ETHIC trials🧵
— The Lancet Haematology (@TheLancetHaem) June 30, 2022
RCT: A single immediate dose of intravenous tenecteplase is noninferior to alteplase for the treatment of patients with acute ischemic stroke.
1 Jul, 2022 | 11:44h | UTCIntravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
News Release: UCalgary researchers with the Calgary Stroke Program make another breakthrough in the treatment of stroke