Pharmacology/Pharmaceutical Industry
Perspective: All eyes on a hurdle race for a SARS-CoV-2 vaccine
20 Oct, 2020 | 01:39h | UTCAll eyes on a hurdle race for a SARS-CoV-2 vaccine – Nature
Cohort study: Exposure to modafinil and armodafinil during pregnancy linked to fetal malformations
20 Oct, 2020 | 01:31h | UTCPregnancy and Fetal Outcomes Following Exposure to Modafinil and Armodafinil During Pregnancy – JAMA Internal Medicine (free for a limited period)
Commentaries: Caution in Prescribing Modafinil and Armodafinil to Individuals Who Could Become Pregnant – JAMA Internal Medicine (free for a limited period) AND Narcolepsy Drugs Tied to Increased Risk for Birth Defects – NEJM Journal Watch
Answering key questions about COVID-19 vaccines
18 Oct, 2020 | 23:10h | UTCAnswering Key Questions About COVID-19 Vaccines – JAMA
Commentary on Twitter
Many individuals are hesitant about receiving #COVID19 vaccines. It is critical that clinicians stay well informed about emerging data so that they can help patients make sound decisions https://t.co/1QDwOKuDqc @JesseGoodmanMD @ImmunizeOrg @pharmacists
— JAMA (@JAMA_current) October 16, 2020
Postlicensure evaluation of COVID-19 Vaccines
18 Oct, 2020 | 23:08h | UTCPostlicensure Evaluation of COVID-19 Vaccines – JAMA
[Abstract Only] Study: Comparison of amisulpride, aripiprazole, and olanzapine in patients with schizophrenia-spectrum disorders
18 Oct, 2020 | 23:00h | UTCAmisulpride, aripiprazole, and olanzapine in patients with schizophrenia-spectrum disorders (BeSt InTro): a pragmatic, rater-blind, semi-randomised trial – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentary on Twitter
https://twitter.com/TheLancetPsych/status/1317014163823104000
Guideline on anesthesia and sedation in breastfeeding women
18 Oct, 2020 | 23:01h | UTCGuideline on anaesthesia and sedation in breastfeeding women 2020 – Anaesthesia
Commentary: Guidelines Indicate Breastfeeding Is Safe After Maternal Anesthesia – Physician’s Briefing
Commentary on Twitter
🔐These new @Assoc_Anaes guidelines for anaesthesia and sedation in breastfeeding women are new for 2020 and #FOAMed forever!
An excellent read for #WorldAnaesthesiaDay!@jmitchelldoc @ElaineW14626897 @BfWendy @mikekinsella10
🔗https://t.co/nMAyWjdW0G pic.twitter.com/pRKzcUaNhY
— 𝘈𝘯𝘢𝘦𝘴𝘵𝘩𝘦𝘴𝘪𝘢 (@Anaes_Journal) October 16, 2020
[Preprint] WHO SOLIDARITY trial results published; Remdesivir, Hydroxychloroquine, Lopinavir, and Interferon do not improve outcomes in Covid-19
16 Oct, 2020 | 09:42h | UTCRepurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results – medRxiv
Commentary: Remdesivir and interferon fall flat in WHO’s megastudy of COVID-19 treatments – Science
Commentaries on Twitter
Results of the @WHO SOLIDARITY trial:
4 drugs tested in 11,266 patients with COVID in 405 hospitals in 30 countries:
– hydroxychloroquine
– lopinavir
– remdesevir
– interferonNo clear benefit of any of them on survival. https://t.co/ohtTAFaSnc pic.twitter.com/2fO9E8zs8h
— Martin Landray (@MartinLandray) October 16, 2020
This is blockbuster from @WHO: 'Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens have little or no effect on hospitalized COVID-19, as indicated by mortality, initiation of ventilation and duration of hospital stay. @medrxivpreprint https://t.co/aNGLzLL5uW pic.twitter.com/daOAMVW62u
— Harlan Krumholz (@hmkyale) October 15, 2020
Review: Why and how vaccines work
16 Oct, 2020 | 09:32h | UTCWhy and How Vaccines Work – Cell
Commentary on Twitter
Why and how vaccines work, including how the covid-19 vaccines are positioned, new adjuvants
New @CellCellPress by @VirusesImmunity and @SaadOmer3 https://t.co/ydGfLJh0Uv pic.twitter.com/8niIaMVlAQ— Eric Topol (@EricTopol) October 15, 2020
[Abstract Only] Randomized trial: Upadacitinib vs. Abatacept in rheumatoid arthritis
16 Oct, 2020 | 09:28h | UTCTrial of Upadacitinib or Abatacept in Rheumatoid Arthritis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Rheumatoid Arthritis: When DMARDs Fail, Can JAK Inhibitors Step In? – Physician’s Weekly
Coronavirus vaccine: What we know so far – a comprehensive guide by academic experts
15 Oct, 2020 | 09:17h | UTC
Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2020 Recommendations of the International Antiviral Society–USA Panel
15 Oct, 2020 | 09:13h | UTC
Commentary on Twitter
Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults https://t.co/J3zHm9rpkY via @JAMA_current The new @IAS_USA ART guidelines document is out. Enormous effort led by @msaagmd with @RMKGandhi @doc_in_a_box @drmt @PaulSaxMD @joseph_eron and others on panel.
— Carlos del Rio (@CarlosdelRio7) October 14, 2020
Phase 3 trials show positive results for cefiderocol, but questions remain
15 Oct, 2020 | 09:07h | UTCPhase 3 trials show positive results for cefiderocol, but questions remain – CIDRAP
Podcast: Ten things every new doctor should know about drug reactions
15 Oct, 2020 | 09:02h | UTCTen Things Every New Doctor Should Know About Drug Reactions – JAMA
Study: Polypharmacy (taking > 10 medications) is common in older patients with heart failure
15 Oct, 2020 | 09:03h | UTCPolypharmacy in Older Adults Hospitalized for Heart Failure – Circulation: Heart Failure
Commentaries: Ten or more medications, often prescribed to older heart failure patients, raises concerns – American Heart Association AND Polypharmacy Common Among Older Heart Failure Patients – Physician’s Weekly
Commentary on Twitter
New work from @OzanUnluMD @ParagGoyalMD indicates that polypharmacy (taking > 10 medications) is common in older patients with #heartfailure, and is primarily due to non-cardiovascular meds #AHAJournals @WeillCornell | https://t.co/hL0GZLaCnT pic.twitter.com/BHppxDQgor
— Circ: Heart Failure (@CircHF) October 13, 2020
Updated NIH COVID-19 Treatment Guidelines
14 Oct, 2020 | 09:41h | UTCCoronavirus Disease 2019 (COVID-19) Treatment Guidelines – National Institutes of Health
See also: What’s New in the Guidelines
Johnson & Johnson Covid-19 vaccine study paused due to unexplained illness in participant
14 Oct, 2020 | 09:31h | UTCJohnson & Johnson Covid-19 vaccine study paused due to unexplained illness in participant – STAT
News Release: Johnson & Johnson Temporarily Pauses All Dosing in Our Janssen COVID-19 Vaccine Candidate Clinical Trials
Commentaries: Johnson & Johnson ‘Pauses’ COVID-19 Vaccine Trial Due To Unexplained Illness In Participant; Eli Lilly Reportedly Suspending Trial Of Antibody Treatment – Health Policy Watch AND Johnson & Johnson pauses Covid-19 vaccine trial after ‘unexplained illness’ – CNN
Monoclonal antibody trial halted for safety concern
14 Oct, 2020 | 09:30h | UTCMonoclonal Antibody Trial Halted for Safety Concern – Brief19
Covid-19: how to prioritize worse-off populations in allocating safe and effective vaccines
14 Oct, 2020 | 09:25h | UTC
[Abstract Only] Randomized trials: Efficacy and safety of a plant-derived influenza vaccine in adults
14 Oct, 2020 | 09:23h | UTCEfficacy, immunogenicity, and safety of a plant-derived, quadrivalent, virus-like particle influenza vaccine in adults (18–64 years) and older adults (≥65 years): two multicentre, randomised phase 3 trials – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
NEW—First large-scale studies of plant-derived, quadrivalent, virus-like particle influenza vaccine show substantial protection against respiratory illness & influenza-like illness caused by influenza viruses in adults: two randomised phase 3 trials https://t.co/oQbs2uJTXY pic.twitter.com/C6b6Qi6qZ7
— The Lancet (@TheLancet) October 13, 2020
Study: Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters
13 Oct, 2020 | 01:10h | UTC
Commentary on Twitter
👨⚕️ Researchers from @HKUniversity test a set of metallodrugs and related compounds, and identify ranitidine bismuth citrate, a commonly used drug for the treatment of Helicobacter pylori #infection, as a potent anti-#SARS-CoV-2 agent.
👁️ Full article https://t.co/Oz5O7hL9js pic.twitter.com/izMRdRTT27
— Immunology of Infectious Disease News (@infdisease_news) October 12, 2020
Infecting volunteers with coronavirus may be one way to test potential vaccines. But there are risks.
13 Oct, 2020 | 01:02h | UTC
RECOVERY trial: Effect of hydroxychloroquine in hospitalized patients with Covid-19
9 Oct, 2020 | 09:15h | UTC
Remdesivir for the treatment of Covid-19 — final report
9 Oct, 2020 | 09:13h | UTCRemdesivir for the Treatment of Covid-19 — Final Report – New England Journal of Medicine
Commentary: BREAKING NEWS: Final remdesivir results published after 139 days of waiting – Brief19
Commentary on Twitter
📍Remdesivir trial (ACTT-1) final results finally out.
📍Still no mortality benefit. A study with tons of patients could show some small mortality benefit.
📍Those who recover, do so a bit faster.
📍Not the game-changer that was hyped.via @Brief_19https://t.co/jWRJypJIuS
— Jeremy Faust MD MS (ER physician) (@jeremyfaust) October 8, 2020
[News release – not published yet] Eli Lilly says its monoclonal antibody cocktail is effective in treating Covid-19
9 Oct, 2020 | 09:09h | UTCEli Lilly says its monoclonal antibody cocktail is effective in treating Covid-19 – STAT
Editorial: The ten reasons why corticosteroid therapy reduces mortality in severe COVID-19
8 Oct, 2020 | 09:15h | UTC