Neurology
RCT | Strength training of the nonhemiplegic side promotes motor function recovery in patients with stroke
13 Jan, 2023 | 13:05h | UTC
Cohort Study | Association of early progression independent of relapse activity with long-term disability after a first demyelinating event in MS
12 Jan, 2023 | 13:09h | UTC
Commentary on Twitter
Study suggests that presenting with progression independent of relapse activity (PIRA) after a first demyelinating event in multiple sclerosis is an unfavorable long-term prognosis, especially if it occurs early in the disease course. https://t.co/Mao0Wf8GXI
— JAMA Neurology (@JAMANeuro) December 19, 2022
RCT | Tenecteplase does not improve outcomes in patients with wake-up stroke assessed by non-contrast CT
12 Jan, 2023 | 13:08h | UTCSafety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial – The Lancet Neurology (free for a limited period)
Commentary on Twitter
Here's the result from the TWIST trial, link is available for reading in the Lancet Neurology for 50 days.
Spoiler alert: 0,25 mg/kg, max 25 mg tenecteplase does not improve outcome in wake-up stroke (selected with non-contrast CT of the brain).https://t.co/eCDINM0a1k— Erik Lundström (@lundstrom_erik) December 20, 2022
Acute kidney injury-associated delirium: a review of clinical and pathophysiological mechanisms
12 Jan, 2023 | 12:50h | UTC
Review | The outcome of neurorehabilitation efficacy and management of traumatic brain injury
12 Jan, 2023 | 12:46h | UTC
Nonconvulsive status epilepticus following cardiac arrest: overlooked, untreated and misjudged
12 Jan, 2023 | 12:43h | UTC
Podcast | Delirium in the hospital
11 Jan, 2023 | 14:12h | UTC#375 Delirium in the Hospital featuring Dr. Esther Oh – The Curbsiders
M-A | Association of hearing aids and cochlear implants with cognitive decline and dementia
10 Jan, 2023 | 14:43h | UTCAssociation of Hearing Aids and Cochlear Implants With Cognitive Decline and Dementia: A Systematic Review and Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)
Commentary: Review Links Hearing Aid Devices With Reduced Cognitive Decline – HealthDay
Related: Dementia and hearing-aid use: a two-way street – Age and Ageing
Dementia and hearing-aid use: a two-way street
10 Jan, 2023 | 14:42h | UTCDementia and hearing-aid use: a two-way street – Age and Ageing
Related: Association of Hearing Aids and Cochlear Implants With Cognitive Decline and Dementia: A Systematic Review and Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)
Consensus Paper | Antipsychotic medication deprescribing among adult patients with critical illness
10 Jan, 2023 | 14:37h | UTC
Commentary on Twitter
#CritCareExplore @SCCM Prescribing recommendations in ICU patients: limit antipsychotics to those with hyperactive delirium, at risk of harm to self/others or w/ care impacts. @n_jaworska@kiramakuk@KarlaKrewulak@dan_niven@lisa_burry@geetamehta0 @kmfiest https://t.co/73GUvrfJls pic.twitter.com/TbjbnGxD8Y
— Critical Care Explorations (@CritCareExplore) December 4, 2022
M-A | Physical exercise for people with Parkinson’s disease
10 Jan, 2023 | 14:35h | UTC
Scientists tie third clinical trial death to experimental Alzheimer’s drug
9 Jan, 2023 | 14:47h | UTCScientists tie third clinical trial death to experimental Alzheimer’s drug – Science
Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.
M-A | Vestibular suppressants do not reduce symptoms in patients with benign paroxysmal positional vertigo.
16 Dec, 2022 | 13:18h | UTCVestibular suppressants for benign paroxysmal positional vertigo: A systematic review and meta-analysis of randomized controlled trials – Academic Emergency Medicine (link to abstract – $ for full-text)
RCT | Mindfulness training and exercise did not improve cognitive function in older adults.
15 Dec, 2022 | 13:48h | UTCEffects of Mindfulness Training and Exercise on Cognitive Function in Older Adults: A Randomized Clinical Trial – JAMA (free for a limited period)
See also: Visual Abstract
News Release: Exercise, mindfulness don’t appear to boost cognitive function in older adults – Washington University School of Medicine
RCT | Safety and efficacy of continuous subcutaneous foslevodopa-foscarbidopa in patients with advanced Parkinson’s disease.
15 Dec, 2022 | 13:38h | UTCSafety and efficacy of continuous subcutaneous foslevodopa-foscarbidopa in patients with advanced Parkinson’s disease: a randomised, double-blind, active-controlled, phase 3 trial – The Lancet Neurology (link to abstract – $ for full-text)
Commentary on Twitter
In a phase 3, randomised controlled trial, Michael Soileau and colleagues aimed to assess the safety and efficacy of a soluble formulation of levodopa and carbidopa in patients with advanced Parkinson's disease. Read the results at: https://t.co/9G8S01juSC pic.twitter.com/0SG0oTe8na
— The Lancet Neurology (@TheLancetNeuro) November 17, 2022
Review | Management of chronic migraine.
15 Dec, 2022 | 13:41h | UTCManagement of chronic migraine – The BMJ
Review | Management of psychiatric and cognitive complications in Parkinson’s disease.
15 Dec, 2022 | 13:39h | UTCManagement of psychiatric and cognitive complications in Parkinson’s disease – The BMJ
Pictorial Review | Nerve entrapment syndromes of the upper limb.
15 Dec, 2022 | 13:25h | UTCNerve entrapment syndromes of the upper limb: a pictorial review – Insights into Imaging
Cohort Study | Prenatal carbamazepine exposure and academic performance in adolescents.
13 Dec, 2022 | 14:22h | UTCPrenatal Carbamazepine Exposure and Academic Performance in Adolescents: A Population-Based Cohort Study – Neurology (link to abstract – $ for full-text)
Consensus Paper | Standardized treatment pathway algorithm for lumbar spinal stenosis.
13 Dec, 2022 | 14:25h | UTC
Case-control study | Association of psychosocial stress with risk of acute stroke.
12 Dec, 2022 | 12:30h | UTCAssociation of Psychosocial Stress With Risk of Acute Stroke – JAMA Network Open
Commentary: Increased Risk of Stroke Linked to Stress at Home, Work – Psychiatric News Alert
M-A | Evaluation of direct oral anticoagulant reversal agents in intracranial hemorrhage.
9 Dec, 2022 | 13:17h | UTC
Commentary on Twitter
Meta-analysis finds mostly successful DOAC reversal with 4F-PCC (77%), andexanet alfa (AA)(75%), and idarucizumab (82%) in patients with ICH. 4F-PCC and AA had comparable success in factor Xa inhibitor reversal, mortality, and thromboembolic outcomes. #OA https://t.co/aieJd9h5jo
— JAMA Network Open (@JAMANetworkOpen) November 4, 2022
Cohort Study | Comparative safety of antiseizure medication monotherapy in pregnancy for major malformations.
9 Dec, 2022 | 13:10h | UTCComparative safety of antiseizure medication monotherapy for major malformations – Annals of Neurology (link to abstract – $ for full-text)
Related:
Risks of 23 Specific Malformations Associated with Prenatal Exposure to 10 Antiepileptic Drugs
Research: Topiramate Use Early in Pregnancy and the Risk of Oral Clefts
Educational attainment of children born to mothers with epilepsy – Journal of Neurology, Neurosurgery, and Psychiatry (link to abstract – $ for full-text)
Acute ischemic stroke: recent advances in reperfusion treatment.
8 Dec, 2022 | 13:05h | UTCAcute ischaemic stroke: recent advances in reperfusion treatment – European Heart Journal
RCT | Iron chelation with Deferiprone fails to improve outcomes in Parkinson’s Disease.
6 Dec, 2022 | 13:46h | UTCTrial of Deferiprone in Parkinson’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Deferiprone Not Beneficial for Newly Diagnosed Parkinson Disease – HealthDay
Commentary on Twitter
Iron deposition in the substantia nigra has been implicated in Parkinson’s disease. Chelation with deferiprone reduced brain iron content but led to worse scores on scales of the movement disorder at 36 weeks. https://t.co/aXYCzAt2JM pic.twitter.com/Lw07VK5ZJX
— NEJM (@NEJM) December 3, 2022