Neurology
Selected issues in sport-related concussion for the team physician: a consensus statement – “Current evidence suggests strict rest after SRC slows recovery and increases the probability of prolonged symptoms”.
25 Jun, 2021 | 10:15h | UTCNews release: Strict Rest Slows Recovery after Sports-Related Concussions – American College of Sports Medicine
Cohort study: no association was found between statin therapy and cognitive decline or incident dementia in older adults.
23 Jun, 2021 | 10:14h | UTCCommentaries: Statin Therapy Not Associated With Cognitive Decline, Dementia in Older Adults, Study Says – American College of Cardiology AND Effect of Statins on Cognitive Decline and Dementia in Older Adults – American College of Cardiology
2021 MAGNIMS–CMSC–NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis.
22 Jun, 2021 | 09:58h | UTC2021 MAGNIMS–CMSC–NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis – The Lancet Neurology (free registration required)
Commentary on Twitter
ONLINE FIRST: The 2021 MAGNIMS–CMSC–NAIMS international consensus recommendations on MRI in patients with multiple sclerosis provide updated guidance on how and when to use MRI for diagnosis, prognosis, and treatment monitoring of multiple sclerosishttps://t.co/bLnRo40tgw
— The Lancet Neurology (@TheLancetNeuro) June 15, 2021
Study commentary: a history of hypothermia for cardiac arrest, 2002-2021 (RIP).
18 Jun, 2021 | 08:20h | UTCA history of hypothermia for cardiac arrest, 2002-2021 (RIP) – PulmCrit
Original study: RCT: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not improve outcomes.
Commentary on Twitter
A history of hypothermia for cardiac arrest, 2002-2021 (RIP)🪦
🥶2002 studies supporting hypothermia were weak
🥶robust studies refute benefit (TTM1 & TTM2)
🥶growing evidence of iatrogenic harm
🥶post-arrest hypothermia should be restricted to within RCTshttps://t.co/GZbpgHXWoD pic.twitter.com/ILUAiqqLQl— 𝙟𝙤𝙨𝙝 𝙛𝙖𝙧𝙠𝙖𝙨 💊 (@PulmCrit) June 17, 2021
RCT: Effects of intravenous Eptinezumab vs. placebo on headache pain and most bothersome symptom when initiated during a migraine attack.
18 Jun, 2021 | 08:16h | UTCEffects of Intraven.ous Eptinezumab vs Placebo on Headache Pain and Most Bothersome Symptom When Initiated During a Migraine Attack: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Acute Treatment for Migraine: Contemporary Treatments and Future Directions (free for a limited period)
Commentary: Migraine Prevention Drug Eptinezumab Shows Efficacy in Treating Acute Attacks – Physician’s Weekly
Commentary on Twitter (thread – click for more)
Science marches breathlessly forward – or, at least tries to expand its indication.
Anti–calcitonin gene-related peptide antibody infusion, again, vs. placebo.
— Ryan Radecki, MD MS (@emlitofnote) June 17, 2021
M-A: Acute treatments for episodic migraine in adults.
18 Jun, 2021 | 08:18h | UTCAcute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis – JAMA (free for a limited period)
Editorial: Acute Treatment for Migraine: Contemporary Treatments and Future Directions (free for a limited period)
Commentary on Twitter (thread – click for more)
Science marches breathlessly forward – or, at least tries to expand its indication.
Anti–calcitonin gene-related peptide antibody infusion, again, vs. placebo.
— Ryan Radecki, MD MS (@emlitofnote) June 17, 2021
RCT: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not improve outcomes.
17 Jun, 2021 | 09:39h | UTCNews release: Induced hypothermia after cardiac arrest did not improve survival – Lund University
Infographic: The TTM2 Trial – CanadianEM
Commentary: Hypothermia or Normothermia after Cardiac Arrest – NEJM Resident 360
Video: TTM2 Results Presentation Livestream – Critical Care Reviews
Commentary on Twitter (thread – click for more)
The #TTM2trial was published today in the @NEJM https://t.co/jccLB1MO64
Here’s a summary of what we did, what I think the trial means, and what next.@ttm2trial @nielsen_niklas @CritCareReviews @NEJM— Paul Young (@DogICUma) June 16, 2021
Randomized, sham-controlled pilot study: percutaneous peripheral nerve stimulation (neuromodulation) for postoperative pain.
16 Jun, 2021 | 08:17h | UTCCommentary: Peripheral Nerve Stimulation May Cut Pain After Orthopedic Surgery – HealthDay
Systematic review: Endovascular thrombectomy and intra‐arterial interventions for acute ischemic stroke – “In individuals with acute ischemic stroke due to large artery occlusion in the anterior circulation, endovascular thrombectomy can increase the chance of survival with a good functional outcome”.
15 Jun, 2021 | 08:56h | UTCSummary: Endovascular thrombectomy for acute ischaemic stroke – Cochrane Library
M-A: Effectiveness of telerehabilitation in physical therapist practice.
10 Jun, 2021 | 09:29h | UTC
FDA approvement of Alzheimer’s drug sparks controversy among doctors.
9 Jun, 2021 | 08:18h | UTCNews release: FDA Grants Accelerated Approval for Alzheimer’s Drug – U.S. Food & Drug Administration
Commentaries: ICER Issues Statement on the FDA’s Approval of Aducanumab for Alzheimer’s Disease – Institute for Clinical and Economic Review AND Landmark Alzheimer’s Drug Approval Confounds Research Community – Nature AND FDA approves Alzheimer’s drug from Biogen, against experts’ advice – NBC News AND F.D.A. Approves Alzheimer’s Drug Despite Fierce Debate Over Whether It Works – The New York Times (a few articles per month are free) AND Alzheimer’s drug approved despite doubts about effectiveness – Science (a few articles per month are free) AND The FDA Has Approved A New Alzheimer’s Drug — Here’s Why That’s Controversial – NPR AND Opinion: Bad medicine: aducanumab is a lackluster drug with a high price tag – STAT
Short review: Neurological complications of COVID-19.
8 Jun, 2021 | 09:36h | UTCNeurological complications of COVID-19 – Intensive Care Medicine
Commentary on Twitter
NeuroCOVID potential mechanism(s)?
🧠 #COVID19 neuro-complications
🧠 direct neuroinvasion
🧠 inflammatory/autoimmune
🧠 vascular
+
🧠 #ICU complications
🧠 drugs toxicity/side effects
🧠 PICS/PACS & PTSD
Challenging to identify/diagnose: strictly monitor! https://t.co/0YlAoanUFo pic.twitter.com/unM0SWFR7L— Intensive Care Medicine (@yourICM) June 7, 2021
2 new meta-analysis detail neurologic and psychiatric conditions in COVID-19.
6 Jun, 2021 | 23:54h | UTCNeurologic, psychiatric conditions common in COVID-19 – CIDRAP
RCT: Early, intensive mobilization poststroke may harm patients.
6 Jun, 2021 | 23:45h | UTCFatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke – Neurology
M-A: The benefit of dysphagia screening in adult patients with stroke.
6 Jun, 2021 | 23:43h | UTC
RCT: Among patient with recent ischemic stroke without known atrial fibrillation, implantable loop recorder monitoring for 12 months detects more occurrences of AF compared with conventional external loop recorder monitoring for 30 days (15.3% vs. 4.7%) – “further research is needed to compare clinical outcomes associated with these monitoring strategies”.
2 Jun, 2021 | 08:30h | UTCEffect of Implantable vs. Prolonged External Electrocardiographic Monitoring on Atrial Fibrillation Detection in Patients With Ischemic Stroke: The PER DIEM Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Detection of Subclinical Atrial Fibrillation After Stroke: Is There Enough Evidence to Treat? – JAMA (free for a limited period)
Commentary: Implantable device more effective at detecting atrial fibrillation than standard of care – News Medical
RCT: Insertable cardiac monitors used for 12 months detect more atrial fibrillation than usual care in patients with a recent ischemic stroke (12.1% vs. 1.8%) – “further research is needed to understand whether identifying AF in these patients is of clinical importance”.
2 Jun, 2021 | 08:29h | UTCEffect of Long-term Continuous Cardiac Monitoring vs Usual Care on Detection of Atrial Fibrillation in Patients With Stroke Attributed to Large- or Small-Vessel Disease: The STROKE-AF Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Detection of Subclinical Atrial Fibrillation After Stroke: Is There Enough Evidence to Treat? – JAMA (free for a limited period)
Systematic review: Driving performance under treatment of most frequently prescribed drugs for mental disorders – 31% of schizophrenic or schizoaffective patients under antipsychotics, and 18% of unipolar and bipolar patients under antidepressants showed severe impairment in skills relevant for driving.
2 Jun, 2021 | 08:24h | UTC
Observational study suggests ceftriaxone is similarly effective to benzylpenicillin for the treatment of neurosyphilis, potentially decreasing the length of hospital stay (mean 13.8 days vs. 8.9 days).
31 May, 2021 | 08:06h | UTCCeftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Advance Care Planning for people with dementia: recognizing moral dilemmas faced by physicians.
28 May, 2021 | 08:14h | UTC
Study suggests it is safe to discontinue antiseizure medication for most neonates with acute symptomatic seizures prior to discharge from the hospital.
27 May, 2021 | 08:14h | UTCSafety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures – JAMA Neurology (free for a limited period)
Editorial: Discontinuing Antiseizure Medication in Neonates With Acute Symptomatic Seizures—Primum non nocere – JAMA Neurology (free for a limited period)
Commentaries: Stopping Antiseizure Medication After Acute Symptomatic Neonatal Seizures Is Found to Be Safe – Neurology Today AND Babies with Seizures May Be Overmedicated – Michigan Medicine
Commentary on Twitter
New CER study on @JAMANeuro finds no difference in functional neurodevelopment or epilepsy at 24 mnths in children whose antiseizure meds was discont'd vs maintained at discharge after resolution of acute symptomatic neonatal seizures: https://t.co/yvKbrJuCvQ #ebneoalerts #neoEBM pic.twitter.com/810weSUSgb
— Evidence-Based Neo (@EBNEO) May 26, 2021
RCT: Continuous infusion of 20% hypertonic saline does not improve neurological outcomes in patients with traumatic brain injury
26 May, 2021 | 08:22h | UTCEffect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury: The COBI Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Among patients with moderate to severe traumatic brain injury, treatment with continuous infusion of 20% hypertonic saline compared with standard care did not result in a significantly better neurological status at 6 months https://t.co/zyPhO0Y2Yy
— JAMA (@JAMA_current) May 25, 2021
AHA/ASA Guideline: Prevention of stroke in patients with previous stroke and transient ischemic attack – prevention efforts should be based on the cause of the first ischemic event.
25 May, 2021 | 08:43h | UTCNews Release: Risk of second stroke can be reduced with prevention efforts based on cause of first stroke – American Heart Association
RCT: Endovascular therapy for stroke due to basilar-artery occlusion – “endovascular therapy and medical therapy did not differ significantly with respect to a favorable functional outcome”.
24 May, 2021 | 08:27h | UTCEndovascular Therapy for Stroke Due to Basilar-Artery Occlusion – New England Journal of Medicine (link to abstract – $ for full-text)
[Preprint] No safe level of alcohol consumption for brain health: observational cohort study of 25,378 UK Biobank participants.
24 May, 2021 | 08:20h | UTCCommentaries: Drinking any amount of alcohol causes damage to the brain, study finds – CNN AND Expert reaction to a preprint looking at alcohol consumption and brain health – Science Media Centre AND Any amount of alcohol consumption harmful to the brain, finds study – The Guardian