Neurology
RCT: Aspirin NOT noninferior to vitamin K antagonists in the treatment of cervical artery dissection
24 Mar, 2021 | 08:09h | UTCAspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial – The Lancet Neurology (link to abstract – $ for full-text)
Researchers identify head impact rates in four major high school sports
21 Mar, 2021 | 21:30h | UTCNews release: Researchers Identify Head Impact Rates in Four Major High School Sports – Children’s Hospital of Philadelphia
Original study: Sport- and Gender-Based Differences in Head Impact Exposure and Mechanism in High School Sports – Orthopaedic Journal of Sports Medicine
Commentary on Twitter
Excited to share our publication in @OJSM_SportsMed with @kristyarb and @drtinamaster! Male and female high school soccer had the highest head impact rate across four sports. Male teams also had higher impact rates than female teams of the same sport.https://t.co/eMOL925s04 https://t.co/elutojRfwJ
— Colin Huber, PhD (@Colin_M_Huber) March 18, 2021
Diagnosing and treating brain tumors: reflections on the latest Cochrane evidence
19 Mar, 2021 | 08:06h | UTC
M-A: Cholinesterase inhibitors for vascular dementia and other vascular cognitive impairments
19 Mar, 2021 | 07:52h | UTC
Review: Diagnosis and Management of Transient Ischemic Attack and Acute Ischemic Stroke
18 Mar, 2021 | 08:54h | UTCDiagnosis and Management of Transient Ischemic Attack and Acute Ischemic Stroke: A Review – JAMA
Five-year outcomes of PFO closure or antiplatelet therapy for cryptogenic stroke
17 Mar, 2021 | 02:40h | UTCPFO Closure for Stroke Is Safe, Effective at 5 Years: REDUCE – TCTMD
Original study: Five-Year Outcomes of PFO Closure or Antiplatelet Therapy for Cryptogenic Stroke – New England Journal of Medicine ($)
Imaging review of peripheral nerve injuries in patients with COVID-19
17 Mar, 2021 | 02:48h | UTCImaging Review of Peripheral Nerve Injuries in Patients with COVID-19 – Radiology
Consensus Statement on Analgo-sedation in Neurocritical Care and Review of Literature
17 Mar, 2021 | 02:09h | UTC
Central nervous system–active polypharmacy common among older adults with dementia in the US
16 Mar, 2021 | 01:45h | UTCPrevalence of Central Nervous System–Active Polypharmacy Among Older Adults With Dementia in the US – JAMA (free for a limited period)
Commentaries: CNS-Active Polypharmacy Examined in Seniors With Dementia – HealthDay AND A Trio That Could Spell Trouble: Many with Dementia Take Risky Combinations of Medicines – Michigan Medicine – University of Michigan AND Older Adults With Dementia at Risk From Taking Multiple Psychotropics, Study Suggests – Psychiatric News Alert
Commentary on Twitter
In this cross-sectional study of Medicare claims, 14% of older adults with dementia filled prescriptions consistent with CNS-active polypharmacy in 2018 (eg 3+ antidepressants, antipsychotics, BNZ, Z-drugs, or opioids) https://t.co/85BmGgeYil @dtmaust @umichmedicine @PennMedicine
— JAMA (@JAMA_current) March 9, 2021
Systematic Review: Encephalitis induced by immune checkpoint inhibitors
16 Mar, 2021 | 01:36h | UTCEncephalitis Induced by Immune Checkpoint Inhibitors: A Systematic Review – JAMA Neurology
Best practice recommendations for stroke patients with dysphagia
16 Mar, 2021 | 01:26h | UTC
Phase 2 RCT: Donanemab in early Alzheimer’s Disease
14 Mar, 2021 | 20:21h | UTCDonanemab in Early Alzheimer’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Experimental Alzheimer’s drug could slow cognitive decline in patients, early results suggest – CNN AND Alzheimer’s study shows mixed results for Lilly’s donanemab on secondary outcomes – First World Pharma
Commentary on Twitter
In a phase 2 trial, patients with early Alzheimer’s disease who received donanemab, an antibody that targets amyloid deposits, showed a better composite score for cognition & ability to perform activities of daily living at 76 weeks than those who received placebo. #ADPD2021
— NEJM (@NEJM) March 13, 2021
Neurologic involvement in children and adolescents with COVID-19 or Multisystem Inflammatory Syndrome
10 Mar, 2021 | 08:29h | UTC
Commentary on Twitter
Neurologic involvement in US children and adolescents hospitalized for #COVID19 is common, mostly transient, and ranges from mild to life threatening https://t.co/Dy7fZhSMDR
— JAMA Neurology (@JAMANeuro) March 5, 2021
Gabapentin add‐on treatment for drug‐resistant focal epilepsy
9 Mar, 2021 | 02:11h | UTCGabapentin add‐on treatment for drug‐resistant focal epilepsy – Cochrane Library
Summary: Gabapentin as an add-on for drug-resistant focal epilepsy – Cochrane Library
Diagnosis of non-consensus transient ischemic attacks with focal, negative, and non-progressive symptoms: population-based validation by investigation and prognosis
7 Mar, 2021 | 19:32h | UTC
Commentary on Twitter
Some patients present with symptoms that are considered not definitive for TIA (isolated dysarthria, vertigo, etc). Are these patients at risk for later stroke? Fascinating results in @TheLancet from the Oxford Vascular Study@ESOstroke @WorldStrokeOrg https://t.co/l0tJXseE3Y
— Seemant Chaturvedi (@ChaturvediNeuro) March 5, 2021
Comprehensive review of topical analgesics for chronic pain
4 Mar, 2021 | 08:19h | UTCComprehensive Review of Topical Analgesics for Chronic Pain – Current Pain and Headache Reports
RCT: Cognitive prehabilitation reduces the incidence of postoperative delirium among older adults undergoing major noncardiac surgery
4 Mar, 2021 | 08:12h | UTCEffect of Cognitive Prehabilitation on the Incidence of Postoperative Delirium Among Older Adults Undergoing Major Noncardiac Surgery: The Neurobics Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)
Commentaries: Ohio State study finds playing brain games before surgery helps improve recovery – Ohio State University Medical Center AND Cognitive Exercises May Lower Risk for Postoperative Delirium – HealthDay
Commentary on Twitter
Results of a 268-patient prospective randomized-controlled clinical trial show patients meeting at least minimum compliance with a preoperative cognitive exercise intervention had a decreased incidence of postoperative delirium https://t.co/QZUCfef6bf #VisualAbstract pic.twitter.com/jDbsfDSWxV
— JAMA Surgery (@JAMASurgery) November 11, 2020
RCT: No effect from Vitamin D and/or Marine n-3 fatty acid supplementation on changes in migraine frequency and severity
4 Mar, 2021 | 08:04h | UTCEffect of Vitamin D and/or Marine n-3 Fatty Acid Supplementation on Changes in Migraine Frequency and Severity: A randomized placebo-controlled trial – The American Journal of Medicine (link to abstract – $ for full-text)
Review: Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy
3 Mar, 2021 | 08:29h | UTCDiagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy – Brain
M-A: Role of Cilostazol in prevention of vasospasm following aneurysmal subarachnoid hemorrhage
3 Mar, 2021 | 08:16h | UTCRole of Cilostazol in prevention of vasospasm following aneurysmal subarachnoid hemorrhage – A systematic review, meta-analysis and trial sequential analysis – World Neurosurgery (link to abstract – $ for full-text)
Cohort study: Recovery of consciousness and functional outcome in moderate and severe traumatic brain injury
2 Mar, 2021 | 01:34h | UTCRecovery of Consciousness and Functional Outcome in Moderate and Severe Traumatic Brain Injury – JAMA Neurology (free for a limited period)
Editorial: Holding Out Hope After Traumatic Brain Injury (free for a limited period)
Commentary on Twitter
In this study in @JAMANeuro:
most individuals who became comatose after moderate/severe traumatic brain injury recovered consciousness and ~50% regained functional independence, cautioning early decisions to withdraw/withhold treatment in these patients. https://t.co/jIz38AwCXO— Saleh Almenawer, MD (@SalehAlmenawer) March 1, 2021
Teleneurology-enabled determination of death by neurologic criteria after cardiac arrest or severe neurologic injury
2 Mar, 2021 | 01:32h | UTCTeleneurology-Enabled Determination of Death by Neurologic Criteria After Cardiac Arrest or Severe Neurologic Injury – Neurology (link to abstract – $ for full-text)
RCT: Prescribed light exercise vs. standard management for emergency department patients with acute mild traumatic brain injury
2 Mar, 2021 | 01:30h | UTCA randomized trial comparing prescribed light exercise to standard management for emergency department patients with acute mild traumatic brain injury – Academic Emergency Medicine (link to abstract – $ for full-text)
Commentary: Exercise After Concussion in Adults? – Journal Feed
To beta-amyloid or not to beta-amyloid? An innovative meta-analysis offers new insight into Alzheimer’s drugs
2 Mar, 2021 | 01:18h | UTCOriginal study: Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis – The BMJ
Commentary on Twitter
https://twitter.com/artwalaszek/status/1365098101845987328
Consensus guidelines for botulinum toxin therapy: general algorithms and dosing tables for dystonia and spasticity
2 Mar, 2021 | 01:16h | UTC