Pharmacology/Pharmaceutical Industry
[Abstract Only] Cohort study: SGLT-2 inhibitors associated with an almost 3-fold increased risk for diabetic ketoacidosis
29 Jul, 2020 | 09:31h | UTC
Penicillin allergy labels increase second-line broad-spectrum antibiotic prescribing for pediatric respiratory tract infections
29 Jul, 2020 | 09:23h | UTC
Related Commentary on Twitter
In this large cohort study in @InfectDis_Ther
Patients with penicillin allergy labels accounted for ~50% of all second-line antibiotic prescriptions in pediatrics with ARTI
2nd line Abx prescribed in 91% of encounters for penicillin-allergic pts#IDTwitter https://t.co/KjzVkdpXc2— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) July 19, 2020
Perspective: Covid-19 vaccines may cause mild side effects, experts say, stressing need for education, not alarm
28 Jul, 2020 | 07:44h | UTC
Perspective: A vaccine reality check
28 Jul, 2020 | 07:45h | UTCA Vaccine Reality Check – The Atlantic
[Preprint] Cluster-randomized trial of hydroxychloroquine as prevention of Covid-19 transmission and disease
27 Jul, 2020 | 10:07h | UTC
Coalition Covid-19 Brazil – Randomized trial: hydroxychloroquine with or without azithromycin in mild-to-moderate Covid-19
24 Jul, 2020 | 09:37h | UTCCommentary: Another study finds hydroxychloroquine does not help Covid-19 patients – CNN
Meta-analysis: No clinically meaningful difference in postoperative pain with perioperative gabapentinoids
24 Jul, 2020 | 09:16h | UTC
Audio interview: Dexamethasone and Covid-19
23 Jul, 2020 | 08:44h | UTCAudio Interview: Dexamethasone and Covid-19 – New England Journal of Medicine
Observational study: Glucocorticoid treatment linked to reduced mortality in patients with Covid-19 and initial C-reactive protein ≥20 mg/dL
23 Jul, 2020 | 08:49h | UTCCommentaries: A blood test may show which COVID-19 patients steroids will help — or harm – Science News AND Common blood test identifies benefits and risks of steroid treatment in COVID-19 patients – Albert Einstein College of Medicine
Perspective: Covid-19 vaccines with ‘minor side effects’ could still be pretty bad
23 Jul, 2020 | 08:37h | UTCCovid-19 Vaccines With ‘Minor Side Effects’ Could Still Be Pretty Bad – Wired
Controversial ‘human challenge’ trials for COVID-19 vaccines gain support
23 Jul, 2020 | 08:34h | UTCControversial ‘human challenge’ trials for COVID-19 vaccines gain support – Science
Coronavirus vaccines leap through safety trials — but which will work is anybody’s guess
23 Jul, 2020 | 08:39h | UTCCoronavirus vaccines leap through safety trials — but which will work is anybody’s guess – Nature
Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice
23 Jul, 2020 | 08:22h | UTCPlacebos in chronic pain: evidence, theory, ethics, and use in clinical practice – The BMJ (free for a limited period)
[Abstract Only] Randomized trial: Vitamin D does not prevent tuberculosis or acute respiratory infections in children
23 Jul, 2020 | 08:24h | UTC
Medication management in frail older people: Consensus principles for clinical practice, research, and education
22 Jul, 2020 | 02:17h | UTCNews Release: Monash University researchers develop new international consensus principles for medicines management in frail older people
[Abstract Only] Randomized trial: Carfilzomib, dexamethasone, and daratumumab vs. carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma
22 Jul, 2020 | 02:11h | UTC
Phase 2 randomized trial: immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults
21 Jul, 2020 | 09:29h | UTCCommentaries: China’s Ad5 vectored COVID-19 vaccine safe and induces immune response – News Medical AND CanSino COVID-19 vaccine generates immune response in 90% of patients – UPI
Related Commentary on Twitter
https://twitter.com/TheLancet/status/1285209554775617536
Editorial: encouraging results from phase 1/2 COVID-19 vaccine trials
21 Jul, 2020 | 09:35h | UTCEncouraging results from phase 1/2 COVID-19 vaccine trials – The Lancet
Commentaries: Promising early findings for 2 more COVID-19 vaccines – CIDRAP AND Expert reaction to two vaccine candidate studies: a phase 1/2 trial of the University of Oxford’s ChAdOx1 vaccine candidate; and a phase 2 trial of China’s Ad5-vectored COVID-19 vaccine candidate – Science Media Centre
[Press release-based medicine…] Synairgen announces positive results from trial of SNG001 in hospitalized COVID-19 patients
21 Jul, 2020 | 09:27h | UTCSynairgen announces positive results from trial of SNG001 in hospitalised COVID-19 patients
Commentaries: New Treatment for Covid-19 Shows Promise, but Scientists Urge Caution – The New York Times AND Expert reaction to announcement by Synairgen that their drug SNG001 has had positive results in initial trials on COVID-19 patients – Science Media Centre AND Trial of Covid-19 drug given via inhaler ‘very promising’, say scientists – The Guardian
Phase 1/2 randomized trial: safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2
21 Jul, 2020 | 09:33h | UTCCommentaries: New study reveals Oxford coronavirus vaccine produces strong immune response – University of Oxford AND Oxford’s Covid-19 vaccine appears safe and induces immune response, early results suggest, but more research is needed – CNN AND Early Oxford-AstraZeneca Coronavirus Vaccine Data ‘Encouraging,’ Scientists Say – NPR
Related Commentary on Twitter
NEW—UK’s #COVID19 vaccine is safe and induces an immune reaction, according to preliminary results https://t.co/rDPlB9fDKr pic.twitter.com/z2t9Aubjim
— The Lancet (@TheLancet) July 20, 2020
[Abstract Only] Randomized trial: Dexmedetomidine does not decrease postoperative atrial arrhythmias or delirium in patients recovering from cardiac surgery
21 Jul, 2020 | 09:16h | UTC
Related Commentary on Twitter
https://twitter.com/NydahlPeter/status/1285199896958644231
Randomized trial: dexamethasone in hospitalized patients with Covid-19
20 Jul, 2020 | 08:18h | UTCCommentary: Trial data support dexamethasone, but not hydroxychloroquine, for COVID-19 – CIDRAP
Related Commentary on Twitter
A randomized controlled trial testing dexamethasone for Covid-19 (the RECOVERY trial) showed that, compared with usual care, this corticosteroid drug reduced 28-day mortality in hospitalized patients. #COVID19 #SARSCoV2
— NEJM (@NEJM) July 18, 2020
Why those most at risk of COVID-19 are least likely to respond to a vaccine
20 Jul, 2020 | 07:55h | UTCWhy those most at risk of COVID-19 are least likely to respond to a vaccine – National Geographic
Review: clinical presentation and management of COVID ‐19
20 Jul, 2020 | 07:51h | UTCClinical presentation and management of COVID ‐19 – Medical Journal of Australia
How effective does a COVID-19 coronavirus vaccine need to be to stop the pandemic? A new study has answers
17 Jul, 2020 | 08:50h | UTC
Related Commentary on Twitter
How 'good' does a COVID-19 coronavirus vaccine need to be to stop the pandemic? Study: “If only 75% of the population gets vaccinated, the vaccine efficacy would have to be around 70%.” So we still might need a “Plan B” https://t.co/aoHu4L0SYU
— Paul Glasziou (@PaulGlasziou) July 16, 2020