Pharmacology/Pharmaceutical Industry
WHO updates recommendations on HPV vaccination schedule
9 Jan, 2023 | 14:57h | UTCNews Release: WHO updates recommendations on HPV vaccination schedule – World Health Organization
Guideline: Human papillomavirus vaccines: WHO position paper, December 2022 – World Health Organization
Commentaries:
WHO supports 1-dose HPV vaccine strategy – CIDRAP
Commentary on Twitter
🆕 WHO has revised its recommendations on possible schedules for human papillomavirus (#HPV) vaccines & now recommends:
👉1 or 2-doses for girls & women aged 9-20
👉2 doses with a 6-month interval for women 21+https://t.co/m0KZyH6sPR pic.twitter.com/W4PeS4raV9— World Health Organization (WHO) (@WHO) December 21, 2022
Scientists tie third clinical trial death to experimental Alzheimer’s drug
9 Jan, 2023 | 14:47h | UTCScientists tie third clinical trial death to experimental Alzheimer’s drug – Science
Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.
RCT | The addition of Olanzapine to a triple antiemetic regimen effectively prevents nausea and vomiting during highly emetogenic chemotherapy.
16 Dec, 2022 | 13:32h | UTCRelated:
Cohort Study | Assessment of depression and adherence to guideline-directed medical therapies following PCI.
14 Dec, 2022 | 14:59h | UTCCommentaries:
Cohort Study | Association of in utero antipsychotic medication exposure with risk of congenital malformations.
8 Dec, 2022 | 13:00h | UTCAssociation of In Utero Antipsychotic Medication Exposure With Risk of Congenital Malformations in Nordic Countries and the US – JAMA Psychiatry (free for a limited period)
Related:
Commentary on Twitter
New findings from a large cohort study including 26,000 antipsychotic-exposed pregnancies from 6 countries suggest that prenatal exposure to individual antipsychotics is generally not associated with an increase in risk of major congenital malformations https://t.co/4cUm8sXgsi
— JAMA Psychiatry (@JAMAPsych) December 7, 2022
ASCO Guideline | Use of opioids for adults with pain from cancer or cancer treatment.
7 Dec, 2022 | 14:32h | UTC
Case Report | Vitamin D intoxication and severe hypercalcemia complicating nutritional supplements misuse.
6 Dec, 2022 | 13:56h | UTCCommentaries:
Vitamin D supplement ‘overdosing’ is possible and harmful, warn doctors – Medical Dialogues
How an increasingly popular supplement landed a man in the hospital – CNN
You Can Take Too Much Vitamin D — One Man Found Out the Hard Way – HealthDay
Consensus Recommendations | Antiretroviral drugs for treatment and prevention of HIV infection in adults.
2 Dec, 2022 | 14:45h | UTCAntiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults2022 Recommendations of the International Antiviral Society–USA Panel – JAMA (free for a limited period)
Invited Commentary: Ending the HIV Epidemic: We Have the Tools, Do We Have the Will? – JAMA (free for a limited period)
Author Interview: Advances in Treatment and Prevention of HIV – JAMA
RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.
2 Dec, 2022 | 14:40h | UTCLecanemab in Early Alzheimer’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Heralded Alzheimer’s drug works — but safety concerns loom – Nature
Lecanemab and Alzheimer’s: More Data – Science
Alzheimer’s Drug is Hailed Amid Safety Concerns – Health Policy Watch
Related: Second death linked to potential antibody treatment for Alzheimer’s disease – Science
Commentary on Twitter
In a phase 3 trial, participants with early Alzheimer’s disease who received the monoclonal antibody lecanemab had less decline on measures of cognitive function at 18 months than those who received placebo. https://t.co/NjEloWVk1V pic.twitter.com/n33yjV9117
— NEJM (@NEJM) November 30, 2022
Perspective | Push to use antibiotics to prevent sexually transmitted infections raises concerns.
2 Dec, 2022 | 14:27h | UTCPush to use antibiotics to prevent sexually transmitted infections raises concerns – Nature
M-A | Efficacy and safety of COVID-19 inactivated vaccine.
1 Dec, 2022 | 14:00h | UTCEfficacy and safety of COVID-19 inactivated vaccine: A meta-analysis – Frontiers in Medicine
SR | Antipsychotic dose reduction compared to dose continuation for people with schizophrenia.
29 Nov, 2022 | 13:59h | UTCSummary: Reduction in the dose of antipsychotics for people with schizophrenia – Cochrane Library
Improving antimicrobial stewardship with penicillin allergy testing: a review of current practices and unmet needs.
27 Nov, 2022 | 22:25h | UTCRelated:
M-A: Most patients with allergy to Penicillin can be given Cefazolin
Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk
Review | Deprescribing proton pump inhibitors.
27 Nov, 2022 | 22:06h | UTCDeprescribing proton pump inhibitors – Australian Journal of General Practice
BMJ Investigation | FDA oversight of clinical trials is “grossly inadequate,” say experts.
25 Nov, 2022 | 12:35h | UTCFDA oversight of clinical trials is “grossly inadequate,” say experts – The BMJ
News Release: Investigation raises concerns about poor FDA oversight of clinical trials – BMJ Newsroom
Commentary: FDA Oversight of Clinical Trials Described as ‘Grossly Inadequate’ – HealthDay
Cohort Study | Development of interstitial lung disease among patients with atrial fibrillation receiving oral anticoagulants.
25 Nov, 2022 | 12:23h | UTCCommentaries:
Slight Risk of Interstitial Lung Disease Seen With Certain DOACs – TCTMD
RCT | New drug can improve constipation in patients with Parkinson Disease.
22 Nov, 2022 | 13:00h | UTCOral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries:
New Drug Could Ease Parkinson’s-Related Constipation – HealthDay
Commentary on Twitter
A #RTC of 150 persons with #ParkinsonDisease has found that ENT-01 is safe for up to 25 days of treatment and significantly improves constipation and possibly neurological symptoms: https://t.co/JdDhaHiFOA @MayoClinic pic.twitter.com/IWWCBzvrWV
— Annals of Int Med (@AnnalsofIM) November 8, 2022
M-A | Pharmacological interventions on smoking cessation.
18 Nov, 2022 | 13:12h | UTC
RCT | Comparative effects of low-dose rosuvastatin vs. dietary supplements on lipids and inflammatory biomarkers.
16 Nov, 2022 | 13:41h | UTCNews Release: 6 common “heart-health” supplements ineffective at lowering cholesterol compared to statins – American Heart Association
Commentaries:
Study – For Lowering Cholesterol, Statins Work, Supplements Don’t – Science-Based Medicine
Statins vs. supplements: New study finds one is ‘vastly superior’ to cut cholesterol – NPR
RCT | Evaluation of two short, standardized regimens for the treatment of rifampicin-resistant tuberculosis.
15 Nov, 2022 | 12:57h | UTCCommentary:
Shorter treatment effective for drug-resistant tuberculosis – University College London
Shorter Treatment Regimen for Drug-Resistant TB is More Effective – Health Policy Watch
RCT | No benefit from a model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients.
11 Nov, 2022 | 13:46h | UTC
Commentary on Twitter
Individualising beta-lactam ABTs/ciprofoxacin therapy in #ICU using model-informed precision dosing vs standard dosing, multicentre 🇳🇱 RCT
No evidence for clinical effect of MIPD on LOS or other secondary outcomes in critically ill pts#FOAMcc @yourICM
🗞️https://t.co/6HzLBBnFdU pic.twitter.com/uErsHNAV5p— Intensive Care Medicine (@yourICM) November 9, 2022
SR | The availability, cost, and affordability of essential medicines for asthma and COPD in low- and middle-income countries.
11 Nov, 2022 | 13:04h | UTCInvited Commentary: Access to essential respiratory medications remains elusive in LMICs – The Lancet Global Health
M-A | Medication reviews and deprescribing as a single intervention in falls prevention.
11 Nov, 2022 | 12:53h | UTC
Cohort Study | Association of hormone therapy with depression during menopause.
9 Nov, 2022 | 12:17h | UTCCommentaries:
Expert reaction to study looking at HRT and depression during the menopause – Science Media Centre
Commentary on Twitter
Systemic hormone therapy (HT) before and during menopause is associated with higher risk of depression, especially in the years immediately after initiation; locally administered HT is associated with lower risk of depression for women ≥54 years. https://t.co/8k44K8SVtp
— JAMA Network Open (@JAMANetworkOpen) November 1, 2022
Review | Direct oral anticoagulants for the prevention and acute treatment of cancer-associated thrombosis.
9 Nov, 2022 | 12:13h | UTC