Neurology
RCT: In patients with chronic migraine and overuse of symptomatic medications, migraine preventive therapy without switching or limiting the frequency of the overused medication was non-inferior to switching to a different symptomatic medication with a maximum limit of two treatment days/week.
25 Mar, 2022 | 08:44h | UTCPatient-Centered Treatment of Chronic Migraine With Medication Overuse: A Prospective, Randomized, Pragmatic Clinical Trial – Neurology (link to abstract – $ for full-text)
Cohort Study: Risk of mental health problems in children and youths following concussion.
25 Mar, 2022 | 08:29h | UTCRisk of Mental Health Problems in Children and Youths Following Concussion – JAMA Network Open
Commentaries:
Concussion Linked to Mental Health Issues Among Children Aged 5 to 18 Years – HealthDay
Associations of alcohol consumption and smoking with disease risk and neurodegeneration in individuals with multiple sclerosis.
25 Mar, 2022 | 08:30h | UTC
RCT: Single-dose Liposomal Amphotericin B treatment for Cryptococcal Meningitis.
24 Mar, 2022 | 09:56h | UTCSingle-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Cryptococcal meningitis is a major complication of HIV infection. Single-dose liposomal amphotericin B combined with flucytosine and fluconazole was noninferior to the WHO-recommended treatment and was associated with fewer adverse events. https://t.co/cg9DqSDhyN pic.twitter.com/SrKx4tDaph
— NEJM (@NEJM) March 23, 2022
Delirium linked to increase in hospital deaths.
24 Mar, 2022 | 08:24h | UTCNews Release: Delirium linked to increase in hospital deaths – University of Edinburgh
Commentary on Twitter
Positive scores on the 4AT delirium assessment tool at hospital admission are linked to mortality, length of stay and home time: two-centre study of 82,770 emergency admissions.
Thank you @emmavardy2 @A_MacLullich @atula_tweets Michael Cheng, Temi Ibitoye https://t.co/bBjBQ3xpTd— Age_and_Ageing (@Age_and_Ageing) March 16, 2022
Review: Restless legs syndrome.
23 Mar, 2022 | 09:57h | UTCRestless legs syndrome – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Infographic: Restless legs syndrome (if the link is paywalled, try this one)
Related: The Management of Restless Legs Syndrome: An Updated Algorithm
Commentary on Twitter
#RestlessLegs syndrome is a sleep-related disorder characterized by an urge to move the legs, often accompanied by #insomnia and involuntary periodic leg movements during resting wakefulness or sleep.#WorldSleepDay https://t.co/qkpZhWIZke pic.twitter.com/yDO3P87KbL
— Nature Reviews Disease Primers (@DiseasePrimers) March 19, 2022
ANN Guideline: Stroke prevention in symptomatic large artery intracranial atherosclerosis practice advisory.
22 Mar, 2022 | 09:51h | UTCNews Release: AAN issues guidance on preventing second stroke in those with plaque in brain arteries – American Academy of Neurology
Evaluation of glial and neuronal blood biomarkers compared with clinical decision rules in assessing the need for computed tomography in patients with mild traumatic brain injury.
22 Mar, 2022 | 08:33h | UTC
Commentary on Twitter
In this prospective cohort of mTBI/concussion patients, CCHR, NOC and blood test GFAP/UCH-L1 were equally sensitive in detecting traumatic intracranial lesions on CT but CCHR had the highest specificity; GFAP combined with CCHR detected lesions best. https://t.co/hYwxg76uu8
— JAMA Network Open (@JAMANetworkOpen) March 14, 2022
Daytime napping and Alzheimer’s dementia: A potential bidirectional relationship.
22 Mar, 2022 | 08:14h | UTCCommentaries:
Long naps may be early sign of Alzheimer’s disease, study shows – The Guardian
Excessive daytime naps may be a sign of early cognitive decline – MedicalResearch
Investigating cognition in midlife.
22 Mar, 2022 | 08:13h | UTCInvestigating cognition in midlife – Alzheimer’s & Dementia
Phase 2 RCT: Repeated intravenous cardiosphere-derived cell therapy in late-stage Duchenne muscular dystrophy.
22 Mar, 2022 | 07:59h | UTC
Commentary on Twitter
In patients with late-stage Duchenne muscular dystrophy, CAP-1002 cell therapy appears safe & effective in reducing deterioration of upper limb & cardiac function, trial suggests. Longer-term extension studies needed.
Explore full findings: https://t.co/bCLtsbuJH3 pic.twitter.com/h7vareAMC7
— The Lancet (@TheLancet) March 21, 2022
Guideline: Management of chronic low back, osteoarthritic, and neuropathic pain in primary care.
21 Mar, 2022 | 10:02h | UTC
Large sleep database from the UK Biobank reveals a landscape of human sleep phenotypes.
21 Mar, 2022 | 08:41h | UTCCommentary: Half a million nights’ sleep reveal 16 kinds of snoozer – Nature
Study on traumatic brain injury highlights global inequality in causes and treatment.
18 Mar, 2022 | 09:37h | UTCNews Release: Largest ever study on traumatic brain injury highlights global inequality in causes and treatment – University of Cambridge
Study finds no increased risk of rare neurological events after covid vaccination.
18 Mar, 2022 | 09:31h | UTCNews Release: Study finds no increased risk of rare neurological events after covid vaccination – BMJ Newsroom
Editorial: The neurological safety of covid-19 vaccines
State of the Art Review: Recent advances in the diagnosis and management of cluster headache.
17 Mar, 2022 | 09:21h | UTCRecent advances in the diagnosis and management of cluster headache – The BMJ
Neurocognitive impairment in night and shift workers: a meta-analysis of observational studies.
17 Mar, 2022 | 08:13h | UTCNeurocognitive impairment in night and shift workers: a meta-analysis of observational studies – Occupational & Environmental Medicine (link to abstract – $ for full-text)
News Release: Shift work linked to poorer working memory and slower mental processing speed – BMJ Newsroom
Commentary: Shift Work Linked to Decreased Cognitive Performance – HealthDay
Review: Role of imaging in rare COVID-19 vaccine multiorgan complications.
16 Mar, 2022 | 10:00h | UTCRole of imaging in rare COVID-19 vaccine multiorgan complications – Insights into Imaging
Cohort Study: Risk factors associated with mortality and neurologic disability after intracerebral hemorrhage in a racially and ethnically diverse cohort.
16 Mar, 2022 | 09:45h | UTCInvited Commentary: The Never-Ending Quest of Intracerebral Hemorrhage Outcome Prognostication – JAMA Network Open
Commentary on Twitter
Large, multi-ethnic cohort study finds outcomes for patients with intracerebral hemorrhage (ICH) are associated with pre-ICH functional status (modified Rankin Scale) and infection while hospitalized. https://t.co/rfpgjUenUq
— JAMA Network Open (@JAMANetworkOpen) March 15, 2022
Electroencephalography in delirium assessment: a scoping review.
16 Mar, 2022 | 08:31h | UTCElectroencephalography in delirium assessment: a scoping review – BMC Neurology
Clinical practice guidelines for pain, agitation, delirium, immobility, and sleep disturbance in the intensive care unit.
15 Mar, 2022 | 08:45h | UTC
Cohort Study: Evaluating rates of recurrent ischemic stroke among young adults with embolic stroke of undetermined source.
15 Mar, 2022 | 08:33h | UTCEvaluating Rates of Recurrent Ischemic Stroke Among Young Adults With Embolic Stroke of Undetermined Source: The Young ESUS Longitudinal Cohort Study – JAMA Neurology (free for a limited period)
Commentary: Embolic Stroke of Undetermined Source in the Young: Low Recurrence, but Few Answers — Growing evidence that role of atrial fibrillation is less important than originally believed – MedPage Today (free registration required)
Commentary on Twitter
Study found relatively low rate of subsequent ischemic stroke and new onset #AF in young patients with ESUS compared to older patients. History of stroke/TIA, diabetes, and coronary artery disease were predictive of recurrence. https://t.co/mzTgMkVFGN @PereraKanjana
— JAMA Neurology (@JAMANeuro) March 14, 2022
Review: Diagnosis and management of postural orthostatic tachycardia syndrome.
15 Mar, 2022 | 08:26h | UTC
Cohort Study: History of neurological or psychiatric conditions increases the likelihood of developing more.
15 Mar, 2022 | 08:08h | UTCNews Release: History of neurological or psychiatric conditions increases the likelihood of developing more – University of Waterloo
Original Study: Incidence of neurological and psychiatric comorbidity over time: a population-based cohort study in Ontario, Canada – Age and Ageing (link to abstract – $ for full-text)
Review: Post-acute COVID-19 syndrome.
14 Mar, 2022 | 01:34h | UTCPost-acute COVID-19 syndrome – European Respiratory Journal
Related:
ESCMID rapid guidelines for assessment and management of long COVID.
ERS statement on Long COVID-19 follow-up.
Proposed subtypes of long-Covid and their respective potential therapies.
EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.
Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.
Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.
Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.
WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).
Characterizing long COVID: a living systematic review.
Long Covid – The illness narratives.
New guidelines to help doctors manage long COVID patients published.
M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)