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Pharmacology/Pharmaceutical Industry

Meta-analysis: Effectiveness of honey for symptomatic relief in upper respiratory tract infections

20 Aug, 2020 | 09:15h | UTC

Effectiveness of honey for symptomatic relief in upper respiratory tract infections: a systematic review and meta-analysis – BMJ Evidence-based Medicine

Commentaries: Honey may be better at treating coughs and colds than over-the-counter medicines – CNN AND Honey found to be a better treatment for upper respiratory tract infections than traditional remedies – MedicalXpress AND Honey better treatment for coughs and colds than antibiotics, study claims – The Guardian

 

[Abstract Only] Observational study: Atypical femur fracture risk vs. fragility fracture prevention with bisphosphonates

20 Aug, 2020 | 09:12h | UTC

Atypical Femur Fracture Risk versus Fragility Fracture Prevention with Bisphosphonates – New England Journal of Medicine

 

Perspective: What the immune response to the coronavirus says about the prospects for a vaccine

19 Aug, 2020 | 09:39h | UTC

What the immune response to the coronavirus says about the prospects for a vaccine – Nature

 

Meta-analysis: Use of inhibitors of the renin‐angiotensin system in hypertensive patients and COVID‐19 severity

19 Aug, 2020 | 09:35h | UTC

Use of inhibitors of the renin‐angiotensin system in hypertensive patients and COVID‐19 severity: A systematic review and meta‐analysis – Journal of Clinical Pharmacy and Therapeutics

 

Study: 75% of Patients with dementia using psychotropic and opioid medications not made for the disease

19 Aug, 2020 | 09:27h | UTC

Prevalence of Psychotropic and Opioid Prescription Fills Among Community-Dwelling Older Adults With Dementia in the US – JAMA (free for a limited period)

Commentaries: These Drugs Carry Risks and May Not Help, But Many Dementia Patients Get Them Anyway – Michigan Medicine AND 3 in 4 Elders with Dementia Fill Prescriptions for Psychotropics or Opioids – NEJM Journal Watch

 

Commentary from the author (Thread – click for more)

 

Prior routine use of NSAIDs and outcomes in hospitalized patients with COVID-19

18 Aug, 2020 | 07:36h | UTC

Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19 – Journal of Clinical Medicine

Commentary: Study finds ibuprofen does not increase risk of death from COVID-19 – University of Aberdeen

 

[Abstract Only] Randomized trial: Effect of sustained-release morphine for refractory breathlessness in COPD

18 Aug, 2020 | 07:25h | UTC

Effect of Sustained-Release Morphine for Refractory Breathlessness in Chronic Obstructive Pulmonary Disease on Health Status: A Randomized Clinical Trial – JAMA Internal Medicine

 

Commentary on Twitter

 

ACP/AAFP Guideline: Nonpharmacologic and pharmacologic management of acute pain from non–low back, musculoskeletal injuries in adults

18 Aug, 2020 | 07:30h | UTC

Nonpharmacologic and Pharmacologic Management of Acute Pain From Non–Low Back, Musculoskeletal Injuries in Adults: A Clinical Guideline From the American College of Physicians and American Academy of Family Physicians – Annals of Internal Medicine

News Release: ACP, AAFP release new guideline for treatment of non-low back pain – American College of Physicians

Commentary: ACP, AAFP issue joint guideline on non-low back pain from musculoskeletal injuries in adults – ACP Internist

 

Randomized trial: Imipenem/Cilastatin/Relebactam vs. Piperacillin/Tazobactam in adults with hospital-acquired or ventilator-associated bacterial pneumonia

16 Aug, 2020 | 22:12h | UTC

A Randomized, Double-blind, Multicenter Trial Comparing Efficacy and Safety of Imipenem/Cilastatin/Relebactam Versus Piperacillin/Tazobactam in Adults With Hospital-acquired or Ventilator-associated Bacterial Pneumonia (RESTORE-IMI 2 Study) – Clinical Infectious Diseases

 

Randomized trial: Methylprednisolone as adjunctive therapy for patients hospitalized with COVID-19

14 Aug, 2020 | 01:53h | UTC

Methylprednisolone as Adjunctive Therapy for Patients Hospitalized With COVID-19 (Metcovid): A Randomised, Double-Blind, Phase IIb, Placebo-Controlled Trial – Clinical Infectious Diseases

Related Study: Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report – New England Journal of Medicine

 

Commentary on Twitter

 

These Covid-19 vaccine candidates could change the way we make vaccines — if they work

14 Aug, 2020 | 01:43h | UTC

These Covid-19 vaccine candidates could change the way we make vaccines — if they work – Vox

 

Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes

14 Aug, 2020 | 01:44h | UTC

Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes: Interim Analysis of 2 Randomized Clinical Trials – JAMA

 

Commentary on Twitter

 

Systematic review: The use of erythropoietin plus iron to correct anemia before surgery to reduce the risk of blood transfusion

14 Aug, 2020 | 01:04h | UTC

Erythropoietin plus iron versus control treatment including placebo or iron for preoperative anaemic adults undergoing non‐cardiac surgery – Cochrane Library

Summary: The use of erythropoietin plus iron to correct anaemia before surgery to reduce the risk of blood transfusion – Cochrane Library

 

Randomized trial: AVIFAVIR for Treatment of Patients with Moderate COVID-19

13 Aug, 2020 | 00:28h | UTC

AVIFAVIR for Treatment of Patients with Moderate COVID-19: Interim Results of a Phase II/III Multicenter Randomized Clinical Trial – Clinical Infectious Diseases

 

Commentary on Twitter

 

Russia’s rapid COVID-19 vaccine approval draws intense criticism from some – and offers to collaborate from others

13 Aug, 2020 | 00:25h | UTC

Russia’s Rapid COVID-19 Vaccine Approval Draws Intense Criticism From Some – And Offers To Collaborate From Others – Health Policy Watch

 

[Abstract Only] Randomized trial: Effect of aspirin on cancer incidence and mortality in older adults

12 Aug, 2020 | 23:59h | UTC

Effect of aspirin on cancer incidence and mortality in older adults – JNCI: Journal of the National Cancer Institute

Commentary: Aspirin may accelerate progression of advanced cancers in older adults – Massachusetts General Hospital

 

Randomized trial: No benefit from combination therapy of vitamin C and thiamine for septic shock

13 Aug, 2020 | 00:01h | UTC

Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study – Intensive Care Medicine

 

Antibody therapies could be a bridge to a coronavirus vaccine — but will the world benefit?

12 Aug, 2020 | 02:38h | UTC

Antibody therapies could be a bridge to a coronavirus vaccine — but will the world benefit? – Nature

Related: Antibody drugs could be one of the best weapons against Covid-19. But will they matter? – STAT AND Designer antibodies could battle COVID-19 before vaccines arrive – Science

 

Russia has approved ‘world first’ Covid-19 vaccine. But questions over its safety remain

12 Aug, 2020 | 02:28h | UTC

Putin says Russia has approved ‘world first’ Covid-19 vaccine. But questions over its safety remain – CNN

See also: Russia has launched the world’s first COVID-19 vaccine: Here’s all you need to know – Firstpost AND Coronavirus: Putin says vaccine has been approved for use – BBC AND Russia Approves Coronavirus Vaccine Before Completing Tests – The New York Times AND The Russian Vaccine – Science Translational Medicine AND Russia claims first coronavirus vaccine as global cases top 20 million – MedicalXpress

 

Opinion – “Covid-19 drug research is a big huge mess”

11 Aug, 2020 | 10:25h | UTC

Covid-19 Drug Research Is a Big Huge Mess – Wired

 

[Preprint] Immunogenicity and safety of a SARS-CoV-2 inactivated vaccine in healthy adults aged 18-59 years: Report of the randomized, double-blind, and placebo-controlled phase 2 clinical trial

11 Aug, 2020 | 10:19h | UTC

Immunogenicity and Safety of a SARS-CoV-2 Inactivated Vaccine in Healthy Adults Aged 18-59 years: Report of the Randomized, Double-blind, and Placebo-controlled Phase 2 Clinical Trial – medRxiv

 

Commentary on Twitter

 

[Abstract Only] Randomized trial: Prevention of benign paroxysmal positional vertigo with Vit D supplementation

10 Aug, 2020 | 01:49h | UTC

Prevention of Benign Paroxysmal Positional Vertigo with Vit D Supplementation: A Randomized Trial – Neurology

Commentary: Fewer Vertigo Recurrences with Vitamin D, Calcium – Physician’s Weekly

 

[Abstract Only] Case-control study: Maternal use of specific antidepressant medications during early pregnancy and the risk of selected birth defects

10 Aug, 2020 | 01:51h | UTC

Maternal Use of Specific Antidepressant Medications During Early Pregnancy and the Risk of Selected Birth Defects – JAMA Psychiatry

 

AAP Clinical Report: Long-acting reversible contraception: specific issues for adolescents

7 Aug, 2020 | 03:10h | UTC

Long-Acting Reversible Contraception: Specific Issues for Adolescents – Pediatrics

Commentary: Teens need easy access to condoms and long-acting reversible contraception, say pediatricians – CNN

 

[Abstract Only] Randomized trial: Continuing vs. tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis

6 Aug, 2020 | 02:53h | UTC

Continuing versus tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis (SEMIRA): a double-blind, multicentre, randomised controlled trial – The Lancet

Commentary: Reducing corticosteroid use in rheumatoid arthritis – Charité – Universitätsmedizin Berlin

 

Commentary on Twitter

 

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