Neurology
Systematic review shows there is insufficient evidence on the best approaches to stop long‐term antidepressant use – “Future studies should distinguish carefully between relapse and withdrawal symptoms”
23 Apr, 2021 | 08:19h | UTCAuthor interview: Stopping long-term antidepressants in people with depression or anxiety – Cochrane Library
Commentary: ‘Urgent’ need for more evidence on safely stopping antidepressants, say experts – Metro
“Future studies should distinguish carefully between relapse and withdrawal symptoms and follow emerging guidance to use taper schemes of many weeks or months (or longer for long-term users) down to very low doses before stopping. Such studies would give us a clearer idea of the ability of antidepressants to prevent relapse.”
Commentary on Twitter (thread – click for more)
Outline of the Cochrane study a bit for those scared of its length. Metro article: https://t.co/3c32xjGJsr Lead author: the dauntless Ellen van Leuween. Co-author @tony_kendrick https://t.co/tt4Lzyacq4 While there are hundreds of studies looking at starting antidepressants(1/n)
— Mark Horowitz @markhoro.bsky.social (@markhoro) April 22, 2021
Podcast: Dementia Made Simple
20 Apr, 2021 | 05:21h | UTC#268 Dementia Made Simple with Dr. Josh Uy – The Curbsiders
RCT: No benefit from second intravenous immunoglobulin dose in patients with Guillain-Barré syndrome with poor prognosis
18 Apr, 2021 | 21:21h | UTCSecond intravenous immunoglobulin dose in patients with Guillain-Barré syndrome with poor prognosis (SID-GBS): a double-blind, randomised, placebo-controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
RCT: Comparison of Levetiracetam vs. Zonisamide vs. Lamotrigine for newly diagnosed focal epilepsy shows Lamotrigine should remain the first-line treatment option
12 Apr, 2021 | 00:51h | UTCCommentary: Clinical trials assess best first-line drugs for epilepsy – University of Liverpool
RCT: Comparison of Valproate vs. Levetiracetam for newly diagnosed generalized and unclassifiable epilepsy shows Valproate should remain the first-line treatment option
12 Apr, 2021 | 00:52h | UTCCommentary: Clinical trials assess best first-line drugs for epilepsy – University of Liverpool
AHA/ASA Scientific Statement: Perioperative Neurological Evaluation and Management to Lower the Risk of Acute Stroke in Patients Undergoing Noncardiac, Nonneurological Surgery
12 Apr, 2021 | 00:50h | UTC
Commentary on Twitter
NEW GUIDELINE – now codifies what has been discussed for a while "If history of stroke exists, consider delaying elective surgery at least 6 mo
and preferably 9 mo from time of incident stroke." @SPAQIedu @LeeAFleisher @preopconsult @afedwardMD https://t.co/0ewdlPGVlj— Kurt Pfeifer (@KurtPfeifer) April 9, 2021
Concussion in para sport: the first position statement of the Concussion in Para Sport (CIPS) Group
12 Apr, 2021 | 00:37h | UTC
Commentary on Twitter
The ink is still wet .. fresh out in @BJSM_BMJ. Para athletes suffer concussions too, but specific guidelines for care did not exist .. until now ‼️ Open access ➡️ https://t.co/ld1BENeoho pic.twitter.com/lkwsa8HsKd
— Evert Verhagen (@EvertVerhagen) April 10, 2021
RCT: Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy
9 Apr, 2021 | 03:18h | UTCAuthor Interview: Effect of High-Frequency (10 kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy
Commentary on Twitter
Thrilled to see our publication out today in @JAMANeuro using #SCS to treat #diabetic #pain. 86% of patients with over 50% pain relief at 6 months with better sleep and walking! #progress #needherscience #neuromodulation @UAMSneurosurg @UAMSPain @uamshealth https://t.co/TJQPHsHvSa
— Dr. Erika Petersen (@ErikaPetersenMD) April 5, 2021
NICE Guideline: Assessment and Management of Chronic Pain in Over 16s
8 Apr, 2021 | 08:54h | UTC
Large study finds 1 in 3 Covid-19 survivors have subsequent mental health and neurological conditions
8 Apr, 2021 | 09:14h | UTCCommentaries: 1 in 3 Covid-19 patients are diagnosed with a neuropsychiatric condition in the next six months, large study finds – STAT AND A longer look at COVID-19 and neuropsychiatric outcomes – The Lancet Psychiatry AND Largest study to date suggests link between COVID-19 infection and subsequent mental health and neurological conditions – The Lancet AND Covid-19: One in three has neurological or psychiatric condition diagnosed after covid infection, study finds – The BMJ AND One in three survivors of severe Covid diagnosed with mental health condition – The Guardian AND Covid-19 linked to depression and dementia, study suggests – BBC AND Expert reaction to observational study looking at neurological and psychiatric outcomes 6 months after COVID-19 – Science Media Centre AND 1 in 3 COVID Survivors Struggle With Mental Health Issues Months Later – HealthDay
Commentary on Twitter (thread – click for more)
📍HUGE STUDY—One in 3 #COVID19 survivors received a neurological diagnosis within 6 months of infection—1 in 8 with first ever diagnosis, says study of 230,000 patient records. Also COVID patients had higher risk of dementia, anxiety, Parkinson’s vs flu.🧵https://t.co/BlhtUrOsvL pic.twitter.com/ZAcHZviGKR
— Eric Feigl-Ding (@DrEricDing) April 7, 2021
Cohort study: One in ten have long-term effects 8 months following mild COVID-19
8 Apr, 2021 | 09:12h | UTCOne in ten have long-term effects 8 months following mild COVID-19 – Karolinska Institutet
Original study: Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers – JAMA
Commentary on Twitter
#LongCovid in #Frontline: JAMA
Worrisome! N=323 COVID+ #Healthcare Workers vs. N=1072 w no COVID. At 8 mos, up to 4x risk of fxnl impairment in work, social & home life. REAL ongoing suffering in low-risk humans after #COVID.https://t.co/EwZWdW4ZtL#medtwitter #nurse pic.twitter.com/tofIx4p647— WesElyMD (@WesElyMD) April 7, 2021
Cohort study: Risk of suicide attempt in patients with recent diagnosis of mild cognitive impairment or dementia
7 Apr, 2021 | 01:08h | UTCRisk of Suicide Attempt in Patients With Recent Diagnosis of Mild Cognitive Impairment or Dementia – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries: Recent Diagnosis of Cognitive Impairment, Dementia May Increase Suicide Risk – Psychiatric News Alert AND Suicide Attempts Spike Soon After Dementia Diagnosis – HealthDay
Exceedingly rare side effects reported with AstraZeneca vaccine in the UK – 22 cases of cerebral venous sinus thrombosis with low levels of platelets out of 18 million vaccinated individuals
5 Apr, 2021 | 01:45h | UTCCovid-19: Seven UK blood clot deaths after AstraZeneca vaccine – BBC
Original report: Coronavirus vaccine – weekly summary of Yellow Card reporting – Medicines and Healthcare products Regulatory Agency
Related opinion: Undermining the AstraZeneca jab is a dangerous act of political folly – The Guardian
“Based on current experience, the expected benefits of both COVID-19 vaccines in preventing COVID-19 and its serious complications far outweigh any known side effects”
M-A: Non-drug therapies as good as or better than drugs for treating depression in people with dementia
2 Apr, 2021 | 09:05h | UTCCommentaries: Non-drug therapies as good as or better than drugs for treating depression in people with dementia – The BMJ AND Social prescribing may help reduce symptoms of depression in people with dementia – The BMJ Opinion AND Nondrug Interventions Can Help Alleviate Depression in Dementia Patients – HealthDay
Long Covid in the UK – More than a million affected in February, survey suggests
2 Apr, 2021 | 09:31h | UTCLong Covid: More than a million affected in February, survey suggests – BBC
Commentary on Twitter
YOUNG ADULTS MOST AFFECTED—Long-Covid symptoms are affecting about 1.1 million people in the U.K., with about half that number saying the disease is harming their day-to-day lives, government statistics show. Top #LongCovid age group? 25-34! Thread 🧵 https://t.co/Fwo8Opeqr6
— Eric Feigl-Ding (@DrEricDing) April 1, 2021
Study shows unique diagnostic signatures of concussion in the saliva of Rugby players
31 Mar, 2021 | 03:08h | UTCCommentaries: Concussion in sport: Saliva test is 94% accurate in rugby union trial – BBC AND Rugby study identifies new method to diagnose concussion using saliva – University of Birmingham AND Saliva test boosts efforts to detect concussions in rugby – Associated Press
COVID associated with hearing loss, tinnitus and vertigo – new study confirms link
30 Mar, 2021 | 03:19h | UTCOriginal study: One year on: an updated systematic review of SARS-CoV-2, COVID-19 and audio-vestibular symptoms – International Journal of Audiology
Long term outcomes of participants in the PARAMEDIC2 randomized trial of adrenaline in out-of-hospital cardiac arrest – although survival was improved, adrenalin was not associated with favorable neurologic outcomes
28 Mar, 2021 | 22:21h | UTCCommentary: PARAMEDIC2 – Epinephrine vs Placebo OHCA 6-12 Months – Journal Feed
Original study: Randomized Trial: Epinephrine in Out-of-Hospital Cardiac Arrest (study and commentaries) AND Opinion: Epinephrine Harms/Helps in Out of Hospital Cardiac Arrest
NICE Guideline Update: Cannabis-based medicinal products
28 Mar, 2021 | 22:24h | UTCCannabis-based medicinal products – National Institute for Health and Care Excellence
Choosing Wisely: Five things clinicians and patients should question in Neurological Surgery in Children
28 Mar, 2021 | 22:04h | UTCAmerican Academy of Pediatrics – Section on Neurological Surgery – Choosing Wisely
Commentary: Choosing Wisely: 5 Things to Avoid in Pediatric Neurologic Surgery – NEJM Journal Watch
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
Covid-19: Middle aged women face greater risk of debilitating long term symptoms
28 Mar, 2021 | 22:49h | UTCCovid-19: Middle aged women face greater risk of debilitating long term symptoms – The BMJ
Linked Opinion: The stigma is real for people living with long covid – The BMJ Opinion
How COVID-19 Affects the Brain
28 Mar, 2021 | 22:51h | UTCHow COVID-19 Affects the Brain – JAMA Psychiatry
Commentary on Twitter
#COVID19 brain symptoms are a rising concern. Mechanisms of brain damage by the virus include lasting neuroinflammation, thrombotic events and alteration of neurotransmitters release. Consequently, people suffer cognitive, emotional and behavioral symptoms https://t.co/pTzJo6DLV8
— JAMA Psychiatry (@JAMAPsych) March 26, 2021
Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers”
28 Mar, 2021 | 22:48h | UTCCommentary: 85% of COVID-19 long-haulers have multiple brain-related symptoms – LiveScience AND ‘Brain fog’ and other neurologic symptoms can last for months after Covid – NBC News AND Neurologic Symptoms Persistent for Many COVID-19 ‘Long-Haulers’ – Health Day
RCT: Metoclopramide + diphenhydramine more efficacious than placebo for acute post-traumatic headache in the ED
26 Mar, 2021 | 08:24h | UTCRandomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic Headache – Neurology (link to abstract – $ for full-text)
Commentary: Drug Combo Superior to Placebo for Posttraumatic Headache – HealthDay
RCT: Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc
25 Mar, 2021 | 08:12h | UTC
Commentary on Twitter
NEW RESEARCH—Surgical microdiscectomy and
transforaminal epidural steroid injection are similarly effective at reducing #pain and disability from #sciatica secondary to herniated lumbar disc https://t.co/xXOr1aOX8K #LancetRheumatology #OpenAccess pic.twitter.com/2CHh1YD2gm— The Lancet Rheumatology (@TheLancetRheum) March 19, 2021