Pediatrics (all articles) | Page 36 of 119 | Links Medicus Content Curation & Alerts in Medicine

RCT: Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder.

19 Apr, 2022 | 01:20h | UTC

Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder: results from the double-blind phase of a randomised, placebo-controlled, phase 3 trial – The Lancet Neurology (link to abstract – $ for full-text)

Public health doctors and scientists are investigating 74 cases of hepatitis in children living in the UK that were not caused by hepatitis A to E virus.

18 Apr, 2022 | 10:56h | UTC

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

Commentaries:

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

Commentary on Twitter (thread – click for more)

An update on hepatitis cases in children:

We are continuing to investigate 74 cases of hepatitis (liver inflammation) in children in the UK since January 2022. 1/2

— UK Health Security Agency (@UKHSA) April 12, 2022

Analysis: Changing the assortment of available food and drink for leaner, greener diets.

18 Apr, 2022 | 10:39h | UTC

Changing the assortment of available food and drink for leaner, greener diets – The BMJ

News Release: Changing products on offer in shops and restaurants can lead to leaner, greener diets – BMJ

Review: Management challenges and therapeutic advances in congenital adrenal hyperplasia.

18 Apr, 2022 | 10:10h | UTC

Management challenges and therapeutic advances in congenital adrenal hyperplasia – Nature Reviews Endocrinology (if the link is paywalled, try this one)

Commentary on Twitter

New content online: Management challenges and therapeutic advances in congenital adrenal hyperplasia https://t.co/RCH4mRmvYe pic.twitter.com/76Jm00ISV1

— Nature Reviews Endocrinology (@NatureRevEndo) April 11, 2022

RCT: Long-term efficacy and safety of up to 108 weeks of Ixekizumab in pediatric patients with moderate to severe plaque psoriasis.

18 Apr, 2022 | 09:49h | UTC

Long-term Efficacy and Safety of Up to 108 Weeks of Ixekizumab in Pediatric Patients With Moderate to Severe Plaque Psoriasis: The IXORA-PEDS Randomized Clinical Trial – JAMA Dermatology

Original Study: Efficacy and safety of ixekizumab in a phase III, randomized, double-blind, placebo-controlled study in paediatric patients with moderate-to-severe plaque psoriasis (IXORA-PEDS) – British Journal of Dermatology

Commentary on Twitter

In this RCT, by 108 weeks of use of ixekizumab for pediatric psoriasis, PASI 75/90/100 were achieved in 92%/79%/55%, respectively, of children, with clearance of nails in 68%, scalp in 76%, genital lesions in 88%, and palm/sole involvement in 90%. https://t.co/vk73Z3MKi4

— JAMA Dermatology (@JAMADerm) April 13, 2022

Study showed low rates of severe COVID-19 in children hospitalized with confirmed SARS-CoV-2 infection.

14 Apr, 2022 | 08:49h | UTC

Very low rates of severe COVID-19 in children hospitalised with confirmed SARS-CoV-2 infection in London, England – Journal of Infection

Commentary: Severe COVID-19 extremely rare among children – News Medical

[Preprint] Risk of Hospitalization, severe disease, and mortality due to COVID-19 in children with SARS-CoV-2 infection in Germany – “overall hospitalization rate associated with SARS-CoV-2 infection was 35.9 per 10,000 children, ICU admission rate was 1.7 per 10,000 and case fatality was 0.09 per 10,000”.

Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year – “In total, 99.995% of children and young people with a positive SARS-CoV-2 test survived”.

Editorial: COVID-19 vaccines for children – “Although it is true that most children experience asymptomatic or mild disease, some will get quite sick, and a small number will die. It’s why children are vaccinated against influenza, meningitis, chickenpox, and hepatitis”.

COVID-19 disease severity in children infected with the Omicron variant.

Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year.

Study identifies risk factors for severe CoviD-19 in children.

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

International study identifies predictors of severe outcomes in children with COVID-19.

RCT: Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children.

14 Apr, 2022 | 08:43h | UTC

Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children: a multiregion, double-blind, randomised, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Discharge preparation and readiness after birth: a scoping review of global policies, guidelines and literature.

14 Apr, 2022 | 08:07h | UTC

Discharge preparation and readiness after birth: a scoping review of global policies, guidelines and literature – BMC Pregnancy & Childbirth

WHO recommendations on maternal and newborn care for a positive postnatal experience.

Putting positive experiences at the center of postnatal care.

USPSTF draft statement recommends screening for anxiety and depression in children and adolescents ages 8 to 18 years.

13 Apr, 2022 | 11:05h | UTC

Draft Statements:

Screening for Anxiety in Children and Adolescents – US Preventive Services Task Force

Screening for Depression and Suicide Risk in Children and Adolescents – US Preventive Services Task Force

Commentary:

USPSTF Recommends Anxiety, Depression Screening for Children – HealthDay

RCT: Dapagliflozin did not significantly improve glycemic control in children and young adults with type 2 diabetes.

13 Apr, 2022 | 10:46h | UTC

Efficacy and safety of dapagliflozin in children and young adults with type 2 diabetes: a prospective, multicentre, randomised, parallel group, phase 3 study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

M-A: Adverse perinatal outcomes associated with protease inhibitor-based antiretroviral therapy in pregnant women living with HIV.

13 Apr, 2022 | 10:18h | UTC

Adverse perinatal outcomes associated with protease inhibitor-based antiretroviral therapy in pregnant women living with HIV: A systematic review and meta-analysis – EClinicalMedicine

News Release: Protease inhibitors safer than thought for pregnant women with HIV – University of Oxford

Cohort Study: Risk of adverse events after covid-19 in Danish children and adolescents and effectiveness of the Pfizer vaccine in adolescents.

12 Apr, 2022 | 10:07h | UTC

Risk of adverse events after covid-19 in Danish children and adolescents and effectiveness of BNT162b2 in adolescents: cohort study – The BMJ

RCT: Single-dose HPV vaccination found effective among young African women.

12 Apr, 2022 | 10:08h | UTC

Efficacy of Single-Dose Human Papillomavirus Vaccination among Young African Women – NEJM Evidence

News Releases:

Study boosts support for single-dose HPV vaccine regimen – University of Washington

One-dose Human Papillomavirus (HPV) vaccine offers solid protection against cervical cancer – World Health Organization

Three-year follow-up of 2-dose versus 3-dose HPV vaccine

Commentary on Twitter (thread – click for more)

🚨 GAME CHANGER 🚨
One-dose Human Papillomavirus (#HPV) vaccine offers solid protection against cervical cancer: WHO https://t.co/3uWlZlCCVK pic.twitter.com/ZKDvpf2qog

— World Health Organization (WHO) (@WHO) April 11, 2022

AHA Scientific Statement: SARS-CoV-2 infection and associated cardiovascular manifestations and complications in children and young adults.

12 Apr, 2022 | 09:59h | UTC

SARS-CoV-2 Infection and Associated Cardiovascular Manifestations and Complications in Children and Young Adults: A Scientific Statement From the American Heart Association – Circulation

News Release: Heart issues after COVID-19 uncommon in children and young adults, more research needed – American Heart Association

Commentary: COVID-19 CV Complications in Children Are Rare, Treatable: AHA Statement – TCTMD

Cohort Study: Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection.

12 Apr, 2022 | 09:57h | UTC

Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study – Canadian Medical Association Journal

News Release: Children older than 5 at higher risk of COVID-19-related multisystem inflammatory syndrome – Canadian Medical Association Journal

Commentary: Older Kids More Vulnerable to MIS-C: Study – HealthDay

COVID-19 disease severity in children infected with the Omicron variant.

12 Apr, 2022 | 09:47h | UTC

COVID-19 Disease Severity in Children Infected with the Omicron Variant – Clinical Infectious Diseases

Commentary on Twitter

COVID-19 Disease Severity in Children Infected with Omicron
Among Delta infected
84.2% had mild
15.7% had moderate
0.1% had severe/critical disease
Among Omicron infected
97.8% had mild
2.2% had moderate
None had severe/critical disease (P < .001 https://t.co/ZHhVpY8LuG

— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) April 11, 2022

M-A: The clinical effect and safety of new preoperative fasting time guidelines for elective surgery.

12 Apr, 2022 | 09:51h | UTC

The clinical effect and safety of new preoperative fasting time guidelines for elective surgery: a systematic review and meta-analysis – Gland Surgery

An international multidisciplinary consensus statement on fasting before procedural sedation in adults and children – Anaesthesia

Does my hospitalized patient need an NPO-after-midnight order preoperatively?

ESPEN practical guideline: Clinical nutrition in surgery – “Preoperative fasting from midnight is unnecessary in most patients. Patients undergoing surgery, who are considered to have no specific risk of aspiration, shall drink clear fluids until 2 h before anesthesia. Solids shall be allowed until 6 h before anesthesia.”

Pro-Con Debate: 1- vs 2-Hour Fast for Clear Liquids Before Anesthesia in Children.

Editorial: The rationale for the recommendations of the European Pediatric Fasting Guideline – “the authors of the 2021 ESAIC pediatric guideline have found reasons to recommend reductions to the minimum fasting times for infant formula to 4 h, for breast milk to 3 h and for clear fluids to 1 h”.

Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration: Application to Healthy Patients Undergoing Elective Procedures: An Updated Report by the American Society of Anesthesiologists Task Force on Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration

Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology

Clear fluids fasting for elective paediatric anaesthesia: The European Society of Anaesthesiology consensus statement – European Journal of Anaesthesiology

Canadian Pediatric Anesthesia Society statement on clear fluid fasting for elective pediatric anesthesia – Canadian Journal of Anesthesia (free)

Cohort Study: Association of birth defects with child mortality before age 14 years.

12 Apr, 2022 | 08:43h | UTC

Association of Birth Defects With Child Mortality Before Age 14 Years – JAMA Network Open

Acute phase of Kawasaki disease: a review of national guideline recommendations.

12 Apr, 2022 | 08:32h | UTC

Acute phase of Kawasaki disease: a review of national guideline recommendations – European Journal of Pediatrics

AHA Scientific Statement: addressing social determinants of health and mitigating health disparities across the lifespan in congenital heart disease.

11 Apr, 2022 | 01:31h | UTC

Addressing Social Determinants of Health and Mitigating Health Disparities Across the Lifespan in Congenital Heart Disease: A Scientific Statement From the American Heart Association – Circulation

Commentary: Social determinants of health affect care for people with congenital heart disease – American Heart Association

M-A: Effect of obesity treatment interventions in preschool children aged 2–6 years.

11 Apr, 2022 | 00:47h | UTC

Effect of obesity treatment interventions in preschool children aged 2–6 years: a systematic review and meta-analysis – BMJ Open

RCT: In critically ill children requiring noninvasive respiratory support following extubation, high-flow nasal cannula therapy was NOT noninferior to CPAP, resulting in increased time to liberation from respiratory support.

8 Apr, 2022 | 11:07h | UTC

Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Following Extubation on Liberation From Respiratory Support in Critically Ill Children: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Selecting Intermediate Respiratory Support Following Extubation in the Pediatric Intensive Care Unit – JAMA (free for a limited period)

News Release: Trial identifies most effective breathing support for children in intensive care – Imperial College London

Commentary on Twitter

In this study, among critically ill children requiring noninvasive respiratory support following extubation, HFNC vs CPAP failed to meet the criterion for noninferiority for time to liberation from respiratory support. https://t.co/X1lNAO28le #CCR pic.twitter.com/XBnUpsqUNq

— JAMA (@JAMA_current) April 7, 2022