Pharmacology/Pharmaceutical Industry
Anticoagulation in Chronic Kidney Disease: From Guidelines to Clinical Practice
19 May, 2019 | 13:00h | UTC
Study: Incident Exposure to Benzodiazepines in Early Pregnancy and Risk of Spontaneous Abortion
17 May, 2019 | 06:39h | UTCAssociation Between Incident Exposure to Benzodiazepines in Early Pregnancy and Risk of Spontaneous Abortion – JAMA Psychiatry (free for a limited period)
Commentaries: Benzodiazepine Use in Early Pregnancy Increases Risk of Miscarriage, Study Suggests – Psychiatry News Alert (free) AND Assess benzodiazepines’ risk-benefit before use in early pregnancy – OnMedica (free) AND Benzodiazepine Use in Early Pregnancy Linked to Spontaneous Abortion – MPR (free)
Cohort Study: Chronic Use of Tramadol After Acute Pain Episode
16 May, 2019 | 05:19h | UTCChronic use of tramadol after acute pain episode: cohort study – The BMJ (free)
Commentaries: Risk of Prolonged Use With Tramadol vs Other Short Acting Opioids Examined – MPR (free) AND ‘There really is no safe opioid’: Study finds tramadol isn’t a less addictive painkiller – CBC (free)
Related Commentary on Twitter
Tramadol use is associated with a higher risk of prolonged opioid use in patients with an acute episode of pain compared with other short acting opioids, finds new research @mollyjeffery https://t.co/PK0SYpINT7
— The BMJ (@bmj_latest) May 14, 2019
Meta-Analysis: Potentially Inappropriate Prescribing Among Older Persons
15 May, 2019 | 06:39h | UTCNews Release: Inappropriate prescribing can lead to adverse outcomes – American Academy of Family Physicians (free)
Perspective: The Dangers of Ignoring the Beers Criteria—The Prescribing Cascade
15 May, 2019 | 06:43h | UTCThe Dangers of Ignoring the Beers Criteria—The Prescribing Cascade – JAMA Internal Medicine (free for a limited period)
Original Article: AGS 2019 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults (link to abstract – $ for full-text)
Cohort Study: High Intakes of Vitamins B6 and B12 From Food and Supplements are Associated with Increased Risk of Hip Fracture
13 May, 2019 | 01:25h | UTC
Meta-analysis: Vasopressin in Septic Shock
10 May, 2019 | 05:07h | UTC“Vasopressin therapy in septic shock had no effect on 28-day mortality”
Randomized Trial Shows High Levels of Systemic Absorption of Sunscreen Ingredients
9 May, 2019 | 08:09h | UTCEditorial: Filling in the Evidence About Sunscreen (free)
Commentaries: Expert reaction to study looking at sunscreen ingredients and bloodstream concentrations – Science Media Centre (free) AND High levels of sunscreen ingredients end up in the bloodstream: study – Reuters (free) AND How Sunscreen Chemicals Can Get Into Your Blood – Forbes (free) AND How Much of Your Sunscreen is Absorbed? – MedicalResearch.com (free)
Study: Fournier Gangrene Associated with SGLT2 Inhibitors
7 May, 2019 | 01:13h | UTCFournier Gangrene Associated With Sodium–Glucose Cotransporter-2 Inhibitors: A Review of Spontaneous Postmarketing Cases – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: SGLT2 inhibitors associated with rare, life-threatening necrotizing genital infections – ACP Internist (free) AND Potentiall fatal infection of genitals identified as rare side effect of SGLT2 Inhibitors – American College of Physicians (free) AND Postmarketing data support Fournier gangrene link with SGLT2 inhibitors – Medicine Matters (free)
Related: SGLT2 inhibitors: reports of Fournier’s gangrene (necrotising fasciitis of the genitalia or perineum) – GOV.UK (free)
FDA Safety Alert: Serious Incidents Related to Certain Prescription Insomnia Medicines
2 May, 2019 | 04:34h | UTCFor Consumers: Taking Z-drugs for Insomnia? Know the Risks – U.S. Food & Drug Administration (free)
Commentaries: Drug Agency Calls for Strong Warning Labels on Popular Sleep Aids – The New York Times (10 articles per month are free) AND FDA Requires Stronger Warnings for Common Insomnia Medications – Psychiatric News Alert (free)
Study: Fluoroquinolones Associated with Peripheral Neuropathy
30 Apr, 2019 | 02:40h | UTCAssociation Between Peripheral Neuropathy and Exposure to Oral Fluoroquinolone or Amoxicillin-Clavulanate Therapy – JAMA Neurology (free for a limited period)
Editorial: On the Association Between Fluoroquinolones and Neuropathy (free)
Related: Committee Recommends New Restrictions on the use of Fluoroquinolones (free report and commentaries)
Meta-Analysis: Proton Pump Inhibitors may Increase the Risk of Hip Fractures
28 Apr, 2019 | 13:25h | UTCMedication to reduce stomach acid may increase risk of hip fractures – NIHR Signal (free)
Original Article: Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies – Osteoporosis International (link to abstract – $ for full-text)
PANLAR Consensus Statement on Biosimilars
28 Apr, 2019 | 13:13h | UTCPANLAR consensus statement on biosimilars – Clinical Rheumatology (free)
Cohort Study: Increased Duration of Antimicrobial Prophylaxis is Associated with Increased Risk of Adverse Events and No Reductions in Surgical Site Infections
26 Apr, 2019 | 02:01h | UTCAssociation of Duration and Type of Surgical Prophylaxis With Antimicrobial-Associated Adverse Events – JAMA Surgery (free for a limited period)
Commentaries: Balancing the Risks and Benefits of Surgical Prophylaxis: Timing and Duration Do Matter – JAMA Surgery (free for a limited period) AND Longer Antibiotic Rx After Surgery Tied to Increasing Harms, Limited Benefits – NEJM Journal Watch (free)
Detection and Management of Common Medication Errors in Internal Medicine Wards: Impact on Medication Costs and Patient Care
25 Apr, 2019 | 17:22h | UTCSource: Hospital Medicine Virtual Journal Club
Cochrane Review: Nicotine Replacement for Smoking Cessation More Successful in Combination Form
19 Apr, 2019 | 08:42h | UTCDifferent doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation – Cochrane Library (free)
Commentaries: Nicotine replacement: when quitting cigarettes, consider using more nicotine, not less – The Conversation (free) AND Nicotine replacement therapy: new evidence on help to quit smoking – Evidently Cochrane (free) AND Nicotine replacement therapy more successful in combination form – Nuffield Department of Primary Care Health Sciences (free)
Related Commentary on Twitter
Featured Cochrane Review: Different doses, durations and modes of delivery of #nicotine replacement therapy for #smoking cessation from @CochraneTAG – Read comments from lead author https://t.co/WBvMA74iaK and the full review https://t.co/QFLx9Wb9Xc pic.twitter.com/tk2J6WRT3Z
— Cochrane (@cochranecollab) April 18, 2019
Another Observational Study Showing Association of Statin Use with Risk of New‐Onset Diabetes Mellitus
19 Apr, 2019 | 08:25h | UTCEditorial: Perils of Observational Data Analyses (free)
Commentary: Statins for primary prevention: do benefits outweigh DM risk? – Univadis (free registration required)
Related: Cohort Study: Statin Use Associated with a 38% Higher Risk of Incident Type 2 Diabetes (free study and commentaries)
NCCN Guideline: Management of Immunotherapy-Related Toxicities
18 Apr, 2019 | 08:00h | UTCRelated Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Related Reviews: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know? – Annals of Intensive Care (free) AND Checkpoint Inhibitors: The diagnosis and treatment of side effects – Deutsches Ärzteblatt international (free)
Meta-Analysis: Direct Oral Anticoagulants in Patients with Venous Thromboembolism and Thrombophilia
15 Apr, 2019 | 02:06h | UTC
EASL Guideline: Drug-induced Liver Injury
15 Apr, 2019 | 00:48h | UTCEASL Clinical Practice Guidelines: Drug-induced liver injury – Journal of Hepatology (free)
Related Review: Drug-induced liver injury: recent advances in diagnosis and risk assessment – Gut (free)
Related Commentary on Twitter
The @EASLedu guidelines on drug-induced liver injury are now available.
Including a special section on liver manifestations in cancer #Immunotherapy https://t.co/ptqeIRoFvO #liverdisease #DILI @EASLnews pic.twitter.com/SLrMGYsFQn— Journal of Hepatology (@JHepatology) April 6, 2019
Cohort Study: 5α-reductase Inhibitors Linked to Increased Risk of Type 2 Diabetes
11 Apr, 2019 | 00:34h | UTCCommentary: Reducing the risk of type 2 diabetes in men with benign prostatic hyperplasia—old steroids, new tricks – The BMJ Opinion (free)
Checkpoint Inhibitors: The Diagnosis and Treatment of Side Effects
10 Apr, 2019 | 06:10h | UTCRelated Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Related Reviews: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know? – Annals of Intensive Care (free)
Review: Unusual Effects of Common Antibiotics
10 Apr, 2019 | 06:00h | UTCUnusual Effects of Common Antibiotics – Cleveland Clinic Journal of Medicine (free)
Cohort Study: Supplements and Vitamins Do Not Lower Mortality Risk
10 Apr, 2019 | 05:58h | UTCAssociation Among Dietary Supplement Use, Nutrient Intake, and Mortality Among U.S. Adults: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Nutrients from food, not supplements, linked to lower risks of death, cancer – Tufts University (free) AND Taking Vitamins Doesn’t Seem to Lower Mortality Risk – NEJM Journal Watch (free) AND Elevated cancer risk linked to excessive calcium intake, study says – UPI (free) AND Expert reaction to nutrient intake, dietary supplement use and mortality in the US – Science Media Centre (free)
Related: The Multivitamin Industry Rakes in Billions of Dollars. But Science Says We’re Not Getting Healthier (free commentary)
Study: Cost Avoidance Associated with Clinical Pharmacist Presence in a Medical Intensive Care Unit
9 Apr, 2019 | 02:16h | UTCCost Avoidance Associated with Clinical Pharmacist Presence in a Medical Intensive Care Unit – Journal of the American College of Clinical Pharmacy (free PDF) (via @ABsteward)