Neurology
Review: Pharmacologic Considerations Surrounding Sedation, Delirium, and Sleep in Critically Ill Adults
29 Jul, 2019 | 20:16h | UTC
Meta-Analysis: Very Early Mobilization After Stroke Does Not Improve Outcomes
29 Jul, 2019 | 20:32h | UTCVery Early Versus Delayed Mobilization After Stroke: Systematic Review and Meta-Analysis – Stroke (free PDF)
[Abstract Only] Measures of Obesity are Associated with MRI Markers of Brain Aging
29 Jul, 2019 | 20:10h | UTCMeasures of obesity are associated with MRI markers of brain aging – Neurology (link to abstract – $ for full-text)
Commentaries: Extra Weight in 60s May Be Linked to Brain Thinning Years Later – American Academy of Neurology (free) AND Study links higher body weight later in life to faster brain aging – Medical News Today (free)
NICE Guideline: Multiple Sclerosis in Adults
28 Jul, 2019 | 23:10h | UTCMultiple sclerosis in adults: management – National Institute for Health and Care Excellence (free)
Related Guidelines: AAN Guideline: Disease-modifying Therapies for Adults with Multiple Sclerosis (free guideline and commentaries) AND ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis – European Journal of Neurology (free) AND Brazilian Consensus for the Treatment of Multiple Sclerosis: Brazilian Academy of Neurology and Brazilian Committee on Treatment and Research in Multiple Sclerosis (free PDF) AND Diagnosis of Multiple Sclerosis: 2017 Revisions of the McDonald Criteria (free registration required)
Pharmacologic Management of Agitation in Patients with Dementia
27 Jul, 2019 | 20:07h | UTCPharmacologic Management of Agitation in Patients with Dementia – Current Geriatrics Reports (free)
Related: Nonpharmacological Interventions to Reduce Behavioral and Psychological Symptoms of Dementia: A Systematic Review – BioMed Research International (free) AND Systematic review of systematic reviews of non-pharmacological interventions to treat behavioural disturbances in older patients with dementia. The SENATOR-OnTop series – BMJ Open (free)
[Abstract Only] Subarachnoid Hemorrhage: Large Observational Study Suggests Early Endovascular Treatment May Reduce the Risk of Delayed Cerebral Ischemia and Poor Functional Outcomes
27 Jul, 2019 | 15:01h | UTCEndovascular treatment of cerebral vasospasm after subarachnoid hemorrhage – Neurology (link to abstract – $ for full-text) (via Besen BA)
Meta-analysis: Diagnosis of Elevated Intracranial Pressure in Critically Ill Adults
26 Jul, 2019 | 01:08h | UTCCommentary: Review examines methods for diagnosis of elevated ICP in critically ill – MedicalXpress (free)
Related Guidelines: Management of severe traumatic brain injury (first 24 hours) – Anaesthesia Critical Care & Pain Medicine (free) AND Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury – Acta Neurochirurgica (free)
Related Reviews: Emergency Neurological Life Support: Intracranial Hypertension and Herniation – Neurocritical Care (free) AND Acute Management of Traumatic Brain Injury – Surgical Clinics of North America (free)
Related Commentary on Twitter
A question we often ask in the ED/ICU: Does this patient have increased ICP?
Our @bmj_latest study found that traditional physical exam and CT signs had poor accuracy for elevated ICP. If suspected, consider treatment & transfer for invasive monitoring.https://t.co/1Eb8PtYLFJ pic.twitter.com/bQFIgWnuur
— Shannon Fernando (@shanfernands) July 25, 2019
Preventing Dementia by Preventing Stroke: The Berlin Manifesto
25 Jul, 2019 | 01:59h | UTCPreventing dementia by preventing stroke: The Berlin Manifesto – Alzheimer’s & Dementia (free)
Commentaries: Group calls on international community to prevent dementia by preventing stroke – University of Western Ontario (free) AND Stroke Prevention Best Path to Dementia Reduction, Experts Say – Medscape (free registration required)
Systematic Review: Palliative Care for People with Dementia Living at Home
25 Jul, 2019 | 01:32h | UTC
Randomized Trial: Intensive Treatment of Hyperglycemia Does Not Improve Outcomes in Patients with Acute Ischemic Stroke
24 Jul, 2019 | 09:18h | UTCIntensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Researchers get a handle on how to control blood sugar after stroke – NIH News Releases (free) AND Study Doesn’t Support Intensive Glucose Control in Patients with Stroke and Hyperglycemia – NEJM Journal Watch (free)
NICE Guideline: Motor Neuron Disease
24 Jul, 2019 | 09:32h | UTCMotor neurone disease: assessment and management – National Institute for Health and Care Excellence (free)
Related Guideline: EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force (free)
Study: Persistent HIV-infected Cells in Cerebrospinal Fluid Associated with Cognitive Impairment
19 Jul, 2019 | 09:41h | UTCCommentaries: Persistent HIV in central nervous system linked to cognitive impairment – NIH News Release (free) AND HIV-infected cells persist in cerebrospinal fluid, linked to poorer neurocognitive performance – University of North Carolina School of Medicine (free)
Guideline Synopsis: Management of Patients with Acute Ischemic Stroke
19 Jul, 2019 | 09:48h | UTCManagement of Patients with Acute Ischemic Stroke – JAMA (free for a limited period)
Original Guideline: 2018 AHA/ASA Guidelines for the Early Management of Patients With Acute Ischemic Stroke (free)
Related Guidelines: Stroke and transient ischaemic attack in over 16s: diagnosis and initial management – National Institute for Health and Care Excellence (free) AND Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ (free) AND Canadian Stroke Best Practice Recommendations for Acute Stroke Management (free)
New Blood Test Seems Promising for the Diagnosis of Alzheimer’s Disease
18 Jul, 2019 | 09:49h | UTCAssociation of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging – JAMA Neurology (free for a limited period)
Commentaries: Scientists close in on blood test for Alzheimer’s – STAT (free) AND Predicting Alzheimer’s – Blood markers close in on helping determine who will develop Alzheimer’s disease – MedPage Today (free registration required)
“What good will that do without a cure?” (from STAT)
Meta-Analysis: Antiplatelet Therapy After Noncardioembolic Stroke
17 Jul, 2019 | 10:47h | UTCSource: EvidenceAlerts
“Results favor clopidogrel and aspirin/dipyridamole combination for long-term secondary prevention after noncardioembolic stroke or transient ischemic attack”.
Cohort Study: Shorter Time to Endovascular Recanalization in Acute Ischemic Stroke is Associated with Better Outcomes
17 Jul, 2019 | 10:46h | UTCAssociation Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice – JAMA (free for a limited period)
Editorial: Endovascular Therapy for Acute Ischemic Stroke Treated in Clinical Practice (free for a limited period)
Video Summary: Association Between Time to Treatment With Endovascular Reperfusion Therapy and Acute Ischemic Stroke Outcomes (free)
News Release: Treating stroke patients just 15 minutes earlier can save lives – UCLA (free)
Editorial: The Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms
17 Jul, 2019 | 09:19h | UTCThe Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms – JAMA Neurology (free for a limited period)
Original Article: Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework – JAMA Neurology (free)
Related Commentary on Twitter
The term "Alzheimer Clinical Syndrome", as opposed to "probable Alzheimer disease", distinguishes the biology from the associated clinical syndrome. https://t.co/9RwdaTEpUR
— JAMA Neurology (@JAMANeuro) July 16, 2019
Study: Health Lifestyle May Reduce the Incidence of Dementia Even in Patients with High Genetic Risk
16 Jul, 2019 | 09:42h | UTCAssociation of Lifestyle and Genetic Risk With Incidence of Dementia – JAMA (free for a limited period)
Commentaries: Healthy lifestyle reduces dementia risk even in those with genetic risk factors – NHS Choices (free) AND Healthy lifestyle may offset genetic risk of dementia – University of Exeter (free) AND Genes vs. lifestyle: Study ‘undermines fatalistic view of dementia’ – Medical News Today (free) AND Healthy living may help offset genetic risk of dementia: study – Reuters (free) AND Healthy lifestyle may cut risk of dementia regardless of genes – The Guardian (free)
Editorial: How I Manage Intracranial Hypertension
14 Jul, 2019 | 19:01h | UTCHow I manage intracranial hypertension – Critical Care (free)
Related Commentary on Twitter
https://twitter.com/Crit_Care/status/1148602481028583424
[Abstract Only] Study: The Benefits of Clopidogrel-aspirin Combination after Minor Stroke/TIA occurs Predominantly Within the First 21 Days
12 Jul, 2019 | 08:03h | UTCTime Course for Benefit and Risk of Clopidogrel and Aspirin after Acute Transient Ischemic Attack and Minor Ischemic Stroke: A Secondary Analysis from the POINT Randomized Trial – Circulation (link to abstract – $ for full-text)
Commentary: Clopidogrel-Aspirin in Minor Stroke/TIA of Maximum Benefit in First 21 Days – TCTMD (free)
Related Guideline: Dual Antiplatelet Therapy for Acute High-Risk TIA and Minor Ischemic Stroke – The BMJ (free)
Viewpoint: Preclinical Alzheimer Disease—Early Diagnosis or Overdiagnosis?
12 Jul, 2019 | 07:52h | UTCPreclinical Alzheimer Disease—Early Diagnosis or Overdiagnosis? – JAMA Internal Medicine (free for a limited period)
Related Commentary on Twitter
Preclinical #AlzheimerDisease: may identify high-risk group to target new preventive medications, but may also lead to overdiagnosis and high costs https://t.co/GK3soETwd1
— JAMA Internal Medicine (@JAMAInternalMed) July 9, 2019
Cohort Study: Quantity and Quality of Mental Activities and the Risk of Mild Cognitive Impairment
12 Jul, 2019 | 06:18h | UTCCommentary: Mentally stimulating activities linked to lower risk or delay of age-related memory loss – News Medical (free)
Related Commentary on Twitter
Mayo Clinic researchers study in the @GreenJournal finds doing more than one mentally stimulating activity like using a computer, playing games, and social activities is linked to a lower risk or delay of age-related memory loss, mild cognitive impairment. https://t.co/o2Eph8hJPd
— Mayo Clinic (@MayoClinic) July 12, 2019
Androgen Deprivation Therapy Linked to Increased Risk of Dementia in Men with Prostate Cancer
10 Jul, 2019 | 09:30h | UTCCommentaries: Hormone therapy for prostate cancer may raise risk of Alzheimer’s, Dementia – Penn Medicine (free) AND Prostate cancer treatment linked to heightened Alzheimer’s risk – UPI (free) AND Men’s dementia risk higher after androgen deprivation therapy – OnMedica (free) AND Risk of dementia rises with prostate cancer hormone-blocking therapy – Reuters (free)
[Abstract Only] Study: Very Low LDL Linked to Increased Risk of Intracerebral Hemorrhage
9 Jul, 2019 | 10:08h | UTCLow-density lipoprotein cholesterol and risk of intracerebral hemorrhage: A prospective study – Neurology (link to abstract – $ for full-text)
Commentaries: Cholesterol that is too low may boost risk for hemorrhagic stroke – Penn State (free) AND Low cholesterol may increase risk for haemorrhagic stroke – OnMedica (free) AND Very low levels of ‘bad’ cholesterol may raise stroke risk – Medical News Today (free)
Viewpoint: Advances in Understanding the Pathophysiology of Chronic Fatigue Syndrome
8 Jul, 2019 | 10:17h | UTCAdvances in Understanding the Pathophysiology of Chronic Fatigue Syndrome – JAMA (free for a limited period)