[Abstract Only] Randomized, open-label trial: Olanzapine seems effective for the prevention of vomiting in children and adolescents receiving highly emetogenic chemotherapy

Olanzapine for Prevention of Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy: Investigator-Initiated, Randomized, Open-Label Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentary on Twitter

RCT of adding Olanzapine to Nausea regimen (aprepitant, ondan, dex)

231 children, cycle 1 of highly emetogenic chemo

Primary endpoint: complete response= no vomiting + no rescue med use

78% v 59% day 1
74% v 47% days 1-5
64% v 38% overall#supponc https://t.co/cZFM8bLXKg

— Arjun Gupta (@guptaarjun90) September 16, 2020