Systematic review shows there is insufficient evidence on the best approaches to stop long‐term antidepressant use – “Future studies should distinguish carefully between relapse and withdrawal symptoms”

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety disorders in adults – Cochrane Library

Author interview: Stopping long-term antidepressants in people with depression or anxiety – Cochrane Library

Commentary: ‘Urgent’ need for more evidence on safely stopping antidepressants, say experts – Metro

“Future studies should distinguish carefully between relapse and withdrawal symptoms and follow emerging guidance to use taper schemes of many weeks or months (or longer for long-term users) down to very low doses before stopping. Such studies would give us a clearer idea of the ability of antidepressants to prevent relapse.”

Commentary on Twitter (thread – click for more)

Outline of the Cochrane study a bit for those scared of its length. Metro article: https://t.co/3c32xjGJsr Lead author: the dauntless Ellen van Leuween. Co-author @tony_kendrick https://t.co/tt4Lzyacq4 While there are hundreds of studies looking at starting antidepressants(1/n)

— Mark Horowitz (@markhoro) April 22, 2021