Neurology
Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson’s Disease
20 Jan, 2021 | 01:20h | UTC
Study: Seizure frequency does not increase during Pregnancy
15 Jan, 2021 | 08:28h | UTCChanges in Seizure Frequency and Antiepileptic Therapy during Pregnancy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: MONEAD Study: Does Pregnancy Lead to Increased Seizure Frequency in Women with Epilepsy? – Physician’s Weekly AND Pregnancy Does Not Increase Seizures in Women With Epilepsy – Medscape
Systematic review: Acute treatments for episodic migraine
13 Jan, 2021 | 01:56h | UTCAcute Treatments for Episodic Migraine – Agency for Healthcare Research and Quality
Full text: Acute Treatments for Episodic Migraine
Evidence summary: Acute Treatments for Episodic Migraine
Systematic review: There is no evidence that Souvenaid is useful for preventing dementia or provide benefit for patients with Alzheimer’s disease
13 Jan, 2021 | 01:47h | UTCSouvenaid for Alzheimer’s disease – Cochrane Library
AASM Guideline: Behavioral and psychological treatments for chronic insomnia disorder in adults
13 Jan, 2021 | 01:58h | UTCCommentary: New guideline encourages use of cognitive behavioral therapy for insomnia in adults – ACP Internist
Cohort study: Prevalence and risk factors for delirium in critically ill patients with COVID-19
12 Jan, 2021 | 01:55h | UTCCommentaries: Sedation in mechanically ventilated patients with COVID-19 – The Lancet Respiratory Medicine AND Large study finds higher burden of acute brain dysfunction for COVID-19 ICU patients – Vanderbilt University Medical Center
Randomized trial: Ultra-early tranexamic acid does not improve outcomes after subarachnoid hemorrhage
10 Jan, 2021 | 21:02h | UTCUltra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Tranexamic acid treatment in spontaneous subarachnoid haemorrhage, started immediately after CT diagnosis and continued until start of the aneurysm treatment as early as possible, does not improve clinical outcome, finds new randomised controlled trial: https://t.co/R0AhtszaY5 pic.twitter.com/Bnft9XgBA9
— The Lancet (@TheLancet) December 22, 2020
Guideline Synopsis: Management of patients with a patent foramen ovale with history of stroke or TIA
10 Jan, 2021 | 20:19h | UTCManagement of Patients With a Patent Foramen Ovale With History of Stroke or TIA – JAMA (free for a limited period)
Original Guideline: Practice advisory update summary: Patent foramen ovale and secondary stroke prevention: Report of the Guideline Subcommittee of the American Academy of Neurology – Neurology
Meta-analysis: Effectiveness of bundle interventions on ICU delirium
10 Jan, 2021 | 20:16h | UTCEffectiveness of Bundle Interventions on ICU Delirium: A Meta-Analysis – Critical Care Medicine
Commentary: ICU bundles do not appear to improve delirium but may help other outcomes – ACP Hospitalist
Commentary on Twitter
Meta-Analysis incl 11 studies and 26,384 patients for bundle-interventions of delirium treatment showed no effects on delirum duration ( –1.42 d; 95% CI –3.06 to 0.22) or prevalence (risk ratio = 0.92; 95% CI, 0.68–1.24)https://t.co/PzZBGttOL8
— Peter Nydahl (@NydahlPeter) December 18, 2020
Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicenter collaborative study
18 Dec, 2020 | 09:50h | UTCCommentary: Study highlights neurological impact of COVID-19 on children – University of Manchester
Commentary on Twitter (thread – click for more)
New #COVID19 Research: An international call for cases identified 38 children with neurological disease related to #SARSCoV2 infection
Recurring patterns of disease were identified, with #neuroimaging abnormalities ranging from mild to severehttps://t.co/a3bjPlOY0z pic.twitter.com/W0lxLP4aAh
— The Lancet Child & Adolescent Health (@LancetChildAdol) December 16, 2020
Randomized trial: Dexamethasone for chronic subdural hematoma resulted in fewer favorable outcomes and more adverse events than placebo at 6 months
17 Dec, 2020 | 09:02h | UTCTrial of Dexamethasone for Chronic Subdural Hematoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Dexamethasone should be avoided in patients with chronic subdural haematoma – University of Cambridge AND Dexamethasone for Chronic Subdural Hematoma? – NEJM Journal Watch
Commentary on Twitter
In a trial that compared a 2-week course of dexamethasone with placebo in patients with a chronic subdural hematoma, a favorable outcome on the modified Rankin scale at 6 months was more common in the placebo group than in the dexamethasone group.
— NEJM (@NEJM) December 17, 2020
“Neurological manifestations of COVID-19” – guideline of the German society of neurology
9 Dec, 2020 | 08:15h | UTC
Could COVID delirium bring on dementia?
4 Dec, 2020 | 08:11h | UTCCould COVID delirium bring on dementia? – Nature
Cohort study: Higher dose Z-drug use in dementia is associated with increased fracture and stroke risks, similar or greater to that for higher dose benzodiazepines
1 Dec, 2020 | 08:25h | UTCCommentary: The danger of Z-drugs for dementia patients – University of Exeter
Randomized trial: Prednisone is an effective short-term preventive therapy in patients with episodic cluster headache
25 Nov, 2020 | 09:01h | UTCSafety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
Commentary from the author on Twitter
Finally published online! After countless years and a lot of work our study on prednisone for the treatment of episodic cluster headache. Thanks to all the many people that were involved in this study, Very proud!!! #PredCH #Clusterheadachehttps://t.co/d88TUWTY5i
— Mark Obermann (@moeb07) November 25, 2020
Opinion – Football and dementia: heading must be banned until the age of 18
24 Nov, 2020 | 09:24h | UTCFootball and dementia: heading must be banned until the age of 18 – The Conversation
Randomized, placebo-controlled, crossover trial: Amantadine, modafinil, and methylphenidate are no better than placebo for fatigue in multiple sclerosis
24 Nov, 2020 | 09:02h | UTCSafety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial – The Lancet Neurology (link to abstract – $ for full-text)
Older adults with COVID-19 commonly present to the ED with delirium
20 Nov, 2020 | 08:46h | UTCDelirium in Older Patients With COVID-19 Presenting to the Emergency Department – JAMA Network Open
Commentaries: Delirium could signal Covid-19 infection in older adults, study finds – STAT AND Delirium fairly common in older COVID-19 patients – CIDRAP AND Delirium is first symptom for many elderly COVID-19 patients – UPI
Commentary on Twitter
In older ED patients w/ COVID-19 only 56% had a fever, 51% SOB & 50% cough. 28% had delirium & one third of delirious pts lacked typical symptoms. In the ED delirium may the only symptom of #COVID19. @sharon_inouye @ACEPNow @GeriatricEDNews @AGEM_SAEM @JAMANetworkOpen pic.twitter.com/MxjSTx3Ffi
— Maura Kennedy (@MauraKennedyMD) November 19, 2020
Systematic review: Management of primary headaches in pregnancy
18 Nov, 2020 | 09:00h | UTCManagement of Primary Headaches in Pregnancy – Agency for Healthcare Research and Quality
Full report: Management of Primary Headaches in Pregnancy
Evidence Summary: Management of Primary Headaches in Pregnancy
Sleep problems in dementia: Despite many drugs being widely prescribed, systematic review finds lack of evidence and no randomized controlled trials to guide decisions about drug treatment
17 Nov, 2020 | 09:29h | UTCPharmacotherapies for sleep disturbances in dementia – Cochrane Library
Case-control study: COVID-19-associated stroke is associated with worse outcomes and increased mortality
12 Nov, 2020 | 09:24h | UTCCommentary: Risk of death, disability after stroke much higher for COVID-19 patients – Cardiovascular Business
Meta-analysis: Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging can reduce cases of severe disability but increases symptomatic intracranial hemorrhage and deaths
11 Nov, 2020 | 09:06h | UTCIntravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data – The Lancet (free registration required)
Commentary on Twitter
Latebreaking at #ESOWSO2020—Intravenous alteplase for #stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data https://t.co/KDX2lHisbj pic.twitter.com/cnoiRhIReF
— The Lancet (@TheLancet) November 8, 2020
Another study shows improved outcomes with dual antiplatelet therapy in the first weeks after an acute ischemic stroke or transient ischemic attack
9 Nov, 2020 | 01:16h | UTCRelated Guideline: Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ
International consensus guidance for management of myasthenia gravis: The 2020 version includes updated recommendations for thymectomy, for early immunosuppression in ocular MG, and for the management of MG associated with immune checkpoint inhibitor treatment
6 Nov, 2020 | 09:46h | UTCInternational consensus guidance for management of myasthenia gravis: 2020 update – Neurology
[Abstract Only] More than a third of older adults are prescribed potentially inappropriate drugs, study finds
6 Nov, 2020 | 09:42h | UTCOriginal study: Potentially Inappropriate Medications Are Associated with Increased Healthcare Utilization and Costs – Journal of the American Geriatrics Society (link to abstract – $ for full-text)