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Pharmacology/Pharmaceutical Industry

Evolution of the COVID-19 vaccine development landscape

8 Sep, 2020 | 01:18h | UTC

Evolution of the COVID-19 vaccine development landscape – Nature Reviews Drug Discovery

 

Meta-analysis: Chloroquine and Hydroxychloroquine do not improve outcomes in COVID-19

8 Sep, 2020 | 01:08h | UTC

Chloroquine and Hydroxychloroquine for the Treatment of COVID-19: a Systematic Review and Meta-analysis – Journal of General Internal Medicine

Related Meta-analysis: Antirheumatic Disease Therapies for the Treatment of COVID‐19: A Systematic Review and Meta‐analysis – Arthritis & Rheumatology

 

[Abstract Only] Randomized trial: Once-daily, subcutaneous vosoritide therapy in children with achondroplasia

8 Sep, 2020 | 01:06h | UTC

Once-daily, subcutaneous vosoritide therapy in children with achondroplasia: a randomised, double-blind, phase 3, placebo-controlled, multicentre trial – The Lancet

Commentary: New drug shown to improve bone growth in children with achondroplasia in global phase III trial – Murdoch Children’s Research Institute

 

Commentary on Twitter

 

Coalition Covid-19 Brazil – Randomized trial: Azithromycin not beneficial for patients admitted to the hospital with severe Covid-19

6 Sep, 2020 | 22:06h | UTC

Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial – The Lancet

Invited Commentary: Azithromycin for severe COVID-19

 

Commentaries on Twitter

 

 

A living WHO guideline on drugs for Covid-19

6 Sep, 2020 | 22:04h | UTC

A living WHO guideline on drugs for covid-19 – The BMJ

 

Commentary on Twitter

 

Phase 1–2 trial of a SARS-CoV-2 recombinant spike protein nanoparticle vaccine

6 Sep, 2020 | 21:44h | UTC

Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine – New England Journal of Medicine

 

Russian coronavirus vaccine results have been published

6 Sep, 2020 | 21:48h | UTC

Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia – The Lancet

Commentaries: COVID-19 vaccines: early success and remaining challenges – The Lancet AND The Russian vaccine for COVID-19 – The Lancet Respiratory Medicine AND Early-phase Russian trials reveal safety and immunogenicity of two formulations of a two-part vaccine – News Medical / The Lancet AND Russian coronavirus vaccine results have been published – here’s what they reveal – The Conversation

 

Commentary on Twitter

 

[Abstract Only] Randomized trial: Aspirin increases major GI bleeding risk by 60% in older individuals

6 Sep, 2020 | 21:30h | UTC

Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial – Gut

Source: EvidenceAlerts

 

Commentary on Twitter

 

COVID-19 and mRNA vaccines—first large test for a new approach

4 Sep, 2020 | 02:08h | UTC

COVID-19 and mRNA Vaccines—First Large Test for a New Approach – JAMA

 

Challenges in evaluating SARS-CoV-2 vaccines during the COVID-19 pandemic

4 Sep, 2020 | 02:06h | UTC

Challenges in evaluating SARS-CoV-2 vaccines during the COVID-19 pandemic – Canadian Medical Association Journal

 

Coalition Covid-19 Brazil – Randomized trial: Dexamethasone improves outcomes in patients with Acute Respiratory Distress Syndrome and COVID-19

3 Sep, 2020 | 11:24h | UTC

Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial – JAMA

Editorial: Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic

Related studies: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial – JAMA AND Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial – JAMA

Commentary: Inexpensive Steroids Can Save Lives Of Seriously Ill COVID-19 Patients – NPR

 

Commentary on Twitter

 

Video: Corticosteroids for COVID-19 – New Evidence of Benefit

3 Sep, 2020 | 11:21h | UTC

Corticosteroids for COVID-19 – New Evidence of Benefit – JAMA

 

Meta-analysis: Corticosteroids for critically ill patients with COVID-19

3 Sep, 2020 | 11:23h | UTC

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis – JAMA

Editorial: Corticosteroids in COVID-19 ARDS: Evidence and Hope During the Pandemic

Commentaries: Analysis of seven trials finds that corticosteroids reduce risk of death by 20 per cent in critically ill COVID-19 patients – University of Bristol  AND Multiple studies confirm steroids can fight severe COVID-19 – MedicalXpress

 

Commentary on Twitter

 

Incidence of malformations after early pregnancy exposure to Modafinil

4 Sep, 2020 | 02:02h | UTC

Incidence of Malformations After Early Pregnancy Exposure to Modafinil in Sweden and Norway – JAMA (free for a limited period)

Commentary: Narcolepsy drug did not increase risk of fetal malformation – Karolinska Institutet

 

Commentary on Twitter

 

New WHO Guidance: Corticosteroids for COVID-19

3 Sep, 2020 | 11:20h | UTC

Corticosteroids for COVID-19 – World Health Organization

News Release: WHO updates clinical care guidance with corticosteroid recommendations – World Health Organization

Commentaries: The WHO Now Recommends Cheap Steroids As a Life-Saving Treatment for Severe Covid-19 – Gizmodo AND Inexpensive steroids reduce deaths of hospitalized Covid-19 patients, WHO analysis confirms – STAT

 

Commentary on Twitter

 

[Preprint] Randomized trial: Tocilizumab does not improve clinical status or mortality in hospitalized patients with COVID-19 pneumonia

3 Sep, 2020 | 11:19h | UTC

Tocilizumab in Hospitalized Patients With COVID-19 Pneumonia – medRxiv

 

Fauci says COVID vaccine trials could end early if results are overwhelming

3 Sep, 2020 | 11:02h | UTC

Fauci Says COVID Vaccine Trials Could End Early If Results Are Overwhelming – Kaiser Health News

 

[Abstract Only] CAR T-cell therapy for patients with relapsed or refractory large B-cell lymphomas

3 Sep, 2020 | 10:56h | UTC

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study – The Lancet (link to abstract – $ for full-text)

 

U.S. advisory group lays out detailed recommendations on how to prioritize Covid-19 vaccine

2 Sep, 2020 | 09:46h | UTC

U.S. advisory group lays out detailed recommendations on how to prioritize Covid-19 vaccine – STAT

 

ADA Guideline synopsis: Pharmacologic approaches to glycemic treatment of Type 2 Diabetes

2 Sep, 2020 | 09:41h | UTC

Pharmacologic Approaches to Glycemic Treatment of Type 2 Diabetes: Synopsis of the 2020 American Diabetes Association’s Standards of Medical Care in Diabetes Clinical Guideline – Annals of Internal Medicine

 

#ESCCongress – [Not Published Yet] First randomized trial backs safety of ACE Inhibitors and ARBs in COVID-19 patients

2 Sep, 2020 | 09:48h | UTC

News Release: First randomised trial backs safety of common heart drugs in COVID-19 patients – European Society of Cardiology

Commentary: Continuing Versus Suspending Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers – BRACE CORONA – American College of Cardiology

 

Commentary on Twitter

 

Anticoagulation in COVID-19: A systematic review, meta-analysis and rapid guidance from the Mayo Clinic

1 Sep, 2020 | 06:26h | UTC

Anticoagulation in COVID-19: A Systematic Review, Meta-Analysis and Rapid Guidance From The Mayo Clinic – Mayo Clinic Proceedings

 

Viewpoint – Regulatory decision-making on COVID-19 vaccines during a public health emergency

1 Sep, 2020 | 06:08h | UTC

Regulatory Decision-making on COVID-19 Vaccines During a Public Health Emergency – JAMA

 

Viewpoint – Emergency use authorizations during the COVID-19 pandemic: Lessons from hydroxychloroquine for vaccine authorization and approval

1 Sep, 2020 | 06:09h | UTC

Emergency Use Authorizations During the COVID-19 Pandemic: Lessons From Hydroxychloroquine for Vaccine Authorization and Approval – JAMA

 

#ESCCongress – [Abstract Only] Randomized trial: Colchicine in patients with chronic coronary disease

1 Sep, 2020 | 06:04h | UTC

Colchicine in Patients with Chronic Coronary Disease – New England Journal of Medicine

Commentaries: LoDoCo2: Colchicine Protective in Large RCT of Chronic Coronary Disease – TCTMD AND Low Dose Colchicine for Secondary Prevention of Cardiovascular Disease 2 – LoDoCo2 – American College of Cardiology

 

Commentary on Twitter

 

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