Neurology
RCT: Preemptive intervention may improve developmental outcomes in infants showing early signs of autism.
21 Sep, 2021 | 09:01h | UTCEffect of Preemptive Intervention on Developmental Outcomes Among Infants Showing Early Signs of Autism: A Randomized Clinical Trial of Outcomes to Diagnosis – JAMA Pediatrics (free for a limited period)
Commentaries:
Autism therapy aimed at infants may reduce likelihood of later diagnosis – The Guardian
Commentary on Twitter
An Australian randomized clinical trial found that ‘pre-emptive’ therapy during infancy reduced #autism diagnostic behaviors and improved language ability across early childhood https://t.co/Sybbu4hRWL
— JAMA Pediatrics (@JAMAPediatrics) September 20, 2021
Editorial: Brain health and its social determinants.
19 Sep, 2021 | 23:28h | UTCBrain health and its social determinants – The Lancet
Commentary on Twitter
Strong statement from @TheLancet on social determinants of mental health. The American Psychiatric Association has embraced it, as has @rcpsych https://t.co/JfRcj7KXvq
— Sir Michael Marmot (@MichaelMarmot) September 17, 2021
Systematic Review: Interventional treatments for acute and chronic pain.
17 Sep, 2021 | 10:01h | UTC
AAN Position Statement: Ethical Considerations in Dementia Diagnosis and Care.
17 Sep, 2021 | 10:04h | UTCEthical Considerations in Dementia Diagnosis and Care: AAN Position Statement – Neurology
Case series: Vaccine-induced thrombocytopenia with severe headache may precede cerebral venous sinus thrombosis by several days – patients with severe headache 5 to 20 days after adenovirus vector vaccination against Covid-19 should undergo immediate testing for thrombocytopenia and d-dimer levels and, if available, testing for anti–PF4–heparin IgG antibodies.
16 Sep, 2021 | 10:14h | UTCVaccine-Induced Thrombocytopenia with Severe Headache – New England Journal of Medicine
Commentary on Twitter
Experience with 11 patients suggests that elements of VITT (severe headache, elevated d-dimer levels, and positivity for anti-PF4 antibodies) after ChAdOx1 nCoV-19 vaccination may precede VITT. #Covid19Vaccines #COVID19 #SARSCoV2 #IDTwitter https://t.co/mzBgjJIE6l pic.twitter.com/wGqb1gKFXk
— NEJM (@NEJM) September 15, 2021
People with Parkinson’s may benefit from seven walking strategies.
12 Sep, 2021 | 21:40h | UTCNews release: People with Parkinson’s may benefit from seven walking strategies – American Academy of Neurology
Original study: Perception and Use of Compensation Strategies for Gait Impairment by Persons With Parkinson Disease – Neurology
Commentary: Compensation Strategies Benefit Parkinson Patients With Gait Impairment – HealthDay
Commentary on Twitter (thread – click for more)
In this paper, which was published today in @GreenJournal, we studied the use of compensation strategies for gait impairments in people with Parkinson’s disease. To this aim, we conducted a survey in 4.324 people with PD. https://t.co/Bn4Tn5sYEO
1/4— Jorik Nonnekes (@NonnekesJorik) September 9, 2021
Study suggests mobile stroke units (ambulances with staff and a CT scanner that may enable faster thrombolysis) may improve outcomes for ischemic stroke patients.
12 Sep, 2021 | 21:41h | UTCProspective, Multicenter, Controlled Trial of Mobile Stroke Units – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter (video – click to view)
https://twitter.com/NEJM/status/1436690999426748416
RCT: Limiting screen time for young adults after concussion results in shorter duration of symptoms.
12 Sep, 2021 | 21:38h | UTCOriginal study: Effect of Screen Time on Recovery From Concussion: A Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)
Commentary on Twitter
The use of electronic screen time in the first 48 hours after sustaining a concussion is associated with a longer time to recovery, a single-center randomized-clinical trial reports https://t.co/PFAj5OoqNc
— JAMA Pediatrics (@JAMAPediatrics) September 7, 2021
Guideline: Medical cannabis or cannabinoids for chronic pain.
10 Sep, 2021 | 05:22h | UTCMedical cannabis or cannabinoids for chronic pain: a clinical practice guideline – The BMJ
Editorial: Medical cannabis for chronic pain – The BMJ
Related: Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.” (several resources on the subject)
Commentary on Twitter
A panel of international experts make a weak recommendation for a trial of non-inhaled medical cannabis or cannabinoids for people living with chronic pain, if standard care is not sufficient
Guideline includes a visual summary #BMJInfographic @will_s_t https://t.co/25ML4DZcvz pic.twitter.com/mjbDOyYVLL
— The BMJ (@bmj_latest) September 9, 2021
Secondary Progressive Multiple Sclerosis: New Insights.
10 Sep, 2021 | 05:05h | UTCSecondary Progressive Multiple Sclerosis: New Insights – Neurology
Editorial | Anticholinergic drugs and dementia: time for transparency in the face of uncertainty.
9 Sep, 2021 | 08:57h | UTCSystematic review: Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome – Cochrane Library
Commentary on Twitter
Anticholinergic drugs may double the risk of developing dementia. What should we be doing right now?
Editorial with @JenMStevenson for @CochraneLibrary published todayhttps://t.co/808wSGPUtm— Henry Woodford (@woodford_henry) September 8, 2021
Case series: COVID-19 mRNA vaccination leading to CNS inflammation.
7 Sep, 2021 | 10:49h | UTCCOVID-19 mRNA vaccination leading to CNS inflammation: a case series – Journal of Neurology
Cohort study: Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest.
7 Sep, 2021 | 10:41h | UTC
Commentary on Twitter
Established/novel blood brain injury markers early predict good neuro-outcome/absence of pathological prognostic findings post CA
🧠NSE/S100B may prevent premature WLST
🧠NFL highest predictive capacity
Here visual abstract, full results #FOAMcc @yourICM https://t.co/3klcew33bD pic.twitter.com/1agsFCw6RF— Intensive Care Medicine (@yourICM) September 4, 2021
Tube feeding for people with severe dementia: making decisions.
7 Sep, 2021 | 10:39h | UTCTube feeding for people with severe dementia: making decisions – Evidently Cochrane
Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.
6 Sep, 2021 | 10:45h | UTCInvited commentary: Integrated approach to stroke burden: are we doing enough? (free registration required)
Commentaries on Twitter
Released today! The analysis within @IHME_UW (@GBD) on #stroke #prevalence and the RFs of stroke has just been published in @TheLancetNeuro! The annual number of strokes (12,2 mln) and #deaths (6,5 mln) due to stroke increased substantially in lat 30 yrs. https://t.co/DUi7SYGyjt pic.twitter.com/7rVcrxZzNF
— Maciej Banach (@maciejbanach) September 3, 2021
📣 This new #GBDstudy released on @TheLancet examines the #global, regional, and national burden of #stroke and its risk factors
Findings:
▫️The annual number of strokes ⬆️ from 1990-2019
▫️2nd cause of death globally
▫️High Risk factor = high body-mass https://t.co/jnZauEH79M— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) September 3, 2021
Differentiating central from peripheral causes of acute vertigo in an emergency setting with the HINTS, STANDING, and ABCD2 tests: A diagnostic cohort study.
6 Sep, 2021 | 10:36h | UTCDifferentiating central from peripheral causes of acute vertigo in an emergency setting with the HINTS, STANDING, and ABCD2 tests: A diagnostic cohort study – Academic Emergency Medicine (link to abstract – $ for full-text)
Commentary: Can We Detect Central Vertigo on Exam? – Journal Feed
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management.
1 Sep, 2021 | 09:04h | UTC
#ESCCongress – RCT: In individuals at risk for stroke, screening for atrial fibrillation using loop recorder resulted in a three-times increase in atrial fibrillation detection and anticoagulation initiation but did not reduce the risk of stroke or systemic arterial embolism.
31 Aug, 2021 | 08:50h | UTCNews release: Continuous heart rhythm monitoring and treatment if indicated does not prevent stroke – European Society of Cardiology
#ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.
29 Aug, 2021 | 19:21h | UTCEffect of Salt Substitution on Cardiovascular Events and Death – New England Journal of Medicine (link to abstract – $ for full-text)
News release: Low-sodium salt prevents stroke – European Society of Cardiology
Commentary: Massive SSaSS Study Shows Switch to Salt Substitute Cuts Stroke, CVD – TCTMD
Commentary on Twitter
SSaSS: In RCT that compared salt substitute w/ regular salt, rates of stroke, major CV events, death lower with salt sub. #ESCCongress https://t.co/Yt6vMrYSDh pic.twitter.com/jtymS36zqs
— NEJM (@NEJM) August 29, 2021
#ESCCongress – RCT: Among asymptomatic patients with severe carotid stenosis, carotid surgery and stenting carry similar risks, and the long-term risk of stroke was comparable. There was no medically treated arm in this study.
29 Aug, 2021 | 18:06h | UTC
Commentary on Twitter
#ACST-2 stent CAS 🆚surgery CEA
For asymptotic carotid stenosis >= 60%https://t.co/lyLBn8C8cv
🔺No difference in death 30d MI, stroke 5 yr f/u
🔺Slight ⬆️in minor 30d strokes w Stenting but no QOL change at 6 mo
🔺no medical Rx arm
🔺both arms 1% procedural risk #ESCCongress pic.twitter.com/8ptcrstn0D— Ritu Thamman MD (@iamritu) August 29, 2021
#ESCCongress – RCT: Small benefit from systematic screening for atrial fibrillation in older adults – After a median follow-up of 6.9 y there were fewer events (stroke, embolism, bleeding, and death) in the intervention group (31·9%) vs. control group (33·0%).
29 Aug, 2021 | 18:08h | UTCClinical outcomes in systematic screening for atrial fibrillation (STROKESTOP): a multicentre, parallel group, unmasked, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
News release: Screening for atrial fibrillation could reduce risk of stroke – Karolinska Institutet
A multinational consensus on dysphagia in Parkinson’s disease: screening, diagnosis and prognostic value.
27 Aug, 2021 | 08:51h | UTC
RCT: A single-session of pain management skills intervention was noninferior to 8 sessions of cognitive behavioral therapy in adults with chronic low back pain.
24 Aug, 2021 | 08:39h | UTCCommentaries:
New approach effectively relieves chronic low back pain – Stanford Medicine
Commentary on Twitter
NEW STUDY: Our Empowered Relief trial just published!
A *single-session* pain relief skills class was non-inferior to 8-session CBT for pain & symptom reduction at 3 months post-treatmenthttps://t.co/HYmWNkxUoR via @JAMANetworkOpen part of @JAMANetwork
funded by @NIH_NCCIH
— Beth Darnall, PhD (@BethDarnall) August 16, 2021
Study: Macrolide use significantly associated with both prevalent and incident tinnitus.
22 Aug, 2021 | 22:11h | UTCCommentary: Macrolide Use and Tinnitus: A New Safety Ringtone? – NEJM Journal Watch (free for a limited period)
Treatment escalation vs. immediate initiation of highly effective treatment for patients with relapsing-remitting multiple sclerosis: data from 2 different national strategies.
22 Aug, 2021 | 22:06h | UTCTreatment Escalation vs Immediate Initiation of Highly Effective Treatment for Patients With Relapsing-Remitting Multiple Sclerosis: Data From 2 Different National Strategies – JAMA Neurology (free for a limited period)
Commentary on Twitter
Study suggests that escalation of #multiplesclerosis treatment was inferior to initial treatment with a more effective disease-modifying agent https://t.co/hkHsAXP5se
— JAMA Neurology (@JAMANeuro) August 16, 2021