Pharmacology/Pharmaceutical Industry
Randomized Trial: No Benefit from Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
19 Mar, 2020 | 11:01h | UTCEditorial: Covid-19 — The Search for Effective Therapy (free)
See also: Interview with Dr. Eric Rubin and Dr. Lindsey Baden on new research on possible treatments for Covid-19 – New England Journal of Medicine (free)
Perspective: Confirmatory Trial for Drug to Prevent Preterm Birth Finds No Benefit, So Why Is It Still Prescribed?
19 Mar, 2020 | 10:52h | UTCConfirmatory Trial for Drug to Prevent Preterm Birth Finds No Benefit, So Why Is It Still Prescribed? – JAMA (free for a limited period)
Original Article: Randomized Trial: Injectable 17-α-hydroxyprogesterone Not Effective for the Prevention of Recurrent Preterm Birth (free study and commentaries)
Related Study: A Randomized Trial of Progesterone in Women with Recurrent Miscarriages – New England Journal of Medicine (free)
Randomized, Phase 2 Trial: Safety and Immunogenicity of a Tetravalent Dengue Vaccine in Children Aged 2–17 Years
18 Mar, 2020 | 09:47h | UTCSafety and immunogenicity of a tetravalent dengue vaccine in children aged 2–17 years: a randomised, placebo-controlled, phase 2 trial – The Lancet (link to abstract – $ for full-text)
[Abstract Only] Study: Consequences of Measles Undervaccination
18 Mar, 2020 | 09:49h | UTCConsequences of Undervaccination – Measles Outbreak, New York City, 2018-2019 – New England Journal of Medicine (link to abstract – $ for full-text)
Cohort Study: Proton Pump Inhibitors Linked to Small Increased Risk of Fracture in Children
18 Mar, 2020 | 09:46h | UTCAssociation Between Proton Pump Inhibitor Use and Risk of Fracture in Children – JAMA Pediatrics (free for a limited period)
Commentary: Proton-Pump Inhibitors: Small Increased Risk of Fractures in Children – MedicalResearch.com (free)
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
17 Mar, 2020 | 08:37h | UTCDevelopment and Validation of a Penicillin Allergy Clinical Decision Rule – JAMA Internal Medicine (free for a limited period)
Meta-Analysis of Randomized Trials: Little Benefit from Omega-3 Intake to Reduce Cardiovascular Disease Risk
13 Mar, 2020 | 07:52h | UTCSummary: Omega-3 intake for cardiovascular disease – Cochrane Library (free)
Author Interview: Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease – Cochrane Library (free)
Commentary: Omega-3s Show No Overall Benefits for Heart Health or Cancer Prevention – The New York Times (free)
[Abstract Only] Meta-analysis of Randomized trials: Omega-3 Fats do not Protect Against Cancer
13 Mar, 2020 | 07:51h | UTCOmega-3, omega-6 and total dietary polyunsaturated fat on cancer incidence: systematic review and meta-analysis of randomised trials – British Journal of Cancer (link to abstract – $ for full-text)
Commentary: Omega-3 fats do not protect against cancer – University of East Anglia (free)
Randomized Trial: Therapies for Uncomplicated Plasmodium Falciparum Malaria Compared
12 Mar, 2020 | 08:13h | UTCInvited Commentary: Are three drugs for malaria better than two? – The Lancet (free)
[Abstract Only] Observational Study Suggests Apixaban May Be a Better Choice than Rivaroxaban for Patients with Atrial Fibrillation
11 Mar, 2020 | 08:20h | UTCEffectiveness and Safety of Apixaban Compared With Rivaroxaban for Patients With Atrial Fibrillation in Routine Practice: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Choosing a DOAC? Apixaban May Have an Edge Over Rivaroxaban – TCTMD (free)
Systematic Review: Safety of Ceftriaxone in Pediatrics
11 Mar, 2020 | 08:21h | UTCSafety of ceftriaxone in paediatrics: a systematic review – Archives of Disease in Childhood (free)
[Abstract Only] Preliminary Study Suggests Efficacy of a Standalone Universal Influenza Vaccine
11 Mar, 2020 | 08:18h | UTCImmunogenicity, Safety, and Efficacy of a Standalone Universal Influenza Vaccine, FLU-v, in Healthy Adults: A Randomized Clinical Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Is a ‘Universal’ Flu Vaccine on the Horizon? – HealthDay (free) AND Adjuvanted FLU-v Vaccine Immunogenic in Healthy Adults – MPR (free)
Estimation of the Percentage of Patients with Cancer Who Are Eligible for Immune Checkpoint Inhibitor Drugs
11 Mar, 2020 | 08:17h | UTC
Observational Study Suggests Continuing ACE-I/ARBs in Patients with Declining kidney Function May Reduce Cardiovascular Risk Without Increased Risk of Progression to End-stage Kidney Disease
10 Mar, 2020 | 08:28h | UTCAssociation Between Renin-Angiotensin System Blockade Discontinuation and All-Cause Mortality Among Persons With Low Estimated Glomerular Filtration Rate – JAMA Internal Medicine (free for a limited period)
Editorial: Continuation of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in the Face of Kidney Disease Progression—Safe and Possibly Life Saving (free for a limited period)
Related Commentary on Twitter
Continuing ACE-I/ARB in patients with declining kidney function may provide cardiovascular and survival benefits without excessive harm of ESKD. https://t.co/h74imGHRbv
— JAMA Internal Medicine (@JAMAInternalMed) March 9, 2020
Randomized Trial: Efficacy of Gabapentin for the Treatment of Alcohol Use Disorder in Patients with Alcohol Withdrawal Symptoms
10 Mar, 2020 | 08:27h | UTCEfficacy of Gabapentin for the Treatment of Alcohol Use Disorder in Patients With Alcohol Withdrawal Symptoms: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Commentaries: Drug eases withdrawal, improves abstinence in alcohol use disorder – UPI (free) AND Gabapentin Found to Work Best for Those With Severe Alcohol Withdrawal Syndrome – Psychiatric News Alert (free)
Short Review: Drug Interactions with Cannabinoids
8 Mar, 2020 | 20:23h | UTCDrug interactions with cannabinoids – Canadian Medical Association Journal (free)
NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities
8 Mar, 2020 | 20:19h | UTCRelated Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Related Reviews: A review of cancer immunotherapy toxicity – CA: A Cancer Journal for Clinicians (free) AND Immune Checkpoint Inhibitor Toxicities – Mayo Clinic Proceedings (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know? – Annals of Intensive Care (free) AND Checkpoint Inhibitors: The diagnosis and treatment of side effects – Deutsches Ärzteblatt international (free)
[Abstract Only] Randomized Trial: Pembrolizumab for Early Triple-Negative Breast Cancer
8 Mar, 2020 | 20:17h | UTCPembrolizumab for Early Triple-Negative Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Neoadjuvant and Adjuvant Pembrolizumab in Early Triple-Negative Breast Cancer – ASCO Post (free)
FDA Safety Alert: Montelukast May Cause Serious Mental Health Side Effects
6 Mar, 2020 | 10:22h | UTCCommentary: Montelukast to Get Boxed Warning – NEJM Journal Watch (free)
[Abstract Only] Randomized Trials: Monthly Injections Noninferior to Daily Oral Treatment for HIV
5 Mar, 2020 | 10:29h | UTCOriginal Articles: Long-Acting Cabotegravir and Rilpivirine after Oral Induction for HIV-1 Infection – New England Journal of Medicine (link to abstract – $ for full-text) AND Long-Acting Cabotegravir and Rilpivirine for Maintenance of HIV-1 Suppression – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Monthly Injections Noninferior to Daily Treatment for HIV – NEJM Journal Watch (free) AND A more convenient, monthly treatment for HIV cleared a key hurdle – ScienceNews (free)
Study: New 3-Drug Treatment Regimen Effective for Highly Drug-Resistant Pulmonary Tuberculosis
5 Mar, 2020 | 10:30h | UTCTreatment of Highly Drug-Resistant Pulmonary Tuberculosis – New England Journal of Medicine (free)
Visual Abstract: Treatment of Highly Drug-Resistant Pulmonary TB (free)
Commentary: New TB drug regimen controls resistant disease in 9 of 10 cases: study – Reuters (free)
Systematic Review: Systemic Causes of In-Hospital Intravenous Medication Errors
5 Mar, 2020 | 10:26h | UTCSource: PSNet
Study: Association of QT-Prolonging Medications with Risk of Autopsy-Defined Causes of Sudden Death
4 Mar, 2020 | 08:29h | UTCAssociation of QT-Prolonging Medications with Risk of Autopsy-Defined Causes of Sudden Death – JAMA Internal Medicine (free for a limited period)
Commentary: QT-Prolonging Medications and Sudden Death – American College of Cardiology (free)
[Abstract Only] Observational Study Suggests Flu Vaccine May Not Decrease Hospitalization or Mortality Among Elderly Persons
4 Mar, 2020 | 08:27h | UTCThe Effect of Influenza Vaccination for the Elderly on Hospitalization and Mortality: An Observational Study With a Regression Discontinuity Design – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Flu vaccine may not decrease hospitalization or mortality among elderly persons – American College of Physicians (free) AND Expert reaction to study looking at the flu vaccine and hospitalisation and mortality in older people – Science Media Centre (free) AND Isolated flu vaccination of elderly may not decrease hospitalization or mortality rates – ACP Internist (free)
Meta-Analysis: Efficacy of Antidepressants are of Questionable Importance to the Average Patient
1 Mar, 2020 | 19:39h | UTCRelated: Evidence Synthesis: Should Antidepressants be Used for Major Depressive Disorder? (free studies on the subject)