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Oncology – Gastrointestinal

RCT | Effect of interval between neoadjuvant chemoradiotherapy and surgery on disease recurrence and survival in rectal cancer

20 Jan, 2023 | 14:19h | UTC

Effect of interval between neoadjuvant chemoradiotherapy and surgery on disease recurrence and survival in rectal cancer: long-term results of a randomized clinical trial – BJS Open

 

Commentary on Twitter

 


Study shows patients with circulating tumor DNA are at increased risk of relapse after surgery for resectable colorectal cancer

19 Jan, 2023 | 14:18h | UTC

Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer – Nature Medicine – Nature Medicine

Commentary: Data Support ctDNA as a Prognostic Marker for Recurrence/Benefit in Colorectal Cancer – Cancer Network

 

Commentary on Twitter

 


Consensus Paper | Management of early-onset colorectal cancer

19 Jan, 2023 | 14:14h | UTC

Delphi initiative for early-onset colorectal cancer (DIRECt). International Management Guidelines – Clinical Gastroenterology and Hepatology

 


ACG Clinical Guideline | Diagnosis and management of gastrointestinal subepithelial lesions

18 Jan, 2023 | 14:39h | UTC

ACG Clinical Guideline: Diagnosis and Management of Gastrointestinal Subepithelial Lesions – The American Journal of Gastroenterology

Related: AGA Clinical Practice Update on Management of Subepithelial Lesions Encountered During Routine Endoscopy: Expert Review – Clinical Gastroenterology and Hepatology

 


M-A | Does neoadjuvant treatment in resectable pancreatic cancer improve overall survival?

17 Jan, 2023 | 13:07h | UTC

Does neoadjuvant treatment in resectable pancreatic cancer improve overall survival? A systematic review and meta-analysis of randomized controlled trials – ESMO Open

 


RCT | Adjuvant nab-Paclitaxel + Gemcitabine in resected pancreatic ductal adenocarcinoma

10 Jan, 2023 | 14:13h | UTC

Adjuvant nab-Paclitaxel + Gemcitabine in Resected Pancreatic Ductal Adenocarcinoma: Results From a Randomized, Open-Label, Phase III Trial – Journal of Clinical Oncology

 


RCT | Neoadjuvant chemotherapy with CAPOX vs. chemoradiation for locally advanced rectal cancer with uninvolved mesorectal fascia

10 Jan, 2023 | 14:09h | UTC

Neoadjuvant Chemotherapy with CAPOX versus Chemoradiation for Locally Advanced Rectal Cancer with Uninvolved Mesorectal Fascia (CONVERT): Initial Results of a Phase III Trial – Annals of Surgery

 


ASCO Guideline | Immunotherapy and targeted therapy for advanced gastroesophageal cancer

9 Jan, 2023 | 14:40h | UTC

Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline – Journal of Clinical Oncology

News Release: First ASCO Guideline for Immunotherapy and Targeted Therapy in Advanced Gastroesophageal Cancer Now Available – ASCO Daily News

 


Phase 1-2 study | Adagrasib with or without Cetuximab in colorectal cancer with mutated KRAS G12C

9 Jan, 2023 | 14:04h | UTC

Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Advanced Colorectal Cancer Treatment Targets KRAS Gene With Drug Combo – Memorial Sloan Kettering Cancer Center

 

Commentary on Twitter

 


M-A | Laparoscopic vs. open pancreatoduodenectomy in patients with periampullary tumors

9 Jan, 2023 | 14:02h | UTC

Laparoscopic versus Open Pancreatoduodenectomy in Patients with Periampullary Tumors: A Systematic Review and Meta-analysis – Annals of Surgery (link to abstract – $ for full-text)

Related: Comparison of safety and effectiveness between laparoscopic and open pancreatoduodenectomy: A systematic review and meta-analysis – International Journal of Surgery

 


Review | Role of AI and digital pathology for colorectal immuno-oncology.

16 Dec, 2022 | 13:11h | UTC

Role of AI and digital pathology for colorectal immuno-oncology – British Journal of Cancer

 


A comprehensive systematic review of colorectal cancer screening clinical practices guidelines and consensus statements.

16 Dec, 2022 | 13:09h | UTC

A comprehensive systematic review of colorectal cancer screening clinical practices guidelines and consensus statements – British Journal of Cancer

 


RCT | Assessment of spleen-preserving hilar lymphadenectomy for advanced proximal gastric cancer without invasion into the greater curvature.

15 Dec, 2022 | 13:30h | UTC

Assessment of Laparoscopic Spleen-Preserving Hilar Lymphadenectomy for Advanced Proximal Gastric Cancer Without Invasion Into the Greater Curvature: A Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)

See also: Visual Abstract and Video Summary

 


Phase 2 RCT | Immediate surgery vs. short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderline resectable pancreatic cancer.

14 Dec, 2022 | 15:01h | UTC

Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderline resectable pancreatic cancer (ESPAC5): a four-arm, multicentre, randomised, phase 2 trial – The Lancet Gastroenterology & Hepatology

News Release: Chemotherapy before surgery can improve survival rates in pancreatic cancer patients – University of Liverpool

 

Commentary on Twitter

 


Review | Interventional gastroenterology in oncology.

12 Dec, 2022 | 12:46h | UTC

Interventional gastroenterology in oncology – CA: A Cancer Journal for Clinicians

 


Post-trial follow-up | Bursectomy vs. omentectomy alone for resectable gastric cancer.

12 Dec, 2022 | 12:26h | UTC

Five-year follow-up of a randomized clinical trial comparing bursectomy and omentectomy alone for resectable gastric cancer (JCOG1001) – British Journal of Surgery (link to abstract – $ for full-text)

 


Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

15 Nov, 2022 | 12:52h | UTC

Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up – Annals of Oncology

 

Commentary from the author on Twitter

https://twitter.com/ArndtVogel/status/1590634413377081344

 


Phase 2 RCT | Efficacy of Bemarituzumab in patients with FGFR2b-selected gastric or gastro-esophageal junction adenocarcinoma.

11 Nov, 2022 | 13:02h | UTC

Bemarituzumab in patients with FGFR2b-selected gastric or gastro-oesophageal junction adenocarcinoma (FIGHT): a randomised, double-blind, placebo-controlled, phase 2 study – The Lancet Oncology (link to abstract – $ for full-text)

 

Commentary on Twitter

 


NICE Guideline Update | Colonoscopic surveillance in adults with inflammatory bowel disease or adenomas.

10 Nov, 2022 | 14:16h | UTC

Colorectal cancer prevention: colonoscopic surveillance in adults with ulcerative colitis, Crohn’s disease or adenomas – National Institute for Health and Care Excellence

Related:

British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England post-polypectomy and post-colorectal cancer resection surveillance guidelines – Gut

Consensus Statement: U.S. Multi-Society Task Force on Colorectal Cancer now suggests average-risk CRC screening begins at age 45.

USPSTF Statement: Start colorectal cancer screening at 45 years for most patients.

ACG Clinical Guidelines: Start colorectal cancer screening at 45

Evidence-based clinical practice guidelines for management of colorectal polyps – Journal of Gastroenterology

Meta-analysis: Risk of colorectal cancer and cancer related mortality after detection of low-risk or high-risk adenomas, compared with no adenoma, at index colonoscopy

Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer – Gastroenterology

Endoscopic surveillance after surgical or endoscopic resection for colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Digestive Oncology (ESDO) Guideline – Endoscopy

 


M-A | Efficacy of neoadjuvant immunotherapy combined with chemotherapy for patients with resectable esophageal cancer.

4 Nov, 2022 | 13:22h | UTC

Evaluation of Clinical and Safety Outcomes of Neoadjuvant Immunotherapy Combined With Chemotherapy for Patients With Resectable Esophageal Cancer: A Systematic Review and Meta-analysis – JAMA Network Open 

 


Cohort Study | Mental health morbidities and time to cancer diagnosis among adults with colon cancer in England.

3 Nov, 2022 | 13:55h | UTC

Mental Health Morbidities and Time to Cancer Diagnosis Among Adults With Colon Cancer in England – JAMA Network Open 

Invited Commentary: The Interface Between Colon Cancer and Mental Health Morbidities – JAMA Network Open

 


Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

31 Oct, 2022 | 13:51h | UTC

Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up – Annals of Oncology

Related Guideline: ASCO Guideline | Treatment of metastatic colorectal cancer.

 


Cohort Study | Risk factors of pancreatic cancer in patients with Type 2 DM.

31 Oct, 2022 | 13:47h | UTC

Risk Factors of Pancreatic Cancer in Patients With Type 2 Diabetes Mellitus: The Hong Kong Diabetes Study – Journal of the Endocrine Society

 


Cohort Study | Diverticular disease linked to increased risk of cancer outside the GI tract.

31 Oct, 2022 | 13:33h | UTC

Cancer risk in patients with diverticular disease: a nationwide cohort study – JNCI: Journal of the National Cancer Institute (link to abstract – $ for full-text)

News Release: Diverticular disease associated with cancer outside gastrointestinal tract – Karolinska Institutet

 


Expert Consensus | Imaging standardization in metastatic colorectal cancer.

26 Oct, 2022 | 14:36h | UTC

Imaging standardisation in metastatic colorectal cancer: A joint EORTC-ESOI-ESGAR expert consensus recommendation – European Journal of Cancer

 


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