Pharmacology/Pharmaceutical Industry
Meta-analysis: Benzodiazepines or Related Drugs and Risk of Pneumonia
16 Jan, 2019 | 00:32h | UTCCommentary: Benzodiazepines May Boost Pneumonia Risk, Especially in Seniors – Medscape (free registration required)
Cohort Study: Maternal Ondansetron Use and Risk of Cardiac Malformations and Oral Clefts in Offspring
15 Jan, 2019 | 00:20h | UTCAssociation of Maternal First-Trimester Ondansetron Use With Cardiac Malformations and Oral Clefts in Offspring – JAMA (link to abstract – $ for full-text)
Commentaries: Does Zofran (ondansetron) for Nausea & Vomiting Cause Birth Defects? – MedicalResearch.com (free) AND Risk of malformations in offspring likely minimal with use of ondansetron (Zofran) in first trimester – MedicalResearch.com (free) AND Morning sickness pill study finds small link to increased risk of clefts but ‘not a cause for alarm’ – CNN (free)
Use of Hormone Replacement Therapy and Risk of Venous Thromboembolism
13 Jan, 2019 | 23:19h | UTCCommentaries: HRT patches and gels ‘may be safer’ than tablets for older women – NHS News (free) AND HRT tablets associated with increased risk of blood clots – MedicalXpress (free) AND Expert reaction to HRT and blood clots – Science Media Centre (free)
Cohort Study: Acute Kidney Injury in Patients Receiving Systemic Treatment for Cancer
13 Jan, 2019 | 21:08h | UTCCommentaries: Incidence of Acute Kidney Injury in Patients Receiving Systemic Therapy for Cancer – The ASCO Post (free) AND AKI Risk High in Cancer Patients Receiving Systemic Therapy – Renal & Urology News (free) AND Serious kidney injury common during cancer chemotherapy – Reuters (free)
Review: Neurological Complications of Immune Checkpoint Inhibitors
13 Jan, 2019 | 19:49h | UTC
Review: Probiotic Supplements Might Not be Universally-effective and Safe
13 Jan, 2019 | 15:59h | UTC
Study: The Best Dose of Aspirin for Cardiovascular protection may Depend on Body Weight
10 Jan, 2019 | 00:14h | UTCThe best dose of aspirin for cardiovascular protection may depend on body weight – NIHR Signal (free)
Original Article: Effects of Aspirin for CV Disease Prevention According to Bodyweight and Dose (free study and commentaries)
Randomized Trial: Temporarily Quadrupling the Dose of Inhaled Steroid to Prevent Asthma Exacerbations
10 Jan, 2019 | 00:07h | UTC
Related Commentary on Twitter
FAST; An asthma self-management plan that advised patients to temporarily quadruple their dose of inhaled corticosteroid reduced asthma exacerbations, with fewer serious adverse events and at lower cost; NIHR Journals Library https://t.co/dlsZrAl1A4 @MedicineUoN @Tharris2Tim
— NIHR Nottm BRC Lung (@NottmBRCLung) December 10, 2018
Proton Pump Inhibitors: Review of Reported Risks and Controversies
9 Jan, 2019 | 16:40h | UTCRelated: Proton Pump Inhibitors: Review of Emerging Concerns (free reviews) AND Deprescribing Proton Pump Inhibitors (free guidelines and reviews)
Systematic Review: Vitamin and Mineral Supplementation for Maintaining Cognitive Function Mid and Late Life
8 Jan, 2019 | 20:12h | UTCVitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life – Cochrane Library (free)
Summary: Vitamin and mineral supplementation for preventing cognitive deterioration in cognitively healthy people in mid and late life – Cochrane Library (free)
Commentary: Preventing dementia: do vitamin and mineral supplements have a role? – Evidently Cochrane (free)
Related Commentary on Twitter
New @CochraneDCIG Review finds 'no good evidence to suggest that middle‐aged or older people can preserve cognitive function or prevent dementia by taking vitamin or mineral supplements' https://t.co/8cyuiG8mtw 28 studies, 83,000 participants. #CochraneEvidence pic.twitter.com/N1VK0C6BuR
— The Cochrane Library (@CochraneLibrary) December 23, 2018
Cohort Study: Prenatal Exposure to Anticonvulsivant and Risk for ADHD in Offspring
8 Jan, 2019 | 19:53h | UTCInvited Commentary: Fetal Valproate Exposure and Attention-Deficit/Hyperactivity Disorder (free)
FDA Warns About Increased Risk of Aortic Dissection and Ruptures of Aortic Aneurism with Fluoroquinolones
7 Jan, 2019 | 21:26h | UTCCommentary: FDA: Fluoroquinolones may cause aortic rupture in some – CIDRAP (free)
Related: Meta-analysis: Fluoroquinolones and the Risk of Aortopathy (free) AND Fluoroquinolone use and risk of aortic aneurysm and dissection (free study and commentaries) AND Committee Recommends New Restrictions on the use of Fluoroquinolones (free report and commentaries) AND FDA Safety Alert: Warnings for Fluoroquinolones on Risks of Mental Health and Low Blood Sugar Adverse Reactions (free report and commentaries) AND When antibiotics turn toxic (free commentary)
Meta-Analysis: Proton Pump Inhibitors and Risk of Hip Fracture
7 Jan, 2019 | 19:35h | UTCProton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies – Osteoporosis International (link to abstract – $ for full-text)
Commentary: PPIs up risk for hip fracture in large meta-analysis – Univadis (free registration required)
Related Commentary on Twitter
Metanalysis of 24 PPI studies, 319,568 hip fracture pts, suggests PPIs associated with a greater risk of hip fracture (RR 1.20, 95% CI 1.14–1.28, p < 0.0001) and may be greater with higher dose (RR 1.30, 95% CI 1.20–1.40, p < 0.0001). https://t.co/nbiEIPRaXg
— Dr. John Cush (@RheumNow) December 17, 2018
Consensus Statement on Statin Intolerance
7 Jan, 2019 | 03:45h | UTC
Review: Defining Pediatric Polypharmacy
3 Jan, 2019 | 11:17h | UTCDefining pediatric polypharmacy: A scoping review – PLOS One (free)
Guideline: ADA 2019 Standards of Medical Care in Diabetes
22 Dec, 2018 | 12:35h | UTCJust Out! Guideline: ADA 2020 Standards of Medical Care in Diabetes (free guideline and topics)
ADA 2019 Standards of Medical Care in Diabetes (free supplement)
News Release: Patient-centered Care is the Focus and Priority of the 2019 Standards of Medical Care in Diabetes, Published Today by the American Diabetes Association (free)
Summary of Revisions: Standards of Medical Care in Diabetes—2019 (free)
See also: Standards of Medical Care in Diabetes—2019 Abridged for Primary Care Providers (free PDF)
Related Commentary on Twitter
ADA releases annual clinical practice guidelines: with more treatment algorithms to provide decision support for individualized care, the 2019 Standards create a roadmap for individualized therapeutic approaches and medication selection. https://t.co/r5eWD92WhY pic.twitter.com/h3VqkLCf0w
— DiabetesJournals.org (@ADA_Journals) December 19, 2018
A Prescription for Enhancing Electronic Prescribing Safety
13 Dec, 2018 | 23:51h | UTCA Prescription for Enhancing Electronic Prescribing Safety – Health Affairs (free)
Commentary: A prescription for enhancing electronic prescribing safety – PSNet (free)
CDC Report: Drugs Most Frequently Involved in Drug Overdose Deaths
13 Dec, 2018 | 23:48h | UTCCommentary: CDC: Top 10 Drugs Involved in Drug Overdose Deaths – MPR (free)
Report: Medication Administration Errors and Mortality
13 Dec, 2018 | 19:48h | UTCCommentary: New study sheds light on medication administration errors leading to death — omission is a common cause – University of Eastern Finland (free)
AHA Statement: Statin Safety and Associated Adverse Events
13 Dec, 2018 | 19:46h | UTCNews Release: Statins have low risk of side effects (free)
Special Issue: Comorbidities, Deprescribing, and the Healthcare of Older People
13 Dec, 2018 | 19:24h | UTCComorbidities, Deprescribing, and the Healthcare of Older People – Public Policy & Aging Report (free articles)
Commentary: Deprescribing can be valuable tool in managing polypharmacy, experts say – The Gerontological Society of America (free)
Related: Deprescribing: the fightback against polypharmacy has begun – The Pharmaceutical Journal (free) AND Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)
Review: Immune-related Adverse Events of Immune Checkpoint Inhibitors
13 Dec, 2018 | 19:02h | UTCImmune-related adverse events of immune checkpoint inhibitors: a brief review – Current Oncology (free)
Related: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)
Review: Increased Risk of Metabolic Syndrome in Antidepressants Users
13 Dec, 2018 | 18:06h | UTC
Guidelines for Older People with Multimorbidity and Life-Limiting Illness: Implications for Deprescribing
4 Dec, 2018 | 00:01h | UTC
Review: Medical Treatment of Female Overactive Bladder Syndrome and Treatment-Related Effects
2 Dec, 2018 | 21:14h | UTC