To beta-amyloid or not to beta-amyloid? An innovative meta-analysis offers new insight into Alzheimer’s drugs

To beta-amyloid or not to beta-amyloid? An innovative meta-analysis offers new insight into Alzheimer’s drugs – UCSF Department of Epidemiology & Biostatistics

Original study: Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis – The BMJ

See also: Instrumental variable meta-analysis of aggregated randomized drug trial data for evaluating proposed target mechanisms – The BMJ

Commentary on Twitter

Anti-amyloid therapy is unlikely to be effective in #Alzheimer’s disease.

Meta-analysis of 14 RCTs found that reducing amyloid levels is associated with little, if any, improvement in cognition.

It’s time for a new paradigm.#GeriTwitter
https://t.co/ZlL39Ondkp

— Art Walaszek (@artwalaszek) February 26, 2021