Pharmacology/Pharmaceutical Industry | Page 136 of 166 | Links Medicus Content Curation & Alerts in Medicine

Systematic Review: Phosphate Binders to Prevent Complications of Chronic Kidney Disease

23 Aug, 2018 | 23:40h | UTC

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) – Cochrane Library (free for a limited period)

Summary: Phosphate binders to prevent complications of chronic kidney disease – Cochrane Library (free)

Extended Antibiotic Infusions Could Save Lives: Here’s How to Do It

23 Aug, 2018 | 23:40h | UTC

Extended antibiotic infusions could save lives: Here’s how to do it – PulmCCM (free)

“The simplest (and cheapest) technique is simply to reduce the time between doses.”

Study: Seven Days of Antibiotics Were as Good as 14 for Gram-Negative Bacteremia

23 Aug, 2018 | 23:39h | UTC

Seven days of antibiotics were as good as 14 for gram-negative bacteremia – PulmCCM (free)

“It’s important to note that source control was believed to be achieved in all enrolled patients. If source control cannot be achieved (e.g., an abscess, or an infected heart valve or indwelling catheter that cannot safely be removed), prolonged antibiotic courses are often advisable.”

Study: Anticonvulsant and the Risk for Opioid-Related Death

23 Aug, 2018 | 23:21h | UTC

Pregabalin and the Risk for Opioid-Related Death: A Nested Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Pregabalin may increase the risk of death when coprescribed with opioids – 2 Minute Medicine (free) AND Pregabalin Linked To Increased Risk for Opioid-Related Deaths – MedicalResearch.com (free) AND Anticonvulsant With Opioids Tied To Higher Mortality – MedPage Today (free registration required)

Perspective: This Drug Is Safe and Effective. Wait. Compared With What?

23 Aug, 2018 | 22:59h | UTC

This Drug Is Safe and Effective. Wait. Compared With What? – The New York Times (10 articles per month are free)

Perspective: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It

23 Aug, 2018 | 22:32h | UTC

Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It – The New York Times (10 articles per month are free) (via @CarlosdelRio7 see Tweet)

“Only test vitamin D status if someone has symptoms of deficiency or is at very high risk” (from NICE Guideline)

Randomized Trial: Letters with Peer Comparison May Reduce Overprescribing

17 Aug, 2018 | 02:34h | UTC

Effect of Peer Comparison Letters for High-Volume Primary Care Prescribers of Quetiapine in Older and Disabled Adults: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Behavioral nudges lead to striking drop in prescriptions of potent antipsychotic – Columbia University’s Mailman School of Public Health, via ScienceDaily (free) AND Study Reduces Over-prescription of Antipsychotics in Older Adults – Mad in America (free) AND ‘Dear Doctor’ Letters Use Peer Pressure, Government Warning To Stop Overprescribing – NPR (free) AND Peer Pressure Tactic Successfully Curbs Overprescribing – Medscape (free registration required)

Research: Treatments for First-Episode Schizophrenia Compared

17 Aug, 2018 | 02:13h | UTC

Amisulpride and olanzapine followed by open-label treatment with clozapine in first-episode schizophrenia and schizophreniform disorder (OPTiMiSE): a three-phase switching study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Switching Anti-Psychotic Medications Doesn’t Improve Outcomes in First-Episode Schizophrenia Patients – Mount Sinai (free) AND No Benefit of Switching Antipsychotics in Early Schizophrenia – Medscape (free registration required) AND No Gain with Antipsych Meds Switch in Schizophrenia – MedPage Today (free registration required)

Randomized Trial: Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control

17 Aug, 2018 | 02:06h | UTC

Fixed Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control in Patients With Mild to Moderate Hypertension in Sri Lanka: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Video Summary: Fixed-Dose Combination Pill for Hypertension Treatment in Sri Lanka (free)

Commentaries: Three-in-one pill lowers blood pressure significantly, study says – UPI (free) AND Innovative triple pill significantly lowers blood pressure, study finds – George Institute for Global Health, via EurekAlert (free)

Perspective: The Polypill and the Long Journey to Major Impact

17 Aug, 2018 | 02:05h | UTC

Richard Smith: The polypill and the long journey to major impact – The BMJ Opinion (free)

Meta-Analysis: Substandard and Falsified Medicines in Low- and Middle-Income Countries

17 Aug, 2018 | 01:47h | UTC

Prevalence and Estimated Economic Burden of Substandard and Falsified Medicines in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: Prevalence of Substandard and Falsified Essential Medicines: Still an Incomplete Picture – JAMA Network Open (free) AND New Study Finds Fake, Low-Quality Medicines Prevalent in the Developing World – University of North Carolina at Chapel Hill, via R&D (free)

The Multivitamin Industry Rakes in Billions of Dollars. But Science Says We’re Not Getting Healthier

17 Aug, 2018 | 01:38h | UTC

The multivitamin industry rakes in billions of dollars. But science says we’re not getting healthier – by Timothy Caulfield, in NBC News THINK (free)

“Unless you have a clinically identified deficiency, the research tells us there is little reason to consume supplements.”

Guideline: Pediatric CAR T-Cell Therapy

16 Aug, 2018 | 23:16h | UTC

Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy – Nature Reviews Clinical Oncology (free)

Commentary: Guidelines for Pediatric CAR T-Cell Therapy Developed – The ASCO Post (free)

Study: Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes

16 Aug, 2018 | 23:09h | UTC

Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data – Diabetes Care (link to abstract – $ for full-text)

Commentary: Doctors should use gender and body mass to personalise diabetes care, study says – The Irish News (free)

Source: The BMJ Research News ($)

Study: Opioid Prescribing Decreases After Learning of a Patient’s Fatal Overdose

11 Aug, 2018 | 03:25h | UTC

Opioid prescribing decreases after learning of a patient’s fatal overdose – Science (free for a limited period)

Commentary: Notification of patient overdose deaths reduces clinician opioid prescriptions – NIH News Releases (free) AND Clinicians were told their patient had died of an overdose. Then opioid prescribing dropped – STAT (free)

Meta-Analysis: Treatment Choices for ADHD

11 Aug, 2018 | 03:23h | UTC

Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis – The Lancet Psychiatry (free)

Commentaries: Refining treatment choices for ADHD – The Lancet Psychiatry (free) AND ADHD medications: Of all available drugs, methylphenidate should be first option for short-term treatment in children – ScienceDaily (free) AND Analysis of ADHD Drugs: Use Methylphenidate in Kids, Amphetamines in Adults – Physician’s First Watch (free)

Meta-Analysis: Corticosteroid use and Intensive Care Unit-Acquired Weakness

11 Aug, 2018 | 02:36h | UTC

Corticosteroid use and intensive care unit-acquired weakness: a systematic review and meta-analysis – Critical Care (free)

Study: Cardiotoxicity and Cardiac Monitoring Among Chemotherapy-Treated Breast Cancer Patients

11 Aug, 2018 | 02:30h | UTC

Cardiotoxicity and Cardiac Monitoring Among Chemotherapy-Treated Breast Cancer Patients – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)

Commentaries: Prioritize cardiac monitoring for high-risk breast cancer patients, study suggests – ACP Internist (free) AND Cardiac monitoring may benefit high-risk breast cancer patients against heart failure – Cardiovascular Business (free) AND After Cardiotoxic Chemo, Less Than Half of Women With Breast Cancer Get Recommended Monitoring – TCTMD (free) AND Study Shows Importance of Cardiac Monitoring in High-Risk Breast Cancer Patients – American College of Cardiology (free)

Randomized Trials: Rifampin vs. Isoniazid for Latent TB

3 Aug, 2018 | 11:44h | UTC

Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults – New England Journal of Medicine (free)

Quick Take Video Summary: Rifampin or Isoniazid for Latent Tuberculosis (free)

Commentaries: New tuberculosis treatment could help tackle global epidemic – The Guardian (free) AND Rifampin Promising for Latent TB in Phase 3 Trials – Medscape (free registration required)

Evidence Synopsis: Aspirin Plus Clopidogrel vs Aspirin Alone for Patients at High Risk for Cardiovascular Events

3 Aug, 2018 | 11:36h | UTC

Aspirin Plus Clopidogrel vs Aspirin Alone for Preventing Cardiovascular Events Among Patients at High Risk for Cardiovascular Events – JAMA (free for a limited period)

“Clopidogrel+ASA: Reduced risk for MI and ischemic stroke – Increased risk for major bleeding compared with aspirin alone. Combined therapy is NOT associated with lower mortality.” (via @ehlJAMA see Tweet)