Pharmacology/Pharmaceutical Industry
Case Report: Use of Vitamin D Drops Leading to Kidney Failure in a 54-year-old Man
9 Apr, 2019 | 02:07h | UTC“Vitamin D toxicity is rare, but clinicians must be aware of the risks of vitamin D use to limit complications related to hypercalcemia”.
Randomized Trial: Automated Insulin Dosing Guidance to Optimize Insulin Management in Type 2 Diabetes
4 Apr, 2019 | 22:12h | UTCAutomated insulin dosing guidance to optimise insulin management in patients with type 2 diabetes: a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Promoting Better Glucose Management for Type 2 Diabetes – NEJM Journal Watch (free for a limited period) AND Automated insulin system improves glycemic control – MedicalXpress (free)
REPORT – Medication Overload: How the Drive to Prescribe is Harming Older Americans
4 Apr, 2019 | 02:24h | UTCREPORT – Medication Overload: America’s Other Drug Problem – Lown Institute (free PDF)
Executive Summary: Medication Overload: America’s Other Drug Problem – Lown Institute (free PDF)
Press Release: Growing epidemic of medication overload impacting millions of older Americans (free)
Commentaries: Medication Overload: How the drive to prescribe is harming older Americans – Lown Institute (free) AND Overprescribed: High cost isn’t America’s only drug problem – STAT (free)
Related: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)
Guideline: Valproate Use in Women and Girls Of Childbearing Years
1 Apr, 2019 | 02:06h | UTCValproate Use In Women and Girls Of Childbearing Years (free PDF)
News Release: Thirteen UK healthcare bodies launch ‘pragmatic’ guidance on valproate use – Royal College of General Practitioners (free)
Commentary: New guidance on valproate use in women – OnMedica (free)
Meta-Analysis: Cefazolin vs. Anti-staphylococcal Penicillins for the Treatment of Staphylococcus aureus Bacteremia
29 Mar, 2019 | 07:47h | UTC
Systematic Review: Adverse Effects of Pharmacological Treatments of Major Depression in Older Adults
29 Mar, 2019 | 07:45h | UTCSee also: Full Report (free PDF) AND Evidence Summary (free PDF)
Omega-3 Supplements Do Not Reduce the Risk of Cancer or Cardiovascular Disease
28 Mar, 2019 | 07:24h | UTCOriginal Article: Randomized Trial: Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer (free)
Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free article and commentary)
Related Systematic Review: Omega-3 fatty Acids for the Prevention of Cardiovascular Disease (free review and commentaries)
Study: Proton Pump Inhibitors and Risk of Acute and Chronic Kidney Disease
28 Mar, 2019 | 07:11h | UTCCommentary: Study: Research ties common heartburn medications to kidney disease and failure – University at Buffalo (free)
Related: Meta-Analysis of Observational Studies: Proton Pump Inhibitors are Associated with Increased Risk of Kidney Disease (link to abstract – $ for full-text) AND Proton Pump Inhibitors: Review of Emerging Concerns (free reviews) AND Deprescribing Proton Pump Inhibitors (free guidelines and reviews)
Randomized Trial: Antithrombotic Strategies Compared after Acute Coronary Syndrome or PCI in Patients with Atrial Fibrillation
27 Mar, 2019 | 06:10h | UTCAntithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Atrial Fibrillation: Antithrombotic Therapy after Acute Coronary Syndrome or PCI – MedicalResearch.com (free) AND Antithrombotic Regimens Evaluated in Patients With Nonvalvular Atrial Fibrillation After ACS or PCI – MPR (free)
Less is More: A Clinical Overview of Off-label Use of Gabapentinoid Drugs
26 Mar, 2019 | 01:42h | UTCA Clinical Overview of Off-label Use of Gabapentinoid Drugs – JAMA Internal Medicine (free for a limited period)
Related Meta-Analysis: Anticonvulsants in the Treatment of Low Back Pain and Lumbar Radicular Pain (free study and commentaries)
“Clinicians who prescribe gabapentinoids off-label for pain should be aware of the limited evidence and should acknowledge to patients that potential benefits are uncertain for most off-label uses.”
Randomized Trial: Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery
24 Mar, 2019 | 20:54h | UTCVolatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery – New England Journal of Medicine (free for a limited period)
Commentary: Volatile anesthetics do not reduce deaths in elective CABG – MedicalXpress (free)
Large Observational Study Suggests Some Drugs for ADHD may Increase the Risk of Psychosis More than Others
21 Mar, 2019 | 06:32h | UTCPsychosis with Methylphenidate or Amphetamine in Patients with ADHD – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Some ADHD medicines may increase psychosis more than others, ‘real-world’ data show – STAT (free) AND With ADHD, amphetamine has double the psychosis risk of methylphenidate – Reuters (free) AND Big data study identifies drugs that increase risk of psychosis in youth with ADHD – McLean Hospital (free)
Large Observational Study Suggests High-Dose Nifedipine is Associated with Higher Cardiac Arrest Risk
20 Mar, 2019 | 03:29h | UTCPresented at the European Heart Rhythm Association 2019 Congress.
High-Dose Nifedipine Tied to Higher Cardiac Arrest Risk – TCTMD (free)
See also: Nifedipine linked with cardiac arrest – Pharmacy News (free) AND Common blood pressure drug may increase cardiac arrest risk – Medical News Today (free)
Systematic Review: Multiple‐Micronutrient Supplementation for Women During Pregnancy
19 Mar, 2019 | 03:18h | UTCMultiple‐micronutrient supplementation for women during pregnancy – Cochrane Library (free)
Summary: Vitamin and mineral supplements for women during pregnancy – Cochrane Library (free)
British Guidelines on the Use of HIV Pre–exposure Prophylaxis (PrEP)
19 Mar, 2019 | 02:54h | UTCBHIVA/BASHH guidelines on the use of HIV pre–exposure prophylaxis (PrEP) 2018 – HIV Medicine (free)
Related guidelines: WHO implementation tool for pre-exposure prophylaxis of HIV infection – World Health Organization (free) AND Draft Recommendation Statement: Prevention of Human Immunodeficiency Virus (HIV) Infection: Pre-Exposure Prophylaxis – U.S. Preventive Services Task Force (free) AND Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis – Canadian Medical Association Journal (free) AND Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine HIV pre-exposure prophylaxis: clinical guidelines. Update April 2018 – Journal of Virus Eradication (free) AND Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: a Clinical Practice Guideline (free)
Perioperative Care of Cannabis Users: A Comprehensive Review of Pharmacological and Anesthetic Considerations
13 Mar, 2019 | 03:38h | UTC
Viewpoint: Reexamining Recommendations for Treatment of Hypercholesterolemia in Older Adults
12 Mar, 2019 | 02:46h | UTCReexamining Recommendations for Treatment of Hypercholesterolemia in Older Adults – JAMA (free for a limited period)
“This Viewpoint discusses the 2018 ACC/AHA cholesterol management guideline recommendation to consider statin treatment in adults aged >75 years with LDL levels 70-189 mg/dL, arguing that trial evidence does not support it…”
FDA Approves Ketamine-like drug for Treatment-resistant Depression
7 Mar, 2019 | 12:44h | UTCCommentaries: A ketamine-like drug is the first new antidepressant to get FDA approval in years: But it’s also controversial. – Vox (free) AND FDA Approves Intranasal Esketamine as Adjunctive Treatment for Depression – NEJM Journal Watch (free)
“But while some patient and doctor groups are hailing the approval, others aren’t so sure there’s enough evidence to justify it. That’s because the benefits of ketamine and esketamine aren’t yet well-understood. According to the FDA, the drug has only been studied in four clinical trials, three of them lasting just four weeks. And the results were pretty mixed.” (from Vox)
Related Commentary on Twitter
#FDA never learns from its past mistakes.
20 yrs ago, approved #Oxycontin, supposedly w restrictions.
We know how well those safety checks worked.
Now same blindness to risks of promoting #esketamine.
Doesnt it know people with #Depression will self medicate with street Special K https://t.co/FEj8S4QIFw— Allen Frances (@AllenFrancesMD) March 6, 2019
Cohort Study: Statin Use Associated with a 38% Higher Risk of Incident Type 2 Diabetes
7 Mar, 2019 | 02:37h | UTCCommentaries: Statins associated with 38 per cent increased risk of type 2 diabetes – Diabetes.co.uk (free) AND Cholesterol-lowering drugs linked to higher risk for developing type 2 diabetes – News Medical (free)
Big Pharma is Embracing Open-access Publishing Like Never Before
6 Mar, 2019 | 20:05h | UTCBig pharma is embracing open-access publishing like never before – Nature News (free)
See also: UC Terminates Subscriptions with World’s Largest Scientific Publisher in Push for Open Access (resources and commentaries on the subject)
Study: Doctors are Prescribing Antibiotics for Longer than Guidelines Recommend
5 Mar, 2019 | 03:08h | UTCCommentaries: Doctors may be prescribing antibotics for longer than needed – The Conversation (free) AND UK primary care study finds overly long antibiotic courses – CIDRAP (free) AND Antibiotics courses often longer than guidelines – OnMedica (free)
Study: Risk of Heart Failure in Breast Cancer Patients After Treatment with Trastuzumab
28 Feb, 2019 | 05:55h | UTCLong-Term Risk of Heart Failure in Breast Cancer Patients After Adjuvant Chemotherapy With or Without Trastuzumab – JACC: Heart Failure (link to abstract – $ for full-text) (via @md_arianemacedo)
Commentary: Long-Term Risk of Heart Failure After Chemotherapy With Trastuzumab – American College of Cardiology (free)
“Trastuzumab treatment is associated with a 2-fold increased risk of late HF compared with chemotherapy treatment alone.”
FDA Adds Boxed Warning for Increased Risk of Death with Gout Medicine Febuxostat
25 Feb, 2019 | 01:15h | UTCCommentaries: FDA Adds Boxed Warning About CV Risks to Gout Drug Febuxostat – TCTMD (free) AND FDA: Gout Drug Raises Death Risk – MedPage Today (free)
Related Research: Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout (free study and commentaries)
Meta-Analysis: Pharmacological Treatments for Generalized Anxiety Disorder
25 Feb, 2019 | 01:11h | UTCPharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)
Commentary: Pharmacotherapy for Generalized Anxiety: An Update – NEJM Journal Watch (free for a limited period)
Review: Immune Checkpoint Inhibitors-induced Endocrinopathies in Cancer Patients
25 Feb, 2019 | 00:55h | UTCRelated Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)