Neurology
Cohort Study | Premenopausal bilateral oophorectomy linked to increased risk of Parkinsonism and Parkinson Disease.
11 Nov, 2022 | 12:56h | UTCNews Release: Removal of Both Ovaries in Younger Women Associated with Increased Risk of Parkinson’s – Discovery’s Edge
WHO Report | A blueprint for dementia research.
10 Nov, 2022 | 14:17h | UTCA blueprint for dementia research – World Health Organization
News Release: Launch of WHO’s first blueprint for dementia research – World Health Organization
Commentary on Twitter (thread – click for more)
#Dementia is one of the greatest health challenges of our generation. By the end of this decade, 7⃣8⃣ million people will be living with dementia.
WHO's 🆕 blueprint for dementia research sets much needed guidelines to drive innovation to beat dementia ⬇️
— World Health Organization (WHO) (@WHO) October 4, 2022
Associations between social connections and cognition: a global collaborative individual participant data meta-analysis.
10 Nov, 2022 | 13:44h | UTCNews Release: Living with others and community engagement are keys to reduced dementia risk – University of New South Wales
Commentary on Twitter (thread – click for more)
Our paper on associations between social health and cognitive decline led by @samtani_suraj in the SHARED consortium https://t.co/nZ9JKSY8Pg is now out in Lancet Healthy Longev followed by a brilliant commentary by Dr. Adam Roth at @OkStateSocio https://t.co/QVbG4IG4u3
— Anna Marseglia (@anna_marseglia_) October 21, 2022
Review | New horizons in the ageing autonomic nervous system: orthostatic hypotension and supine hypertension.
10 Nov, 2022 | 13:37h | UTC
RCT | Chronic remote ischemic conditioning is not beneficial for patients with symptomatic intracranial atherosclerotic stenosis.
9 Nov, 2022 | 12:18h | UTCChronic remote ischaemic conditioning in patients with symptomatic intracranial atherosclerotic stenosis (the RICA trial): a multicentre, randomised, double-blind sham-controlled trial in China – The Lancet Neurology (link to abstract – $ for full-text)
RCT | Precuneus magnetic stimulation for Alzheimer’s disease.
8 Nov, 2022 | 12:12h | UTCPrecuneus magnetic stimulation for Alzheimer’s disease: a randomized, sham-controlled trial – Brain
Commentary: Novel Approach to TMS May Slow Cognitive Decline in Alzheimer’s – Medscape (free registration required)
Commentary on Twitter
In a randomized, double-blind, phase II trial, Koch et al. find that 24 weeks of repetitive transcranial magnetic stimulation of the precuneus slows down cognitive and functional decline in patients with Alzheimer’s disease. https://t.co/jODfVG3GAJ pic.twitter.com/p9ncGTfS7J
— Brain (@Brain1878) October 27, 2022
Cohort Study | Association of obesity with disease outcome in multiple sclerosis.
8 Nov, 2022 | 12:07h | UTCNews Release: Obesity at MS diagnosis linked to higher current and subsequent levels of disability – BMJ
Commentary: Obesity Linked to Greater Disability, Poorer Outcomes in MS – HealthDay
Updated systematic review on cannabis and other plant-based treatments for chronic pain.
7 Nov, 2022 | 12:39h | UTCRelated:
Systematic Review: Cannabis-based products for chronic pain.
Podcast: #338 LIVE! Medical Cannabis: Is it still dope? – The Curbsiders
M-A: Birth outcomes of neonates exposed to marijuana in utero.
Cannabis-related allergies: an international overview and consensus recommendations.
Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.
Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.
Guideline: Medical cannabis or cannabinoids for chronic pain.
NICE Guideline: Cannabis-Based Medicinal Products
Short Review: Drug Interactions with Cannabinoids
Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain
Review: Considerations for cannabinoids in perioperative care by anesthesiologists.
Review: Cannabis-based Medicines and the Perioperative Physician
Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know
M-A | Association of intraventricular fibrinolysis with clinical outcomes in intracerebral hemorrhage.
7 Nov, 2022 | 12:31h | UTCAssociation of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis – Stroke (free for a limited period)
Commentary on Twitter
#STROKE #IntraventricularFibrinolysis is associated with better functional outcomes and reduced mortality in #ICH patients with #IVH, with treatment effect linked to an early time window <48h #MetaAnalysis https://t.co/hRQJ9w5ppv @WendyZiai @GuidoFalconeMD @sheth_kevin pic.twitter.com/INeDIIHCBw
— Stroke AHA/ASA (@StrokeAHA_ASA) September 30, 2022
M-A | Blood pressure lowering and prevention of dementia.
4 Nov, 2022 | 13:46h | UTCNews Release: Best evidence yet that lowering blood pressure can prevent dementia – George Institute for Global Health
Commentary: Meta-Analysis Shows Decrease in Dementia Risk With HTN Treatment – HealthDay
Cohort Study | Moderate to heavy drinking is linked to an increased risk of hemorrhagic stroke in young adults.
4 Nov, 2022 | 13:36h | UTCCumulative Alcohol Consumption Burden and the Risk of Stroke in Young Adults: A Nationwide Population-Based Study – Neurology (link to abstract – $ for full-text)
Commentaries:
Moderate-to-Heavy Drinking Linked to Stroke Risk in Young Adults – HealthDay
Moderate to heavy drinking could increase the risk of stroke in young adults – News Medical
RCT | Computerized games vs. crosswords training in mild cognitive impairment.
4 Nov, 2022 | 13:34h | UTCComputerized Games versus Crosswords Training in Mild Cognitive Impairment – NEJM Evidence
News Release: Crossword puzzles beat computer video games in slowing memory loss – Columbia University Irving Medical Center
Cohort Study | Association of Taxane type with chemotherapy-induced peripheral neuropathy in patients with breast cancer.
4 Nov, 2022 | 13:15h | UTC
RCT | Intensive BP control after thrombectomy for ischemic stroke is associated with increased risk of poor functional outcomes.
2 Nov, 2022 | 14:26h | UTCIntensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter (thread – click for more)
1/ A #MorningPaper from @TheLancet on #Stroke. This large study randomised 821 patients into aggressive BP management (sBP <120mmHg) vs 140-180mmHg. Trial stopped early due to safety concerns. @neuro_at_ic @e1v1m1 @SomaBanerjee73 @StrokeImperialhttps://t.co/vnvnnI1KLq
— Kevin Tsang (@drtintin99) October 29, 2022
Post-trial follow-up | Endarterectomy vs. stenting vs. best medical treatment for asymptomatic carotid artery stenosis.
2 Nov, 2022 | 14:25h | UTCCarotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
Commentary on Twitter
5 year results of SPACE 2 in @TheLancetNeuro show low event rates in all groups. With best medical therapy only 3.1%, CEA+BMT 2.5%, CAS+BMT 4.4%. Study underpowered for firm conclusions. @CREST2_Study will have close to 2500 pts@ESOstroke @WorldStrokeOrg https://t.co/nUE0WxWidk
— Seemant Chaturvedi (@ChaturvediNeuro) September 17, 2022
Phase 2/3 RCT | Zavegepant nasal spray for the acute treatment of migraine.
1 Nov, 2022 | 12:01h | UTC
Asymptomatic carotid artery stenosis: a summary of current state of evidence for revascularization and emerging high-risk features.
1 Nov, 2022 | 11:46h | UTCRelated:
Commentary on Twitter
Latest in #carotid– https://t.co/ugL2tGBoLn – Woo Kim H et al. compile the evidence surrounding high-risk clinical and imaging features of #asymptomatic carotids that might identify higher-risk lesions. @s_hyunwookim pic.twitter.com/3E8P0EWRRl
— JNIS (@JNIS_BMJ) September 14, 2022
Cohort Study | Clinical diagnosis and magnetic resonance imaging in patients with transient and minor neurological symptoms.
31 Oct, 2022 | 13:31h | UTC
Commentary on Twitter
Clinical Diagnosis and Magnetic Resonance Imaging in Patients With Transient and Minor Neurological Symptoms: A Prospective Cohort Study https://t.co/8S9zWuBRYe @mattreed73 @edinburghstroke @EdinUniBrainSci @bleedingstroke @emerge_research @strokeblokeFAST @EdinUniNeuroImg pic.twitter.com/5wjWZS8YwH
— Stroke AHA/ASA (@StrokeAHA_ASA) August 9, 2022
RCT | Haloperidol for the treatment of delirium in ICU patients did not significantly improve outcomes.
28 Oct, 2022 | 13:29h | UTCHaloperidol for the Treatment of Delirium in ICU Patients – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In this randomized trial, treatment with haloperidol did not increase the number of days alive and out of the hospital among ICU patients with delirium. #LIVES2022 https://t.co/SCRUg3ff9X pic.twitter.com/0dInueHE76
— NEJM (@NEJM) October 26, 2022
Case-control study | Alcohol intake as a risk factor for acute stroke.
27 Oct, 2022 | 12:26h | UTCAlcohol Intake as a Risk Factor for Acute Stroke: The INTERSTROKE Study – Neurology (PDF)
Commentary on Twitter
In this study, high and moderate alcohol intake were associated with increased odds of stroke, while low intake was not associated with #stroke. However, there were important regional variations. Read the full article: https://t.co/lrczN0KBmD #NeuroTwitter pic.twitter.com/95QXuwczEA
— Neurology Journal (@GreenJournal) October 19, 2022
Cohort study | MRI visible perivascular spaces and risk of incident dementia.
27 Oct, 2022 | 12:25h | UTC
Commentary on Twitter
This study investigates the association between MRI-visible perivascular space burden and the risk of incident #dementia. https://t.co/TsuZqtQhFp #Neurology #NeuroTwitter pic.twitter.com/mpvthiqznp
— Neurology Journal (@GreenJournal) October 9, 2022
RCT | Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery.
26 Oct, 2022 | 14:34h | UTC
Review | Smartphone apps in stroke management.
26 Oct, 2022 | 14:31h | UTCSmartphone App in Stroke Management: A Narrative Updated Review – Journal of Stroke
Commentary: Stroke Management: There’s an App for That – Medscape (free registration required)
M-A | Non-affective psychotic disorders and risk of dementia.
26 Oct, 2022 | 14:30h | UTCCommentaries:
Psychotic Disorders May Raise Risk for Later Dementia – HealthDay
Phase 2 RCT | Immunoglobulin has no corticosteroid-sparing effects in Myasthenia Gravis.
26 Oct, 2022 | 14:25h | UTC