RCT | Tenecteplase does not improve outcomes in patients with wake-up stroke assessed by non-contrast CT

Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial – The Lancet Neurology (free for a limited period)

Commentary on Twitter

Here's the result from the TWIST trial, link is available for reading in the Lancet Neurology for 50 days.
Spoiler alert: 0,25 mg/kg, max 25 mg tenecteplase does not improve outcome in wake-up stroke (selected with non-contrast CT of the brain).https://t.co/eCDINM0a1k

— Erik Lundström (@lundstrom_erik) December 20, 2022