Neurology
[Abstract Only] Study: Nerve Transfer Surgery Restores Hand Function and Elbow Extension in Patients with Complete Paralysis
5 Jul, 2019 | 02:53h | UTCExpanding traditional tendon-based techniques with nerve transfers for the restoration of upper limb function in tetraplegia: a prospective case series – The Lancet (link to abstract – $ for full-text)
Commentary: Nerve transfer surgery restores hand function and elbow extension in 13 young adults with complete paralysis – The Lancet (free) AND Expert reaction to study on successful nerve transfer surgery in paralysis patients – Science Media Centre (free)
Related Study: Recovery of Walking after Complete Spinal Cord Injury (free)
Review: Nonnarcotic Methods of Pain Management
4 Jul, 2019 | 11:05h | UTCNonnarcotic Methods of Pain Management – New England Journal of Medicine (free for a limited period)
Report: Consumers Should Not Take any Supplements for Brain Health
2 Jul, 2019 | 06:24h | UTCCommentaries: On supplements preventing cognitive decline, ‘science says that doesn’t work’ – University of Pennsylvania (free) AND Supplements for Brain Health Panned – Medscape (free registration required)
Related Cochrane Review: Supplements for Preventing Cognitive Decline in People with Mild Cognitive Impairment (free)
Cohort Study: Cognitive Decline After Coronary Events
26 Jun, 2019 | 00:23h | UTCCommentaries: Cognitive decline may accelerate after heart attack, angina – American College of Cardiology (free) AND Ischemic Events Worsen Long-term Cognitive Decline – TCTMD (free) AND Heart problems may hasten cognitive decline – Reuters (free)
Study: Anticholinergic Drug Exposure and the Risk of Dementia
25 Jun, 2019 | 07:03h | UTCCommentaries: Preventing Alzheimer Disease by Deprescribing Anticholinergic Medications – JAMA Internal Medicine (free for a limited period) AND Commonly prescribed anticholinergic drugs linked to dementia risk – UPI (free) AND Expert reaction to anticholinergic drug exposure and risk of dementia – Science Media Centre (free) Commonly prescribed drugs are tied to nearly 50% higher dementia risk in older adults, study says – CNN (free)
WHO Report: Epilepsy: A Public Health Imperative
24 Jun, 2019 | 01:15h | UTCEpilepsy: a public health imperative – World Health Organization (free PDF)
News Releases: WHO highlights scarcity of treatment for epilepsy in low-income countries – World Health Organization (free) AND First-ever WHO global report on epilepsy highlights care gap in poorer countries – United Nations (free)
Cohort Study: Long Working Hours Linked to Increased Stroke Risk
21 Jun, 2019 | 07:32h | UTCCommentaries: Long work hours associated with increased risk of stroke – American Heart Association (free) AND Longer work hours may raise stroke risk – UPI (free) AND Long working hours ‘linked to stroke risk’ – BBC (free)
Recent Advances in Spontaneous Intracerebral Hemorrhage
17 Jun, 2019 | 05:40h | UTCRecent advances in spontaneous intracerebral hemorrhage – F1000Research (free)
[Abstract Only] Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis
17 Jun, 2019 | 01:35h | UTCClinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis – New England Journal of Medicine (link to abstract $ for full-text)
Commentaries: Metagenomic Sequencing Enhanced Diagnosis of Meningitis and Encephalitis Infections – MedicalResearch.com (free) AND Superfast gene sequencing helps diagnose critically ill patients – University of California – San Francisco (free) AND Rapid DNA analysis helps diagnose mystery diseases – The Conversation (free)
[Abstract Only] Risks of 23 Specific Malformations Associated with Prenatal Exposure to 10 Antiepileptic Drugs
14 Jun, 2019 | 02:33h | UTCRisks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs – Neurology (link to abstract – $ for full-text)
Commentaries: Epilepsy drugs linked to higher risk of birth defects, study says – CNN (free) AND Study Confirms Teratogenicity of Valproic Acid, Topiramate – MPR (free)
Related: Guideline: Valproate Use in Women and Girls Of Childbearing Years (free) AND Research: Topiramate Use Early in Pregnancy and the Risk of Oral Clefts (free)
Cohort Study: Gabapentinoids linked to Increased Risk of Suicidal Behavior
14 Jun, 2019 | 02:26h | UTCEditorial: Gabapentinoids linked to new risks, including suicidal behavior (free)
Commentaries: Epilepsy drugs linked to increased risk of suicidal behavior, particularly in young people – The BMJ (free) AND Expert reaction to study on gabapentinoids and risk of suicidal behavior – Science Media Centre (free)
Consensus Recommendations: Management of Antibody-mediated Autoimmune Encephalitis in Adults and Children
9 Jun, 2019 | 19:36h | UTC
Guidelines on Mechanical Thrombectomy in Acute Ischemic Stroke
9 Jun, 2019 | 19:26h | UTC
ASCO/SNO Joint Endorsement Summary: Anticonvulsant Prophylaxis and Steroid Use in Adults With Metastatic Brain Tumors
30 May, 2019 | 08:30h | UTCOriginal Guideline: Anticonvulsant Prophylaxis and Steroid Use in Adults With Metastatic Brain Tumors: ASCO and SNO Endorsement of the Congress of Neurological Surgeons Guidelines – Journal of Clinical Oncology (free)
Guideline: Current Endovascular Strategies for Posterior Circulation Large Vessel Occlusion Stroke
29 May, 2019 | 10:37h | UTC
Meta-Analysis of Delirium Preventive Models of Care
28 May, 2019 | 00:55h | UTCPreventing Delirium Takes a Village: Systematic Review and Meta-Analysis of Delirium Preventive Models of Care – Journal of Hospital Medicine (free PDF via Unpaywall)
Source: Hospital Medicine Virtual Journal Club
Study: Vision Impairment and Subjective Cognitive Decline–Related Functional Limitations
26 May, 2019 | 12:44h | UTCCommentary: Vision Impairment Tied to Higher Rates of Cognitive Decline Limitations – NEJM Journal Watch (free)
Randomized Trial: Restarting Antiplatelet Therapy Safe after Intracerebral Hemorrhage
23 May, 2019 | 08:05h | UTCCommentaries: Restarting antiplatelet therapy after intracerebral haemorrhage – The Lancet (free) AND Aspirin unlikely to cause more brain bleeds for stroke patients – UPI (free) AND Aspirin green light for brain bleed stroke patients, study suggests – University of Edinburgh (free)
“The risk of recurrent intracerebral hemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention.”
[Abstract Only] Meta-Analysis: Extending Thrombolysis to 4·5–9 h and Wake-up Stroke Using Perfusion Imaging
23 May, 2019 | 08:04h | UTCExtending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data – The Lancet (link to abstract – $ for full-text)
“Patients with ischemic stroke 4·5–9 h from stroke onset or wake-up stroke with salvageable brain tissue who were treated with alteplase achieved better functional outcomes than did patients given placebo. The rate of symptomatic intracerebral hemorrhage was higher with alteplase, but this increase did not negate the overall net benefit of thrombolysis.”
Related Commentary on Twitter
Presenting now at #ESOC2019 @ESOstroke—Extending #thrombolysis to 4·5–9 h and wake-up #stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data https://t.co/Ep0JDiGzoF pic.twitter.com/lHqiWc63ji
— The Lancet (@TheLancet) May 22, 2019
Acute Flaccid Myelitis: Something Old and Something New
21 May, 2019 | 18:42h | UTCAcute Flaccid Myelitis: Something Old and Something New – mBio (free)
Related: Acute Flaccid Myelitis: A Clinical Overview for 2019 – Mayo Clinic Proceedings (free) AND CDC Investigates Acute Flaccid Myelitis Cases (free study and commentaries)
Review: Neuroimaging in Lewy Body Dementia
21 May, 2019 | 18:34h | UTCNeuroimaging in Lewy body dementia – Journal of Neurology (free)
ASA Policy Statement: Recommendations for the Establishment of Stroke Systems of Care
21 May, 2019 | 13:43h | UTCNews Release: New recommendations for stroke systems of care to improve patient outcomes (free)
Viewpoint – “Millions Take Gabapentin for Pain. But There’s Scant Evidence It Works.”
21 May, 2019 | 06:04h | UTCMillions Take Gabapentin for Pain. But There’s Scant Evidence It Works. – The New York Times (10 articles per month are free)
Related: Meta-Analysis: Anticonvulsants in the Treatment of Low Back Pain and Lumbar Radicular Pain (free) AND Benefits and safety of gabapentinoids in chronic low back pain (free) AND Less is More: A Clinical Overview of Off-label Use of Gabapentinoid Drugs (link to abstract)
Meta-Analysis: Perioperative/Postoperative Atrial Fibrillation and Risk of Subsequent Stroke and/or Mortality
19 May, 2019 | 21:15h | UTCPerioperative/Postoperative Atrial Fibrillation and Risk of Subsequent Stroke and/or Mortality – Stroke (link to abstract – $ for full-text)
Commentary: Perioperative Atrial Fibrillation and Risk of Stroke, Mortality – American College of Cardiology (free)
Randomized Trial: Anticoagulation Not Effective for Prevention of Stroke after Embolic Stroke of Undetermined Source
19 May, 2019 | 21:44h | UTCDabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Dabigatran After Embolic Stroke of Undetermined Source – American College of Cardiology (free)
Related Study: Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source – New England Journal of Medicine (free)