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Internal Medicine

Editorial – SARS-CoV2 Vaccines: Slow is Fast

25 May, 2020 | 01:54h | UTC

SARS-CoV2 vaccines: Slow is fast – Science

 


Promising Early Results with New Vaccine from China in Phase I Trial

25 May, 2020 | 01:57h | UTC

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial – The Lancet

Commentaries: First human trial of COVID-19 vaccine finds it is safe and induces rapid immune response – The Lancet AND Early Study Of Covid-19 Vaccine Developed In China Sees Mixed Results – Forbes AND Coronavirus Vaccine Shows Promising Early Results in China – The New York Times AND A Chinese biotech just published the first human data for its coronavirus vaccine candidate, supporting further trials – Business Insider AND Experts skeptical after researchers report positive vaccine results – CNN AND Two COVID-19 Vaccine Candidates Induce Immune Response In Healthy Volunteers – Health Policy Watch

 


Study: 10 of 60 Patients Treated for COVID-19 Persisted with Positive RT-PCR Results from 4 to 24 Days After Hospital Discharge

25 May, 2020 | 01:50h | UTC

Coronavirus Disease 2019 Test Results After Clinical Recovery and Hospital Discharge Among Patients in China – JAMA Network Open

Commentaries: Expert reaction to study on PCR testing results from 60 people after clinical recovery from COVID-19 – Science Media Centre AND 16% of recovered patients test positive for COVID-19 weeks after discharge: study – UPI

 


Meta-Analysis: Corticosteroids May Reduce Mortality for Patients with COVID-19 and ARDS

25 May, 2020 | 01:45h | UTC

Efficacy and safety of corticosteroids in COVID-19 based on evidence for COVID-19, other coronavirus infections, influenza, community-acquired pneumonia and acute respiratory distress syndrome: a systematic review and meta-analysis – Canadian Medical Association Journal

Related: Early Short Course Corticosteroids in Hospitalized Patients with COVID-19 – Clinical Infectious Diseases

 


Clinical Guidance: Thromboembolism and Anticoagulant Therapy During the COVID-19 Pandemic

25 May, 2020 | 01:43h | UTC

Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum – Journal of Thrombosis and Thrombolysis

Related: Coagulation abnormalities and thrombosis in patients with COVID-19 – The Lancet AND COVID-19 and its implications for thrombosis and anticoagulation – Blood AND Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 Infection: A Consensus Statement before Guidelines – Thrombosis and Haemostasis AND Thrombosis and COVID-19: FAQs For Current Practice – American College of Cardiology

 


Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach

25 May, 2020 | 01:42h | UTC

Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach – Annals of Internal Medicine

 


[Abstract Only] Randomized Trial: Haloperidol Effective for the Treatment of Headache in the Emergency Department

25 May, 2020 | 01:33h | UTC

Treatment of Headache in the Emergency Department: Haloperidol in the Acute Setting (THE-HA Study): A Randomized Clinical Trial – The Journal of Emergency Medicine

 


Cohort Study: Prognostic Factors Associated with Adverse Outcomes Among Patients with Covid-19

25 May, 2020 | 01:35h | UTC

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study – The BMJ

Related Study: Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study – The BMJ

Editorial: Covid-19 care before, during, and beyond the hospital

Commentary: Age, male sex, obesity, and underlying illness risk factors for severe COVID-19 or death – The BMJ

 


Cohort Study: Fluconazole Use in the First Trimester of Pregnancy Linked to Increased Risk of Musculoskeletal Malformations

25 May, 2020 | 01:31h | UTC

Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study – The BMJ

Commentary: Musculoskeletal Malformations Up With Fluconazole in Pregnancy – Physician’s Weekly

 


Choosing Wisely in the COVID-19 Era: Preventing Harm to Healthcare Workers

22 May, 2020 | 04:58h | UTC

Choosing Wisely in the COVID-19 Era: Preventing Harm to Healthcare Workers – Journal of Hospital Medicine

 


Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

22 May, 2020 | 04:59h | UTC

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 – New England Journal of Medicine

Commentary: Lungs of deceased COVID-19 patients show distinctive features – Brigham and Women’s Hospital

Related: Postmortem Examination of Patients With COVID-19 – JAMA AND Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series – Annals of Internal Medicine AND Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19 – Journal of Thrombosis and Haemostasis

 


How Coronavirus Lockdowns Stopped Flu in its Tracks

22 May, 2020 | 04:53h | UTC

How coronavirus lockdowns stopped flu in its tracks – Nature

“Reported rates of influenza and other infections have fallen sharply, but some communicable diseases may see a rise.”

 


15 Drugs Being Tested to Treat COVID-19 and How They Would Work

22 May, 2020 | 04:52h | UTC

15 drugs being tested to treat COVID-19 and how they would work – Nature

 


[Preprint] IL6 Inhibition in Critically Ill COVID-19 Patients is Associated with Increased Secondary Infections

22 May, 2020 | 04:44h | UTC

IL6 inhibition in critically ill COVID-19 patients is associated with increased secondary infections – medRxiv

 


Opinion: Revisiting the No Visitors Policy

22 May, 2020 | 04:43h | UTC

Revisiting the No Visitors Policy – CMAJ Blogs

“I follow the policy, as I must, but neither my heart nor my mind believe that the harm we aim to prevent with current no visitors edicts outweighs the harm we are causing.”

 


Wide Complex Tachycardia Differentiation: A Reappraisal of the State‐of‐the‐Art

22 May, 2020 | 04:38h | UTC

Wide Complex Tachycardia Differentiation: A Reappraisal of the State‐of‐the‐Art – Journal of the American Heart Association

 


Observational Study Suggests Possible Benefit from Early Short Course Corticosteroids in Hospitalized Patients with COVID-19

21 May, 2020 | 09:23h | UTC

Early Short Course Corticosteroids in Hospitalized Patients with COVID-19 – Clinical Infectious Diseases

Related: Study Commentary: Before/after Study of Short-Course Steroid in COVID-19

 


Olfactory Dysfunction in COVID-19: Diagnosis and Management

21 May, 2020 | 09:24h | UTC

Olfactory Dysfunction in COVID-19: Diagnosis and Management – JAMA

Related: Loss of smell and taste as symptoms of COVID-19: what does the evidence say? – CEBM Oxford

 


Characteristics and Outcomes of Patients Hospitalized for COVID-19 and Cardiac Disease

21 May, 2020 | 09:18h | UTC

Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy – European Heart Journal

Commentary: Outcomes of Patients Hospitalized for COVID-19 and Cardiac Disease – American College of Cardiology

 


Cardiovascular Considerations in Treating Patients with COVID-19

21 May, 2020 | 09:16h | UTC

Cardiovascular Considerations in Treating Patients With Coronavirus Disease 2019 (COVID-19) – Journal of Cardiovascular Pharmacology

Related: Association of Cardiovascular Disease With Coronavirus Disease 2019 (COVID-19) Severity: A Meta-Analysis – Current Problems in Cardiology AND Cardiology After COVID-19: Physicians Predict Lasting Change – TCTMD

See also: COVID-19: Updates for Cardiologists

 


Rate of Diagnostic Errors and Related Harms for Major Vascular Events, Infections, and Cancers

21 May, 2020 | 09:14h | UTC

Rate of diagnostic errors and serious misdiagnosis-related harms for major vascular events, infections, and cancers: toward a national incidence estimate using the “Big Three” – Diagnosis

Commentary: Misdiagnoses Common, With Permanent Disability, Death for Many – Medscape (free registration required)

 


Neurologic Complications of COVID-19

21 May, 2020 | 09:15h | UTC

Neurologic complications of COVID-19 – American Journal of Emergency Medicine

Related: Neurologic Features in Severe SARS-CoV-2 Infection – New England Journal of Medicine AND Neurologic Manifestations Common in Hospitalized Patients with Covid-19 (study and commentaries) AND Scoping review of prevalence of neurologic comorbidities in patients hospitalized for COVID-19 – Neurology

 


[No Publication Available] Covid-19 Patients Testing Positive After Recovery Aren’t Infectious

20 May, 2020 | 10:00h | UTC

Covid Patients Testing Positive After Recovery Aren’t Infectious, Study Shows – Bloomberg

See also: People who recover from coronavirus and test positive again are NOT contagious: Korean CDC finds ‘re-positive’ patients did not infect any of their 790 contacts – Daily Mail

 


Why Saliva Tests Could Offer a Better Alternative to Nasal COVID-19 Swabs

20 May, 2020 | 09:58h | UTC

Keep your nose out of it: why saliva tests could offer a better alternative to nasal COVID-19 swabs – The Conversation

Original Article: Saliva—Friend and Foe in the COVID-19 Outbreak – Diagnostics

Related Study: Saliva sample as a non-invasive specimen for the diagnosis of coronavirus disease-2019 (COVID-19): a cross-sectional study – Clinical Microbiology and Infection

 


Editorial: Lack of Efficacy of Hydroxychloroquine in Covid-19

20 May, 2020 | 10:01h | UTC

Lack of efficacy of hydroxychloroquine in covid-19 – The BMJ

Original Research: Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial – The BMJ

Related Meta-analysis (preprint) Hydroxychloroquine in COVID-19: A systematic review and meta-analysis – medRxiv

 


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