Neurology
SR: Plasma and cerebrospinal fluid ABeta42 for the differential diagnosis of Alzheimer’s disease dementia
12 Feb, 2021 | 01:53h | UTC
RCT: In patients with generalized myasthenia gravis prescribed azithromycin, rapid tapering of prednisone is beneficial and safe compared to slow tapering
10 Feb, 2021 | 01:32h | UTC
Commentary on Twitter
Rapid tapering of high-dose #prednisone therapy in patients with moderate to severe generalized #myastheniagravis on azathioprine appears to be well tolerated and associated with good outcome https://t.co/1nHZuy8kPN
— JAMA Neurology (@JAMANeuro) February 8, 2021
Canadians Win Again – Syncope Score Systematic Review
9 Feb, 2021 | 01:03h | UTCCanadians Win Again – Syncope Score Systematic Review – Journal Feed
See calculator: Canadian Syncope Risk Score – MdCalc
Prospective validation of Canadian TIA Score for subsequent stroke risk after transient ischemic attack
7 Feb, 2021 | 20:54h | UTCSee calculator: Canadian TIA Score
Commentary on Twitter
Jeff Perry is at it again! The ABCD2 score lacks the ability to discriminate low and high risk patients following TIA, so Perry et al. have validated the Canadian TIA Score.
Infographic and bedside calculator: https://t.co/OcbaK1aG3t
Full publication: https://t.co/wt87PKzNkO pic.twitter.com/q3QdgVxp6x
— EM Ottawa (@emergmedottawa) February 4, 2021
Review: Dysphagia in older adults
5 Feb, 2021 | 01:22h | UTCDysphagia in Older Adults – Mayo Clinic Proceedings
USPSTF recommends against screening for asymptomatic carotid artery stenosis in the general adult population
3 Feb, 2021 | 01:29h | UTCEditorials: Screening for Asymptomatic Carotid Artery Stenosis: Lack of Clinical Benefit, Potential for Harm – JAMA AND Screening for Asymptomatic Carotid Artery Stenosis in Adult Patients: Unclear Benefit but Downstream Risks – JAMA Internal Medicine AND USPSTF Recommendations for Screening for Carotid Stenosis to Prevent Stroke—The Need for More Data – JAMA Network Open
Author interview: USPSTF Recommendation: Carotid Artery Stenosis
JAMA Patient Page: Screening for Carotid Artery Stenosis
Living systematic review on Cannabis and other plant-based treatments for chronic pain
2 Feb, 2021 | 01:01h | UTC
Meta-analysis of longitudinal studies: Frequent or dependent cannabis use in youth linked to decline IQ
2 Feb, 2021 | 01:02h | UTC
fMRI identifies smell and taste malfunction in COVID-19 patients
2 Feb, 2021 | 01:16h | UTCfMRI Identifies Smell and Taste Malfunction in COVID-19 Patients – Clinical Imaging
Commentary on Twitter
Absent BOLD fMRI Activation of Orbitofrontal Cortex in a Patient With Persistent Cacosmia and Cacogeusia After COVID-19 https://t.co/bAa7sf6wNR
— Nat Rev Neurology (@NatRevNeurol) January 25, 2021
Association of dilated perivascular spaces with cognitive decline and incident dementia
1 Feb, 2021 | 01:38h | UTCThe Association of Dilated Perivascular Spaces with Cognitive Decline and Incident Dementia – Neurology (link to abstract – $ for full-text)
Commentaries: Large, Fluid-Filled Spaces Seen on Brain MRI Could Indicate Future Dementia – Diagnostic Imaging AND Perivascular Space Pathology Linked to Dementia in Seniors – HealthDay
Commentary on Twitter
.@GreenJournal: Severe perivascular space pathology in both centrum semiovale and basal ganglia was correlated with a greater risk of #dementia and #cognitive decline, regardless of other small vessel disease markers. #neurology @UNSW https://t.co/pHUhNBGpYw pic.twitter.com/dfaVvrTObx
— Neurology Today (@NeurologyToday) January 28, 2021
Blood test to detect psychogenic nonepileptic seizures shows promise
1 Feb, 2021 | 01:37h | UTCBlood Test to Detect Psychogenic Nonepileptic Seizures Shows Promise – Physician’s Weekly
Original study: Association of Epileptic and Non-epileptic Seizures and Changes in Circulating Plasma Proteins Linked to Neuroinflammation – Neurology (link to abstract – $ for full-text)
Systematic review: Worldwide incidence and prevalence of Neuromyelitis Optica
29 Jan, 2021 | 01:31h | UTCWorldwide Incidence and Prevalence of Neuromyelitis Optica: A Systematic Review – Neurology
Cohort study: Incidence of transient ischemic attack and association with long-term risk of stroke
28 Jan, 2021 | 01:28h | UTCIncidence of Transient Ischemic Attack and Association With Long-term Risk of Stroke – JAMA (free for a limited period)
Commentary: New study provides both good and bad news about transient ischemic attacks – News Medical
Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association
28 Jan, 2021 | 01:23h | UTC
DEVT, SKIP Trials Add Support for Omitting IV tPA Before Stroke Thrombectomy
27 Jan, 2021 | 01:01h | UTCDEVT, SKIP Trials Add Support for Omitting IV tPA Before Stroke Thrombectomy – TCTMD
Original studies and commentaries: Randomized trial: Endovascular treatment alone noninferior to intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke
American Clinical Neurophysiology Society’s Standardized Critical Care EEG Terminology: 2021 Version
25 Jan, 2021 | 01:15h | UTC
Cohort study: Long-term clinical outcomes of hematopoietic stem cell transplantation in 210 patients with multiple sclerosis
25 Jan, 2021 | 01:15h | UTCLong-Term Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis – Neurology (link to abstract – $ for full-text)
Meta-analysis: Clinical presentation, investigation findings, and treatment outcomes of spontaneous intracranial hypotension syndrome
22 Jan, 2021 | 08:12h | UTC
Commentary on Twitter
This meta-analysis offers a comprehensive and objective summary of the evidence on SIH. Spontaneous intracranial hypotension should not be excluded on the basis of a non-orthostatic headache, normal neuroimaging or normal lumbar puncture opening pressure https://t.co/BcVk2ftcs3
— JAMA Neurology (@JAMANeuro) January 4, 2021
Meta-analysis: Prevalence of postural hypotension in primary, community and institutional care
22 Jan, 2021 | 08:09h | UTC
Randomized trial: Oral Rimegepant for preventive treatment of migraine
21 Jan, 2021 | 01:04h | UTCOral rimegepant for preventive treatment of migraine: a phase 2/3, randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary: Rimegepant bests placebo for preventing migraine – MedicalXpress
Against placebo? It would be interesting to know how this new drug works against other established treatments.
Randomized trial: In pediatric acute CNS infections, 3% Hypertonic saline is superior to 20% Mannitol for reducing intracranial pressure
21 Jan, 2021 | 01:08h | UTCRandomized Clinical Trial of 20% Mannitol Versus 3% Hypertonic Saline in Children With Raised Intracranial Pressure Due to Acute CNS Infections – Pediatric Critical Care Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Feature w/#VisualAbstract
RCT of 20% mannitol vs. 3% hypertonic saline in children w/raised ICP due to acute CNS infections: Which is superior?
Rameshkumar, @drarunbansal, Jayashree ??: https://t.co/ZGWaPMhPvr
Editorial by Argent ??: https://t.co/BsbZKsEG03#PedsICU @WFPICCS pic.twitter.com/5asM9HNQaN
— Pediatric Critical Care Medicine (@PedCritCareMed) December 21, 2020
Acute flaccid myelitis: Cause, diagnosis, and management
21 Jan, 2021 | 00:58h | UTCAcute flaccid myelitis: cause, diagnosis, and management – The Lancet (free registration required)
Case series: Portable Magnetic Resonance Imaging for ICU Patients
21 Jan, 2021 | 00:54h | UTCPortable Magnetic Resonance Imaging for ICU Patients – Critical Explorations
Consensus statement: Electrodiagnostic assessment of the autonomic nervous system
21 Jan, 2021 | 00:34h | UTC
Randomized trial: Endovascular treatment alone noninferior to intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke
20 Jan, 2021 | 01:35h | UTCEffect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial – JAMA (free for a limited period)
Related study: Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke: The SKIP Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Intravenous Thrombolysis Before Endovascular Thrombectomy for Acute Ischemic Stroke – JAMA (free for a limited period)
Video: Thrombolysis Before Thrombectomy for Stroke