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Neurology

Dementia at younger ages is more prevalent than previously estimated, meta-analysis suggests.

20 Aug, 2021 | 08:53h | UTC

Dementia at Younger Ages More Prevalent Than Previously Estimated, Meta-Analysis Suggests – Psychiatric News Alert

Original study: Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)

 

Opinion: The case against Watchman device for stroke prevention.

19 Aug, 2021 | 08:43h | UTC

The Case Against Watchman for Stroke Prevention – Stop and Think

 

Delirium in critical illness: clinical manifestations, outcomes, and management.

18 Aug, 2021 | 08:47h | UTC

Delirium in critical illness: clinical manifestations, outcomes, and management – Intensive Care Medicine (if this link does not work, try this one)

Related:

M-A: Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients.

ICU Survivorship—The relationship of delirium, sedation, dementia, and acquired weakness.

Systematic review: In hospitalized non‐ICU patients, multicomponent non-pharmacological interventions are estimated to reduce the incidence of delirium by 43% compared to usual care.

 

Commentary on Twitter

 

Dementia risk in former professional footballers is related to player position and career length.

18 Aug, 2021 | 08:39h | UTC

News release: Dementia risk in former professional footballers is related to player position and career length – University of Glasgow

Original study: Association of Field Position and Career Length With Risk of Neurodegenerative Disease in Male Former Professional Soccer Players – JAMA Neurology

Commentaries:

Dementia risk greatest for defenders, says new research – BBC

Soccer (football) given the risk of brain damage, is heading the ball really necessary? – MedicalResearch

 

Commentary on Twitter

 

Professional rugby may be associated with changes in brain structure.

18 Aug, 2021 | 08:38h | UTC

News release: Professional rugby may be associated with changes in brain structure

Original study: White matter abnormalities in active elite adult rugby players – Brain Communications

 

Commentary on Twitter

 

[Preprint] Impact of the COVID-19 pandemic on early child cognitive development: initial findings in a longitudinal observational study of child health.

16 Aug, 2021 | 01:11h | UTC

Impact of the COVID-19 Pandemic on Early Child Cognitive Development: Initial Findings in a Longitudinal Observational Study of Child Health – medRxiv

Commentary: Children born during pandemic have lower IQs, US study finds – Researchers blame lack of stimulation as parents balanced childcare with working from home – The Guardian

 

Commentary on Twitter (thread – click for more)

 

Systematic review: Enteral tube feeding for people with severe dementia – “We found no evidence that tube feeding improves survival; improves quality of life; reduces pain; reduces mortality; decreases behavioural and psychological symptoms of dementia”.

16 Aug, 2021 | 00:54h | UTC

Enteral tube feeding for people with severe dementia – Cochrane Library

Summary: Enteral tube feeding for people with severe dementia – Cochrane Library

Related: Viewpoint: Tube Feeding and Deteriorating Patients (resources on the subject)

 

Commentary on Twitter

 

European guideline and expert statements on the management of narcolepsy in adults and children.

13 Aug, 2021 | 09:02h | UTC

European guideline and expert statements on the management of narcolepsy in adults and children – European Journal of Neurology

 

Randomized phase III trial of prophylactic cranial irradiation with or without hippocampal avoidance for small-cell lung cancer – “This trial provides the first clinical evidence that sparing the hippocampus during PCI in patients with SCLC better preserves cognitive function”.

13 Aug, 2021 | 08:54h | UTC

Randomized Phase III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small-Cell Lung Cancer (PREMER): A GICOR-GOECP-SEOR Study – Journal of Clinical Oncology

 

M-A: More than 50 long-term effects of COVID-19.

11 Aug, 2021 | 08:47h | UTC

More than 50 long-term effects of COVID-19: a systematic review and meta-analysis – Scientific Reports

Related:

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Cohort study: Risk factors for long covid in previously hospitalized children.

Viewpoint: The road to addressing Long Covid.

Review: Long covid—mechanisms, risk factors, and management.

Review: Symptoms, complications and management of long COVID.

Long Covid: fatigue, post-exertional malaise, and cognitive dysfunction are the most common symptoms, according to an international survey.

Studies elucidate poorly understood long COVID.

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Long Covid: 39% of patients report persistent symptoms more than seven months after diagnosis of COVID-19 in an outpatient setting.

[Preprint] Long Covid: Persistent symptoms following SARS-CoV-2 infection in a random community sample of 508,707 people.

Long COVID or post-acute sequelae of COVID-19 (PASC): An overview of biological factors that may contribute to persistent symptoms.

Long Covid: Half of young adults with COVID-19 have persistent symptoms 6 months after, study finds.

[Preprint] Long Covid: Third of people infected have long term symptoms.

Opinion | Causation or confounding: why controls are critical for characterizing long COVID – “Many of the self-reported symptoms, such as intermittent headaches or tiredness, are nonspecific and prevalent in the general population”.

Almost 25% of COVID-19 patients develop long-lasting symptoms, according to a new report.

Perspective | The four most urgent questions about long COVID.

Systematic review: Frequency, signs and symptoms, and criteria adopted for long COVID-19.

Report: 376,000 people in UK have had long Covid symptoms for at least a year.

Systematic review of 45 studies including 9751 participants, most of which were hospitalized, found 73% had at least 1 persistent symptom for weeks after Covid-19.

COVID Morbidity – The emerging burden of long COVID is significant, and needs to be considered when evaluating the risk vs. benefit of pandemic measures.

One year after hospital discharge due to SARS-CoV-2 Infection, the prevalence of long-term cough, chest pain, dyspnea, and fatigue was 2.5%, 6.5%, 23.3%, and 61.2%, respectively

Population-based cohort study: Non-hospitalized COVID-19 patients have low-risk of serious long-term effects, but visits to general practitioners and outpatient hospital visits are increased.

One third of patients hospitalized with COVID-19 have lung changes after a year

Long Covid: Largest post-acute COVID-19 study to date examined the health outcomes in more than 73,000 people who’d had COVID-19 and were not hospitalized

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Perspective | They Tested Negative for Covid. Still, They Have Long Covid Symptoms.

Large study finds 1 in 3 Covid-19 survivors have subsequent mental health and neurological conditions

Cohort study: One in ten have long-term effects 8 months following mild COVID-19

Long Covid Implications for the workplace

Long Covid in the UK – More than a million affected in February, survey suggests

Covid-19: Middle aged women face greater risk of debilitating long term symptoms

Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers”

Opinion | We need to start thinking more critically — and speaking more cautiously — about long Covid

Review | Post-acute COVID-19 syndrome

Long Covid | Four-month clinical status of a cohort of patients after hospitalization for COVID-19

Perspective | Long Covid isn’t as unique as we thought

Attributes and predictors of long COVID

WHO Report: Preparing for Long COVID 2021

Long Covid: Sequelae in adults at 6 Months after COVID-19 infection

How many people get ‘long COVID’ – and who is most at risk?

Long Covid: Respiratory and psychophysical sequelae among patients with COVID-19 four months after hospital discharge

Managing the long term effects of covid-19: summary of NICE, SIGN, and RCGP rapid guideline

Patients, clinicians seek answers to the mystery of ‘Long COVID’

Long Covid: 6-month consequences of COVID-19 in patients discharged from hospital

[Preprint] Characterizing Long COVID in an International Cohort: 7 Months of Symptoms and Their Impact

NICE Guideline: Managing the long-term effects of COVID-19

 

Commentary on Twitter

https://twitter.com/svillapol/status/1425032774793285648

 

New WHO toolkit promotes inclusion of people with dementia in society.

11 Aug, 2021 | 08:31h | UTC

New WHO toolkit promotes inclusion of people with dementia in society – World Health Organization

See Guidance: Towards a dementia inclusive society: WHO toolkit for dementia-friendly initiatives (DFIs) – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

Antibody-mediated autoimmune encephalitis: A practical approach.

8 Aug, 2021 | 23:29h | UTC

Antibody-mediated autoimmune encephalitis: A practical approach – Cleveland Clinic Journal of Medicine

 

Researchers tell doctors to avoid routine urinary tests for older patients with delirium.

6 Aug, 2021 | 09:01h | UTC

Researchers tell doctors to avoid routine urinary tests for older patients with delirium – Johns Hopkins University School of Medicine

Original article: Things We Do for No Reason™: Obtaining Urine Testing in Older Adults With Delirium Without Signs or Symptoms of Urinary Tract Infection – Journal of Hospital Medicine ($)

 

Commentary on Twitter (thread – click for more)

 

Guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy.

5 Aug, 2021 | 08:47h | UTC

European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force—Second revision – European Journal of Neurology

 

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

4 Aug, 2021 | 09:07h | UTC

International Association for the Study of Pain Presidential Task Force on Cannabis and Cannabinoid Analgesia position statement – Pain

See also:

Cannabinoids, cannabis, and cannabis-based medicine for pain management: a systematic review of randomised controlled trials – Pain

General risks of harm with cannabinoids, cannabis, and cannabis-based medicine possibly relevant to patients receiving these for pain management: an overview of systematic reviews – Pain

Commentary:

More evidence needed to back cannabis as pain treatment, says review – Imperial College London

Medicinal cannabis to manage chronic pain? We don’t have evidence it works – The Conversation

Related:

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

 

RCT: Routine treatment with fluoxetine does not reduce the incidence of depression after stroke.

4 Aug, 2021 | 08:56h | UTC

Depression Outcomes Among Patients Treated With Fluoxetine for Stroke Recovery: The AFFINITY Randomized Clinical Trial – JAMA Neurology (free for a limited period)

Editorial: Poststroke Selective Serotonin Reuptake Inhibitors—Do They Work for Anything? (free for a limited period)

Related:

[Abstract Only] Randomized trial: Fluoxetine does not improve functional recovery after acute stroke

Randomized Trial: Effects of Fluoxetine on Functional Outcomes After Acute Stroke

 

RCT: Midodrine can reduce the recurrence of vasovagal syncope.

4 Aug, 2021 | 08:54h | UTC

Midodrine for the Prevention of Vasovagal Syncope: A Randomized Clinical Trial – Annals of Internal Medicine

Commentary: Midodrine Cuts Recurrent Syncope in Young, Healthy Patients – HealthDay

Summary for patients: Summary for Patients: Midodrine to Prevent Fainting – Annals of Internal Medicine

 

Commentary on Twitter

 

RCT: Pimavanserin in dementia-related psychosis.

3 Aug, 2021 | 02:06h | UTC

Trial of Pimavanserin in Dementia-Related Psychosis – New England Journal of Medicine

 

Post-viral effects of COVID-19 in the olfactory system and their implications.

2 Aug, 2021 | 00:24h | UTC

Post-viral effects of COVID-19 in the olfactory system and their implications – The Lancet Neurology

Related:

Study finds 96.1% of patients objectively recovered from anosmia 1 year after COVID-19 diagnosis.

Eight out of ten people hospitalized with COVID-19 develop neurological problems – the most common self-reported symptoms included headache (37%) and anosmia or ageusia (26%).

Loss of smell in mild Covid-19 cases occurs 86% of the time, study says

Management of anosmia and loss of smell in the era of Covid-19

 

Observational study: Positive Fluid balance linked to worse outcomes in critically ill patients with traumatic brain injury.

1 Aug, 2021 | 23:57h | UTC

Fluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI): a prospective, multicentre, comparative effectiveness study – The Lancet Neurology (link to abstract – $ for full-text)

Commentary: Traumatic Brain Injury: Fluid Overload Tied to Higher Mortality in ICU Patients – Physician’s Weekly

 

Commentary on Twitter

 

Study: Patients who have recovered from COVID-19 may have persistent cognitive symptoms.

30 Jul, 2021 | 12:03h | UTC

Cognitive deficits in people who have recovered from COVID-19 – EClinicalMedicine

 

Commentary on Twitter (thread – click for more)

 

Risk of acute myocardial infarction and ischemic stroke following COVID-19 in Sweden – “the true risk is increased by between three and eight times for acute myocardial infarction and by between three and seven times for ischaemic stroke following COVID-19.”

30 Jul, 2021 | 12:06h | UTC

Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study – The Lancet

Invited commentary: What is the association of COVID-19 with heart attacks and strokes? – The Lancet

 

Commentary on Twitter

 

Self-reported memory problems 8 months after COVID-19 infection.

30 Jul, 2021 | 12:02h | UTC

Self-reported Memory Problems 8 Months After COVID-19 Infection – JAMA Network Open

Commentary: Post-acute Sequelae of SARS-CoV-2 Infection and Subjective Memory Problems – JAMA Network Open

 

Commentary on Twitter (thread – click for more)

 

Cohort study: Evidence of a potentially inappropriate and harmful prescribing cascade of gabapentinoid followed by a diuretic among older adults with lower back pain.

29 Jul, 2021 | 11:02h | UTC

Evidence of a gabapentinoid and diuretic prescribing cascade among older adults with lower back pain – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

Related:

Are you the victim of a prescribing cascade?

Study: Evaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults with Hypertension

Prescribing Cascade in a Cardiology Practice

 

Research provides vital insights about excess coffee consumption and brain health.

27 Jul, 2021 | 03:28h | UTC

Commentary: Research provides vital insights about excess coffee consumption and brain health – University of South Australia/ News Medical

Original study: High coffee consumption, brain volume and risk of dementia and stroke – Nutritional Neuroscience (link to abstract – $ for full-text)

 

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