Pharmacology/Pharmaceutical Industry
[Abstract Only] Vitamin D Fails to Prevent Type 2 Diabetes in Patients with Pre-diabetes
9 Jun, 2019 | 21:55h | UTCVitamin D Supplementation and Prevention of Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: NIH-funded trial finds vitamin D does not prevent type 2 diabetes in people at high risk – NIH News Releases (free) AND Vitamin D fails to prevent type 2 diabetes in large study – Reuters (free) AND Vitamin D Supplements Do Not Significantly Reduce Risk of Developing Type 2 Diabetes, According to Research Presented Today at the ADA’s Scientific Sessions – American Diabetes Association (free)
Meta-analysis: Optimal Dose of Antidepressants in Major Depression
9 Jun, 2019 | 22:07h | UTCCommentaries: Which antidepressant doses are optimal? – The Lancet Psychiatry (free) AND Expert reaction to systematic review and dose-response meta-analysis of antidepressants – Science Media Centre (free)
Statin Toxicity: Mechanistic Insights and Clinical Implications
9 Jun, 2019 | 21:48h | UTCStatin Toxicity: Mechanistic Insights and Clinical Implications – Circulation Research (free)
Consensus Paper: Management of Targeted Therapies in Cancer Patients with Chronic Kidney Disease, or on Hemodialysis
9 Jun, 2019 | 13:59h | UTC
[Abstract Only] Anaphylaxis in Children: Observational Shows that Pre-hospital Treatment with Epinephrine is Associated with Improved Outcomes
9 Jun, 2019 | 14:48h | UTCEvaluation of Prehospital Management in a Canadian Emergency Department Anaphylaxis Cohort – Journal of Allergy and Clinical Immunology: In Practice (link to abstract – $ for full-text)
Commentary: Guidelines for managing anaphylaxis in children need an update – McGill University Health Centre (free)
[Abstract Only] Children and Young Adults May Have Severe Medical Events from Dietary Supplements Sold for Weight Loss, Muscle Building, and Energy
6 Jun, 2019 | 06:05h | UTCTaking Stock of Dietary Supplements’ Harmful Effects on Children, Adolescents, and Young Adults – Journal of Adolescent Health (link to abstract – $ for full-text)
Commentaries: Dietary supplements linked with severe health events in children, young adults – Harvard T.H. Chan School of Public Health (free) AND Harvard Study: Supplements For Energy, Weight Loss, Muscle-Building Carry Risk For Youth – CommonHealth (free) AND Study: Dietary supplements may raise death risk in children, teens – UPI (free)
Position Paper on Fall-Risk-Increasing Drugs
6 Jun, 2019 | 05:52h | UTC
[Abstract Only] Randomized Trial: Lisinopril vs. Carvedilol vs. Placebo to Prevent Trastuzumab Cardiotoxicity in Patients with Breast Cancer
5 Jun, 2019 | 04:13h | UTCRandomized Trial of Lisinopril Versus Carvedilol to Prevent Trastuzumab Cardiotoxicity in Patients With Breast Cancer – Journal of the American College of Cardiology (link to abstract – $ for full-text)
“In patients with HER2-positive breast cancer treated with trastuzumab, both lisinopril and carvedilol prevented cardiotoxicity in patients receiving anthracyclines.”
Meta-Analysis: Safety of Opioids in Osteoarthritis
5 Jun, 2019 | 04:06h | UTC
Study: Most Antibiotics Prescribed Before Dental Procedures are Unnecessary
3 Jun, 2019 | 07:26h | UTCCommentaries: Antibiotic Use in Dentistry—What We Know and Do Not Know – JAMA Network Open (free) AND Most preventive antibiotics prescribed by dentists are unnecessary – University of Illinois at Chicago (free) AND Study finds 81% of dental antibiotic prescribing not needed – CIDRAP (free)
Guideline: Reversal of Direct Oral Anticoagulants
3 Jun, 2019 | 07:14h | UTCCommentary: Reversal of Direct Oral Anticoagulants – NEJM Journal Watch (free for a limited period)
Review: Menopausal Hormone Therapy
31 May, 2019 | 06:30h | UTCMenopausal Hormone Therapy – JAMA (free for a limited period)
Podcast: Menopausal Hormone Therapy (free audio)
Cohort Study: Use of Proton Pump Inhibitors Associated with Increased Mortality
31 May, 2019 | 06:28h | UTCCommentaries: Investigating the causes of death attributable to use of proton pump inhibitors – The BMJ Opinion (free) AND Heartburn drugs linked to fatal heart and kidney disease, stomach cancer – Washington University in St. Louis (free) AND Overuse of heartburn drugs linked to heart, kidney disease, cancer – UPI (free) AND Proton-pump inhibitors (PPIs) Linked to Increased Risk of Death – MedicalResearch.com (free)
Systematic Review: Tramadol for Osteoarthritis
30 May, 2019 | 08:28h | UTCTramadol for osteoarthritis – Cochrane Library (free)
Summary: Tramadol for osteoarthritis – Cochrane Library (free)
“tramadol alone or in combination with acetaminophen probably has no important benefit on mean pain or function in people with osteoarthritis, although slightly more people in the tramadol group report an important improvement”
The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice
29 May, 2019 | 10:47h | UTC
Study: Assessment of the Clinical Benefit of Cancer Drugs Receiving Accelerated Approval
29 May, 2019 | 02:00h | UTCAssessment of the Clinical Benefit of Cancer Drugs Receiving Accelerated Approval – JAMA Internal Medicine (free for a limited period)
Related Study: An Overview of Cancer Drugs Approved by the US Food and Drug Administration Based on the Surrogate End Point of Response Rate – JAMA Internal Medicine (free for a limited period)
Invited Commentaries: An International Perspective on Drugs for Cancer: The Best of Times, the Worst of Times (free for a limited period) AND Accelerated Approval of Cancer Drugs—Righting the Ship of the US Food and Drug Administration (free for a limited period)
Commentaries: Cancer Drugs Approved Quickly Often Fail To Measure Up Later – NPR (free) AND Questions raised over cancer drugs in FDA’s accelerated approval program – CNN (free)
A Safety Update on Sodium Glucose Co‐transporter 2 Inhibitors
28 May, 2019 | 10:32h | UTCA safety update on sodium glucose co‐transporter 2 inhibitors – Diabetes, Obesity and Metabolism (free)
Review: From Molecular Mechanisms to Clinical Management of Antineoplastic Drug-Induced Cardiovascular Toxicity
28 May, 2019 | 10:22h | UTCRelated: AHA Scientific Statement on Cardio-Oncology: Vascular and Metabolic Perspectives (several guidelines on the subject)
JACC Review: Deprescribing in Older Adults with Cardiovascular Disease
26 May, 2019 | 20:18h | UTCDeprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology (free for a limited period)
Related: Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)
Related Commentary on Twitter
Deprescribing in Older Adults With Cardiovascular Disease
– its hard, it takes time, but it is probably as important as prescribing!#Cardiology #Cardiotwitter #publichealth https://t.co/1urlIi61RD pic.twitter.com/hOXUlZ5M7u
— Konstantin Krychtiuk (@krychtiukmd) May 25, 2019
At $2.1 Million, New Gene Therapy Is The Most Expensive Drug Ever
26 May, 2019 | 19:56h | UTCAt $2.1 Million, New Gene Therapy Is The Most Expensive Drug Ever – NPR (free)
See also: No Miracle Drug Should Cost $2.1 Million – Bloomberg Opinion (free) AND This New Treatment Could Save the Lives of Babies. But It Costs $2.1 Million. – The New York Times (10 articles per month are free)
“The price set by the Swiss drugmaker Novartis may be the world’s highest for a single treatment — prompting renewed debate about how society will pay for gene-therapy breakthroughs.” (from the New York Times)
Antidepressant Withdrawal: Slower and Lower Tapering of SSRIs
23 May, 2019 | 12:42h | UTCAntidepressant withdrawal: slower and lower tapering of SSRIs – The Mental Elf (free)
Related: Antidepressant Withdrawal Syndrome – Therapeutics Initiative (free) AND Many People Taking Antidepressants Discover They Cannot Quit – The New York Times (10 articles per month are free)
Treatment of Infections Due to MDR Gram-Negative Bacteria
23 May, 2019 | 12:26h | UTCTreatment of Infections Due to MDR Gram-Negative Bacteria – Frontiers in Medicine (free)
A Review of Novel Antidepressants: A Guide for Clinicians
21 May, 2019 | 14:56h | UTCA Review of Novel Antidepressants: A Guide for Clinicians – Cureus (free)
Viewpoint – “Millions Take Gabapentin for Pain. But There’s Scant Evidence It Works.”
21 May, 2019 | 06:04h | UTCMillions Take Gabapentin for Pain. But There’s Scant Evidence It Works. – The New York Times (10 articles per month are free)
Related: Meta-Analysis: Anticonvulsants in the Treatment of Low Back Pain and Lumbar Radicular Pain (free) AND Benefits and safety of gabapentinoids in chronic low back pain (free) AND Less is More: A Clinical Overview of Off-label Use of Gabapentinoid Drugs (link to abstract)
Observational Study Suggests Opioids, SSRIs and Steroids May Increase Fracture Risk in Patients with Rheumatoid Arthritis
20 May, 2019 | 22:42h | UTCMedications associated with fracture risk in patients with rheumatoid arthritis – Annals of Rheumatic Diseases (link to abstract – $ for full-text)
Commentary: Opioids, SSRIs and Steroids Increase Fracture Risk in RA – RheumNow (free)