Neurology
The Entire Human Brain in ‘Unprecedented’ Detail, Thanks to Powerful MRI
14 Aug, 2019 | 08:26h | UTCThe entire human brain in ‘unprecedented’ detail, thanks to powerful MRI – STAT (free)
Cohort Study: Association of Hearing Loss with Dementia
13 Aug, 2019 | 05:24h | UTCAssociation of Hearing Loss With Dementia – JAMA Network Open (free)
Commentary: Middle-age hearing loss linked to dementia – Reuters (free)
Related Meta-Analysis: Association of Age-Related Hearing Loss With Cognitive Function (free study and commentaries)
Debate: Nonconvulsive Seizures and Nonconvulsive Status Epilepticus in the Neuro ICU Should or Should Not be Treated Aggressively?
13 Aug, 2019 | 01:29h | UTC
Diagnosis and Management of Autonomic Dysfunction in Dementia Syndromes
13 Aug, 2019 | 00:58h | UTC
Cohort Study and Meta-Analysis: Long-term Antithrombotic Therapy and Risk of Intracranial Hemorrhage from Cerebral Cavernous Malformations
11 Aug, 2019 | 21:39h | UTCInvited Commentary: Antithrombotics and bleeding risk: paradoxical findings (free)
Related Commentary on Twitter
Antithrombotic drugs might DECREASE the risk of bleeding from cavernomas! This reassuring finding in our https://t.co/CgTlSJxrek cohort study funded by @TheStrokeAssoc @The_MRC @CSO_Scotland needs to be tested in a RCT next… @CAUK1 @AngiomaAlliance https://t.co/w8Z4oH6Dvg pic.twitter.com/kyZAw9xXNQ
— Rustam Salman (@BleedingStroke) August 8, 2019
Complex Regional Pain Syndrome: A Narrative Review for the Practicing Clinician
9 Aug, 2019 | 07:24h | UTCRelated Guidelines: Standards for the diagnosis and management of complex regional pain syndrome: Results of a European Pain Federation task force – European Journal of Pain (free) AND Complex regional pain syndrome in adults (2nd edition) – UK guidelines for diagnosis, referral and management in primary and secondary care 2018 – Royal College of Physicians (free PDF)
Cohort Study: Major Surgery Linked to Small, Long Term Decline in Brain Functioning
9 Aug, 2019 | 06:45h | UTCCommentaries: Major surgery associated with small, long term decline in brain functioning – The BMJ (free) AND Major surgeries linked to small decline in mental functioning in older age – Reuters (free)
Cohort Study: Ideal Cardiovascular Health at Age 50 Linked to Lower Dementia Later in Life
9 Aug, 2019 | 06:34h | UTCEditorial: The determinants of cognitive decline and dementia (free)
Commentaries: Good heart health at age 50 linked to lower dementia risk later in life – The BMJ (free) AND The implications of cardiovascular health for dementia – The BMJ Opinion (free)
Podcast: Stroke and TIA Deconstructed
6 Aug, 2019 | 08:04h | UTC#164 Stroke and TIA Deconstructed – The Curbsiders Internal Medicine Podcast (free audio)
[Abstract Only] Study: Blood Test Can Identify Pre-Clinical Brain Changes Linked to Alzheimer’s Disease
5 Aug, 2019 | 02:14h | UTCHigh-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis – Neurology (link to abstract – $ for full-text)
Commentaries: Blood test may accurately identify people with early Alzheimer’s brain changes – Washington University School of Medicine in St. Louis (free) AND The new blood test for Alzheimer’s disease: developed in a study without patients – Medium (free)
Perspective: A Brain Scan May Predict Alzheimer’s. Should You Get One?
5 Aug, 2019 | 02:13h | UTCA Brain Scan May Predict Alzheimer’s. Should You Get One? – The New York Times (10 articles per month are free)
Randomized Trial and Meta-analysis: Standard vs. Intensive Blood Pressure Control on the Risk of Recurrent Stroke
2 Aug, 2019 | 02:50h | UTCEffect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke: A Randomized Clinical Trial and Meta-analysis – JAMA Neurology (free for a limited period)
Editorial: Challenges to Realizing Benefits From More Intensive Blood Pressure Control for Preventing Recurrent Stroke – JAMA Neurology (free for a limited period)
Guidelines for the Treatment of Huntington’s Disease
2 Aug, 2019 | 00:51h | UTCInternational Guidelines for the Treatment of Huntington’s Disease – Frontiers in Neurology (free)
Related Guideline: Evidence-based guideline: Pharmacologic treatment of chorea in Huntington disease: Report of the Guideline Development Subcommittee of the American Academy of Neurology (free)
Assessing and Counseling the Older Driver: A Concise Review for the Generalist Clinician
2 Aug, 2019 | 00:53h | UTC
Review: Pharmacologic Considerations Surrounding Sedation, Delirium, and Sleep in Critically Ill Adults
29 Jul, 2019 | 20:16h | UTC
Meta-Analysis: Very Early Mobilization After Stroke Does Not Improve Outcomes
29 Jul, 2019 | 20:32h | UTCVery Early Versus Delayed Mobilization After Stroke: Systematic Review and Meta-Analysis – Stroke (free PDF)
[Abstract Only] Measures of Obesity are Associated with MRI Markers of Brain Aging
29 Jul, 2019 | 20:10h | UTCMeasures of obesity are associated with MRI markers of brain aging – Neurology (link to abstract – $ for full-text)
Commentaries: Extra Weight in 60s May Be Linked to Brain Thinning Years Later – American Academy of Neurology (free) AND Study links higher body weight later in life to faster brain aging – Medical News Today (free)
NICE Guideline: Multiple Sclerosis in Adults
28 Jul, 2019 | 23:10h | UTCMultiple sclerosis in adults: management – National Institute for Health and Care Excellence (free)
Related Guidelines: AAN Guideline: Disease-modifying Therapies for Adults with Multiple Sclerosis (free guideline and commentaries) AND ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis – European Journal of Neurology (free) AND Brazilian Consensus for the Treatment of Multiple Sclerosis: Brazilian Academy of Neurology and Brazilian Committee on Treatment and Research in Multiple Sclerosis (free PDF) AND Diagnosis of Multiple Sclerosis: 2017 Revisions of the McDonald Criteria (free registration required)
Pharmacologic Management of Agitation in Patients with Dementia
27 Jul, 2019 | 20:07h | UTCPharmacologic Management of Agitation in Patients with Dementia – Current Geriatrics Reports (free)
Related: Nonpharmacological Interventions to Reduce Behavioral and Psychological Symptoms of Dementia: A Systematic Review – BioMed Research International (free) AND Systematic review of systematic reviews of non-pharmacological interventions to treat behavioural disturbances in older patients with dementia. The SENATOR-OnTop series – BMJ Open (free)
[Abstract Only] Subarachnoid Hemorrhage: Large Observational Study Suggests Early Endovascular Treatment May Reduce the Risk of Delayed Cerebral Ischemia and Poor Functional Outcomes
27 Jul, 2019 | 15:01h | UTCEndovascular treatment of cerebral vasospasm after subarachnoid hemorrhage – Neurology (link to abstract – $ for full-text) (via Besen BA)
Meta-analysis: Diagnosis of Elevated Intracranial Pressure in Critically Ill Adults
26 Jul, 2019 | 01:08h | UTCCommentary: Review examines methods for diagnosis of elevated ICP in critically ill – MedicalXpress (free)
Related Guidelines: Management of severe traumatic brain injury (first 24 hours) – Anaesthesia Critical Care & Pain Medicine (free) AND Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury – Acta Neurochirurgica (free)
Related Reviews: Emergency Neurological Life Support: Intracranial Hypertension and Herniation – Neurocritical Care (free) AND Acute Management of Traumatic Brain Injury – Surgical Clinics of North America (free)
Related Commentary on Twitter
A question we often ask in the ED/ICU: Does this patient have increased ICP?
Our @bmj_latest study found that traditional physical exam and CT signs had poor accuracy for elevated ICP. If suspected, consider treatment & transfer for invasive monitoring.https://t.co/1Eb8PtYLFJ pic.twitter.com/bQFIgWnuur
— Shannon Fernando (@shanfernands) July 25, 2019
Preventing Dementia by Preventing Stroke: The Berlin Manifesto
25 Jul, 2019 | 01:59h | UTCPreventing dementia by preventing stroke: The Berlin Manifesto – Alzheimer’s & Dementia (free)
Commentaries: Group calls on international community to prevent dementia by preventing stroke – University of Western Ontario (free) AND Stroke Prevention Best Path to Dementia Reduction, Experts Say – Medscape (free registration required)
Systematic Review: Palliative Care for People with Dementia Living at Home
25 Jul, 2019 | 01:32h | UTC
Randomized Trial: Intensive Treatment of Hyperglycemia Does Not Improve Outcomes in Patients with Acute Ischemic Stroke
24 Jul, 2019 | 09:18h | UTCIntensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Researchers get a handle on how to control blood sugar after stroke – NIH News Releases (free) AND Study Doesn’t Support Intensive Glucose Control in Patients with Stroke and Hyperglycemia – NEJM Journal Watch (free)
NICE Guideline: Motor Neuron Disease
24 Jul, 2019 | 09:32h | UTCMotor neurone disease: assessment and management – National Institute for Health and Care Excellence (free)
Related Guideline: EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force (free)