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Internal Medicine

Meta-analysis: Prophylactic macrolides beneficial for patients with COPD with frequent exacerbations

17 Jan, 2021 | 22:09h | UTC

Prophylactic antibiotics for adults with chronic obstructive pulmonary disease: a network meta‐analysis – Cochrane Library

Summary: Prophylactic antibiotics for people with COPD – Cochrane Library

 

Meta-analysis of observational studies: Proton pump inhibitors linked to increased risk for recurrent Clostridioides difficile infection

17 Jan, 2021 | 22:00h | UTC

Proton pump inhibitor use and risk for recurrent Clostridioides difficile infection: A systematic review & meta-analysis – Clinical Microbiology and Infection

 

Cardiovascular complications of opioid use: JACC state-of-the-art review

17 Jan, 2021 | 22:04h | UTC

Cardiovascular Complications of Opioid Use: JACC State-of-the-Art Review – Journal of the American College of Cardiology

 

Randomized trial: In patients hospitalized with community-acquired pneumonia, adjunctive oral dexamethasone reduced the length of stay and ICU admissions, with no difference in mortality rates

17 Jan, 2021 | 21:58h | UTC

Adjunctive treatment with oral dexamethasone in non-ICU patients hospitalised with community-acquired pneumonia: A randomised clinical trial – European Respiratory Journal (link to abstract – $ for full-text)

 

Consensus statement: Diagnosis, treatment, and follow-up of heart failure patients by general practitioners

17 Jan, 2021 | 21:48h | UTC

Diagnosis, treatment, and follow-up of heart failure patients by general practitioners: A Delphi consensus statement – PLOS One

 

Review: Gastroesophageal reflux disease

17 Jan, 2021 | 21:52h | UTC

Gastroesophageal Reflux Disease: A Review – JAMA (free for a limited period)

 

Long-term safety of fecal microbiota transplantation for recurrent Clostridioides difficile infection

17 Jan, 2021 | 21:50h | UTC

Long-term Safety of Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection – Gastroenterology (link to abstract – $ for full-text)

Commentary: Fecal Transplants Safe Long Term for Recurrent C. Diff — But new-onset conditions post-fecal microbiota transplantation need further study – MedPage Today (free registration required)

 

Observational study: Among patients hospitalized with Covid-19 not receiving mechanical ventilation, transfusion of plasma with higher anti–SARS-CoV-2 IgG antibody levels is linked to lower risk of death than transfusion of plasma with lower antibody levels

15 Jan, 2021 | 08:59h | UTC

Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19 – New England Journal of Medicine

Editorial: (A Little) Clarity on Convalescent Plasma for Covid-19 – New England Journal of Medicine

Commentaries: Expert reaction to study looking at convalescent plasma antibody levels and risk of death from COVID-19 – Science Media Centre AND Antibody-rich convalescent plasma may lower risk of COVID death – CIDRAP

 

Opinion: RCTs don’t justify using convalescent plasma or antibody cocktails

15 Jan, 2021 | 08:58h | UTC

RCTs don’t justify using convalescent plasma or antibody cocktails – PulmCrit

 

[Preprint] Past COVID-19 infection provides some immunity but people may still carry and transmit virus

15 Jan, 2021 | 09:02h | UTC

Past COVID-19 infection provides some immunity but people may still carry and transmit virus – Public Health England

See also: Covid-19: Past infection provides 83% protection for five months but may not stop transmission, study finds – The BMJ AND COVID reinfections are unusual — but could still help the virus to spread – Nature AND COVID-19 infection gives some immunity, but virus can still be spread, study finds – Reuters AND Expert reaction to a preprint from the SIREN study looking at SARS-CoV-2 infection rates in antibody positive healthcare workers – Science Media Centre

 

Perspective: Ivermectin for COVID-19 — Breakthrough Treatment or Hydroxychloroquine Redux?

15 Jan, 2021 | 08:51h | UTC

Ivermectin for COVID-19 — Breakthrough Treatment or Hydroxychloroquine Redux? – HIV and ID Observations

Related video: Ivermectin For COVID-19 | A Doctor Explains – ZDoggMD

 

NIH Guideline Statement: “there are insufficient data to recommend either for or against the use of ivermectin for the treatment of COVID-19”

15 Jan, 2021 | 08:53h | UTC

The COVID-19 Treatment Guidelines Panel’s Statement on the Use of Ivermectin for the Treatment of COVID-19 – National Institutes of Health

 

Covid-19 Vaccine — Frequently Asked Questions

15 Jan, 2021 | 08:49h | UTC

Covid-19 Vaccine — Frequently Asked Questions – New England Journal of Medicine

 

Meta-analysis of randomized trials: patients adhering to a low carbohydrate diet for six months may experience remission of diabetes without adverse consequences

15 Jan, 2021 | 08:43h | UTC

Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: systematic review and meta-analysis of published and unpublished randomized trial data – The BMJ

Commentary: Short term low carbohydrate diet linked to remission of type 2 diabetes – The BMJ

 

 

Meta-analysis of randomized trials: SGLT-2 inhibitors and GLP-1 receptor agonists reduce cardiovascular and renal outcomes in type 2 diabetes

15 Jan, 2021 | 08:41h | UTC

Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials – The BMJ

Calculator based on the results: interactive decision support tool for outcomes

 

Cohort study: Even small amounts of alcohol consumption linked to increased risk of atrial fibrillation

15 Jan, 2021 | 08:40h | UTC

Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes – European Heart Journal

Editorial: Alcohol consumption, atrial fibrillation, and cardiovascular disease: finding the right balance

Commentary: One small alcoholic drink a day is linked to an increased risk of atrial fibrillation – European Society of Cardiology

 

Clinical trial finds vitamin D does not ward off colds and flu

15 Jan, 2021 | 08:33h | UTC

Clinical trial finds vitamin D does not ward off colds and flu – QIMR Berghofer Medical Research Institute

Original study: The effect of vitamin D supplementation on acute respiratory tract infection in older Australian adults: an analysis of data from the D-Health Trial – The Lancet Diabetes & Endocrinology

 

Study: Pulmonary embolism detected in 6% of patients with COPD admitted to the hospital with acute worsening of respiratory symptoms

15 Jan, 2021 | 08:37h | UTC

Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms – JAMA (link to abstract – $ for full-text)

 

Cohort study: Piperacillin/tazobactam linked to increased risk of acute kidney injury when compared to cefepime or meropenem

15 Jan, 2021 | 08:24h | UTC

Risk of acute kidney injury and Clostridioides difficile infection with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin – Clinical Infectious Diseases

 

Commentary on Twitter

 

Meta-analysis: Saliva vs. nasopharyngeal swabs equally sensitive for Covid-19 diagnosis

14 Jan, 2021 | 02:13h | UTC

The Sensitivity and Costs of Testing for SARS-CoV-2 Infection With Saliva Versus Nasopharyngeal Swabs: A Systematic Review and Meta-analysis – Annals of Internal Medicine

Commentary: Saliva, Nasopharyngeal Samples Equally Sensitive for SARS-CoV-2 – Physician’s Weekly

 

Commentary on Twitter

https://twitter.com/EricTopol/status/1348758183846703104

 

Pragmatic Recommendations for the Management of COVID-19 in Low- and Middle-Income Countries

14 Jan, 2021 | 02:04h | UTC

 

No ICU beds? Expect double the number of Covid-19 deaths

14 Jan, 2021 | 02:05h | UTC

No ICU beds? Expect double the number of Covid-19 deaths. – Vox

 

Study estimates 50% of new SARS-CoV-2 infections have originated from exposure to asymptomatic or pre-symptomatic individuals

14 Jan, 2021 | 02:08h | UTC

SARS-CoV-2 Transmission From People Without COVID-19 Symptoms – JAMA Network Open

Commentary: At least 50% of COVID-19 cases spread from people without symptoms, a new study found – Business Insider AND More than half of Covid-19 infections acquired from asymptomatic carriers – MedicalResearch

 

Commentary on Twitter

https://twitter.com/TennantRuth/status/1348208811039985665

 

Study: Despite recommendations, less than 2 percent of patients with treatment-resistant hypertension were tested for primary aldosteronism in a large U.S. cohort

14 Jan, 2021 | 01:55h | UTC

Testing for Primary Aldosteronism and Mineralocorticoid Receptor Antagonist Use Among U.S. Veterans: A Retrospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Primary Aldosteronism Testing Rare in Treatment-Resistant HTN – HealthDay AND Primary Aldosteronism Testing Rare for Patients with Resistant Hypertension – NEJM Journal Watch

 

Commentary from the author on Twitter (thread – click for more)

 

Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin

14 Jan, 2021 | 01:57h | UTC

Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis: The APPAC II Randomized Clinical Trial – JAMA

Editorial: Evolving Issues in the Use of Antibiotics for the Treatment of Uncomplicated Appendicitis

Commentary: More Support for Single-Drug Antibiotics for Uncomplicated Appendicitis – Physician’s Weekly

 

Commentary on Twitter

 

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