Pharmacology/Pharmaceutical Industry
Perspective: Ghost Authorship Haunts Industry-funded Clinical Trials
11 Oct, 2018 | 21:53h | UTCGhost authorship haunts industry-funded clinical trials – Nature (free)
Original Article: Collaboration Between Academics and Industry in Clinical Trials (free study and commentaries)
Committee Recommends New Restrictions on the use of Fluoroquinolones
11 Oct, 2018 | 21:47h | UTCCommentaries: EMA committee recommends restrictions on fluoroquinolone, quinolone antibiotics – Reuters (free) AND PRAC Recommends Restrictions on Fluoroquinolone, Quinolones – Medscape (free registration required)
Related FDA Safety Alert: Warnings for Fluoroquinolones on Risks of Mental Health and Low Blood Sugar Adverse Reactions (free statement and commentaries)
Meta-Analysis: Statins Not Benefitial for Noncardiovascular Outcomes
11 Oct, 2018 | 21:31h | UTCStatins and Multiple Noncardiovascular Outcomes: Umbrella Review of Meta-analyses of Observational Studies and Randomized Controlled Trials – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Statin Benefits: Yes for CVD but No for Everything Else, Says New Review – TCTMD (free) AND Statins’ benefits beyond heart health aren’t clear-cut, analysis says – CNN (free)
Study: Outpatient Antibiotics Widely Prescribed Without an Infection Diagnosis
11 Oct, 2018 | 20:10h | UTCOutpatient antibiotics widely prescribed without an infection diagnosis – CIDRAP (free)
Related Commentary: Study Finds Almost Half of Antibiotic Prescriptions Written Without a Diagnosis – Pharmacy Times (free)
Perspective: Given Their Potential for Harm, It’s Time to Focus on the Safety of Supplements
5 Oct, 2018 | 02:41h | UTCGiven Their Potential for Harm, It’s Time to Focus on the Safety of Supplements – JAMA (free for a limited period) (via @NUNESDOC)
“About 23 000 visits to emergency departments each year can be attributed to adverse events from dietary supplements.”
Meta-Analysis: Effects of Vitamin D Supplementation on Musculoskeletal Health
5 Oct, 2018 | 02:44h | UTCEffects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: The Lancet Diabetes & Endocrinology: Vitamin D supplementation in adults does not prevent fractures, falls or improve bone mineral density – The Lancet (free) AND Vitamin D supplements don’t help bone health, major study concludes – The Guardian (free) AND Millions of Americans take vitamin D. Most should just stop – VOX (free)
Related: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It (free commentaries and NICE Guideline) AND Vitamin D Not Linked to Fracture Risk (free study and commentaries)
Study: Effect of Lorcaserin on Prevention and Remission of Type 2 Diabetes in Overweight and Obese Patients
5 Oct, 2018 | 02:38h | UTCEffect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Weight loss drug shows positive effect on diabetes – Brigham and Women’s Hospital (free) AND Weight Loss Drug Helped Prevent Diabetes in Overweight People – MedPage Today (free registration required)
Related Article: Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients (link to abstract and commentaries)
Clinical Update: Immune Checkpoint Inhibitor Toxicity in 2018
5 Oct, 2018 | 02:42h | UTCImmune Checkpoint Inhibitor Toxicity in 2018 – JAMA (free for a limited period)
Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Related Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)
Sytematic Review: Antidepressant Withdrawal Effects
5 Oct, 2018 | 02:06h | UTCA systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based? – Addictive Behaviours (free PDF)
Commentaries: Antidepressant withdrawal ‘hits millions’ – BBC (free) AND Antidepressant withdrawal symptoms severe, says new report – The Guardian (free)
Related: Antidepressant Withdrawal Syndrome (free review and NYT article)
Study: Fracture Prevention in Older Women with Osteopenia
5 Oct, 2018 | 02:03h | UTCEditorial: A Not-So-New Treatment for Old Bones (free)
Commentary: Study Suggests More Older Women May Benefit From Bone Drugs – The Associated Press (free)
The Nobel Prize in Physiology or Medicine 2018
5 Oct, 2018 | 01:58h | UTCPress Release: The Nobel Prize in Physiology or Medicine 2018 – The Nobel Prize (free)
Commentaries: Cancer immunologists scoop medicine Nobel prize – Nature (free) AND Nobel Prize in medicine awarded to two cancer researchers for immune system breakthrough – STAT (free) AND 2018 Nobel Prize in Medicine Awarded to 2 Cancer Immunotherapy Researchers – The New York Times (10 articles per month are free)
Perspective: Failing the Public Health — Rofecoxib, Merck, and the FDA
5 Oct, 2018 | 01:45h | UTCFailing the Public Health — Rofecoxib, Merck, and the FDA – New England Journal of Medicine (free)
Meta-Analysis: Effects of Coenzyme Q10 on Statin‐Induced Myopathy
5 Oct, 2018 | 01:27h | UTCCommentary: Coenzyme Q10 reduces statin-induced myopathy symptoms – Univadis (free registration required)
Deprescribing Recommendations: An Essential Consideration for Clinical Guideline Developers
28 Sep, 2018 | 01:11h | UTCRelated: Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)
““Clinical guidelines often do not accommodate frailty or patients with multiple comorbid conditions. This can give rise to complex medication regimens and risk of medication harm.” Paper discusses the need to include deprescribing in clinical guidelines” (via @Deprescribing see Tweet)
Randomized Trial: Vaccine Against TB May Help Individuals with Latent Infection
28 Sep, 2018 | 01:04h | UTCEditorial: New Promise for Vaccines against Tuberculosis (free)
Commentaries: New TB vaccine protects half of people with latent infection – NBC Health News (free) AND Experimental vaccine shows promise in preventing TB – MedicalXpress (free)
Opinion: STAT’s Cheerleading Coverage of Prescription Fish Oil Capsule Lacks Crucial Context
28 Sep, 2018 | 01:01h | UTCOriginal Commentary: Amarin fish oil capsule shows dramatic benefit for cardiovascular patients, potentially upending market – STAT (free)
Study: Drug–herb and Drug–supplement Interactions in Older Adults
27 Sep, 2018 | 23:05h | UTCCommentaries: New study finds concurrent use of prescription drugs and dietary supplements could pose health risks – University of Hertfordshire (free) AND Concerns raised about older adults mixing prescription drugs and herbal remedies – NHS Choices (free)
Review: Pharmacokinetics–Pharmacodynamics Issues Relevant for the Clinical use of Beta-lactams in Critically Ill Patients
27 Sep, 2018 | 23:02h | UTCRelated: Extended Antibiotic Infusions Could Save Lives: Here’s How to Do It (free commentary) AND Mortality lower with prolonged vs. short-term IV infusion of antipseudomonal beta-lactams (link to abstract and free commentary)
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk
27 Sep, 2018 | 22:41h | UTCRelated Study: Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy (free article and commentaries)
Study: Oral Fluoroquinolone and the Risk of Aortic Dissection
21 Sep, 2018 | 01:50h | UTCOral Fluoroquinolone and the Risk of Aortic Dissection – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: The Fluoroquinolone/Aortic Dissection Association – Emergency Medicine Literature of Note (free)
Related observational studies with similar conclusions: Fluoroquinolone use and risk of aortic aneurysm and dissection (free articles)
Viewpoint: Probiotic Safety—No Guarantees
20 Sep, 2018 | 19:38h | UTCProbiotic Safety—No Guarantees – JAMA Internal Medicine (free for a limited period)
Related: Probiotics: Does the Evidence Match the Hype? (free articles and commentaries) AND Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries)
Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly
20 Sep, 2018 | 19:25h | UTCEffect of Aspirin on All-Cause Mortality in the Healthy Elderly – New England Journal of Medicine (free) (via @EricTopol)
Related Studies: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly – New England Journal of Medicine (free) AND Effect of Aspirin on Disability-free Survival in the Healthy Elderly – New England Journal of Medicine (free)
Commentaries: Daily low-dose aspirin found to have no effect on healthy life span in older people- NIH News Releases (free) AND Low-Dose Aspirin Late in Life? Healthy People May Not Need It – The New York Times (10 articles per month are free)
Review: Optimizing Medications in Older Adults with Cognitive Impairment
20 Sep, 2018 | 19:23h | UTC
Meta-Analysis: Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors
14 Sep, 2018 | 02:22h | UTCFatal Toxic Effects Associated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis – JAMA Oncology (free for a limited period)
Commentaries: Study Discerns Rare Risks of Fatal Side Effects From Cancer Immunotherapy – AJMC (free) AND Fatal Toxicities Rare With Checkpoint Inhibitors – MedicalResearch.com (free)
Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Related Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)
Study: Factors Associated With Long-term Benzodiazepine Use Among Older Adults
14 Sep, 2018 | 02:04h | UTCFactors Associated With Long-term Benzodiazepine Use Among Older Adults – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: 1 in 4 Older Adults Prescribed a Benzodiazepine Goes on to Risky Long-Term Use, Study Finds – Michigan Medicine, via NewsWise (free) AND Long-Term Benzodiazepine Use Common Among Older Adults – Physician’s First Watch (free) AND Factors Predicting Long-term Benzodiazepine Use Identified – Medscape (free registration required) AND Larger Number of Benzodiazepine Pills in Initial Prescription Associated With Long Term Use – MedicalResearch.com (free)
Related: A Quiet Drug Problem Among the Elderly – The New York Times (free) AND Our Other Prescription Drug Problem – New England Journal of Medicine (free) AND Benzodiazepines: our other prescription drug epidemic – STAT (free) AND Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free)