Neurology
Review: The Etiology of Bell’s Palsy
16 May, 2019 | 05:41h | UTCThe etiology of Bell’s palsy: a review – Journal of Neurology (free)
Systematic Review: Deep Brain Stimulation in Parkinson Disease
16 May, 2019 | 05:40h | UTCDeep brain stimulation in parkinson disease – Revista da Associação Brasileira de Medicina (free)
WHO Guideline: Risk Reduction of Cognitive Decline and Dementia
15 May, 2019 | 07:02h | UTCRisk reduction of cognitive decline and dementia – World Health Organization (free PDF)
News Release: Adopting a healthy lifestyle helps reduce the risk of dementia – World Health Organization (free)
Commentaries: WHO issues first advice on dementia: exercise and don’t smoke – Reuters (free) AND Eat well, exercise more: New global guidelines to reduce risk of dementia – CNN (free) AND Expert reaction to WHO Guidelines on risk reduction of cognitive decline and dementia – Science Media Centre (free)
Opinion Piece Suggests Lack of Scientific Rigor in Study Extending the Time Window to IV TPA
13 May, 2019 | 01:21h | UTC“The Case of the Magician’s Sleight” – EMNerd (free)
See also: EXTEND Alteplase Shenanigans! – Emergency Medicine Literature of Note (free)
Original Study: Randomized Trial: Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke (link to abstract and commentary)
Related Cochrane Review: Thrombolysis for acute ischaemic stroke (free)
Related Review: Thrombolytics for stroke: The evidence – First10Em (free)
Related Commentary on Twitter
Using statistical magic to extend the time window for IV tPA by @EMNerd_ https://t.co/s0zgEdbs4x pic.twitter.com/ReHsFqTWWC
— the EMCrit Crew (@emcrit) May 10, 2019
Study: Targeting Huntingtin Expression in Patients with Huntington’s Disease
13 May, 2019 | 01:12h | UTCTargeting Huntingtin Expression in Patients with Huntington’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Experimental Drug For Huntington’s Disease Jams Malfunctioning Gene – NPR (free) AND Huntington drug successfully lowers levels of disease-causing protein, study shows – University of British Columbia (free)
Management of Blood Pressure After Acute Ischemic Stroke
12 May, 2019 | 21:39h | UTC
Stroke Risk Stratification in Atrial Fibrillation: A Review of Common Risk Factors
11 May, 2019 | 15:55h | UTCSource: Hospital Medicine Virtual Journal Club
Acute Cerebellar Ataxia: Differential Diagnosis and Clinical Approach
11 May, 2019 | 14:12h | UTC
Randomized Trial: Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke
9 May, 2019 | 08:13h | UTCThrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: IV Thrombolysis Could Be Given Up to 9 Hours After Stroke Onset in Some – NEJM Journal Watch (free)
Related Randomized Trial: MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset (free study and commentaries)
State of the Art Review: Diagnosis and Management of Sensory Polyneuropathy
9 May, 2019 | 08:05h | UTCState of the Art Review: Diagnosis and management of sensory polyneuropathy – The BMJ (free for a limited period)
Related Commentary on Twitter
This new clinical review discusses the diagnosis and management of peripheral sensory neuropathies that have a clearly pain predominant or ataxia predominant presentation https://t.co/JIV2m60xHp
— The BMJ (@bmj_latest) May 8, 2019
POEMS Syndrome: Clinical Update
9 May, 2019 | 08:02h | UTCPOEMS syndrome: clinical update – Journal of Neurology (free)
Acute Flaccid Myelitis: A Clinical Overview for 2019
9 May, 2019 | 08:03h | UTCAcute Flaccid Myelitis: A Clinical Overview for 2019 – Mayo Clinic Proceedings (free)
Consensus for Management of Polymyositis and Dermatomyositis Among Rheumatologists, Neurologists and Dermatologists
9 May, 2019 | 08:00h | UTC
AHA/ASA Scientific Statement: Management of Stroke in Neonates and Children
8 May, 2019 | 07:15h | UTCRelated: Stroke in Childhood: Clinical guideline for diagnosis, management and rehabilitation (free guideline and resources)
Cohort Study: Patent Foramen Ovale and Ischemic Stroke in Patients With Pulmonary Embolism
8 May, 2019 | 07:02h | UTCPatent Foramen Ovale and Ischemic Stroke in Patients With Pulmonary Embolism: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: PFO Compounds Ischemic Stroke Risk Among Patients with Pulmonary Embolism – TCTMD (free) AND PFO Tied to Increased Stroke Risk in Patients with Pulmonary Embolism – NEJM Journal Watch (free)
Guideline: Treatment of Tics in People with Tourette Syndrome and Chronic Tic Disorders
7 May, 2019 | 01:16h | UTCSystematic review summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders – Neurology (free)
Source: New Guideline Published on Tourette Syndrome, Other Tic Disorders – NEJM Journal Watch (free)
Hypersalivation: Update of the German S2k Guideline
6 May, 2019 | 22:22h | UTC
Randomized Trial: Levetiracetam vs. Phenytoin for Second-line Treatment of Pediatric Convulsive Status Epilepticus
4 May, 2019 | 15:04h | UTCRelated Study: Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Invited Commentary: Levetiracetam no better than phenytoin in children with convulsive status epilepticus – The Lancet (free)
Randomized Trial: IV Dexamethasone, Metoclopramide, Ketorolac, or Chlorpromazine for Migraine Headache
2 May, 2019 | 12:33h | UTCEffectiveness of intravenous dexamethasone, metoclopramide, ketorolac, and chlorpromazine for pain relief and prevention of recurrence in the migraine headache: a prospective double-blind randomized clinical trial – Neurological Sciences (free for a limited period)
NICE Guideline: Stroke and Transient Ischemic Attack
2 May, 2019 | 04:39h | UTCRelated Guidelines: Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the AHA/ASA (free) AND Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ (free) AND Canadian Stroke Best Practice Recommendations for Acute Stroke Management (free)
FDA Safety Alert: Serious Incidents Related to Certain Prescription Insomnia Medicines
2 May, 2019 | 04:34h | UTCFor Consumers: Taking Z-drugs for Insomnia? Know the Risks – U.S. Food & Drug Administration (free)
Commentaries: Drug Agency Calls for Strong Warning Labels on Popular Sleep Aids – The New York Times (10 articles per month are free) AND FDA Requires Stronger Warnings for Common Insomnia Medications – Psychiatric News Alert (free)
Consensus Report: Limbic-predominant Age-related TDP-43 Encephalopathy (LATE)
2 May, 2019 | 04:25h | UTCLimbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report – Brain (free)
Commentaries: Guidelines proposed for newly defined Alzheimer’s-like brain disorder – NIH News Releases (free) AND Researchers define Alzheimer’s-like brain disorder: LATE symptoms resembles Alzheimer’s disease but has different cause – Rush University Medical Center (free) AND Form of dementia that ‘mimics’ Alzheimer’s symptoms discovered – The Guardian (free)
Study: Fluoroquinolones Associated with Peripheral Neuropathy
30 Apr, 2019 | 02:40h | UTCAssociation Between Peripheral Neuropathy and Exposure to Oral Fluoroquinolone or Amoxicillin-Clavulanate Therapy – JAMA Neurology (free for a limited period)
Editorial: On the Association Between Fluoroquinolones and Neuropathy (free)
Related: Committee Recommends New Restrictions on the use of Fluoroquinolones (free report and commentaries)
Randomized Trial: When Is It Best to Start the Parkinson’s Drug, Levodopa?
30 Apr, 2019 | 02:18h | UTCWhen is it best to start the Parkinson’s drug, levodopa? – NIHR Signal (free)
Original Study: Randomized Delayed-Start Trial of Levodopa in Parkinson’s Disease (link to abstract and commentary)
Viewpoint: Treatment of Patients with Psychogenic Nonepileptic Attacks
29 Apr, 2019 | 01:02h | UTCTreatment of Patients With Psychogenic Nonepileptic Attacks – JAMA (free for a limited period)
Author Interview: Treatment of Patients With Psychogenic Nonepileptic Attacks (free audio)