Pharmacology/Pharmaceutical Industry
Antibody therapies could be a bridge to a coronavirus vaccine — but will the world benefit?
12 Aug, 2020 | 02:38h | UTCAntibody therapies could be a bridge to a coronavirus vaccine — but will the world benefit? – Nature
Related: Antibody drugs could be one of the best weapons against Covid-19. But will they matter? – STAT AND Designer antibodies could battle COVID-19 before vaccines arrive – Science
Russia has approved ‘world first’ Covid-19 vaccine. But questions over its safety remain
12 Aug, 2020 | 02:28h | UTCSee also: Russia has launched the world’s first COVID-19 vaccine: Here’s all you need to know – Firstpost AND Coronavirus: Putin says vaccine has been approved for use – BBC AND Russia Approves Coronavirus Vaccine Before Completing Tests – The New York Times AND The Russian Vaccine – Science Translational Medicine AND Russia claims first coronavirus vaccine as global cases top 20 million – MedicalXpress
Opinion – “Covid-19 drug research is a big huge mess”
11 Aug, 2020 | 10:25h | UTCCovid-19 Drug Research Is a Big Huge Mess – Wired
[Preprint] Immunogenicity and safety of a SARS-CoV-2 inactivated vaccine in healthy adults aged 18-59 years: Report of the randomized, double-blind, and placebo-controlled phase 2 clinical trial
11 Aug, 2020 | 10:19h | UTC
Commentary on Twitter
1st human data for an inactivated Covid-19 vaccine is out! Coronavac (by Sinovac) phase 2 data, for 480 people + 120 on placebo. Antibodies but not T-cells reported: 97% seroconversion 28 days after 2nd injection, but less for people over 50 … https://t.co/emJG9DQrkh 1/2 pic.twitter.com/bi72NlmkSH
— Hilda Bastian (@hildabast) August 11, 2020
[Abstract Only] Randomized trial: Prevention of benign paroxysmal positional vertigo with Vit D supplementation
10 Aug, 2020 | 01:49h | UTCCommentary: Fewer Vertigo Recurrences with Vitamin D, Calcium – Physician’s Weekly
[Abstract Only] Case-control study: Maternal use of specific antidepressant medications during early pregnancy and the risk of selected birth defects
10 Aug, 2020 | 01:51h | UTC
AAP Clinical Report: Long-acting reversible contraception: specific issues for adolescents
7 Aug, 2020 | 03:10h | UTCLong-Acting Reversible Contraception: Specific Issues for Adolescents – Pediatrics
Commentary: Teens need easy access to condoms and long-acting reversible contraception, say pediatricians – CNN
[Abstract Only] Randomized trial: Continuing vs. tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis
6 Aug, 2020 | 02:53h | UTCCommentary: Reducing corticosteroid use in rheumatoid arthritis – Charité – Universitätsmedizin Berlin
Commentary on Twitter
NEW Research—Continuing vs tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis (SEMIRA): a double-blind, multicentre, randomised controlled trial https://t.co/gtR7xmZlGS pic.twitter.com/UO1EqItU66
— The Lancet (@TheLancet) July 28, 2020
Review: Heart failure with reduced ejection fraction
6 Aug, 2020 | 02:51h | UTCHeart Failure With Reduced Ejection Fraction: A Review – JAMA (free for a limited period)
Podcast: Update on Congestive Heart Failure – JAMA
AHA Scientific statement: Medical marijuana, recreational cannabis, and cardiovascular health
6 Aug, 2020 | 02:40h | UTCCommentaries: Weed is not good for your heart, studies say – CNN AND Heart risks of marijuana use need more research – American Heart Association
[Abstract Only] Randomized trial: Ofatumumab vs. Teriflunomide in multiple sclerosis
6 Aug, 2020 | 02:43h | UTCOfatumumab versus Teriflunomide in Multiple Sclerosis – New England Journal of Medicine
ACA 2020 Expert consensus: Novel therapies for cardiovascular risk reduction in patients with type 2 diabetes
6 Aug, 2020 | 02:39h | UTCCommentary: Cardiology Group Recommends Diabetes Drugs for CV Prevention – NEJM Journal Watch
Coronavirus vaccine tracker: How close are we to a vaccine?
5 Aug, 2020 | 10:00h | UTCCoronavirus vaccine tracker: how close are we to a vaccine? – The Guardian
Related: Coronavirus Vaccine Tracker – The New York Times
[Preprint] REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters
5 Aug, 2020 | 09:56h | UTCCommentaries: Regeneron’s Monoclonal Antibody Cocktail in Primates – Science Translational Medicine AND Regeneron antibody cocktail shows promise as potential COVID-19 treatment – News Medical
Randomized trial: Vitamin D supplementation does not reduce the risk of depression
5 Aug, 2020 | 09:47h | UTCEffect of Long-term Vitamin D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Vitamin D doesn’t prevent depression in older adults, large study finds – CNN AND Large study confirms vitamin D does not reduce risk of depression in adults – Massachusetts General Hospital
[Abstract Only] Case report: Rosuvastatin myotoxicity after starting canagliflozin treatment
4 Aug, 2020 | 02:46h | UTCCommentary: Rosuvastatin Toxicity Observed After Use of Canagliflozin – NEJM Journal Watch
Drug treatments for Covid-19: Living systematic review and network meta-analysis
3 Aug, 2020 | 01:10h | UTCDrug treatments for covid-19: living systematic review and network meta-analysis – The BMJ
Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: Cohort study including 8.3 million people
3 Aug, 2020 | 00:38h | UTC
[Abstract Only] A Systematic review of the effect of delayed appropriate antibiotic treatment on the outcomes of patients with severe bacterial infections
3 Aug, 2020 | 00:20h | UTCA Systematic Review of the Effect of Delayed Appropriate Antibiotic Treatment on the Outcomes of Patients With Severe Bacterial Infections – CHEST (link to abstract – $ for full-text)
Commentary: Does Delayed Antibiotic for Severe Infection Impact Mortality? – Journal Feed
[Abstract Only] Cohort Study: Cardiovascular and bleeding risks associated with nonsteroidal anti-inflammatory drugs after myocardial infarction
3 Aug, 2020 | 00:17h | UTCCardiovascular and Bleeding Risks Associated With Nonsteroidal Anti-Inflammatory Drugs After Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: NSAIDs Boost CV, Bleeding Risks in Post-MI Patients – TCTMD AND Concomitant NSAID Treatment After MI – American College of Cardiology AND NSAIDs increase cardiovascular, bleeding risk in Korean heart attack patients – American College of Cardiology
Remdesivir for severe Covid-19: A clinical practice guideline
31 Jul, 2020 | 09:01h | UTCRemdesivir for severe covid-19: a clinical practice guideline – The BMJ
Single-shot Ad26 vaccine protects against SARS-CoV-2 in monkeys
31 Jul, 2020 | 08:49h | UTCSingle-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques – Nature
Commentaries: Vaccine Candidate Delivers Protection In A Single Shot (In Monkeys) – NPR AND Novel vaccine candidate robustly protects non-human primates against SARS-CoV-2 – News Medical
‘A huge experiment’: How the world made so much progress on a Covid-19 vaccine so fast
31 Jul, 2020 | 08:40h | UTC‘A huge experiment’: How the world made so much progress on a Covid-19 vaccine so fast – STAT
Things you should think about when you hear “vaccine by end of the year”
31 Jul, 2020 | 08:41h | UTCThings you should think about when you hear “vaccine by end of the year” – Health News Review
Some scientists are taking a DIY coronavirus vaccine, and nobody knows if it’s legal or if it works
31 Jul, 2020 | 08:36h | UTC