Neurology
Preventing Dementia by Preventing Stroke: The Berlin Manifesto
25 Jul, 2019 | 01:59h | UTCPreventing dementia by preventing stroke: The Berlin Manifesto – Alzheimer’s & Dementia (free)
Commentaries: Group calls on international community to prevent dementia by preventing stroke – University of Western Ontario (free) AND Stroke Prevention Best Path to Dementia Reduction, Experts Say – Medscape (free registration required)
Systematic Review: Palliative Care for People with Dementia Living at Home
25 Jul, 2019 | 01:32h | UTC
Randomized Trial: Intensive Treatment of Hyperglycemia Does Not Improve Outcomes in Patients with Acute Ischemic Stroke
24 Jul, 2019 | 09:18h | UTCIntensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Researchers get a handle on how to control blood sugar after stroke – NIH News Releases (free) AND Study Doesn’t Support Intensive Glucose Control in Patients with Stroke and Hyperglycemia – NEJM Journal Watch (free)
NICE Guideline: Motor Neuron Disease
24 Jul, 2019 | 09:32h | UTCMotor neurone disease: assessment and management – National Institute for Health and Care Excellence (free)
Related Guideline: EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force (free)
Study: Persistent HIV-infected Cells in Cerebrospinal Fluid Associated with Cognitive Impairment
19 Jul, 2019 | 09:41h | UTCCommentaries: Persistent HIV in central nervous system linked to cognitive impairment – NIH News Release (free) AND HIV-infected cells persist in cerebrospinal fluid, linked to poorer neurocognitive performance – University of North Carolina School of Medicine (free)
Guideline Synopsis: Management of Patients with Acute Ischemic Stroke
19 Jul, 2019 | 09:48h | UTCManagement of Patients with Acute Ischemic Stroke – JAMA (free for a limited period)
Original Guideline: 2018 AHA/ASA Guidelines for the Early Management of Patients With Acute Ischemic Stroke (free)
Related Guidelines: Stroke and transient ischaemic attack in over 16s: diagnosis and initial management – National Institute for Health and Care Excellence (free) AND Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ (free) AND Canadian Stroke Best Practice Recommendations for Acute Stroke Management (free)
New Blood Test Seems Promising for the Diagnosis of Alzheimer’s Disease
18 Jul, 2019 | 09:49h | UTCAssociation of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging – JAMA Neurology (free for a limited period)
Commentaries: Scientists close in on blood test for Alzheimer’s – STAT (free) AND Predicting Alzheimer’s – Blood markers close in on helping determine who will develop Alzheimer’s disease – MedPage Today (free registration required)
“What good will that do without a cure?” (from STAT)
Meta-Analysis: Antiplatelet Therapy After Noncardioembolic Stroke
17 Jul, 2019 | 10:47h | UTCSource: EvidenceAlerts
“Results favor clopidogrel and aspirin/dipyridamole combination for long-term secondary prevention after noncardioembolic stroke or transient ischemic attack”.
Cohort Study: Shorter Time to Endovascular Recanalization in Acute Ischemic Stroke is Associated with Better Outcomes
17 Jul, 2019 | 10:46h | UTCAssociation Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice – JAMA (free for a limited period)
Editorial: Endovascular Therapy for Acute Ischemic Stroke Treated in Clinical Practice (free for a limited period)
Video Summary: Association Between Time to Treatment With Endovascular Reperfusion Therapy and Acute Ischemic Stroke Outcomes (free)
News Release: Treating stroke patients just 15 minutes earlier can save lives – UCLA (free)
Editorial: The Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms
17 Jul, 2019 | 09:19h | UTCThe Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms – JAMA Neurology (free for a limited period)
Original Article: Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework – JAMA Neurology (free)
Related Commentary on Twitter
The term "Alzheimer Clinical Syndrome", as opposed to "probable Alzheimer disease", distinguishes the biology from the associated clinical syndrome. https://t.co/9RwdaTEpUR
— JAMA Neurology (@JAMANeuro) July 16, 2019
Study: Health Lifestyle May Reduce the Incidence of Dementia Even in Patients with High Genetic Risk
16 Jul, 2019 | 09:42h | UTCAssociation of Lifestyle and Genetic Risk With Incidence of Dementia – JAMA (free for a limited period)
Commentaries: Healthy lifestyle reduces dementia risk even in those with genetic risk factors – NHS Choices (free) AND Healthy lifestyle may offset genetic risk of dementia – University of Exeter (free) AND Genes vs. lifestyle: Study ‘undermines fatalistic view of dementia’ – Medical News Today (free) AND Healthy living may help offset genetic risk of dementia: study – Reuters (free) AND Healthy lifestyle may cut risk of dementia regardless of genes – The Guardian (free)
Editorial: How I Manage Intracranial Hypertension
14 Jul, 2019 | 19:01h | UTCHow I manage intracranial hypertension – Critical Care (free)
Related Commentary on Twitter
How I manage intracranial hypertension #FOAMed #FOAMcc https://t.co/IsQ7L6Recm pic.twitter.com/H5OksdnC1w
— Critical Care (@Crit_Care) July 9, 2019
[Abstract Only] Study: The Benefits of Clopidogrel-aspirin Combination after Minor Stroke/TIA occurs Predominantly Within the First 21 Days
12 Jul, 2019 | 08:03h | UTCTime Course for Benefit and Risk of Clopidogrel and Aspirin after Acute Transient Ischemic Attack and Minor Ischemic Stroke: A Secondary Analysis from the POINT Randomized Trial – Circulation (link to abstract – $ for full-text)
Commentary: Clopidogrel-Aspirin in Minor Stroke/TIA of Maximum Benefit in First 21 Days – TCTMD (free)
Related Guideline: Dual Antiplatelet Therapy for Acute High-Risk TIA and Minor Ischemic Stroke – The BMJ (free)
Viewpoint: Preclinical Alzheimer Disease—Early Diagnosis or Overdiagnosis?
12 Jul, 2019 | 07:52h | UTCPreclinical Alzheimer Disease—Early Diagnosis or Overdiagnosis? – JAMA Internal Medicine (free for a limited period)
Related Commentary on Twitter
Preclinical #AlzheimerDisease: may identify high-risk group to target new preventive medications, but may also lead to overdiagnosis and high costs https://t.co/GK3soETwd1
— JAMA Internal Medicine (@JAMAInternalMed) July 9, 2019
Cohort Study: Quantity and Quality of Mental Activities and the Risk of Mild Cognitive Impairment
12 Jul, 2019 | 06:18h | UTCCommentary: Mentally stimulating activities linked to lower risk or delay of age-related memory loss – News Medical (free)
Related Commentary on Twitter
Mayo Clinic researchers study in the @GreenJournal finds doing more than one mentally stimulating activity like using a computer, playing games, and social activities is linked to a lower risk or delay of age-related memory loss, mild cognitive impairment. https://t.co/o2Eph8hJPd
— Mayo Clinic (@MayoClinic) July 12, 2019
Androgen Deprivation Therapy Linked to Increased Risk of Dementia in Men with Prostate Cancer
10 Jul, 2019 | 09:30h | UTCCommentaries: Hormone therapy for prostate cancer may raise risk of Alzheimer’s, Dementia – Penn Medicine (free) AND Prostate cancer treatment linked to heightened Alzheimer’s risk – UPI (free) AND Men’s dementia risk higher after androgen deprivation therapy – OnMedica (free) AND Risk of dementia rises with prostate cancer hormone-blocking therapy – Reuters (free)
[Abstract Only] Study: Very Low LDL Linked to Increased Risk of Intracerebral Hemorrhage
9 Jul, 2019 | 10:08h | UTCLow-density lipoprotein cholesterol and risk of intracerebral hemorrhage: A prospective study – Neurology (link to abstract – $ for full-text)
Commentaries: Cholesterol that is too low may boost risk for hemorrhagic stroke – Penn State (free) AND Low cholesterol may increase risk for haemorrhagic stroke – OnMedica (free) AND Very low levels of ‘bad’ cholesterol may raise stroke risk – Medical News Today (free)
Viewpoint: Advances in Understanding the Pathophysiology of Chronic Fatigue Syndrome
8 Jul, 2019 | 10:17h | UTCAdvances in Understanding the Pathophysiology of Chronic Fatigue Syndrome – JAMA (free for a limited period)
[Abstract Only] Study: Nerve Transfer Surgery Restores Hand Function and Elbow Extension in Patients with Complete Paralysis
5 Jul, 2019 | 02:53h | UTCExpanding traditional tendon-based techniques with nerve transfers for the restoration of upper limb function in tetraplegia: a prospective case series – The Lancet (link to abstract – $ for full-text)
Commentary: Nerve transfer surgery restores hand function and elbow extension in 13 young adults with complete paralysis – The Lancet (free) AND Expert reaction to study on successful nerve transfer surgery in paralysis patients – Science Media Centre (free)
Related Study: Recovery of Walking after Complete Spinal Cord Injury (free)
Review: Nonnarcotic Methods of Pain Management
4 Jul, 2019 | 11:05h | UTCNonnarcotic Methods of Pain Management – New England Journal of Medicine (free for a limited period)
Report: Consumers Should Not Take any Supplements for Brain Health
2 Jul, 2019 | 06:24h | UTCCommentaries: On supplements preventing cognitive decline, ‘science says that doesn’t work’ – University of Pennsylvania (free) AND Supplements for Brain Health Panned – Medscape (free registration required)
Related Cochrane Review: Supplements for Preventing Cognitive Decline in People with Mild Cognitive Impairment (free)
Cohort Study: Cognitive Decline After Coronary Events
26 Jun, 2019 | 00:23h | UTCCommentaries: Cognitive decline may accelerate after heart attack, angina – American College of Cardiology (free) AND Ischemic Events Worsen Long-term Cognitive Decline – TCTMD (free) AND Heart problems may hasten cognitive decline – Reuters (free)
Study: Anticholinergic Drug Exposure and the Risk of Dementia
25 Jun, 2019 | 07:03h | UTCCommentaries: Preventing Alzheimer Disease by Deprescribing Anticholinergic Medications – JAMA Internal Medicine (free for a limited period) AND Commonly prescribed anticholinergic drugs linked to dementia risk – UPI (free) AND Expert reaction to anticholinergic drug exposure and risk of dementia – Science Media Centre (free) Commonly prescribed drugs are tied to nearly 50% higher dementia risk in older adults, study says – CNN (free)
WHO Report: Epilepsy: A Public Health Imperative
24 Jun, 2019 | 01:15h | UTCEpilepsy: a public health imperative – World Health Organization (free PDF)
News Releases: WHO highlights scarcity of treatment for epilepsy in low-income countries – World Health Organization (free) AND First-ever WHO global report on epilepsy highlights care gap in poorer countries – United Nations (free)
Cohort Study: Long Working Hours Linked to Increased Stroke Risk
21 Jun, 2019 | 07:32h | UTCCommentaries: Long work hours associated with increased risk of stroke – American Heart Association (free) AND Longer work hours may raise stroke risk – UPI (free) AND Long working hours ‘linked to stroke risk’ – BBC (free)