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Neurology

The Entire Human Brain in ‘Unprecedented’ Detail, Thanks to Powerful MRI

14 Aug, 2019 | 08:26h | UTC

The entire human brain in ‘unprecedented’ detail, thanks to powerful MRI – STAT (free)

 


Cohort Study: Association of Hearing Loss with Dementia

13 Aug, 2019 | 05:24h | UTC

Association of Hearing Loss With Dementia – JAMA Network Open (free)

Commentary: Middle-age hearing loss linked to dementia – Reuters (free)

Related Meta-Analysis: Association of Age-Related Hearing Loss With Cognitive Function (free study and commentaries)

 


Debate: Nonconvulsive Seizures and Nonconvulsive Status Epilepticus in the Neuro ICU Should or Should Not be Treated Aggressively?

13 Aug, 2019 | 01:29h | UTC

Nonconvulsive seizures and nonconvulsive status epilepticus in the Neuro ICU should or should not be treated aggressively: a debate – Clinical Neurophysiology Practice (free)

 


Diagnosis and Management of Autonomic Dysfunction in Dementia Syndromes

13 Aug, 2019 | 00:58h | UTC

Diagnosis and Management of Autonomic Dysfunction in Dementia Syndromes – Current Treatment Options in Neurology (free)

 


Cohort Study and Meta-Analysis: Long-term Antithrombotic Therapy and Risk of Intracranial Hemorrhage from Cerebral Cavernous Malformations

11 Aug, 2019 | 21:39h | UTC

Long-term antithrombotic therapy and risk of intracranial haemorrhage from cerebral cavernous malformations: a population-based cohort study, systematic review, and meta-analysis – The Lancet Neurology (free)

Invited Commentary: Antithrombotics and bleeding risk: paradoxical findings (free)

 

Related Commentary on Twitter

 


Complex Regional Pain Syndrome: A Narrative Review for the Practicing Clinician

9 Aug, 2019 | 07:24h | UTC

Complex regional pain syndrome: a narrative review for the practising clinician – British Journal of Anaesthesia (free)

Related Guidelines: Standards for the diagnosis and management of complex regional pain syndrome: Results of a European Pain Federation task force – European Journal of Pain (free) AND Complex regional pain syndrome in adults (2nd edition) – UK guidelines for diagnosis, referral and management in primary and secondary care 2018 – Royal College of Physicians (free PDF)

 


Cohort Study: Major Surgery Linked to Small, Long Term Decline in Brain Functioning

9 Aug, 2019 | 06:45h | UTC

Association between major surgical admissions and the cognitive trajectory: 19 year follow-up of Whitehall II cohort study – The BMJ (free)

Commentaries: Major surgery associated with small, long term decline in brain functioning – The BMJ (free) AND Major surgeries linked to small decline in mental functioning in older age – Reuters (free)

 


Cohort Study: Ideal Cardiovascular Health at Age 50 Linked to Lower Dementia Later in Life

9 Aug, 2019 | 06:34h | UTC

Association of ideal cardiovascular health at age 50 with incidence of dementia: 25 year follow-up of Whitehall II cohort study – The BMJ (free)

Editorial: The determinants of cognitive decline and dementia (free)

Commentaries: Good heart health at age 50 linked to lower dementia risk later in life – The BMJ (free) AND The implications of cardiovascular health for dementia – The BMJ Opinion (free)

 


Podcast: Stroke and TIA Deconstructed

6 Aug, 2019 | 08:04h | UTC

#164 Stroke and TIA Deconstructed – The Curbsiders Internal Medicine Podcast (free audio)

 


[Abstract Only] Study: Blood Test Can Identify Pre-Clinical Brain Changes Linked to Alzheimer’s Disease

5 Aug, 2019 | 02:14h | UTC

High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis – Neurology (link to abstract – $ for full-text)

Commentaries: Blood test may accurately identify people with early Alzheimer’s brain changes – Washington University School of Medicine in St. Louis (free) AND The new blood test for Alzheimer’s disease: developed in a study without patients – Medium (free)

 


Perspective: A Brain Scan May Predict Alzheimer’s. Should You Get One?

5 Aug, 2019 | 02:13h | UTC

A Brain Scan May Predict Alzheimer’s. Should You Get One? – The New York Times (10 articles per month are free)

 


Randomized Trial and Meta-analysis: Standard vs. Intensive Blood Pressure Control on the Risk of Recurrent Stroke

2 Aug, 2019 | 02:50h | UTC

Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke: A Randomized Clinical Trial and Meta-analysis – JAMA Neurology (free for a limited period)

Editorial: Challenges to Realizing Benefits From More Intensive Blood Pressure Control for Preventing Recurrent Stroke – JAMA Neurology (free for a limited period)

 


Guidelines for the Treatment of Huntington’s Disease

2 Aug, 2019 | 00:51h | UTC

International Guidelines for the Treatment of Huntington’s Disease – Frontiers in Neurology (free)

Related Guideline: Evidence-based guideline: Pharmacologic treatment of chorea in Huntington disease: Report of the Guideline Development Subcommittee of the American Academy of Neurology (free)

 


Assessing and Counseling the Older Driver: A Concise Review for the Generalist Clinician

2 Aug, 2019 | 00:53h | UTC

Assessing and Counseling the Older Driver: A Concise Review for the Generalist Clinician – Mayo Clinic Proceedings (free)

 


Review: Pharmacologic Considerations Surrounding Sedation, Delirium, and Sleep in Critically Ill Adults

29 Jul, 2019 | 20:16h | UTC

Pharmacologic Considerations Surrounding Sedation, Delirium, and Sleep in Critically Ill Adults: A Narrative Review – Journal of Pharmacology Practice (free)

Related: Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU – Critical Care Medicine (free)

 


Meta-Analysis: Very Early Mobilization After Stroke Does Not Improve Outcomes

29 Jul, 2019 | 20:32h | UTC

Very Early Versus Delayed Mobilization After Stroke: Systematic Review and Meta-Analysis – Stroke (free PDF)

 


[Abstract Only] Measures of Obesity are Associated with MRI Markers of Brain Aging

29 Jul, 2019 | 20:10h | UTC

Measures of obesity are associated with MRI markers of brain aging – Neurology (link to abstract – $ for full-text)

Commentaries: Extra Weight in 60s May Be Linked to Brain Thinning Years Later – American Academy of Neurology (free) AND Study links higher body weight later in life to faster brain aging – Medical News Today (free)

 


NICE Guideline: Multiple Sclerosis in Adults

28 Jul, 2019 | 23:10h | UTC

Multiple sclerosis in adults: management – National Institute for Health and Care Excellence (free)

Related Guidelines: AAN Guideline: Disease-modifying Therapies for Adults with Multiple Sclerosis (free guideline and commentaries) AND ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis – European Journal of Neurology (free) AND Brazilian Consensus for the Treatment of Multiple Sclerosis: Brazilian Academy of Neurology and Brazilian Committee on Treatment and Research in Multiple Sclerosis (free PDF) AND Diagnosis of Multiple Sclerosis: 2017 Revisions of the McDonald Criteria (free registration required)

 


Pharmacologic Management of Agitation in Patients with Dementia

27 Jul, 2019 | 20:07h | UTC

Pharmacologic Management of Agitation in Patients with Dementia – Current Geriatrics Reports (free)

Related: Nonpharmacological Interventions to Reduce Behavioral and Psychological Symptoms of Dementia: A Systematic Review – BioMed Research International (free) AND Systematic review of systematic reviews of non-pharmacological interventions to treat behavioural disturbances in older patients with dementia. The SENATOR-OnTop series – BMJ Open (free)

 


[Abstract Only] Subarachnoid Hemorrhage: Large Observational Study Suggests Early Endovascular Treatment May Reduce the Risk of Delayed Cerebral Ischemia and Poor Functional Outcomes

27 Jul, 2019 | 15:01h | UTC

Endovascular treatment of cerebral vasospasm after subarachnoid hemorrhage – Neurology (link to abstract – $ for full-text) (via Besen BA)

 


Meta-analysis: Diagnosis of Elevated Intracranial Pressure in Critically Ill Adults

26 Jul, 2019 | 01:08h | UTC

Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis – The BMJ (free)

Commentary: Review examines methods for diagnosis of elevated ICP in critically ill – MedicalXpress (free)

Related Guidelines: Management of severe traumatic brain injury (first 24 hours) – Anaesthesia Critical Care & Pain Medicine (free) AND Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury – Acta Neurochirurgica (free)

Related Reviews: Emergency Neurological Life Support: Intracranial Hypertension and Herniation – Neurocritical Care (free) AND Acute Management of Traumatic Brain Injury – Surgical Clinics of North America (free)

 

Related Commentary on Twitter

 


Preventing Dementia by Preventing Stroke: The Berlin Manifesto

25 Jul, 2019 | 01:59h | UTC

Preventing dementia by preventing stroke: The Berlin Manifesto – Alzheimer’s & Dementia (free)

Commentaries: Group calls on international community to prevent dementia by preventing stroke – University of Western Ontario (free) AND Stroke Prevention Best Path to Dementia Reduction, Experts Say – Medscape (free registration required)

 


Systematic Review: Palliative Care for People with Dementia Living at Home

25 Jul, 2019 | 01:32h | UTC

Palliative care for people with dementia living at home: A systematic review of interventions – Palliative Medicine (free)

 


Randomized Trial: Intensive Treatment of Hyperglycemia Does Not Improve Outcomes in Patients with Acute Ischemic Stroke

24 Jul, 2019 | 09:18h | UTC

Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: Researchers get a handle on how to control blood sugar after stroke – NIH News Releases (free) AND Study Doesn’t Support Intensive Glucose Control in Patients with Stroke and Hyperglycemia – NEJM Journal Watch (free)

 


NICE Guideline: Motor Neuron Disease

24 Jul, 2019 | 09:32h | UTC

Motor neurone disease: assessment and management – National Institute for Health and Care Excellence (free)

Related Guideline: EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force (free)

 


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