Pharmacology/Pharmaceutical Industry
Review: Cannabinoids for Chronic Pain
30 Nov, 2018 | 01:45h | UTCCannabinoids for Chronic Pain – Therapeutics Initiative (free)
Related: Meta-Analysis: Cannabinoids for the Treatment of Chronic Noncancer Pain Conditions (free) AND Guideline for Prescribing Medical Cannabinoids in Primary Care (free article and commentary)
“At the present time we lack good evidence that any cannabis-derived product works for chronic pain”
Review: Opioids and Cardiac Arrhythmia
30 Nov, 2018 | 01:27h | UTCOpioids and Cardiac Arrhythmia: A Literature Review – Medical Principles and Practice (free)
Meta-Analysis: SSRIs Use During Early Pregnancy and Risk of Congenital Malformations
23 Nov, 2018 | 00:17h | UTC
Cohort Study: Diabetes Outcomes in Patients Managed by Physicians, Nurse Practitioners, or Physician Assistants
22 Nov, 2018 | 21:56h | UTCIntermediate Diabetes Outcomes in Patients Managed by Physicians, Nurse Practitioners, or Physician Assistants: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Diabetes outcomes similar when primary care provided by NPs, PAs, or physicians, study finds – ACP Internist Weekly (free) AND Diabetics Cared for by NPs, PAs Do as Well as Those in Physicians’ Care – NEJM Journal Watch (free)
Report: 2018 Access to Medicine Index
22 Nov, 2018 | 21:54h | UTC2018 Access to Medicine Index – Access to Medicine Foundation (free PDF)
Commentaries: Big pharma leaves big gaps: drugmakers urged to do more for poor – Reuters (free) AND Big pharma ‘failing to develop urgent drugs for poorest countries’ – The Guardian (free)
Review: Musculoskeletal and Rheumatic Diseases Induced by Immune Checkpoint Inhibitors
22 Nov, 2018 | 21:25h | UTC
Study: Prevalence of Potentially Inappropriate Prescribing in Older People
20 Nov, 2018 | 15:27h | UTCEditorial: Tackling potentially inappropriate prescribing (free)
Commentary: Half of older patients exposed to potentially inappropriate prescribing – MedicalXpress (free)
Review: Interruption and Reversal of Direct Oral Anticoagulants in Preprocedural and Acute Settings
16 Nov, 2018 | 03:28h | UTCSource: Medscape
Meta-Analysis: Comparative Safety of Immune Checkpoint Inhibitors in Cancer
16 Nov, 2018 | 02:54h | UTCComparative safety of immune checkpoint inhibitors in cancer: systematic review and network meta-analysis – The BMJ (free)
Meta-Analysis: Antipsychotic Drug Use and Pneumonia
16 Nov, 2018 | 02:49h | UTCAntipsychotic drug use and pneumonia: Systematic review and meta-analysis – Journal of Psychopharmacology (link to abstract – $ for full-text)
Commentary: Antipsychotics May Increase Risk of Pneumonia, Meta-Analysis Suggests – Psychiatric News Alert (free)
“Although antipsychotic use was associated with a higher risk of pneumonia, the researchers stopped short of claiming causality, citing a lack of data from randomized, controlled trials and a failure of observational studies to control for relevant confounders like tobacco use and weight.” (from Psychiatric News Alert)
Randomized Trial: Effect of a Pharmacist-Led Educational Intervention on Inappropriate Medication Prescriptions in Older Adults
16 Nov, 2018 | 02:24h | UTCEffect of a Pharmacist-Led Educational Intervention on Inappropriate Medication Prescriptions in Older Adults: The D-PRESCRIBE Randomized Clinical Trial – JAMA (free for a limited period)
Video Summary: Effect of a Pharmacist-Led Intervention on Inappropriate Prescriptions in Older Adults (free)
Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease
16 Nov, 2018 | 01:08h | UTCEditorial: VITAL Signs for Dietary Supplementation to Prevent Cancer and Heart Disease (free)
Commentaries: Vitamin D And Fish Oil Supplements Mostly Disappoint In Long-Awaited Research Results – NPR (free) AND Fish Oil And Vitamin D Pills No Guard Against Cancer Or Serious Heart Trouble – Kaiser Health News (free)
Systematic Review: Supplements for Preventing Cognitive Decline in People with Mild Cognitive Impairment
9 Nov, 2018 | 01:59h | UTCVitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment – Cochrane Library (free)
“The evidence on vitamin and mineral supplements as treatments for MCI is very limited. “
Deprescribing: The Fightback Against Polypharmacy Has Begun
5 Nov, 2018 | 12:11h | UTCDeprescribing: the fightback against polypharmacy has begun – The Pharmaceutical Journal (free) (via @Deprescribing)
Related: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject) AND Deprescribing recommendations: An essential consideration for clinical guideline developers – Research in Social and Administrative Pharmacy (free)
Meta-Analysis: Comparative Efficacy of Inhaled Medications for COPD
5 Nov, 2018 | 11:48h | UTC
NICE Antimicrobial Prescribing Guidelines
2 Nov, 2018 | 03:51h | UTCAntimicrobial prescribing guidelines – National Institute for Health and Care Excellence (free resources)
Just Published Guidelines: Urinary tract infection (lower): antimicrobial prescribing (free) AND Urinary tract infection (recurrent): antimicrobial prescribing (free) AND Pyelonephritis (acute): antimicrobial prescribing (free) AND Prostatitis (acute): antimicrobial prescribing (free)
See also: Summary of antimicrobial prescribing guidance – managing common infections – National Institute for Health and Care Excellence (free PDF)
Review: Side Effects of Long‐Term Proton Pump Inhibitor Use
2 Nov, 2018 | 03:40h | UTC
Systematic Review: Prophylactic Antibiotic Therapy for COPD
2 Nov, 2018 | 03:36h | UTCProphylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)
Summary: Preventative antibiotic therapy for people with COPD – Cochrane Library (free)
“Use of continuous and intermittent prophylactic antibiotics results in a clinically significant benefit in reducing exacerbations in COPD patients.”
Study: Antibiotic and Acid-Suppression Medications During Early Childhood are Associated with Obesity
2 Nov, 2018 | 03:32h | UTCAntibiotic and acid-suppression medications during early childhood are associated with obesity – Gut (free)
Related Study: Early Antibiotic Exposure and Weight Outcomes in Young Children – Pediatrics (free)
Commentaries: Expert reaction to antibiotic and antacid use in early childhood and risk of obesity – Science Media Centre (free) AND Antibiotic Exposure in Early Life Tied to Slightly Higher Obesity Risk – NEJM Journal Watch (free) AND Antibiotics, H2RAs and PPIs linked to child obesity – OnMedica (free) AND Two studies tie early antibiotic exposure to increased obesity risk – CIDRAP (free)
Meta-Analysis: Cannabinoids for the Treatment of Chronic Noncancer Pain Conditions
2 Nov, 2018 | 03:29h | UTC“It seems unlikely that cannabinoids are highly effective medicines for chronic noncancer pain conditions.”
Randomized Trial: Oral Curcumin in Elective Abdominal Aortic Aneurysm Repair
2 Nov, 2018 | 03:19h | UTCEditorial: Take turmeric with a grain of salt (free)
Commentary: Oral curcumin shows no benefit in reducing inflammation following vascular surgery – Canadian Medical Association Journal (free)
Systematic Review: Drug-Induced Interstitial Lung Disease
2 Nov, 2018 | 02:54h | UTCDrug-Induced Interstitial Lung Disease: A Systematic Review – Journal of Clinical Medicine (free)
Commentary: Drugs’ side effects in lungs ‘more widespread than thought’ – The University of Manchester (free)
Guideline: Antiplatelet Therapy in Patients Undergoing Elective Invasive Procedures
26 Oct, 2018 | 02:58h | UTC
Randomized Trial: Proton-Pump Inhibitors Prophylaxis of Little Benefit in the ICU
26 Oct, 2018 | 02:41h | UTCPantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU – New England Journal of Medicine (free for a limited period)
Editorial: Proton-Pump Inhibitor Prophylaxis in the ICU — Benefits Worth the Risks? (free for a limited period)
“Proton pump inhibitors are minimally effective to reduce GI bleeding among the critically ill folks at high risk for stress ulcers. Takeaways: no role for routine PPI for any patients on the WARDS, and shouldn’t be considered ‘routine’ in the ICU” (via @AnilMakam see Tweet)
Cohort Study: Angiotensin Converting Enzyme Inhibitors and Risk of Lung Cancer
26 Oct, 2018 | 02:43h | UTCEditorial: Angiotensin converting enzyme inhibitors and lung cancer (free)
Commentaries: Blood pressure drug linked to possible small increased risk of lung cancer – NHS Choices (free) AND Expert reaction to study looking at blood pressure drugs and lung cancer risk – Science Media Centre (free)