Pediatrics – Endocrinology
M-A | Low-dose insulin infusion is safe and effective in treating diabetic ketoacidosis in children
23 Feb, 2023 | 13:40h | UTCSummary: The article discusses a systematic review and meta-analysis of randomized controlled trials comparing low-dose insulin at 0.05 units/kg/hr to standard dose at 0.1 units/kg/hr for children with diabetic ketoacidosis (DKA). The study found that low-dose insulin infusion is probably as efficacious and safer than standard-dose insulin in treating DKA in children, as it has no effect on the time to resolution of hyperglycemia or acidosis and probably reduces the risk of developing hypokalemia and hypoglycemia. However, the results are limited by imprecision and generalizability to other settings since all studies were performed in a single country. Therefore, further studies are required to identify the optimal insulin dose for children with DKA in terms of safety and effectiveness.
RCT | Outcomes in children of women with type 2 diabetes exposed to metformin vs. placebo during pregnancy
8 Feb, 2023 | 12:32h | UTCOutcomes in children of women with type 2 diabetes exposed to metformin versus placebo during pregnancy (MiTy Kids): a 24-month follow-up of the MiTy randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
The introduction of sugary drinks tax in the UK was followed by a drop in obesity cases among children
1 Feb, 2023 | 13:32h | UTCNews Releases:
UK soft drink taxes associated with decreased obesity in girls – PLOS
Commentaries:
UK sugar tax ‘prevents 5,000 cases of obesity in year 6 girls annually’ – The Guardian
Related:
WHO manual on sugar-sweetened beverage taxation policies to promote healthy diets.
M-A: Outcomes following taxation of sugar-sweetened beverages.
Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents – Pediatrics
Cutting back on sugar-sweetened beverages: What works? – Cochrane Library
Sugar-sweetened beverage taxes: Lessons to date and the future of taxation – PLOS Medicine
Banning the promotion of soft drinks could be more effective than a sugar tax – The Conversation
Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian
Commentary from the author on Twitter (thread – click for more)
📢 19 months after the UK Soft Drinks Industry Levy (sugar tax) was implemented, we found an 8% relative reduction in obesity levels in 10/11 year old girls. Greatest reductions were found in girls from schools in the most deprived areas https://t.co/pYDHZZJrur
— Dr Nina Rogers (@Nina_Tr_Rogers) January 26, 2023
M-A | Association between autism spectrum disorders and cardiometabolic diseases
1 Feb, 2023 | 13:11h | UTCAssociation Between Autism Spectrum Disorders and Cardiometabolic Diseases: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)
Editorial: Autism, Physical Health Conditions, and a Need for Reform – JAMA Pediatrics (free for a limited period)
Commentary on Twitter
Study results suggest that having autism may be associated with a higher risk of developing diabetes, dyslipidemia, and heart disease. https://t.co/T19VAQxdjf
— JAMA Pediatrics (@JAMAPediatrics) January 30, 2023
Cohort Study | Alcohol-related problems before and after metabolic and bariatric surgery in adolescents
26 Jan, 2023 | 12:01h | UTCA Prospective Cohort of Alcohol use and Alcohol-related Problems Before and After Metabolic and Bariatric Surgery in Adolescents – Annals of Surgery (link to abstract – $ for full-text)
News Release: Problems with Alcohol Increase After Weight-Loss Surgery in Adolescence – Ann & Robert H. Lurie Children’s Hospital of Chicago
Related Study: Association Between Bariatric Surgery and Alcohol Use–Related Hospitalization and All-Cause Mortality in a Veterans Affairs Cohort – JAMA Surgery (link to abstract – $ for full-text)
2022 Consensus Guidelines on the management of diabetes in children
19 Jan, 2023 | 14:16h | UTCEditorial: ISPAD Clinical Practice Consensus Guidelines 2022
ISPAD Clinical Practice Consensus Guidelines 2022: Diabetes technologies: Glucose monitoring
ISPAD Clinical Practice Consensus Guidelines 2022: Managing diabetes in preschoolers
AAP Clinical Report | Congenital hypothyroidism: screening and management
17 Jan, 2023 | 13:31h | UTCCongenital Hypothyroidism: Screening and Management – Pediatrics
Technical Report: Congenital Hypothyroidism: Screening and Management – Pediatrics
Commentary: Clinical Report Addresses Screening, Management of Congenital Hypothyroidism – HealthDay
Opinion | The American Academy of Pediatrics is pushing drugs and surgery for obesity
17 Jan, 2023 | 13:27h | UTCThe American Academy of Pediatrics is Pushing Drugs & Surgery for Obesity – Sensible Medicine
Original article and commentaries: AAP Guideline | Evaluation and treatment of children and adolescents with obesity
M-A | The prevalence of obesity among children with type 2 DM
12 Jan, 2023 | 12:53h | UTCCommentary: Not All Pediatric Cases of Type 2 Diabetes Have Obesity – HealthDay
Commentary on Twitter
Meta-analysis finds that 75% of children with type 2 diabetes have obesity; not all pediatric T2DM patients have obesity. Further studies are needed to investigate the mechanisms beyond obesity driving this condition in children. https://t.co/RsDVSDq7rq
— JAMA Network Open (@JAMANetworkOpen) December 16, 2022
AAP Guideline | Evaluation and treatment of children and adolescents with obesity
10 Jan, 2023 | 14:54h | UTCExecutive Summary: Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents With Obesity – Pediatrics
Commentaries:
Childhood obesity requires early, aggressive treatment, new guidelines say – NPR
New guidance: Use drugs, surgery early for obesity in kids – Associated Press
WHO manual on sugar-sweetened beverage taxation policies to promote healthy diets.
16 Dec, 2022 | 13:52h | UTCNews Release: WHO calls on countries to tax sugar-sweetened beverages to save lives – World Health Organization
Related:
M-A: Outcomes following taxation of sugar-sweetened beverages.
Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents – Pediatrics
Cutting back on sugar-sweetened beverages: What works? – Cochrane Library
Sugar-sweetened beverage taxes: Lessons to date and the future of taxation – PLOS Medicine
Banning the promotion of soft drinks could be more effective than a sugar tax – The Conversation
Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian
Commentary on Twitter
Sugar is addictive and keeps you hooked on unhealthy drinks like sodas & energy drinks.
Break the cycle today for a healthier life! https://t.co/M1GQE4136I pic.twitter.com/06aVCYmeK5— World Health Organization (WHO) (@WHO) December 13, 2022
RCT | Small trial suggests butyrate may be effective in reducing pediatric obesity.
14 Dec, 2022 | 14:56h | UTC
Commentary on Twitter
This pilot RCT found 6-month oral butyrate supplementation may be an effective adjunct in treating children with obesity. https://t.co/P4GLdAX7KI #OAResearch
— JAMA Network Open (@JAMANetworkOpen) December 5, 2022
Guideline | Psychological care of children, adolescents and young adults with diabetes.
6 Dec, 2022 | 13:53h | UTC
Study suggests a personalized frequency of urinary albumin screening may be best for patients with Type 1 Diabetes.
3 Nov, 2022 | 13:46h | UTCOptimal Frequency of Urinary Albumin Screening in Type 1 Diabetes – Diabetes Care (link to abstract – $ for full-text)
EASD/ADA Consensus Report | Automated insulin delivery: benefits, challenges, and recommendations.
6 Oct, 2022 | 13:46h | UTCAutomated insulin delivery: benefits, challenges, and recommendations. A Consensus Report of the Joint Diabetes Technology Working Group of the European Association for the Study of Diabetes and the American Diabetes Association – Diabetologia (if the link is paywalled, try this one)
RCT | In patients with Type 1 Diabetes, the use of a “bionic pancreas” reduced HbA1c without increasing hypoglycemia.
29 Sep, 2022 | 13:35h | UTCMulticenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
RCT | Open-source automated insulin delivery in Type 1 Diabetes.
19 Sep, 2022 | 12:41h | UTCOpen-Source Automated Insulin Delivery in Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Video summary: Open-Source Automated Insulin Delivery in Type 1 Diabetes – NEJM
Commentaries:
Automated Insulin Delivery Ups Time in Target Glucose Range in T1D – HealthDay
Consensus recommendations for the use of Automated Insulin Delivery (AID) technologies in clinical practice.
15 Sep, 2022 | 13:06h | UTC
USPSTF Statement | The current evidence is insufficient to recommend routine screening for prediabetes and type 2 diabetes in children and adolescents.
14 Sep, 2022 | 13:23h | UTCEditorials:
Recommendations for Screening Children and Adolescents for Prediabetes and Type 2 Diabetes – JAMA
Broader Screening for Youth-Onset Type 2 Diabetes—We Just Are Not There Yet – JAMA Network Open
Patient Page: Screening for Type 2 Diabetes in Children and Adolescents – JAMA
Author Interview: USPSTF Recommendation: Screening for Prediabetes and Diabetes in Children and Adolescents – JAMA
RCT | In youths with new-onset type 1 diabetes, intensive glucose control for 24 months with a closed-loop system did not help to preserve pancreatic function.
11 Sep, 2022 | 22:57h | UTCClosed-Loop Therapy and Preservation of C-Peptide Secretion in Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Preservation of C-Peptide Secretion Examined in Youth With T1D – HealthDay
Commentary on Twitter (video summary)
In patients with newly diagnosed type 1 diabetes, it is uncertain whether intensive glucose control can prevent the decline in endogenous insulin secretion. New research findings are summarized in a short video. https://t.co/gJeYus4G5z pic.twitter.com/igclSnyanu
— NEJM (@NEJM) September 10, 2022
Systematic Review | Surgery for the treatment of obesity in children and adolescents.
11 Sep, 2022 | 22:29h | UTCSurgery for the treatment of obesity in children and adolescents – Cochrane Library
Summary: Surgery for the treatment of obesity in children and adolescents – Cochrane Library
Prevalence of multiple non-communicable diseases risk factors among adolescents in 140 countries: a population-based study.
29 Aug, 2022 | 12:04h | UTC
Commentary on Twitter
Our study shows that a large proportion of adolescents in all countries are exposed to four or more NCD risk factors, irrespective of region. Insufficient vegetable and fruit consumption, sedentary behaviour and physical inactivity were most prevalent. https://t.co/NKz2VXTiYG pic.twitter.com/E0fM7h7fRz
— M Mamun Huda (@mmamunhuda) August 13, 2022
Cohort Studies | Birth weight and long-term risk of mortality in men and women.
16 Aug, 2022 | 13:45h | UTCCommentary: How does birth weight affect long-term risk of mortality among men and women? – News Medical
Clinical Practice Update | The detection, evaluation, and management of dyslipidemia in children and adolescents.
15 Aug, 2022 | 12:12h | UTC
Study shows the incidence of obesity among US children is increasing.
3 Aug, 2022 | 14:00h | UTCChanges in the Incidence of Childhood Obesity – Pediatrics
Original Study: Childhood Obesity Rate in the U.S. Higher Now Than 12 Years Prior – HealthDay