Randomized Trial: Dexamethasone Reduces Death by Up to One Third in Patients with Severe COVID-19

Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 – Recovery Trial

Commentaries: Coronavirus breakthrough: dexamethasone is first drug shown to save lives – Nature AND WHO welcomes preliminary results about dexamethasone use in treating critically ill COVID-19 patients – World Health Organization AND Major study finds common steroid reduces deaths among patients with severe Covid-19 – STAT AND Dexamethasone reduces death in hospitalised patients with severe respiratory complications of COVID-19 – University of Oxford AND Coronavirus: Dexamethasone proves first life-saving drug – BBC

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Dexamethasone reduced deaths by 1/3rd in ventilated patients (rate ratio 0.65 [95% CI 0.48 to 0.88]; p=0.0003) and by 1/5th in patients receiving oxygen only (0.80 [0.67 to 0.96]; p=0.0021). No benefit in patients not requiring respiratory support (1.22 [0.86 to 1.75; p=0.14).

— Peter Horby (@PeterHorby) June 16, 2020