Pharmacology/Pharmaceutical Industry
Observational study: Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis
26 Aug, 2020 | 03:57h | UTC
Randomized trial: Vitamin D Supplementation does not prevent severe asthma exacerbations in children with asthma and low vitamin D levels
26 Aug, 2020 | 03:52h | UTCEffect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial – JAMA (free for a limited period)
Commentary: Compared to placebo, vitamin D has no benefit for severe asthma attacks, study finds – University of Pittsburgh School of Medicine AND Don’t count on vitamin D to ease childhood asthma – MedicalXpress
Commentary on Twitter
In this RCT, #vitaminD3 supplementation did not improve the time to a severe asthma exacerbation vs placebo in children with persistent asthma and low #vitaminD levels https://t.co/VfYXUrhyT7
— JAMA (@JAMA_current) August 25, 2020
Vaccines targeting SARS-CoV-2 tested in humans
25 Aug, 2020 | 03:56h | UTCVaccines targeting SARS-CoV-2 tested in humans – Nature Medicine
Commentary on Twitter
No #SARSCoV2 vaccine has yet to be shown to be effective or safe.
Effective = it prevents infections.
Safe = it doesn't engender serious adverse effects.https://t.co/dsyk8m6pEx@NatureMedicine
Please keep this in mind now that @US_FDA's @SteveFDA has lost all credibility pic.twitter.com/OgQIpDPv6R— Eric Topol (@EricTopol) August 24, 2020
Randomized trial: Mifepristone and misoprostol vs. misoprostol alone for the management of missed miscarriage
26 Aug, 2020 | 03:54h | UTCInvited commentary: Medical management of miscarriage with mifepristone – The Lancet
WHO: 172 countries and multiple candidate vaccines engaged in COVID-19 vaccine Global Access Facility
25 Aug, 2020 | 03:48h | UTC
Commentary on Twitter
Urgent, broadscale commitment & investment from countries is?to achieve the goal of COVAX to bring the pandemic under control by accelerating the development & manufacture of #COVID19 vaccines, & to guarantee fair & equitable access for all countries?
?https://t.co/CPNzyTjsLz pic.twitter.com/jBupCY7dur
— World Health Organization (WHO) (@WHO) August 24, 2020
The unequal scramble for coronavirus vaccines — by the numbers
25 Aug, 2020 | 03:47h | UTCThe unequal scramble for coronavirus vaccines — by the numbers – Nature
Meta-analysis: Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients
25 Aug, 2020 | 03:40h | UTC
The neuroleptic malignant syndrome—a systematic case series analysis focusing on therapy regimes and outcome
25 Aug, 2020 | 03:37h | UTCCommentary: Treating Neuroleptic Malignant Syndrome: A Case Series – NEJM Journal Watch
Randomized trial: Remdesivir vs. standard care in patients with moderate COVID-19
24 Aug, 2020 | 00:53h | UTCEditorial: Efficacy of Remdesivir in COVID-19
Commentaries: Study: Remdesivir doesn’t boost outcomes in moderate pneumonia from COVID-19 – UPI AND New Remdesivir Study Shows the Trouble With Bad Science – The Wire
Commentary on Twitter
Remdesivir….good editorial, concludes we don't know who to give it to, nor for how long, nor if it improves outcomes, nor whether, if it does, it does that beyond what dexamethasone or other corticosteroids do. https://t.co/Qi1dTSPcYi
— Dr. Tom Frieden (@DrTomFrieden) August 21, 2020
CDC Guideline: Prevention and control of seasonal influenza with vaccines
24 Aug, 2020 | 00:29h | UTC
Dexamethasone and hydroxychloroquine: Why randomized controlled trials matter
21 Aug, 2020 | 02:37h | UTC
Meta-analysis: Effectiveness of honey for symptomatic relief in upper respiratory tract infections
20 Aug, 2020 | 09:15h | UTCCommentaries: Honey may be better at treating coughs and colds than over-the-counter medicines – CNN AND Honey found to be a better treatment for upper respiratory tract infections than traditional remedies – MedicalXpress AND Honey better treatment for coughs and colds than antibiotics, study claims – The Guardian
[Abstract Only] Observational study: Atypical femur fracture risk vs. fragility fracture prevention with bisphosphonates
20 Aug, 2020 | 09:12h | UTC
Perspective: What the immune response to the coronavirus says about the prospects for a vaccine
19 Aug, 2020 | 09:39h | UTCWhat the immune response to the coronavirus says about the prospects for a vaccine – Nature
Meta-analysis: Use of inhibitors of the renin‐angiotensin system in hypertensive patients and COVID‐19 severity
19 Aug, 2020 | 09:35h | UTC
Study: 75% of Patients with dementia using psychotropic and opioid medications not made for the disease
19 Aug, 2020 | 09:27h | UTCPrevalence of Psychotropic and Opioid Prescription Fills Among Community-Dwelling Older Adults With Dementia in the US – JAMA (free for a limited period)
Commentaries: These Drugs Carry Risks and May Not Help, But Many Dementia Patients Get Them Anyway – Michigan Medicine AND 3 in 4 Elders with Dementia Fill Prescriptions for Psychotropics or Opioids – NEJM Journal Watch
Commentary from the author (Thread – click for more)
We wrote a new thing out in @JAMA_current examining the mind-bogglingly high rate of psychotropic and opioid use among older adults with #dementia in the community:https://t.co/4FRGQcp70B pic.twitter.com/hB3KDSnXMg
— Donovan Maust (@dtmaust) August 18, 2020
Prior routine use of NSAIDs and outcomes in hospitalized patients with COVID-19
18 Aug, 2020 | 07:36h | UTCCommentary: Study finds ibuprofen does not increase risk of death from COVID-19 – University of Aberdeen
[Abstract Only] Randomized trial: Effect of sustained-release morphine for refractory breathlessness in COPD
18 Aug, 2020 | 07:25h | UTC
Commentary on Twitter
Sustained-Release Morphine improves quality of life in patients with #COPD and refractory #breathlessness https://t.co/whXcWPlKiv via @JAMAInternalMed part of @JAMANetwork #pallipulm
— Daisy Janssen (@DJAJanssen) August 17, 2020
ACP/AAFP Guideline: Nonpharmacologic and pharmacologic management of acute pain from non–low back, musculoskeletal injuries in adults
18 Aug, 2020 | 07:30h | UTCNews Release: ACP, AAFP release new guideline for treatment of non-low back pain – American College of Physicians
Commentary: ACP, AAFP issue joint guideline on non-low back pain from musculoskeletal injuries in adults – ACP Internist
Randomized trial: Imipenem/Cilastatin/Relebactam vs. Piperacillin/Tazobactam in adults with hospital-acquired or ventilator-associated bacterial pneumonia
16 Aug, 2020 | 22:12h | UTC
Randomized trial: Methylprednisolone as adjunctive therapy for patients hospitalized with COVID-19
14 Aug, 2020 | 01:53h | UTCRelated Study: Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report – New England Journal of Medicine
Commentary on Twitter
Metcovid Double Blind PH. 2
RCT ??~ 400 pts #CID
Methylprednisolon 0.5mg/kg twice daily x5d #COVID19 Hospitalized pts #COVID19 did not reduce 28d mortality V placebo
Is it Right Drug, Dose, Duration
High dose vs RECOVERY
DEX less mineralocorticoid
5 v 10 https://t.co/EBIRWYouSQ pic.twitter.com/OzGJkqjkrJ— Antibiotic Steward? Bassam Ghanem (@ABsteward) August 13, 2020
These Covid-19 vaccine candidates could change the way we make vaccines — if they work
14 Aug, 2020 | 01:43h | UTCThese Covid-19 vaccine candidates could change the way we make vaccines — if they work – Vox
Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes
14 Aug, 2020 | 01:44h | UTC
Commentary on Twitter
Inactivated #COVID19 #vaccine had a low rate of adverse reactions and demonstrated immunogenicity, but longer-term assessment of safety and efficacy will require phase 3 trials https://t.co/atmhXFFHSw
— JAMA (@JAMA_current) August 13, 2020
Systematic review: The use of erythropoietin plus iron to correct anemia before surgery to reduce the risk of blood transfusion
14 Aug, 2020 | 01:04h | UTC
Randomized trial: AVIFAVIR for Treatment of Patients with Moderate COVID-19
13 Aug, 2020 | 00:28h | UTC
Commentary on Twitter
NEW ?? #CID @IDSAInfo
AVIFAVIR(favipiravir) for Treatment of Patients with Moderate #COVID19 : Interim Results of a Phase II/III Multicenter Randomized Clinical Trial #IDTwitter https://t.co/PwUcCWu5KQ pic.twitter.com/6N6lxHUu9K— Antibiotic Steward? Bassam Ghanem (@ABsteward) August 8, 2020